scholarly journals Changes of structural organization of human olfactory bulbs under conditions of severe forms of pneumonia and cerebrovascular pathology

2021 ◽  
Vol 26 (2) ◽  
pp. 97-104
Author(s):  
A.D. Shkodina ◽  
R.M. Grinko ◽  
I.I. Starchenko ◽  
N.I. Vynnyk ◽  
S.M. Sovhyria ◽  
...  
Keyword(s):  
Interpersonal Relationships ◽  
Human Life ◽  
Experimental Studies ◽  
Relative Number ◽  
Mitral Cells ◽  
Olfactory Bulbs ◽  
Cerebrovascular Pathology ◽  
Entire Cell ◽  
Blood Microvessels ◽  
Fibrillar Component

The role of human olfactory bulbs remains one of the most interesting questions concerning work of the brain, because this organ is one in which neurogenesis is continuously generated in post-natal and adult periods. Impaired sense of smell is not a pathology that threatens human life, therefore, often remains unnoticed. However, it can directly affect the quality of life, as it leads to malnutrition and certain problems in interpersonal relationships. The study of the functional structure of the olfactory analyzer plays an important role both in clinical and experimental studies, but the question of its features in humans needs detailed research. The material of the research was 18 pairs of the olfactory bulbs of males and females aged from 30 to 90 years that were received at the Poltava Regional Department of Pathology. In order to objectify the data obtained on micropreparations, the following morphometric indices were determined: the specific gravity of the location of cellular elements; the proportion of mitral neurocytes in the entire cell population; percentage ratio of relative quantity between cellular elements, blood microvessels, fibrillar component and homogeneous eosinophilic structures. Correlation analysis of morphometric indices in the general sample revealed the existence of an inverse communication of average strength between the relative number of homogeneous eosinophilic cells and the relative number of cellular elements and blood microvessels, which in turn indicates the etiopathogenetic mechanisms of the formation of these structures. The conducted research makes it possible to conclude that mitral cells as one of the most differentiated in olfactory bulbs are sensitive to the development of hypoxic states; under the conditions of cerebrovascular pathology, the relative amount of the blood vessels of the microvessels decreases, which leads to the disorder of the trophy of the nervous tissue and as a result can lead to neurocytolysis of mitral cells. Changes in the vascular and cellular com­ponent indicate a different pathogenesis of changes in human olfactory bulbs in these pathologies and suggest that eosinophilic homogeneous cells are the result of apoptotic neurocytolysis against the background of development of hypoxic states.

The Impact of Classroom Chatter Noise on Comprehension: A Systematic Review

2021 ◽  
pp. 003151252110059
Author(s):  
Anne-Sophie Lamotte ◽  
Aziz Essadek ◽  
Gérard Shadili ◽  
Jean-Michel Perez ◽  
Julien Raft
Keyword(s):  
Systematic Review ◽  
Literature Review ◽  
Teaching Methods ◽  
Classroom Environment ◽  
Field Survey ◽  
Human Life ◽  
Experimental Studies ◽  
Noisy Environment ◽  
Student Comprehension ◽  
The Impact

Communication through discussion and conversations is fundamental to human life; but when such discourse escapes the control of a teacher in the classroom, it becomes little more than chatter. This noise challenges teaching methods and the teaching stance with students. Yet, its impact on comprehension has rarely been studied. The aim of this literature review was to examine the research on the impact of classroom noise generated by chatter on students’ comprehension performance. We adopted the PRISMA (Preferred Reporting Items for Systematic Reviews and Metanalysis) guidelines to examine this literature. This review covered a 10-year period (papers written between 2009 and 2019), with nine experimental studies selected from the 2,954 papers screened. In 89% of these nine studies, there were significant comprehension differences on all tests, revealed when comprehension took place in a noisy environment due to chatter. This review indicated an essential need for a field survey to better understand the impact of chatter on comprehension. Other studies are recommended to highlight any correlation between measured chatter and student comprehension in a real classroom environment.

scholarly journals MODERN CONCEPTION AS TO THE FUNCTIONAL MORPHOLOGY OF THE OLFACTORY SYSTEM AND ITS CHANGES UNDER THE INFLUENCE OF SOME EXOGENOUS POLLUTANTS

2019 ◽  
Vol 23 (3-4) ◽  
pp. 37-40
Author(s):  
A.D. Shkodina ◽  
R.M. Hrinko ◽  
I.I. Starchenko
Keyword(s):  
Environmental Factors ◽  
Olfactory Epithelium ◽  
Functional Organization ◽  
Morphological Changes ◽  
Human Life ◽  
Experimental Studies ◽  
Experimental Models ◽  
Functional Changes ◽  
Olfactory Analyzer ◽  
Long Time

The interaction between a body and an environment provides the main aspects of human life. The study of the functional structure of the olfactory analyzer plays an important role both in clinical and in experimental studies, but the question of its features in humans needs detailed research. The paper presents the modern data of the structural and functional organization of the olfactory analyzer. Particular attention is paid to the structural organization of olfactory bulbs as most complicated and least studied component of the olfactory analyzer. The morphological and functional changes of the olfactory analyzer are developing in some diseases and in action of adverse environmental factors are described while the accentuation is placed on the differences of the mechanism in the pathogenesis of damage to the olfactory analyzer, depending on the nature of the influence of pathogenic factors. In this way as the result of short-term intense effects of the pollutant, irreversible atrophic changes are primarily affected to the olfactory epithelium, thus, to some extent, preventing the spread of the toxin to other analyzer structures. Conversely, a long-term exposure to low doses usually retains the functional activity of the olfactory epithelium, while harmful substances penetrate the central unit of the olfactory analyzer. In such cases, the olfactory dysfunction can be diagnosed after a long time after the start of the cohort with certain pollutants. Currently, studies of the influence of exogenous toxins on various parts of the olfactory analyzer on animal experimental models are quite active. At the same time, the issue of functional and morphological changes in various structural components of the human olfactory analyzer under the influence of negative environmental factors remains poorly understood and requires further morphological and biochemical studies, in order to be able to further develop effective therapeutic and prophylactic means.

The Philosophical Concepts in Ryszard Otowicz’s Bioethics

2006 ◽  
Vol 11 (1) ◽  
pp. 69-80
Author(s):  
Piotr Aszyk
Keyword(s):  
Interpersonal Relationships ◽  
Human Life ◽  
Moral Theology ◽  
General Overview ◽  
Self Defense ◽  
The World ◽  
Theological Perspective ◽  
Relationship Of ◽  
The Relationship ◽  
Defense Reflex

This article presents a general overview of philosophical issues undertaken in the work of Richard Otowicz (1953–2003), Jesuit and Professor of Moral Theology at the Pontifical Faculty of Theology in Warsaw. Within the set of views developed by him, the theological perspective undoubtedly assumes pride of place. Often, however, he refers to philosophical issues from which, in his opinion, one cannot escape—issues that bear directly on human life. What is especially striking is Otowicz’s hypothesis that bioethics is a kind of self-defense reflex of mankind, who are attempting by means of it to intellectually grasp the issues relating to the unlimited expansion of technology. Developments and changes observed in the world are forcing humanity to rethink very fundamental issues, such as interpersonal relationships or the relationship of man to nature.

Law in Doctrine and Life According to Martin Luther

2017 ◽  
Author(s):  
Risto Saarinen ◽  
Derek R. Nelson
Keyword(s):  
Interpersonal Relationships ◽  
Human Life ◽  
Golden Rule ◽  
Human Beings ◽  
Christian Life ◽  
God's Will ◽  
Rabbinic Judaism ◽  
Unity In Diversity ◽  
The Law ◽  
The One

The law both is and functions in Martin Luther’s theology. To the extent that it simply is, the law is wholly good, just, and pure. It reveals God’s benevolent providence for creation by instantiating structures of human relationships, natural processes, and social arrangements within which human life and all of creation can flourish. Luther regards the essential character of the law in a way reminiscent of the haggadah tradition of Rabbinic Judaism, where the law is a narrative which reveals features of the lawgiver. Under the conditions of sin, however, the law can be experienced as wrath by humans who cannot fulfill what it requires, and who suffer as a result of their own transgression of the Word of God or as a result of the transgressions of others. It functions thus as a curb against wickedness and as a means of exposing sin to be sin. Its continued presence in the life of the believer is necessary, as Luther clarified in his various debates with Johann Agricola and the so-called “Antinomians.” When the law is understood only in its antinomy with the gospel, the life-affirming elements of the law are occluded, even as the gospel’s life-redeeming elements are thereby rendered clear. While numerous fine distinctions can be found in Luther’s theology of the law, it maintains a basic unity-in-diversity. God wills singly in dealing with human beings as his creatures. Therefore “civil law,” the Decalogue, and other manifestations of the law are facets of the one will of God for the flourishing of creation. Recent Pauline scholarship has criticized Luther for eisegesis on Paul’s view of the law; Luther needed to see his contemporary Roman partisans as Paul’s legalistic Jewish opponents, they say, and so he read Romans as a critique of 16th-century “works righteousness.” This view ignores the fact that Luther (and Augustine) viewed the post-conversion Paul as “continent” in doing the works of the law, neither weak-willed nor perfectly virtuous. Law is necessary for doctrine, but it is also important for the “Christian life” because it helps the believer to understand the reciprocity that underlies interpersonal relationships, seen especially in the “golden rule” that functions as the epitome of the Christian life. The radical receptivity (i.e., passivity) that characterizes the life of faith in believers enables the experience of God’s will, understood as law or command, in a constructive and beneficial way. While Christian life should employ a “faith approach” rather than a “law approach,” genuine faith in God does, in fact, reveal the true meaning of the law. This might be called the “second use of the gospel” in that God’s command (Gebot), viewed in light of the gospel, becomes a source of guidance for the Christian life, the ten commandments, the double love command, and the Sermon on the Mount chief among them.

scholarly journals Biological effects of oxygen-enriched drinking water. Review. Part 2

2021 ◽  
Vol 100 (1) ◽  
pp. 25-29
Author(s):  
Jurii A. Rakhmanin ◽  
Natalija A. Egorova ◽  
Rufina I. Mihajlova ◽  
Irina N. Ryzhova ◽  
Marina G. Kochetkova
Keyword(s):  
Drinking Water ◽  
Biological Effect ◽  
Biological Effects ◽  
Human Life ◽  
Experimental Studies ◽  
The Body ◽  
Molecular Response ◽  
Oxygen Homeostasis ◽  
Generalized Peritonitis ◽  
Negative Effect

Human life on Earth depends on the continuous availability of oxygen. Conditions for the entry of oxygen into the body’s cells change in time and space, are easily broken, thus causing the possibility of development of hypoxia - a condition of oxygen starvation of tissues. The second part of the review is devoted to information about the successful use of oxygen-rich water in domestic therapeutic and surgical practice in complex treatment to reduce the negative effect of hypoxia in patients with chronic heart failure and generalized peritonitis complicated by intestinal insufficiency syndrome. Authors consider a common method for improving the supply of oxygen to the body using enteral oxygen therapy - oxygen cocktails in diseases of the cardiovascular system, lungs, bronchi and gastrointestinal tract, atopic dermatitis, placental insufficiency, as well as to improve physical performance, reduce the level of neuroticism and normalize the psychoemotional status. The first part of the review provides data on the modern understanding processes providing oxygen homeostasis in cells, on the critical component responsible for regulating the molecular response to hypoxia - the Hypoxia-Inducible Factors (HIFs) of the family of transcription factors. The possibility to compensate for the lack of oxygen in the body by delivering it to cells and tissues was indicated to consider water and various oxygen cocktails. Data from experimental studies of the biological effect of oxygenated drinking water are analyzed, as well as the results of studying the effects of oxygen-enriched drinking water with the participation of volunteers. The issue of the formation of oxygen (free) radicals when drinking oxygen-enriched drinking water is considered. The review draws specialist’s attention to the problem of the biological effect of oxygen-enriched drinking water, its insufficient knowledge and the possible yet unrealized potential in terms of preventing various diseases and maintaining optimal human health.

Pallial origin of mitral cells in the olfactory bulbs of Xenopus

Neuroreport ◽  
2003 ◽  
Vol 14 (18) ◽  
pp. 2355-2358 ◽  
Author(s):  
Nerea Moreno ◽  
Isabelle Bachy ◽  
Sylvie Rétaux ◽  
Agustín González
Keyword(s):  
Mitral Cells ◽  
Olfactory Bulbs

scholarly journals Legal liability and risks during infusion therapy

2020 ◽  
pp. 175-177
Author(s):  
N.O. Lisnevska
Keyword(s):  
Medical Care ◽  
Personal Information ◽  
Human Life ◽  
Criminal Liability ◽  
Previous History ◽  
Experimental Studies ◽  
Legal Liability ◽  
Legal Aspects ◽  
Infusion Therapy ◽  
The Right

Background. The issue of legal liability is extremely important for all healthcare workers (HCW). HCW are solely responsible for medical violations during the performance of their professional duties. There is a misconception that in case of non-provision or error in the provision of medical care outside the medical institution, the HCW will be liable. However, this is not always so, as in this case the HCW is considered an ordinary citizen and bears ordinary civil liability. Objective. To describe the legal aspects of MP liability, in particular, during infusion therapy (IT). Materials and methods. Analysis of the legal framework. Results and discussion. The public consciousness has formed the idea of the great responsibility of HCW for human life and health. Unfortunately, in Ukraine, people often do not care about their own health and do not take preventive measures, shifting all responsibility to HCW. Citizens have the right to receive health care and the right for the compensation of improper medical care and damage caused by the actions of the HCW. According to surveys, a lawsuit from a patient is the leading fear of HCW. This fear needs to be reduced, as the doctor and nurse should not be afraid of their patients. According to the objective model of liability, the HCW is guilty of the damage caused to the victim (patient), if the average citizen believes that the actions of HCW were the cause of the unfavorable course of events. This model is often used by domestic media, although in Ukraine it is not enshrined in law. For a long time, criminal liability for medical crimes has dominated Ukraine. Currently, there are criminal, administrative, disciplinary and civil kinds of liability. According to the criminal legislation of Ukraine, criminal liability arises for a crime that contains a crime according to the Criminal Code. Criminal activity contradicts the very essence of medical activity, so special attention is paid to such crimes. It should be noted that the intentional crimes committed by HCW are much less common than crimes of negligence. An important problem is that lawyers do not always understand the specifics of the nature of a medical crime. There are circumstances in which HCW are released from liability for a crime. These circumstances include actions of extreme necessity and actions in risk settings. Extreme necessity often takes place in urgent medical interventions. These circumstances often accompany emergency care in case of accidents, military problems and disasters. IT is often a kind of experiment, because the drugs administered may be perceived differently by the patient, even with a normal previous history. Because treatment is often associated with risk, for example, in case of IT side effects, a nurse who continues to administer the drug on a protocol or off-protocol (subject to consultation with the patient and/or the board of physicians) will not be criminally liable. Similarly, a nurse will not be criminally liable in case of deciding to discontinue IT due to the patient’s deterioration. In such circumstances, the nurse should inform the physician of the situation as soon as possible and eliminate the danger to the patient as soon as possible. Cases in which the damage was caused intentionally for a useful purpose is a separate category of cases. This is most common in chemotherapy and in experimental studies. The HCW should take sufficient, in his opinion, and appropriate to his qualification measures to improve the patient’s condition. Sometimes nurses have to make decisions in time deficit, for example, as for measures for a patient with a psychiatric illness that threatens other people. In such cases, there is also no criminal liability, as the act was committed to save the lives and health of others. Medical crimes are divided into professional and official. The first are directly related to the performance of professional duties (HIV/AIDS, illegal abortion, disclosure of personal information of the patient, violation of the patient’s rights, not providing medical care provision, etc.). It should be noted that the HCW cannot be blamed for not providing medical care if it does not meet his/her qualifications. Conclusions. 1. HCW must know their rights and act for the benefit of patients. 2. Medical crimes are divided into professional and official. 3. There are situations in which HCW are released from criminal liability.

scholarly journals Disturbances in the functioning of the immune system as a consequence of a prolonged expоsure to low dosages of depleted uranium

2018 ◽  
pp. 73-79
Author(s):  
K. I. Stosman ◽  
K. V. Sivak ◽  
T. N. Savateeva-Ljubimova
Keyword(s):  
Chronic Exposure ◽  
Mononuclear Cells ◽  
Early Stage ◽  
Experimental Studies ◽  
Relative Number ◽  
Uranyl Acetate ◽  
Depleted Uranium ◽  
Delayed Type Hypersensitivity ◽  
Industrial Facilities ◽  
Tnf Α

Relevance. Depleted uranium (DU) is actively used in many industries. The problems of the safety of personnel employed at industrial facilities of this kind continue to remain relevant. Experimental studies have shown the toxicity of uranium compounds, especially its soluble forms.Intention.  To identify immunological disorders developing after chronic exposure to low-dose depleted uranium.Methods. The study involved 30 outbred rats and 60 mice CBA. Uranyl acetate dehydrate was used as a toxicant and administered intragastrically for 120 days. The relative number of T-lymphocytes, apoptotic and necrotic cells, the production of TNF-α, IL-1, -4, -6-β, the level of circulating immune complexes, the phagocytic activity of neutrophils, delayed-type hypersensitivity reactions, and production of immunoglobulins were assessed.Results and Discussion.  According to the tests on rats, phagocytic-metabolic activity of neutrophils as well as TNF-α production increased, CD4+/CD8+ ratio decreased, and the early stage apoptosis of mononuclear cells was activated after chronic exposure to uranium salts. Most detected changes were dose-dependent. In experiments on mice it was shown that uranyl acetate dehydrate at a dose of 5 mg/kg had no effect on the functional activity of immunocytes, while the index of the delayed-type hypersensitivity reaction and IgG titers increased in animals which were administered DU at a dose of 10 mg/kg.Conclusion. The results can be used to provide specialized medical care after chronic exposure to depleted uranium.

scholarly journals TRABALHO DOCENTE: REFLEXÕES SOBRE A SAÚDE E O SOFRIMENTO PSÍQUICO DO PROFESSOR

2020 ◽  
Vol 1 ◽  
pp. 16 ◽  
Author(s):  
Glaé Corrêa Machado ◽  
Andréia Mendes dos Santos ◽  
Renata Santos da Silva
Keyword(s):  
Quality Of Life ◽  
Interpersonal Relationships ◽  
Basic Education ◽  
Human Life ◽  
Work Conditions ◽  
Daily Routine ◽  
Human Beings ◽  
Work Activity ◽  
Starting Point

Este texto versa sobre as implicações do trabalho docente na saúde e qualidade de vida do professor. A partir da concepção de que o trabalho é uma atividade fundamental para o desenvolvimento dos seres humanos, consideramos que o ato de trabalhar transforma a si mesmo no e pelo trabalho, relacionando-se diretamente com identidade social. Por outro lado, observa-se também que a centralidade que este ocupa na rotina cotidiana da vida humana, em especial da categoria, impõe uma relação conflituosa, pois, apesar de carregada de diferentes investimentos, as condições e as exigências do trabalho também são causas de doenças físicas e mentais. Nesta atividade laboral, articulam-se diretamente relações interpessoais, envolvendo experiências emocionais constantes. É um campo profissional onde a subjetividade dos afetos emerge no cotidiano, em relações diárias, envolvendo, na maioria das situações, crianças e jovens em desenvolvimento. Como tese, sustenta-se que estes movimentos, que possuem reflexo direto na organização dos processos de trabalho, produzem graves consequências sobre a saúde dos professores, em seus aspectos físicos ou psíquicos. Como ponto de partida, consideramos os resultados de um estudo que analisou aspectos referentes à saúde dos docentes da educação básica de sete estados brasileiros, entre outros, articulando uma discussão com uma análise qualitativa de diários de estágio em Psicologia Escolar. Nossas considerações ampliam as questões que se impõe ao docente na contemporaneidade e que lhes causam desgaste e consequente sofrimento psíquico.Palavras-chave: Trabalho docente. Saúde do trabalhador. Qualidade de vida.ABSTRACTThis text deals with the implications of teaching work on the teacher's health and quality of life. From the conception that work is a fundamental activity for the development of human beings, we consider that the act of working transforms itself into and through work, relating directly to social identity. On the other hand, it is also observed that the centrality it occupies in the daily routine of human life, especially in the category, imposes a conflicting relationship, because despite being loaded with different investments, work conditions and demands are also causes of illness. physical and mental. In this work activity, interpersonal relationships are directly articulated, involving constant emotional experiences. It is a professional field where the subjectivity of affections emerges in daily life, in daily relationships, involving in most situations children and young people in development. As a thesis, it is argued that these movements, which have a direct reflection on the organization of work processes, have serious consequences on teachers' health, in their physical or mental aspects. As a starting point, we consider the results of a study that analyzed aspects related to the health of basic education teachers from seven Brazilian states, among others, articulating a discussion with a qualitative analysis of internship diaries in School Psychology. Our considerations broaden the questions that are imposed on the teacher in contemporary times that cause them to wear and consequent psychic suffering.Keywords: Teaching work. Worker's health. Quality of life.

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