scholarly journals Efficacy and Safety of Omeprazole and Amoxicillin in the Treatment of Gastric Ulcer

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Jie Liu ◽  
Minghui Xiao ◽  
Jianping Hui
Keyword(s):  
Gastric Ulcer ◽  
Recurrence Rate ◽  
Breath Test ◽  
Adverse Reactions ◽  
Effective Rate ◽  
Control Group ◽  
Research Subjects ◽  
Before And After ◽  
Positive Rate ◽  
Experimental Group

Objective: To study the effect of omeprazole and amoxicillin in the treatment of patients with gastric ulcer. Methods: 88 patients with gastric ulcer in our hospital from March 2018 to March 2020 were selected as research subjects and divided into experimental group (44 cases were treated with omeprazole + amoxicillin) and control group (44 cases were treated with omeprazole). The therapeutic effect, positive rate of breath test before and after treatment, recurrence rate within half a year and adverse reactions were compared between the two groups. Results: The total effective rate of the experimental group (97.73%, 43 / 44) was higher than that of the control group (84.09%, 37 / 44), P < 0.05; After treatment, the positive rate of breath test in the experimental group (22.73%, 10 / 44) was lower than that in the control group (47.73%, 21 / 44), P < 0.05; The recurrence rate in the experimental group was 4.55% (2 / 44), which was significantly higher than that in the control group (20.45%, 9 / 44), P < 0.05; The incidence of adverse reactions in the experimental group (9.09%, 4 / 44) was significantly lower than that in the control group (15.91%, 7 / 44), P < 0.05. Conclusion: In the process of clinical treatment of gastric ulcer, omeprazole combined with amoxicillin has significant effect, not only the recurrence rate is low, but also the incidence of adverse events should be less, and the treatment is safer. 

scholarly journals Analysis of the Effect of Pantoprazole and Omeprazole on Pain Relief in Patients with Gastric Ulcer

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Minghui Xiao ◽  
Jie Liu ◽  
Jianping Hui
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Pain Relief ◽  
Recurrence Rate ◽  
Conversion Rate ◽  
Adverse Reactions ◽  
Effective Rate ◽  
Control Group ◽  
Experimental Group ◽  
Negative Conversion

Objective: To analyze the effect of pantoprazole and omeprazole in the treatment of patients with gastric ulcer. Methods: The treatment effect, recurrence rate, helicobacter pylori negative conversion rate, adverse reaction status and pain relief time of the two groups were compared. Results: The total effective rate of the experimental group (97.78%, 44 / 45) was higher than that of the control group (84.44%, 38 / 45), P < 0.05;The recurrence rate (4.44%, 2 / 45) and Helicobacter pylori negative conversion rate (95.56%, 43 / 45) of the experimental group were significantly higher than those of the control group (P < 0.05); The incidence of adverse reactions in the experimental group (11.11%, 5 / 45) was lower than that in the control group (15.56%, 7 / 45) (P > 0.05);The pain relief time of the experimental group was (2.24 ± 1.16) d, which was shorter than that of the control group (P < 0.05). Conclusion: In the process of clinical treatment of gastric ulcer, pantoprazole has significant curative effect and low recurrence rate, which can eradicate Helicobacter pylori as soon as possible, shorten the pain time and make the treatment safer.

scholarly journals Therapeutic effect of nifedipine combined with enalapril on elderly patients with coronary heart disease complicated with hypertension

2018 ◽  
Vol 2 (6) ◽  
Author(s):  
Xiaoye Wang
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Elderly Patients ◽  
Adverse Reactions ◽  
Effective Rate ◽  
Control Group ◽  
Significant Difference ◽  
Pre Treatment ◽  
Experimental Group

【Abstract】Objective: Toanalyze the efficacy of combined drug therapy for elderly patients with coronary heart disease and hypertension.METHODS:Sixty-six elderly patients with coronary heart disease and hypertension were enrolled from December 2017 to November 2018. They were randomly divided into two groups, 33 patients in each group. Patients in the experimental group received nifedipine. In combination with enalapril, patients enrolled in the control group received nifedipine monotherapy.RESULTS:Compared with the control group, the total effective rate, Serum Nitric Oxide (Serum NO) after treatment, CRP after treatment, HCY after treatment, and blood pressure after treatment were significantly improved (P<0.05). Serum NO and treatment before treatment in the 2 groups. There was no significant difference in pre-CRP, pre-treatment HCY, pre-treatment blood pressure, and adverse reactions during treatment (P>0.05).Conclusion: Theelderly patients with coronary heart disease and hypertension are treated with nifedipine and enalapril.

Application Effects of Whole Course High-Quality Nursing on Patients with Liver Cancer during Radiotherapy

2020 ◽  
Author(s):  
Ling PANG ◽  
Yunxia WANG ◽  
Yuexin XING ◽  
Chunxia ZHAO
Keyword(s):  
Liver Cancer ◽  
Adverse Reactions ◽  
Depression Scale ◽  
Control Group ◽  
High Quality ◽  
Nursing Satisfaction ◽  
Self Rating ◽  
Total Incidence ◽  
Before And After ◽  
Experimental Group

Background: To explore the application effects of whole course high-quality nursing on patients with liver cancer during radiotherapy. Methods: One hundred and five patients with liver cancer who received radiotherapy in Liaocheng People’s Hospital, Liaocheng, China from March 2010 to February 2012 were selected and divided into a control group (42 cases with routine nursing) and an experimental group (63 cases with whole course high-quality nursing). The two groups of patients were observed and compared in terms of clinical data and the Activity of Daily Living (ADL) score before and after nursing (1 course of treatment/6 week). The Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to evaluate and compare the patients’ anxiety and depression before and after nursing. Adverse reactions during radiotherapy and nursing satisfactory of patients were observed and compared between the two groups. Results: After nursing, the ADL score and the nursing satisfaction in the experimental group was significantly higher than that in the control group (P<0.05). The SDS and SAS scores in the 2 groups before nursing were significantly higher than those after nursing (P<0.05). The total incidence of adverse reactions in the control group was significantly higher than that in the experimental group (P<0.05). Conclusion: Whole course high-quality nursing can improve the negative emotions, quality of life and nursing satisfaction, and reduce adverse reactions of patients with liver cancer during radiotherapy.

scholarly journals Sanjin Tablets for Acute Uncomplicated Lower Urinary Tract Infection (Syndrome of Dampness-Heat in the Lower Jiao): Protocol for Randomized, Double-Blind, Double Dummy, Parallel Control of Positive Drug, Multicentre Clinical Trial

2019 ◽  
Author(s):  
Jian Lv ◽  
Yan-ming Xie ◽  
Zhan Gao ◽  
Jian-wu Shen ◽  
Yue-yi Deng ◽  
...  
Keyword(s):  
Recurrence Rate ◽  
Effective Rate ◽  
Control Group ◽  
Double Blind ◽  
Lower Urinary Tract Infection ◽  
Parallel Control ◽  
Group 2 ◽  
Experimental Group ◽  
Group 1 ◽  
Lower Urinary

Abstract Background Acute uncomplicated lower urinary tract infection (UTI) is one of the most common bacterial infections. Patients usually present with dysuria, urinary urgency, urinary frequency and suprapubic pain or tenderness. Approximately 150 million people are diagnosed with UTI each year worldwide. The high recurrence rate of lower UTI is a common problem of clinical treatment. The misuse of antibiotics has led to the emergence of a number of resistant bacterial strains. Thus, traditional Chinese medicine is considered as an alternative option for treating acute uncomplicated lower UTI. Thus, this study aims to evaluate the efficacy, safety and recurrence rate of Sanjin tablets (SJT) for the treatment of acute uncomplicated lower UTI; explore whether SJT can reduce or substitute the use of antibiotics in the treatment of acute uncomplicated lower UTI. Methods/Design In this study, a randomized, double blind, double dummy, parallel control of positive drug, multicentre clinical study will be established. A total of 252 patients with acute uncomplicated lower UTI (syndrome of dampness-heat in the lower jiao) will be randomly allocated in the ratio of 1:1:1 to three groups: experimental group, control group 1 and control group 2. The experimental group receives Sanjin tablets plus levofloxacin tablets (LT) placebo; the control group 1 receives LT plus SJT placebo; and the control group 2 receives SJT plus LT on the first 5 days, SJT plus LT placebo on the last 2 days. Each group will be treated for 7 days and followed-up for 1-2 times. The primary outcome measures of effective rate and recurrence rate are symptoms. Secondary outcome measures of effective rate and recurrence rate are the urine leukocyte, bacteriology examination and safety assessment. Outcomes will be assessed at baseline and after treatment. Discussion This study protocol will provide the research data of efficacy, safety and recurrence rate of SJT for the treatment of acute uncomplicated lower UTI; explore the possibility of using SJT to reduce or substitute the use of antibiotics. The results of this study will improve the rational use of drugs, especially the rational application of antibiotics. It will also enable safety evaluation from laboratory indices and adverse events, which will provide reliable evidence for clinical treatment.

scholarly journals Effect of Entecavir Combined with Adefovir Dipivoxil on Clinical Efficacy and TNF-α and IL-6 Levels in Patients with Hepatitis B Cirrhosis

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Yonghuan Yu ◽  
Xinfeng Cui ◽  
Jingjing Zhao ◽  
Ting Jia ◽  
Baofeng Ren ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatitis B ◽  
Liver Function ◽  
Adefovir Dipivoxil ◽  
Adverse Reactions ◽  
Statistical Significance ◽  
Effective Rate ◽  
Control Group ◽  
Tnf Α ◽  
Experimental Group

Objective. The purpose of the study was to investigate the effect of entecavir combined with adefovir dipivoxil on clinical efficacy and TNF-α and IL-6 levels in patients with hepatitis B cirrhosis. Methods. A total of 100 patients with hepatitis B cirrhosis admitted to our hospital between January 2018 and June 2019 were randomly selected and divided into the control group (n = 50) and experimental group (n = 50) according to the order of admission. Among them, the control group patients were treated with entecavir, while the patients in the experimental group received entecavir combined with adefovir dipivoxil. After that, the effective rate of treatment, the incidence of adverse reactions, liver function indexes, liver fibrosis condition, and TNF-α and IL-6 expression levels were all compared between the two groups. Results. The effective rate of treatment in the experimental group was significantly higher than that in the control group, with statistical significance ( p < 0.001 ); the incidence of adverse reactions of the patients in the experimental group was significantly lower than that in the control group, with statistical significance ( p < 0.001 ); the liver function indexes in the experimental group were significantly better than those in the control group, with statistical significance ( p < 0.001 ); the number of patients with liver fibrosis in the experimental group was significantly less than that in the control group, with statistical significance ( p < 0.001 ); the TNF-α and IL-6 expression levels in the experimental group were significantly lower than those in the control group, with statistical significance ( p < 0.001 ). Conclusion. Entecavir combined with adefovir dipivoxil in the treatment of hepatitis B cirrhosis can effectively improve the therapeutic effect and reduce the serum inflammatory factor levels, with high safety, which is worthy of application and popularization.

scholarly journals Efficacy and Safety of Mecobalamin Combined with Prokinetic Agents in the Treatment of Diabetic Gastroparesis: A Meta-Analysis

2021 ◽  
Author(s):  
Jia Yao ◽  
Bo Peng ◽  
Xiayu Gong ◽  
Xiaoyan Shi ◽  
Simin Fan ◽  
...  
Keyword(s):  
Recurrence Rate ◽  
Adverse Reactions ◽  
Meta Analysis ◽  
Diabetic Gastroparesis ◽  
Control Group ◽  
Efficacy Rate ◽  
Efficacy And Safety ◽  
Prokinetic Drugs ◽  
Prokinetic Agents ◽  
Experimental Group

Background: The aim of the present study was to systematically review the efficacy and safety of mecobalamin combined with prokinetic agents in diabetic gastroparesis (DGP). Methods: A variety of databases were searched from inception to Nov 2, 2018. RCTs of mecobalamin combined with prokinetic agents group (experimental group) versus prokinetic agents only group (control group) in DGP were included. RevMan 5.3 and Stata 12.0 were used to perform the meta-analysis. Finally, 24 RCTs with 1,878 patients were included. Results: The total efficacy rate was significantly higher in the experimental group (mecobalamin combined with prokinetic drugs) compared with the control group (prokinetic drugs alone) (P<0.001), and the improvement was observed regardless of the administration route. Furthermore, the treatment group exhibited a significantly improved gastric emption rate (P<0.001), motilin (P<0.001) and recurrence rate (P<0.001), and there was no statistical difference in the incidence of adverse reactions between two groups (P=0.49). Conclusion: Mecobalamin combined with prokinetic agents can significantly improve total efficacy rate and gastric emptying rate, decrease serum motilin and the recurrence rate without increasing adverse reactions in DGP. Thus, mecobalamin may can be used as a new therapeutic option for DGP.

scholarly journals Clinical Evaluation of Pinggan Yiqi Yangshen Recipe Combined with Labetalol Hydrochloride and Magnesium Sulfate in the Treatment of PIH

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Ping Li ◽  
Jie Zhao ◽  
Peipei Gao ◽  
Hongcui Qu
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Magnesium Sulfate ◽  
Pregnancy Outcomes ◽  
Adverse Reactions ◽  
Fetal Distress ◽  
Effective Rate ◽  
Control Group ◽  
Labetalol Hydrochloride ◽  
Experimental Group

Background. To observe the clinical effect of Pinggan Yiqi Yangshen recipe combined with labetalol hydrochloride and magnesium sulfate in the treatment of pregnancy-induced hypertension (PIH). Methods. A total of 126 patients with PIH diagnosed in our hospital from January 2016 to May 2018 were randomly divided into the control group and the experimental group, with 63 cases in each group. The control group was treated with labetalol combined with magnesium sulfate. On the basis of the control group, the experimental group was treated with Pinggan Yiqi Yangshen recipe. Clinical efficacy, blood pressure, renal function, and biochemical indexes were compared between the two groups. Moreover, pregnancy outcomes and adverse reactions were compared between the two groups. Results. After treatment, the total effective rate in the experimental group was higher than in the control group. Blood pressure and mean arterial pressure in the experimental group were more significantly downregulated than the control group. Renal function indexes and biochemical indexes in the experimental group were more significant than those in the control group. The incidence of cesarean section, preterm birth, and abnormal fetal heart rate in the experimental group was significantly lower than that in the control group. There was no difference in the incidence of fetal distress, postpartum hemorrhage, neonatal asphyxia, and adverse reactions between the two groups. Conclusion. Pinggan Yiqi Yangshen recipe combined with labetalol hydrochloride and magnesium sulfate can effectively reduce the blood pressure of patients with PIH, help patients to return to normal levels of biochemical indexes and renal function indexes, and improve pregnancy outcomes with high safety, which is worthy of further promotion and application in clinical practice.

scholarly journals Clinical application effect evaluation of Kanglaite combined with DCF chemotherapy program in patients with gastric cancer

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
Haibin Ding
Keyword(s):  
Quality Of Life ◽  
Gastric Cancer ◽  
Clinical Application ◽  
Adverse Reactions ◽  
Life Quality ◽  
Effective Rate ◽  
Control Group ◽  
Therapeutic Effects ◽  
Experimental Group

Objective: To evaluate the clinical application effect of Kanglaite combined with DCF chemotherapy program in the patients with gastric cancer. Methods: 86 cases who were all the gastric cancer patients admitted to our hospital from February 2014 to June 2016 were selected, according to randomly divided into two groups, control group and experimental group. The control group was treated with DCF treatment, and the experimental group were treated with Kanglaite combined DCF chemotherapy program, and the therapeutic effects, the quality of life of patients and incidence rate of adverse reactions in two groups were observed and compared. Result: Compared with the control group, the total effective rate and the quality of life score of the experimental group were significantly higher, and the incidence of adverse reactions was less (P < 0.05). Conclusion: In clinic, Kanglaitecombined with DCF chemotherapy program on patients with gastric cancer, can improve the treatment effect and life quality of patients, with less adverse reaction and high application value.

scholarly journals Clinical Study of Urinary Kallidinogenase in the Treatment of Progressive Cerebral Infarction

2013 ◽  
Vol 2 ◽  
pp. 13
Author(s):  
Binghui Fan ◽  
Weidong Li
Keyword(s):  
Treatment Group ◽  
Cerebral Infarction ◽  
Adverse Reactions ◽  
Total Effective Rate ◽  
Neurological Impairment ◽  
Effective Rate ◽  
Control Group ◽  
Before And After ◽  
And Control ◽  
Better Than

<p><strong>Objective: </strong>To evaluate the efficacy and safety of Urinary kallidinogenase in the treatment of progressive cerebral infarction. <strong>Method: </strong>104 cases of patients with acute cerebral infarction were randomly divided into treatment group and control group; where control group (52 cases) patients on with only basic medicine, while treatment group (52 cases), besides the basic medicine, patients will on urinary kallidinogenase 0.15 PNAU + 0.9% normal saline 100 mL intravenous injection, 1 times per day, and continuous for 14 days. The degree of neurological impairment (NIHSS) was assessed before and after treatment, and the changes of blood pressure were monitored. The liver, renal function, fibrinogen, platelet, and the adverse reactions were recorded and followed up in three month. <strong>Results</strong><strong>: </strong>After treatment, NIHSS scores of the both groups were decreased (<em>p</em> &lt; 0.05), however, total effective rate for treatment group were better than control group (<em>p</em> &lt; 0.05). <strong>Conclusion: </strong>Urinary kallidinogenase is safe and effective in the treatment of progressive cerebral infarction.</p>

Preparation of Targeted Drug-Loaded Nanobubbles and Its Effect in Improvement of Renal Function in Patients with Hyperuricemia

2021 ◽  
Vol 13 (3) ◽  
pp. 509-515
Author(s):  
Han Xia ◽  
Yujing Zhang ◽  
Gengxin Guo ◽  
Aixiang Liu ◽  
Jing Liu
Keyword(s):  
Renal Function ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Effective Rate ◽  
Control Group ◽  
Before And After ◽  
Targeted Drug ◽  
The Difference ◽  
Experimental Group

The effects of targeted drug-loaded nanobubble (DLNB) on the treatment of patients with hyperuricemia (HUA) and the improvement of renal function were explored by constructing targeted DLNB. G250 targeted allopurinol-loaded NB (ANBs) was prepared by filming-rehydration method and its physicochemical properties were investigated. A total of 80 patients with HUA admitted to the hospital from July 2017 to July 2019 were selected and divided into control group and experimental group, with 40 patients in each group, treated for 4 weeks. Blood UA (UA), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), alanine transaminase (ALT), aspartate transaminase (AST), blood urea nitrogen (BUN), blood creatinine (Cr) and other related indicators were compared before and after treatment. Targeted ANBs was successfully constructed and its targeting in vitro was guaranteed. The effective rate of control group was 65.00%, and that of experimental group was 77.50%, with evident difference (P < 0.05). In contrast to control group, UA, TC, TG, HDL, and LDL were notably decreased in the experimental group after treatment, and the difference was evident (P < 0.05). ALT, AST, BU, and Cr also showed notable improvement (P < 0.05). Targeted ANBs had good therapeutic effect on patients with HUA, and it also played a certain role in improving liver function and kidney function in HUA patients.

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