The structure of cervical diseases in women suffering from pelvic floor dysfunction

Background. The prevalence of pelvic floor dysfunction (PFD) is soaring steadily. The protrusion of the cervix beyond vaginal opening when exposed to environmental factors can lead to the development of dystrophic, sclerotic and neoplastic processes of the cervix, which are mediated by changes in the pH, biocenosis of the vagina and environmental factors. Aim. To study the pathogenesis of cervical diseases in patients with PFD. Materials and methods. The study design is an open-label prospective observational study. The study included 40 patients of reproductive age: 26 patients with cervical disease with PFD (PFD group), 14 patients without cervical disease and PFD made up the second group. Results. The patients included in the study were comparable in terms of age and body mass index. Pap smear analysis revealed that the average number of leukocytes is significantly higher in patients with PFD compared to patients in the group without PFD 5.5 (1.520.0) and 1.5 (1.56.5) respectively (p=0.040). In PFD group, a high prevalence of the following conditions was observed: cervical leukoplakia (15%), CIN1 (38.5%), CIN2 (8%), chronic cervicitis (38.5%). Onco-cytological test results reviewed where the high prevalence of parakeratosis and hyperkeratosis (15%), ASCUS (15%), LSIL (23%) and HSIL (8%) were also noteworthy. It was observed that human papillomavirus type 16 was predominant in PFD patient group. Conclusion. The data obtained indicates an increased risk of developing cervical diseases in patients with PFD.

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Features of Pap smears in women of reproductive life with papillomavirus 16, 18

Ukrainian journal of Perinatology and Pediatrics ◽

10.15574/pp.2021.86.96 ◽

2021 ◽

pp. 96-97

Author(s):

Shafag Eldar Aliyeva ◽

Keyword(s):

Cervical Cancer ◽

Epithelial Cells ◽

Pap Smear ◽

Reproductive Age ◽

Pap Smears ◽

Pathological Changes ◽

Women Of Reproductive Age ◽

Hpv 16 ◽

Sexually Transmitted ◽

Cervical Disease

Introduction. According to modern data, cervical diseases do not occur by chance. Precancerous lesions vary from person to person and become invasive over time. The need for specific diagnostic methods for early detection of cervical cancer in women of reproductive age always remains relevant. Over the years, numerous diagnostic, cytological and histological studies have been carried out to identify malignant lesions of the cervix. Human papillomavirus (HPV) is a widespread sexually transmitted infection that affects both women and men around the world and plays an important role in the development of cervical disease. It is the most common sexually transmitted virus in the United States of America. For the first time in 1942, Papanicolaou emphasized the possibility of using smears (PAP smears) from the cervix and from the vagina to diagnose cervical disease. PAP preparations of smears are mainly multilayered flat epithelial cells of the ectocervix and vagina, endocervical cylindrical cells, including mononuclear and polynuclear inflammatory cells that enter the vagina through diapedesis from the surface of the epithelial layer, mixing with the mucoid fluid produced by the endocervical epithelial fluid. Purpose — using objective criteria for cytological examination to identify neoplastic changes in the cervix. Materials and methods. The study included 100 women of reproductive age (18–45 years old) during 2015–2020. Of these, 20 were in the control group (group I — control) and 80 — in the high-risk group for cervical cancer (group II — the main group). Group II women were also divided into 2 subgroups: II A — with pathology of the cervix (n=41), II B — without pathology of the cervix (n=39). The study included patients with a positive result on HPV 16/18 including patients whose PAP smears revealed intracellular damage. Pap smears were included in the study according to the following criteria. The smears contained a sufficient number of squamous epithelial cells and their integrity was preserved. Endocervical cells were monitored in all PAP smears. The examination was carried out with at least 5 cells in each, not completely, and with 2 clusters of endocervical glandular or squamous metaplastic cells. Squamous epithelial cells covered at least 10% of the preparation. Bloody, technically artifactic preparations without clinical data have not been studied. The deficit rate did not exceed 3%, and high interest rates on artifacts were not included in the study. Despite the small number of cells in the presence of abnormal cells, this was unequivocally considered sufficient. Results. Interpretation of PAP smear results identified n=35 ASCUS patients, n=24 LSIL, n=21 HSIL patients in the PAP smear positive reproductive age group. HPV serotypes 16.18 were found in 24 of these patients. In women of the II B subgroup, no pathological changes in the cervix were observed. Conclusions. In women of reproductive age with positive HPV 16, 18, for the diagnosis of precancerous diseases of the cervix, taking pap smears is an integral part of the study. As a result of the study, it was revealed that, despite the absence of a clinical picture, pathological changes at the cell level are detected. Key words: HPV16, 18, ASCUS, LSIL, HSIL, PAP.

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Do women of reproductive age presenting with pelvic floor dysfunction have undisclosed anal incontinence: A retrospective cohort study

Women and Birth ◽

10.1016/j.wombi.2016.05.009 ◽

2017 ◽

Vol 30 (1) ◽

pp. 18-22 ◽

Cited By ~ 3

Author(s):

Julie Tucker ◽

Luke Grzeskowiak ◽

Elizabeth Mary Ann Murphy ◽

Anne Wilson ◽

Vicki L. Clifton

Keyword(s):

Cohort Study ◽

Pelvic Floor ◽

Anal Incontinence ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Pelvic Floor Dysfunction ◽

Reproductive Age ◽

Women Of Reproductive Age

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GENETIC MARKERS OF IMMUNE RESPONSE DISORDERS IN WOMEN OF REPRODUCTIVE AGE WITH ACUTE PYELONEPHRITIS

Nephrology (Saint-Petersburg) ◽

10.24884/1561-6274-2018-22-5-39-44 ◽

2018 ◽

Vol 22 (5) ◽

pp. 39-44

Author(s):

E. S. Krutikov ◽

O. Yu. Shurigina ◽

L. E. Sorokina ◽

A. I. Gordiyenko ◽

K. D. Malyj

Keyword(s):

Acute Pyelonephritis ◽

Reproductive Age ◽

Genetic Diagnostics ◽

Control Group ◽

Women Of Reproductive Age ◽

Infectious Process ◽

Increased Risk ◽

High Prevalence ◽

Tlr4 Gene ◽

Genetically Determined

Acute pyelonephritis (AP) is an inflammatory and infectious process that occurs due to immunological disorders, occurring mostly in the calyx-pelvic renal system and the tubulointerstitial zone. Pyelonephritis more often occurs in women of reproductive age.THE AIM:to study genetically determined changes in the Toll-like receptor 4, mutations in the genes of interleukin 1β, interleukin 6 in women of reproductive age with acute pyelonephritis.PATIENTS AND METHODS: The study included 26 women with acute pyelonephritis. Control group consisted of 27 practically healthy women comparable ages and without infections of kidneys and urinary tract in anamnsis. The presence of polymorphism of T (-31) C genes IL-1β, C (-174) G IL-6 and Arg299Gly TLR4 was revealed by PCR.RESULTS:Women of reproductive age with acute pyelonephritis have a high prevalence of polymorphism of IL-1β and TLR4 genes. Genotypes of TT and CT and also polymorphism of the T (-31) C gene of IL-1β and the genotype of the GG polymorphism of the gene Asp299Gly TLR-4 were associated with an increased risk of inflammatory infectious process in the kidneys. In healthy individuals, CC genotypes are found for the T (-31) C gene of IL-1β and AA for the Asp299Gly TLR4 gene.CONCLUSIONS:It is useful for women of reproductive age to provide genetic diagnostics to detect reference genes polymorphism. It will allow to reveal AP development risk group for carrying out primary prevention.

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Are Obese Patients at an Increased Risk of Pelvic Floor Dysfunction Compared to Non-obese Patients?

Obesity Surgery ◽

10.1007/s11695-017-2559-z ◽

2017 ◽

Vol 27 (7) ◽

pp. 1822-1827 ◽

Cited By ~ 9

Author(s):

Isaac José Felippe Corrêa Neto ◽

Rodrigo Ambar Pinto ◽

José Marcio Neves Jorge ◽

Marco Aurélio Santo ◽

Leonardo Alfonso Bustamante-Lopez ◽

...

Keyword(s):

Pelvic Floor ◽

Pelvic Floor Dysfunction ◽

Obese Patients ◽

Increased Risk

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Comprehensive assessment of the pelvic floor in women: new approaches to the prediction of pelvic organ prolapse

Journal of obstetrics and women s diseases ◽

10.17816/jowd69313-16 ◽

2020 ◽

Vol 69 (3) ◽

pp. 13-16

Author(s):

Ilnur I. Musin

Keyword(s):

Pelvic Floor ◽

Pelvic Floor Dysfunction ◽

Genital Prolapse ◽

Risk Groups ◽

Vaginal Wall ◽

Pelvic Floor Muscles ◽

Comprehensive Assessment ◽

Reproductive Age ◽

Blood Microcirculation ◽

The Future

Hypothesis/aims of study. Despite the growing prevalence of pelvic floor dysfunction in women in the postpartum period, there is still no consensus on its etiology and pathogenesis. The prerequisite for serious disorders to occur in the future is the initial stages of pelvic floor dysfunction after childbirth, despite the fact that they occur without severe symptoms and, remaining undiagnosed in a timely manner, further reduce the quality of life of women. Despite the availability of information on causal relationships between childbirth and the appearance of pelvic floor dysfunctions, this knowledge among women of reproductive age is still limited, which warrants further study. A number of methods have been developed to assess the pelvic floor, among which are non-invasive techniques, including a quantitative assessment of the strength of contractions of the pelvic floor muscles, as well as techniques that assess the microcirculation of the vaginal wall. The aim of this study was to evaluate the parameters of the strength of contractions of the pelvic floor muscles and to identify possible correlations between the obtained parameters. Study design, materials and methods. The study was carried out using methods for measuring the blood microcirculation of the vaginal wall using laser Doppler blood flowmetry in women after the first birth. Results. We obtained indicators of the strength of contractions of the pelvic floor muscles and indicators of the blood microcirculation of the vaginal wall in primary women, and we revealed the dependence of the obtained indicators on the weight and age of the mother, as well as the weight of the fetus at birth. Conclusion. The obtained indicators will allow a comprehensive assessment of the pelvic floor in primiparous women, as well as to identify possible risk groups for genital prolapse development in the future.

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Diseases of the cervix – non-obvious consequences of pelvic floor muscle failure

GYNECOLOGY ◽

10.26442/20795696.2021.2.200778 ◽

2021 ◽

Vol 23 (2) ◽

pp. 131-136

Author(s):

Mekan R. Orazov ◽

Liliia R. Toktar ◽

Gulirano A. Karimova ◽

Veronica Pak ◽

Ksenia Li

Keyword(s):

Risk Factors ◽

Cervical Cancer ◽

Pelvic Floor ◽

Pelvic Floor Muscle ◽

Pelvic Floor Dysfunction ◽

Intraepithelial Neoplasia ◽

The Past ◽

Cervical Diseases ◽

The Relationship ◽

Methods Of Treatment

The literature review presents domestic and foreign data on the relationship between pelvic floor dysfunction (PFD) and cervical diseases found in PubMed, Scopus, Embase and eLibrary systems over the past 10 years. This relationship is mainly realized due to alterations in vaginal biocenosis as the earliest clinical manifestation of PFD. The article describes PFD prevalence, classification, and risk factors for PFD. It also describes main methods of treatment and their side effects. The article provides data on changes in the vaginal biocenosis in PFD. Attention is paid to the risk for cervical intraepithelial neoplasia and cervical cancer in PFD.

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