STATE OF HOMEOSTASIS IN RATS WITH THERMAL SKIN BURNS OBTAINED IN THE MIDDLE PERIOD OF PREGNANCY

2021 ◽  
Vol 19 (4) ◽  
pp. 418-423
Author(s):  
T. V. Kovalchuk-Bolbatun ◽  
◽  
V. V. Zinchuk ◽  
S. M. Smotryn ◽  
I. E. Gulyai ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Thermal Injury ◽  
Total Content ◽  
Modern Medicine ◽  
The Body ◽  
Oxygen Binding ◽  
Pregnant Rats ◽  
White Rats ◽  
Middle Period

Background. In modern medicine, the problem of treating thermal skin burns in pregnant women remains relevant due to insufficient research of pathological processes occurring in the body of a future mother suffering from thermal injury. The aim of the research. To assess the state of homeostasis in rats with thermal skin burns in the middle period of pregnancy. Material and methods. An experimental study was carried out on 36 female outbred white rats weighing 250-350 g, which underwent thermal skin burns in the middle period of pregnancy. The processes of lipid peroxidation and the total content of nitrate / nitrites were studied, the oxygen transport function of the blood and the main biochemical parameters of the blood were assessed. Results. Thermal skin burn in rats in the middle period of pregnancy leads to the development of hypoxia, as judged by the decrease in pO2 and SO2 values, as well as a decrease in the affinity of hemoglobin for oxygen. At the same time, oxidative stress develops, and an increase in the content of nitrate / nitrites is also observed, which reflects the dysfunction of the L-arginine-NO system, causing changes in the oxygen-binding properties of the blood and forming a prooxidant-antioxidant imbalance. Changes in the main biochemical parameters of blood confirm the presence of endogenous intoxication. Conclusions. The revealed violations of homeostasis in pregnant rats with thermal skin burns indicate the important role of oxygen-dependent processes in the pathogenesis of thermal injury, which must be taken into account when developing appropriate measures aimed at eliminating violations in this pathology.

scholarly journals Effect of estrogens and their metabolites genotoxicity on the pathogenesis and progression of estrogen-dependent breast cancer

2019 ◽  
Vol 73 ◽  
pp. 909-919
Author(s):  
Ewa Sawicka ◽  
Arkadiusz Woźniak ◽  
Małgorzata Drąg-Zalesińska ◽  
Agnieszka Piwowar
Keyword(s):  
Mammary Gland ◽  
Hormone Replacement ◽  
Modern Medicine ◽  
The Body ◽  
Mammary Gland Tissue ◽  
Oncological Diseases ◽  
17Β Estradiol ◽  
Estradiol Metabolites ◽  
Genotoxic Action

Oncological diseases, due to the still increasing morbidity and mortality, are one of the main problems of modern medicine. Cancer of the mammary gland is the most common cancer among women around the world, and is the second cause of cancer deaths in this group, immediately after lung cancer. This kind of cancer belongs to an estrogen-dependent cancer, with proven associations with hormonal disorders in the body, occurring especially in the perimenopausal period and among women using hormone replacement therapy, as well as a result of the action of various xenobiotics that may interact with the estrogen receptor. Hormone steroids are widely used in medicine and their side effects are constantly discussed. The role of these compounds and their metabolites in maintaining hormonal balance is well understood, while many studies indicate the possible contribution of these steroids in the progression of the cancer process, especially in mammary gland tissue. Therefore, the genotoxic action of this group of compounds is still studied. Due to the limited number of scientific reports, the aim of this paper was to review and critically analyze data from the literature regarding the participation of estrogens (17β-estradiol) and their metabolites (2-methoxy estradiol, 4-hydroxy estradiol, 16α-hydroxyestrone) in the induction of carcinogenesis in mammary gland, in particular concerning the genotoxic activity of 17β-estradiol metabolites.

scholarly journals THE MAIN EXOGENOUS AND ENDOGENOUS FACTORS THAT CAN AFFECT THE MORPHOFUNCTIONAL CHARACTERISTICS OF THE THYROID GLAND (LITERATURE REVIEW)

2018 ◽  
Vol 22 (4) ◽  
pp. 760-765
Author(s):  
О.І. Tiron
Keyword(s):  
Thyroid Gland ◽  
Thermal Injury ◽  
Environmental Temperature ◽  
Environmental Chemicals ◽  
The Body ◽  
Endogenous Factors ◽  
Temperature Irradiation ◽  
Excessive Consumption ◽  
And Function

Despite the important role of the thyroid gland in regulating the functions of the body, the gland is quite sensitive to the adverse effects of various factors on the body. The purpose of the work is to analyze modern sources of scientific literature devoted to the study of the influence of exo- and endogenous factors on the morpho-functional properties of the thyroid gland. Literary data on the influence on the thyroid gland of various environmental chemicals, insufficient or excessive consumption of iodine and selenium, vitamin D deficiency, exposure to pharmaceuticals, smoking, environmental temperature, irradiation, infections, stress, as well as factors of the internal environment, such as atherosclerosis and pregnancy. There are a small number of modern scientific studies concerning the influence on the structure and function of the thyroid gland consequences of thermal injury of the skin.

scholarly journals The Role of Phlebotomy (Fasd) and Wet Cupping (Hijamat) to Manage Dizziness and Vertigo From the Viewpoint of Persian Medicine

2016 ◽  
Vol 22 (3) ◽  
pp. 369-373 ◽  
Author(s):  
Gholamreza Kordafshari ◽  
Mohammad Reza Shams Ardakani ◽  
Mansoor Keshavarz ◽  
Mohammad Mehdi Esfahani ◽  
Esmaeil Nazem ◽  
...  
Keyword(s):  
Side Effects ◽  
Health System ◽  
Mechanism Of Action ◽  
Economic Burden ◽  
Modern Medicine ◽  
Pharmacological Therapy ◽  
The Body ◽  
Full Control ◽  
Persian Medicine

Dizziness and vertigo are the most common complaints of patients that has a high economic burden on the health system. In modern medicine, treatment for dizziness and vertigo consists of chemical pharmacological therapy. Although these drugs are useful in controlling the disease, their side effects and inefficiency in full control of the disease require the use of complementary medicine in this field. Persian medicine consists of valuable experiences of Persian medicine scholars based on the theory of humors and temperaments. In Persian medicine, 2 types of disease are presented: dizziness ( sadar) and vertigo ( dovar). Persian medicine physicians expressed a different mechanism of action than modern medicine for these diseases. They believed that accumulation of abnormal humors, reeh (normal bloating) or causative pathologic substances, is the basic cause of sadar and dovar and that the most important treatment is cleansing the body, particularly the head from accumulated substances by bloodletting methods.

scholarly journals Нepatoprotective properties of polyphenolic complexes from woodand cellular culture of maackia amurensis

2008 ◽  
Vol 7 (1) ◽  
pp. 51-55
Author(s):  
A. S. Saratikov ◽  
V. S. Chuchalin ◽  
A. V. Rat`kin ◽  
E. V. Rat`kin ◽  
S. A. Fedoreyev ◽  
...  
Keyword(s):  
Survival Rate ◽  
Therapeutic Effect ◽  
Biochemical Parameters ◽  
Therapeutic Efficiency ◽  
Maackia Amurensis ◽  
White Rats ◽  
Cellular Culture

Annot For finding-out of a role of separate groups of polyphenols in realization hepatoprotective properties of maksar we investigate activity of polyphenolic complexes (PPC) from duramen and cellular culture of maakia amur. Experiments are carried out on 40 not purebred white rats with an experimental СCl4-hepatites. Therapeutic efficiency of researched objects estimated on their influence on survival rate of animals, morphological and biochemical parameters of a liver and wheys of blood. In rat's CCl4-hepatitis PPC from duramen and cellular culture of maakia amur reduce the acute toxity of tetrachloromethane, decrease the necrosis of hepatocytes and cellural infiltration of liver's parenchyma, prevent from development of fatty and protein dystrophy of a liver, normalize the activity of amino transferase, ƒ-glutamyltransferase in blood, the concentration of proteins and lipids, stimulate conjugation of bilirubin. The therapeutic effect of PPC of cellular culture is more evident. The hepatoprotective action is caused by a presence of isoflavonoids daidzein, retuzin, genistein, afromozin, formononetin, orobol, tektorigenin, maakiain and medicarpin. PPC from a culture of cells doesn't influence on a level of cholesterol in blood, that apparently is caused by an absence of mono- and dimeric stilbenes in its structure.

Psychosomatic Knowledge and the Role of the Physician: A Sociological View

1974 ◽  
Vol 5 (4) ◽  
pp. 431-442 ◽  
Author(s):  
Bernard J. Bergen
Keyword(s):  
Psychosocial Factors ◽  
Psychosomatic Medicine ◽  
Modern Medicine ◽  
The Body ◽  
Sociological View ◽  
The Way

One of the important tasks for psychosomatic medicine is that of educating clinical specialties outside of Psychiatry to the way in which psychosocial factors are implicated in illness. There is reason to believe that this educative task is more complicated than it appears at first glance. One of the difficulties may lie in a resistance on the part of physicians to integrating psychosocial knowledge into their ongoing activities because of a threat which that information poses to the historical foundation of their role. Following Foucault's study of the origin of modern medicine, this foundation can be said to be grounded in the belief that the truth of the suffering patient is that which reveals itself in the space of the body to the informed gaze of the physician. Psychosocial knowledge confronts the physician with the need to accept coexistent realities of the suffering of illness. As disruptive as educating physicians to this idea of “coexistent realities of illness” may be, it is essentially a task, belonging to psychosomatic medicine, of bringing the physician into the circle of scientific modernity.

scholarly journals ‘Magic coins’ and ‘magic squares’: the discovery of astrological sigils in the Oldenburg Letters

2008 ◽  
Vol 62 (3) ◽  
pp. 271-288 ◽  
Author(s):  
Anna Marie Roos
Keyword(s):  
Seventeenth Century ◽  
Early Modern ◽  
Natural World ◽  
Modern Medicine ◽  
The Body ◽  
Perceived Efficacy ◽  
Magic Squares ◽  
Early Modern Medicine

Enclosed in a 1673 letter to Henry Oldenburg were two drawings of a series of astrological sigils, coins and amulets from the collection of Strasbourg mathematician Julius Reichelt (1637–1719). As portrayals of particular medieval and early modern sigils are relatively rare, this paper will analyse the role of these medals in medieval and early modern medicine, the logic behind their perceived efficacy, and their significance in early modern astrological and cabalistic practice. I shall also demonstrate their change in status in the late seventeenth century from potent magical healing amulets tied to the mysteries of the heavens to objects kept in a cabinet for curiosos. The evolving perception of the purpose of sigils mirrored changing early modern beliefs in the occult influences of the heavens upon the body and the natural world, as well as the growing interests among virtuosi in collecting, numismatics and antiquities.

scholarly journals EFFICACY OF YOGAABHYAS IN THE MANGEMENT OF MADHUMEHA W.S.R TO NIDDM (TYPE 2)

2021 ◽  
Vol 09 (1) ◽  
pp. 239-242
Author(s):  
Bansode Sheetal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lifestyle Modification ◽  
Modern Medicine ◽  
The Body ◽  
Negative Effects ◽  
Increased Risk ◽  
Conscious Control

Ayurveda is the science of living being. It begins with right lifestyle including daily and seasonal health regime designed for each individual based upon their nature, constitution, environment and life circumstances. Madhumeha is the subtype of Prameha. Due to resemblance of the feature of Madhumeha with that of DM explained in modern medicine, it is correlated with DM. According to WHO approximately 220 million people worldwide have type 2 diabetes mellitus. It is widely recognized that stress may have negative effects on health and that patients with type 2 diabetes may be at an increased risk. Yoga is an ancient Indian psychological and physical exercise regime and a number of controlled studies exist on the effectiveness of yoga on diabetes mellitus. Yogic practices strengthen and increase the tone of weak muscles and help with conscious control over autonomic function of the body. So, the present study on the role of Yogaabhyas as a lifestyle modification in Madhumeha. Keywords: Madhumeha, type 2 diabetes, asana in diabetes

scholarly journals Dolichols and proliferating systems.

1994 ◽  
Vol 41 (3) ◽  
pp. 339-344 ◽  
Author(s):  
A Trentalance
Keyword(s):  
Rat Liver ◽  
Total Content ◽  
The Body ◽  
Model Systems ◽  
In Vivo Model ◽  
Dolichyl Phosphate ◽  
Proliferation And Differentiation ◽  
Developing Rat

The results obtained on dolichol metabolism, in two in vivo model systems, the developing rat liver and the regenerating rat liver, which provide different timing and interplay of proliferation and differentiation processes, have been reported. The regenerating liver presents a marked increase of both synthesis and content of dolichol, a decreased cholesterol/dolichol ratio, unchanged synthesis and content of dolichyl phosphate, or dolichol-kinase and dolichyl phosphate-phosphatase activities; no significantly modified distribution of dolichol homologs, with respect to the control. Total content of dolichols is growing during perinatal development. At fetal stages only short chain dolichols are detectable, while the content of dolichyl phosphate is very low and the activity of dolichyl phosphate-phosphatase is high. The study of the role of liver in dolichol supply to the body in the partially hepatectomized rat shows an increased content of dolichol in the blood; blood dolichol is essentially provided by the release from liver and dolichol traffic in the blood is mediated by multiple carriers.

scholarly journals Human Dignity and Rationality of Modern Medicine in the Aspect of the Biomedical Technologies

2021 ◽  
Vol 16 (5) ◽  
pp. 43-49
Author(s):  
Izutkin Dmitri A. ◽  
Keyword(s):  
Human Dignity ◽  
Modern Medicine ◽  
The Body ◽  
Virtual Space ◽  
Experimental Medicine ◽  
Biomedical Technologies ◽  
Technical Model ◽  
The One ◽  
Relationship Of

Some ethical aspects of the usage of the biomedical technologies in the frame of human bodiness and the relationship of the physician and the sick from the point of human dignity are set forth in the article. Growing tendency of rationalization of medicine and broadening limits of its influence on healthy and diseased organism are highlighted. In particular, it is associated with the introduction in medical practice of different elements of the artificial intellect in the diagnostics and treatment of different diseases, which have found its legislative order in the Edict of the President of the Russian Federation. It challenges the necessity of consideration of this problem in the format of ethics and law with the accent on the dignity of the human as an individual and unique personality. Contradictive character of the usage of different biomedical technologies from the point of science, on the one hand, and human existence – on the other are marked. These positions are regarded in the aspects of the human bodiness and relationships of the physician and the sick. The problem of “vulnerability” of the human body is shown on the example of increase of different biomedical investigations, like experimental medicine and its “commodification”. In this respect, judgement about ontological role of the body in life space and human experience is exposed. In the analysis of the relationships of the physician and the sick through the “prism” of the biomedical technologies special attention is being paid to the change of the subject-object roles in this communicative sphere. As a sequence, technical model is starting dominating in modern medicine. All tye abovementioned ideas reflect transformation of historically assembled traditions of medical and ethical character and strengthening of the ideas of transhumanism when the sick individual loses its uniqueness and is being investigated in the virtual space.

scholarly journals Role of Jalaukavcharana in Netraroga

2015 ◽  
Vol 6 (3) ◽  
Author(s):  
Sumedha J Pundge ◽  
Yogesh T Kotangale
Keyword(s):  
Side Effects ◽  
Alternative Therapy ◽  
Modern Medicine ◽  
The Body ◽  
Bioactive Substances ◽  
Bloodletting Therapy ◽  
Ancient Times ◽  
Health Disorders ◽  
Medicinal Leeches

           Rakthamokshana is the procedures of Panchakarma which helps to eliminate vitiated dosha that accumulate in the body. Jalaukavcharana is the types of Rakthamokshana which is practiced globally in India since ancient times. A detailed description on Jalaukavcharana is available in Ayurveda. It is used in management of various diseases in all the systems of the body including ears, nose, throat, eyes and head. Now a day’s Leeches are also used by ophthalmologists to treat inflammatory, traumatic processes and various diseases of eyes. According to Ayurveda, the diseases of eyes were caused due to vitiation of tridoshas. Jalaukavcharana i.e. leech application is a type of bloodletting therapy. It removes some of these toxins and vitiated doshas which are accumulated in the body. Various bioactive substances are present in saliva of leech. Along with that, it also exerts a therapeutic effect in several diseases. Though despised by most, medicinal leeches can be of immense benefit that may help people to surmount numerous health disorders. Jalaukavcharana is very effective ancient method of Panchakarma neglected by physician. There are many side effects of modern medicine. So it is the need to spread awareness about Jalaukavcharana and its efficacy. Thus Jalaukavcharana is the alternative therapy promising more effective and safer outcomes for the society. 

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