scholarly journals Plantas medicinales como alternativa terapéutica para el trastorno Depresivo Mayor (DMD)

2021 ◽  
Vol 13 (2) ◽  
pp. e5646
Author(s):  
Thallysson Jose Dourado De Sousa ◽  
Pedro Henrique Almeida De Faria ◽  
Kassyo Lenno Sousa Dantas ◽  
Monick Nielly Miranda Pinto ◽  
Gabriella de Assis Malerba ◽  
...  
Keyword(s):  
Depressive Disorders ◽  
Herbal Medicines ◽  
Antidepressant Activity ◽  
Synaptic Cleft ◽  
Mechanisms Of Action ◽  
Adjunctive Treatment ◽  
Easy Access ◽  
Transporter Protein ◽  
Treatment Of Depression ◽  
Serotonin Transporter Protein

Objective: To review the antidepressant activity and mechanisms of action of plants that have antidepressant action. Literature Review: The use of plants for medicinal purposes has been used as an adjunct to the treatment of depression due to easy access by the population, few side effects and lower cost. Based on the studies, the plants St. John's wort, ground turmeric, anona and lavender have antidepressant potential for acting in different ways in depression, either by inhibiting the reuptake of serotonin or by modulation in the dopaminergic and serotonergic pathways. Final Considerations: From the studies of the mechanisms of action it was found that the plants studied can modulate the brain signaling pathways responsible for the patient's mood, with the reuptake of serotonin (inhibition of the serotonin transporter protein) the main mechanism of action shared between them. In addition, some of these plants can modulate not only the concentrations of serotonin in the synaptic cleft, but also dopamine. It is worth mentioning that, although these actions have been scientifically proven, much research is still needed to ensure the safe use of these agents as herbal medicines in the alternative or adjunctive treatment of depressive disorders. 

The paradox of tianeptine

1993 ◽  
Vol 8 (S2) ◽  
pp. 89s-93s ◽  
Author(s):  
M Ansseau
Keyword(s):  
Chronic Conditions ◽  
Depressive Disorders ◽  
Antidepressant Activity ◽  
Synaptic Cleft ◽  
Human Platelets ◽  
Mechanisms Of Action ◽  
Functional Deficit ◽  
Number Of Patients ◽  
Biochemical Studies ◽  
Antidepressant Efficacy

SummaryThe classical biochemical hypothesis of depression posits a functional deficit in central neurotransmitter systems, particularly serotonin (5-HT) and/or noradrenaline. The major support for this theory was that antidepressants increase the amount of neurotransmitters in the synaptic cleft, by inhibiting reuptake mechanisms (tricyclics) or inhibiting enzymatic catabolism (MAOIs). The major role suggested for 5-HT in this theory led to the development of a large number of compounds which selectively inhibit 5-HT reuptake, such as fluvoxamine, fluoxetine, citalopram, sertraline, paroxetine, etc. Numerous clinical studies have demonstrated the antidepressant activity of such types of agents, supporting 5-HT deficit as the main origin of depression. Tianeptine is active in classical animal models of antidepressants. Its antidepressant efficacy has been established in controlled trials involving a large number of patients. Several biochemical studies however demonstrated that tianeptine induces in acute as well as in chronic conditions, a presynaptic increase of 5-HT reuptake, both in animal and human platelets and animal CNS. Therefore, as a 5-HT reuptake enhancer, tianeptine exhibits a mechanism of action totally opposite to 5-HT reuptake blockers such as fluoxetine but, paradoxically, both mechanisms of action are associated with a therapeutic activity in depressive disorders. Several hypotheses to explain these paradoxical findings and different methodologies to test them clinically are proposed.

Prevalence of Self-Medication and Its Factors among University Students in Bandar Abbas City

2018 ◽  
Vol 7 ◽  
Author(s):  
Atefeh Mohammadi
Keyword(s):  
Herbal Medicines ◽  
Target Population ◽  
Easy Access ◽  
Medical Sciences ◽  
Self Medication ◽  
Delay In Diagnosis ◽  
Consumption Culture ◽  
High Prevalence ◽  
The Mean ◽  
Bandar Abbas

Background: Self-medication can lead to the latency of the real severity of disease, delay in diagnosis, a complication of treatment, threatening side effects, and unexpected intoxication. The present research aimed to explore the prevalence of self-medication and its factors among students affiliated to Bandar Abbas universities in 2016. Materials and Methods: This Descriptive Analytic study was performed on 600 students affiliated to the universities in Bandar Abbas; Islamic Azad University, Payam-e-Noor University, and University of Medical Sciences. The sample was selected through a stratified sampling method, and the data were collected by a questionnaire comprised of two parts, demographic information (6 items), and risk factors of self-medication and self-medicated drugs (26 items). SPSS version 19 was used to analyze the data through the required tests. Result: The mean age of the students was 24.11±5.85 years. One hundred and ninety-one subjects (31.8%) were male, and 409 (68.2%) were female. The results revealed the prevalence of self-medication in the target population was 80.2%., the main reasons for self-medication were reported underestimating the disease 461(77.0%), previous experience of the disease 457(76.4%), repeated prescription 441(73.6%), and easy access to drug 423(70.6%). The most prevalent drugs self-medicated by students were acetaminophen, herbal medicines, antibiotics, other drugs, sedatives, and anti-acids, respectively. Conclusion: Considering the high prevalence of self-medication (80.2%) revealed in this research, there is a need for more attentive care for consistent education and drug consumption culture promotion. Specific approaches can help the provision of easy access to medical services in universities.

The epidemiology of psychiatrist-ascertained depression and DSM-III depressive disorders Results from the Eastern Baltimore Mental Health Survey Clinical

1992 ◽  
Vol 22 (3) ◽  
pp. 629-655 ◽  
Author(s):  
A. J. Romanoski ◽  
M. F. Folstein ◽  
G. Nestadt ◽  
R. Chahal ◽  
A. Merchant ◽  
...  
Keyword(s):  
Major Depression ◽  
Life Events ◽  
Depressive Disorders ◽  
Multiple Logistic Regression ◽  
Adverse Life Events ◽  
Future Studies ◽  
Symptom Profiles ◽  
Examination Method ◽  
Treatment Of Depression ◽  
History Of

SynopsisPsychiatrists used a semi-structured Standardized Psychiatric Examination method to examine 810 adults drawn from a probability sample of eastern Baltimore residents in 1981. Of the population, 5·9% was found to be significantly depressed. DSM-III major depression (MD) had a prevalence of 1·1% and ‘non-major depression’ (nMD), our collective term for the other depressive disorder categories in DSM-III, had a prevalence of 3·4%. The two types of depression differed by sex ratio, age-specific prevalence, symptom severity, symptom profiles, and family history of suicide. Analyses using a multiple logistic regression model discerned that both types of depression were influenced by adverse life events, and that nMD was influenced strongly by gender, marital status, and lack of employment outside the home. Neither type of depression was influenced by income, education, or race. This study validates the concept of major depression as a clinical entity. Future studies of the aetiology, mechanism, and treatment of depression should distinguish between these two types of depression.

scholarly journals TA Treatment of Depression. A Simplified Hermeneutic Single-Case Efficacy Design. The Case of “Giovanni”

2019 ◽  
Vol 10 (2) ◽  
pp. 4-31 ◽  
Author(s):  
Mariavittoria Zanchetta ◽  
Laura Farina ◽  
Stefano Morena ◽  
Enrico Benelli
Keyword(s):  
Depressive Disorders ◽  
Depressive Symptomatology ◽  
Single Case ◽  
Case Series ◽  
Evaluation Methodology ◽  
Transactional Analysis ◽  
Major Depressive ◽  
Case Evaluation ◽  
Treatment Of Depression ◽  
Depressive Personality

This study is inspired by previous case series replications of Hermeneutic Single-Case Efficacy Design which aim was to evaluate the effectiveness of a manualized transactional analysis treatment for depressive disorders and depressive personality. We address problems and difficulties emerged in previous case series, such as: spending time in training a group of people to conduct the hermeneutic analysis, organizing the involvement of external judges to give the final adjudication, and dealing with inconsistencies between quantitative and qualitative data. For these reasons, this study suggests a simplified method to conduct the hermeneutic analysis that require one person only, maintaining its validity. Therefore, we integrated hermeneutic design with the pragmatic case evaluation methodology in order to follow pre-defined criteria in analysing qualitative material. Furthermore, we present a way to use the Script System to detect changes in depressive symptomatology and depressive personality. We tested this approach to HSCED in the case of ‘Giovanni, a 17-years old white Italian boy who attended sixteen session of transactional analysis psychotherapy with a white Italian woman specializing in psychotherapy with 2 years of clinical experience. The patient satisfied DSM-5 criteria for moderate major depressive disorder and generalized anxiety disorder.This is the second investigation which has evaluated the effectiveness of Transactional Analysis psychotherapy for depressed adolescents.  

Self-Directed Approaches to the Treatment of Depression

2016 ◽  
pp. 468-477
Author(s):  
Pim Cuijpers ◽  
Annet Kleiboer
Keyword(s):  
Depressive Disorders ◽  
Future Research ◽  
Evidence Based ◽  
Advantages And Disadvantages ◽  
Self Help ◽  
Treatment Of Depression ◽  
High Prevalence ◽  
Evidence Based Treatments ◽  
The Common

This article examines self-directed approaches to the treatment of depression. It first considers some of the reasons why the uptake of mental health services by depressed people is low, despite the high prevalence of depressive disorders and the availability of evidence-based treatments. It then looks at the role of self-management in increasing access to evidence-based treatments for depression. It also defines what self-directed treatments are and goes on to discuss the different types of self-directed therapy, the common components of self-directed interventions for depression, Internet-based interventions for depression, and the advantages and disadvantages of self-directed interventions. Finally, it summarizes the findings from research on self-directed interventions for depression and suggests directions for future research and development in this area. Some titles of self-help books that can be used in self-directed interventions are presented.

scholarly journals Assessing the Evidence of Micronutrients on Depression among Children and Adolescents: An Evidence Gap Map

2020 ◽  
Vol 11 (4) ◽  
pp. 908-927
Author(s):  
Susan C Campisi ◽  
Clare Zasowski ◽  
Shailja Shah ◽  
Ashka Shah ◽  
Glyneva Bradley-Ridout ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Depressive Disorders ◽  
Unipolar Depression ◽  
Eligibility Criteria ◽  
Treatment Of Depression ◽  
Comprehensive Search ◽  
Major Depressive Disorders ◽  
Severity Of Depression ◽  
The Impact

ABSTRACT There is some evidence indicating that nutrition may have the ability to prevent, treat, and/or influence the severity of depression. The aims of this evidence gap map (EGM) are to provide an overview and to determine evidence gaps in the existing research on micronutrients and their impact on depression among children and adolescents. We conducted a comprehensive search in multiple databases of primary and secondary literature assessing the impact of micronutrients on depression-related outcomes such as unipolar depression, major depressive disorders, dysthymia, acute depression, and mood disorders. Abstracts and full-text articles were dual-screened based on predefined eligibility criteria. A total of 30 primary research publications were included in the EGM. About 47% of included studies focused on late adolescents (15–19 y), ∼40% on early adolescents (10–14 y), and ∼13% on children aged 6–9 y. Among the included studies, 8 studies examined a single micronutrient intervention and 22 studies examined micronutrient concentrations (either intake or serum), and their impact on depression. The most frequently studied micronutrients were vitamin D (n = 8), zinc (n = 8), iron (n = 6), folate (n = 7), and vitamin B-12 (n = 5). More longitudinal studies and trials are needed to determine the role of micronutrients in the etiology and treatment of depression among children and adolescents.

scholarly journals The maturing of therapy

2002 ◽  
Vol 180 (3) ◽  
pp. 200-204 ◽  
Author(s):  
Isaac M. Marks
Keyword(s):  
Cost Effectiveness ◽  
Problem Solving ◽  
Needs Assessment ◽  
Depressive Disorders ◽  
Coming Of Age ◽  
Mechanisms Of Action ◽  
Anxiety And Depression ◽  
Cognitive Problem ◽  
Scientific Principles ◽  
Do So

BackgroundPsychiatric therapy needs assessment regarding its maturation as a therapeutic science.AimsJudgement of whether such a science is emerging.MethodFour criteria are used: efficacy; identification of responsible treatment components; knowledge of their mechanisms of action; and elucidation of why they act only in some sufferers.ResultsBrief behavioural, interpersonal, cognitive, problem-solving and other psychotherapies have a mature ability to improve anxiety and depressive disorders reliably and enduringly, often only with instruction from a manual or a computer. Therapy's cost-effectiveness and acceptability deserve more attention. We know little about which treatment components produce improvement, how they do so and why they do not help all sufferers.ConclusionsTherapy is coming of age regarding efficacy for anxiety and depression, but is only a toddler regarding the scientific principles to explain its effects.

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