scholarly journals Levels of some trace metals and related enzymes in workers at storage-battery factories in Iraq

2000 ◽  
Vol 6 (1) ◽  
pp. 76-82 ◽  
Author(s):  
J. K. Mehdi ◽  
F. J. M. Al Imarah ◽  
A. A. Al Suhail
Keyword(s):  
Trace Metals ◽  
Private Sector ◽  
Significant Positive Correlation ◽  
Storage Battery ◽  
Positive Correlation ◽  
Group Iii ◽  
Group I ◽  
Lead And Zinc ◽  
Lead Levels ◽  
Aminolevulinate Dehydratase

Levels of some trace metals [copper, iron, lead and zinc], aminolevulinate dehydratase [ALAD], caeruloplasmin and haemoglobin were measured in the blood of 37 male workers from private-sector storage-battery factories. The men were divided into three groups depending on their jobs: 11 chargers [group I], 8 repair workers [group II]and 18 casting workers [group III]; 60 men were selected as controls. Mean levels were 14.63, 36.35, 58.00 and 71.70 mg/100 mL for lead, 192.54, 133.90, 96.75 and 45.37 U/mL for ALAD, and 14.02, 12.72, 12.20 and 11.40 g/100 mL for haemoglobin for control and groups I, II and III respectively. Significant negative correlations were found between lead and both ALAD and haemoglobin. The only significant positive correlation was between lead levels and duration of exposure

scholarly journals Microbiome signature and diversity regulates the level of energy production under anaerobic condition

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
M. Shaminur Rahman ◽  
M. Nazmul Hoque ◽  
Joynob Akter Puspo ◽  
M. Rafiul Islam ◽  
Niloy Das ◽  
...  
Keyword(s):  
Indicator Species ◽  
Energy Production ◽  
Environmental Temperature ◽  
Group Iv ◽  
Methanosarcina Barkeri ◽  
Spearman Correlation ◽  
Positive Correlation ◽  
Group Iii ◽  
Group I ◽  
Group Ii

AbstractThe microbiome of the anaerobic digester (AD) regulates the level of energy production. To assess the microbiome diversity and composition in different stages of anaerobic digestion, we collected 16 samples from the AD of cow dung (CD) origin. The samples were categorized into four groups (Group-I, Group-II, Group-III and Group-IV) based on the level of energy production (CH4%), and sequenced through whole metagenome sequencing (WMS). Group-I (n = 2) belonged to initial time of energy production whereas Group-II (n = 5), Group-III (n = 5), and Group-IV (n = 4) had 21–34%, 47–58% and 71–74% of CH4, respectively. The physicochemical analysis revealed that level of energy production (CH4%) had significant positive correlation with digester pH (r = 0.92, p < 0.001), O2 level (%) (r = 0.54, p < 0.05), and environmental temperature (°C) (r = 0.57, p < 0.05). The WMS data mapped to 2800 distinct bacterial, archaeal and viral genomes through PathoScope (PS) and MG-RAST (MR) analyses. We detected 768, 1421, 1819 and 1774 bacterial strains in Group-I, Group-II, Group-III and Group-IV, respectively through PS analysis which were represented by Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, Spirochaetes and Fibrobacteres phyla (> 93.0% of the total abundances). Simultaneously, 343 archaeal strains were detected, of which 95.90% strains shared across four metagenomes. We identified 43 dominant species including 31 bacterial and 12 archaeal species in AD microbiomes, of which only archaea showed positive correlation with digester pH, CH4 concentration, pressure and temperature (Spearman correlation; r > 0.6, p < 0.01). The indicator species analysis showed that the species Methanosarcina vacuolate, Dehalococcoides mccartyi, Methanosarcina sp. Kolksee and Methanosarcina barkeri were highly specific for energy production. The correlation network analysis showed that different strains of Euryarcheota and Firmicutes phyla exhibited significant correlation (p = 0.021, Kruskal–Wallis test; with a cutoff of 1.0) with the highest level (74.1%) of energy production (Group-IV). In addition, top CH4 producing microbiomes showed increased genomic functional activities related to one carbon and biotin metabolism, oxidative stress, proteolytic pathways, membrane-type-1-matrix-metalloproteinase (MT1-MMP) pericellular network, acetyl-CoA production, motility and chemotaxis. Importantly, the physicochemical properties of the AD including pH, CH4 concentration (%), pressure, temperature and environmental temperature were found to be positively correlated with these genomic functional potentials and distribution of ARGs and metal resistance pathways (Spearman correlation; r > 0.5, p < 0.01). This study reveals distinct changes in composition and diversity of the AD microbiomes including different indicator species, and their genomic features that are highly specific for energy production.

scholarly journals Study of serum Ceruloplasmin, Malondialdehyde (MDA) and hs-CRP as biomarkers of severity in Psoriasis

2021 ◽  
Vol 8 (3) ◽  
pp. 70-73
Author(s):  
Prashant K. ◽  
MI Khan
Keyword(s):  
General Medicine ◽  
Sampling Technique ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
Serum Ceruloplasmin ◽  
Group Iii ◽  
Medical College ◽  
Group I ◽  
Group Ii ◽  
Hs Crp

Background : Psoriasis is one of the common diseases diagnosed in dermatology clinics. It is characterized by erythematous and sharply demarcated papules covered by silvery micaceous scales. Although, etiology is an unclear genetic predisposition seen in 50% of cases. This study aimed to determine the role of malondialdehyde (MDA), ceruloplasmin, and C-Reactive Protein (hs-CRP) as markers of severity of the disease. Methods: N= 75 patients were selected and divided into three categories of different severity based on PASI scores. Those with PASI score of < 10 were mild cases included in group I and with PASI Scores of 11-15 were moderate cases included in group II and PASI scores >15 were in group III. N=25 age and sex-matched taken from healthy people were included in group IV controls. Results: correlation coefficient (r) values were calculated between PASI and biomarkers. Of the biomarkers, a strong positive correlation was shown by serum ceruloplasmin levels in group I and group II (r = + 0.9). Ironically the values in group III of ceruloplasmin were positive the correlation was not strong. The Malondialdehyde values in group III also showed a strong positive correlation with r values of + 0.93. In the hsCRP group, a strong positive correlation was found in group III however, a weak positive correlation was found in group I and group II. Materials and Methods: A Hospital-based Prospective study was conducted in the Department of Medicine, Santhiram medical college & general hospital for a 2 year period.Universal Sampling Technique was used for the selection of study subjects.The study population included patients admitted with fever, flank pain, and positive urine or blood cultures in the department of general medicine in Santhiram medical college and general hospital.The final sample size was 50 subjects. Conclusion: Serum ceruloplasmin was positively correlated with PASI scores and serum MDA levels were highly correlated in severe cases of psoriasis. The hs-CRP was also found to be elevated in the psoriasis cases as compared to controls however, a significant positive correlation was found in severe cases. Therefore, psoriasis severity can be mo

scholarly journals The level of endogenous testosterone and its correlation with lipid profile in men older than 40 years with acute myocardial infarction

2020 ◽  
Vol 77 (8) ◽  
pp. 804-810
Author(s):  
Branko Barac ◽  
Sanja Stankovic ◽  
Milika Asanin ◽  
Zorana Vasiljevic-Pokrajcic ◽  
Svetlana Vujovic
Keyword(s):  
Lipid Profile ◽  
Significant Positive Correlation ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Apolipoprotein A1 ◽  
Acute Myocardial Infarct ◽  
Healthy Men ◽  
Positive Correlation ◽  
Group I ◽  
Group Ii

Background/Aim. The influence of lipid profile on acute myocardial infarct (AMI) is well known. On the other hand, the role of testosterone (T), as one of the possible predictive factors of AMI in men and its influence on lipid profile in men is still controversial. The aim of the study was to determine levels of T in AMI and six months after AMI in the same group of patients, and to compare with T levels in healthy men. Also we correlated T levels with lipid profile in patients with AMI and 6 months after AMI. Methods. The study was designed as prospective study. Patients were divided into III groups: Group I included 35 men, aged 55 ? 3 years, with AMI. Group II included the same 35 patients, analyzed 6 months after AMI. The group III consisted of 20 healthy men aged 57 ? 2.12 years (control group). Blood samples of the group I (AMI) were taken in the first 12 hours from the AMI beginning and also 6 months after AMI (group II). Following analyses were performed: levels of total cholesterol, triglycerides, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, lipoprotein(a) [Lp(a)], apolipoprotein A1 (Apo A1), apolipoprotein B (Apo B) and T. Results. Levels of T in patients with AMI (16.86 ? 7.18 nmol/L) as well as 6 months after AMI (18.12 ? 7.96 nmol/L) were statistically significantly lower than those in healthy persons of the same age (27.11 ? 10.48 nmol/L) (p < 0.001). In the group I, statistically significant, positive correlation was found between levels of T and HDL cholesterol (r = 0.403, p < 0.05), and levels of T and Apo A1 (r = 0.747, p < 0.01). In the group II, statistically significant, positive correlation was also found between levels of T and HDL cholesterol (r = 0.388, p < 0.05) and T and Apo A1(r = 0.354, p < 0.05). Conclusion. This study showed that men, over 40 years of age, with AMI had statistically significantly lower concentrations of endogenous T compared to healthy male population of the same age. Levels of T in the same patients after 6 months from AMI maintained statistically significantly lower values in comparison to those in healthy men.

scholarly journals Procollagen III amino terminal propeptide (PIIINP): A non invasive marker of methotrexate induced liver fibrosis in Rheumatoid arthritis patients

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
H Amer ◽  
H Ghareeb ◽  
N L Mohamed ◽  
N O El-Azizi ◽  
A M Mansour
Keyword(s):  
Rheumatoid Arthritis ◽  
Liver Fibrosis ◽  
Hepatic Fibrosis ◽  
Negative Correlation ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Positive Correlation ◽  
Non Invasive ◽  
Group I

Abstract Background Rheumatoid Arthritis (RA) is a common autoimmune disease with a complex pathogenesis involving multiple genetic and environmental factors. The management of RA rests on several principles. Drug treatment, which comprises disease-modifying antirheumatic drugs (DMARDs), non-steroidal anti-inflammatory drugs and glucocorticoids (GCs), as well as non-pharmacological measures, such as physical, occupational and psychological therapeutic approaches, together may lead to therapeutic success. However, the mainstay of RA treatment is the application of DMARDs. Methotrexate is an antifolate and antimetabolite; it’s one of the DMARDs. Long term therapy with methotrexate has been associated with development of fatty liver and hepatic fibrosis. Liver biopsy is the standard method for diagnosing liver fibrosis, but it may be associated with significant morbidity and mortality of up to 0.33% thereby limiting its use. So the use of noninvasive markers of hepatic fibrosis such as serial platelet counts, FIB 4 score, ALT/AST ratio and recently serum PIIINP become mandatory. Objectives to evaluate the reliability of PIIINP in the screening for hepatic fibrosis induced by long term methotrexate therapy in rheumatoid arthritis patients compared with FIB 4 score and ALT/AST ratio. Patients and Methods This case study included 90 RA patients categorized into 60 RA patients on MTX therapy (group I), 30 RA patients on other medications (group II). All participants were subjected to full history taking, thorough rheumatological examination and lab investigations including complete blood count (CBC), ESR, CRP, AST, ALT, RF and measurement of serum PIINP levels, DAS and FIB-4 score were calculated. Results Patients in group I showed significant increase in serum PIIINP compared to patients in group II. There was significant negative correlation between disease duration, Platelets count and serum PIIINP levels in patients of both groups. There was significant negative correlation between folic acid intake and serum PIIINP levels of group I. There was significant positive correlation between Mean Corpuscular Volume, AST, ALT, AST/ALT ratio, FIB-4 score and serum PIIINP levels in patients of both groups. There was significant positive correlation between MTX dose and duration and levels of serum PIIINP in patients of group I. Conclusion Serum PIIINP levels could be used as non invasive marker for screening for hepatic fibrosis induced by long term MTX therapy in RA patients.

scholarly journals Enumeration of Salivary Streptococci and Lactobacilli in Children with Differing Caries Experiences in a Rural Indian Population

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Sreeja Ravindran ◽  
Minal Chaudhary ◽  
Madhuri Gawande
Keyword(s):  
Dental Caries ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Mutans Streptococci ◽  
Plate Count ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
Group Iii ◽  
Group I ◽  
Plate Count Method

Objectives. Compare the total salivary Streptococci and Lactobacilli counts in cleft and noncleft children with differing caries experiences, correlate the bacterial counts with dmft/DMFT status and identify the different biotypes of Mutans Streptococci (MS). Patients. Group I included thirty subjects with dental caries (DC) and cleft lip and palate (CL/P); Group II had thirty subjects with DC but without CL/P. Group III comprised a control of thirty subjects with neither DC nor CL/P. Methodology. Enumeration of total salivary Streptococci and Lactobacilli was done by the plate count method and correlation of counts with dmft/ DMFT status examined. Differences in biochemical reactions were used to identify the biotypes. Results. Streptococci colonies in CL/P children with caries (64.30 ± 24.52) was significantly higher than in children with no CL/P or caries (45.57 ± 16.73). No significant differences in the Lactobacilli count were observed. dmft/DMFT status and Streptococci counts showed a strong positive correlation whereas Lactobacilli counts showed a moderate correlation. S. mutans was the predominant biotype. Conclusions. Higher total salivary Streptococci and Lactobacilli counts exist in cleft subjects with caries than in the non-cleft subjects. Positive correlation between dmft/DMFT scores and salivary Streptococci reinforces its role in DC. S. mutans and S. sobrinus are the biotypes more frequently associated with dental caries in children.

scholarly journals Assessment of trace metal in macroalgae and sediment of the Sundarban mangrove estuary

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ayesha Siddiqua Asha ◽  
A. S. M. Saifullah ◽  
Md. Galal Uddin ◽  
Md. Shemul Sheikh ◽  
Muhammad Jasim Uddin ◽  
...  
Keyword(s):  
Trace Metals ◽  
Trace Metal ◽  
Significant Positive Correlation ◽  
Trace Metal Concentration ◽  
Monsoon Period ◽  
Period Analysis ◽  
Positive Correlation ◽  
Mangrove Estuary ◽  
Zn And Cu In ◽  
Sundarban Mangrove

AbstractThis study was carried out to assess the levels of trace metals (Fe, Zn, Mn and Cu) in the macroalgae and sediment of the Sundarban mangrove estuary in Bangladesh. In this connection, macroalgae, water and sediment samples were collected seasonally (pre-monsoon, monsoon and post-monsoon) for a year from the study area. The surface water of the estuary was found to be quite rich in NO3, PO4 and NH4, which is more than that of the sediment pore water. Trace elements were determined using an atomic absorption spectrophotometer. The amount of trace metals in the samples were found in the order of Fe > Mn > Zn > Cu. Enrichment factor was done for trace metals in sediment and showed non-crustal origin of Zn and Cu in the monsoon period. Analysis of variance revealed the seasonal variation of trace metal concentration in sediment (except Mn; p > 0.05) and macroalgae (except Zn; p > 0.05). Iron in sediment showed significant positive correlation both with Fe (r = 0.84, p < 0.05) and Mn (r = 0.87, p < 0.01) in macroalgae. Similarly, Cu in sediment demonstrated a significant positive correlation with Cu in macroalgae (r = 0.81, p < 0.01). The findings reveal a significant communication of metals in sediment and macroalgae.

scholarly journals Evaluation of Serum Fibrinogen, Plasminogen,α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels (PAI) and Their Correlation with Presence of Retinopathy in Patients with Type 1 DM

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Sefika Burcak Polat ◽  
Nagihan Ugurlu ◽  
Fatma Yulek ◽  
Huseyin Simavli ◽  
Reyhan Ersoy ◽  
...  
Keyword(s):  
Plasminogen Activator Inhibitor ◽  
Group Iv ◽  
Control Group ◽  
Positive Correlation ◽  
Group Iii ◽  
Group I ◽  
And Control ◽  
Type 1 Dm ◽  
Activator Inhibitor

Background.Diabetic retinopathy (DR) is the leading cause of blindness in the world. Retinopathy can still progress despite optimal metabolic control. The aim of the study was to determine whether different degrees of DR (proliferative or nonproliferative) were associated with abnormally modulated hemostatic parameters in patients with T1DM.Method.52 T1DM patients and 40 healthy controls were enrolled in the study. Patients were subdivided into three categories. Group I was defined as those without retinopathy, group II with NPRP, and group III with PRP. We compared these subgroups with each other and the control group (Group IV) according to the serum fibrinogen, plasminogen, alpha2-anti-plasmin (α2-anti-plasmin), and PAI.Results. We detected that PAI-1, serum fibrinogen, and plasminogen levels were similar between the diabetic and control groups (P=0.209,P=0.224, andP=0.244, resp.), whereasα2-anti-plasmin was higher in Groups I, II, and III compared to the control group (P<0.01,P<0.05, andP<0.001, resp.). There was a positive correlation between serumα2-anti-plasmin and HbA1c levels (r=0,268,P=0.031).Conclusion. To our knowledge there is scarce data in the literature aboutα2-anti-plasmin levels in type 1 diabetes. A positive correlation betweenα2-anti-plasmin with HbA1c suggests that fibrinolytic markers may improve with disease regulation and better glycemic control.

scholarly journals Thrombocyte indices in dogs infected with Ehrlichia canis and Anaplasma phagocytophilum

2014 ◽  
pp. 4277-4288 ◽  
Author(s):  
Funda Özata ◽  
Kerem Ural
Keyword(s):  
Anaplasma Phagocytophilum ◽  
Significant Positive Correlation ◽  
Point Of Care ◽  
Control Group ◽  
Healthy Controls ◽  
Positive Correlation ◽  
Vector Borne Diseases ◽  
Elisa Kit ◽  
Group I ◽  
Vector Borne

ABSTRACTObjectives. In the present study alterations in trombocyte numbers and trombocyte indices were investigated in 51 dogs naturally infected with E. canis and/or A. phagocytophilum. Achieved results were compared to those of 20 healty dogs comprising control group. Materials and methods. Naturally occuring vector borne diseases were diagnosed by use of a canine point-of-care ELISA kit (Snap 4Dx, Idexx). Dogs were enrolled into 3 groups as follows; II. group involved A. phagocytophilum infected dogs (n=10), III. group (n=13) E. canis+ A. phagocytophilum co-infected, and IV. group (n=28) E. canis infected dogs. Healthy controls (n=20) were enrolled in group I. Results. Mean PLT counts were significantly decreased in II., III. and IV. groups (159.6±63.5, 142.3±44.3, 148.7±33.5, respectively) in comparison to control group (370.4±28.6) (p≤0.01). Mean PCT values in groups II., III. and IV. (0.1530±0.590, 0.1531±0.0441, 0.1450±0.314, respectively) were significantly decreased in contrast to control group (0.3695±0.0283) (p≤0.01). Between PLT and PCT values, statistically significant positive correlation (p≤0.01) (r=0.988, 0.990 and 0.981, respectively) was evident among groups II., III. and IV. Conclusions. Infected dogs showed significant alterations (p≤0.01) among mean PLT and PCT values and a positive correlation was evident between those 2 parameters (p≤0.01), whereas alterations on mean MPV and PDWc were not statistically significant. Finally it was suggested that according to the aforimentioned results, PLT and PCT values may be used as valuable parameters for diagnosis and probably for monitorization and prognosis in infected dogs with Ehrlichiosis and/or Anaplasmosis

scholarly journals Correlation between glycemic control and dyslipidemia in Type 2 Diabetes Mellitus patient

2019 ◽  
Vol 8 (6) ◽  
pp. 1387
Author(s):  
Neha Yadav ◽  
Sujata Singh ◽  
Smita Gupta ◽  
Saurabh Mishra ◽  
Krishna Singh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Correlation Coefficient ◽  
Positive Correlation ◽  
Group Iii ◽  
Group I ◽  
Significant Difference

Background: India is one of the countries with highest number of diabetes patients. Patients of type 2 diabetes mellitus are usually dyslipidemic. The objective of the research was to study the pattern of dyslipidemia and to study the correlation of glycemic control with dyslipidemia in type 2 diabetes mellitus patients.Methods: A cross sectional observational study was performed on patients of type 2 diabetes mellitus over 6 months period. The study included 200 patients and the variables recorded were demographic profile, FBS, PPBS, HbA1C and lipid profile parameters. The patients were divided into 3 groups according to HbA1C level i.e. Group I (Good glycemic control HbA1C 6-7 gm%), group II (Fair glycemic control HbA1C 7.1-8.2 gm%) and group III (poor glycemic control, HbA1C >8.2 gm%).Results: The data showed that TG level was maximum in group III and was minimum in group I. Comparison between the group shows a significant difference between all the groups (P <0.001). A significant positive correlation (Correlation coefficient 0.67, P <0.001) was also observed between level of TG and HbA1C. Similarly, LDL level was also highest in group III with a significant difference with other two groups (P <0.05). Also, a positive correlation (Correlation coefficient 0.64, P <0.05) was observed between LDL and HbA1C. On the other hand, HDL was lowest in group III as compared to groups I and II (P <0.001) and a negative correlation (Correlation coefficient -0.716, P <0.001) was seen between HDL and HbA1C.Conclusions: Dyslipidemia is less prevalent in diabetics who have better glycemic control.

Ultrastructural Lesions Produced by Alcohol and Sucrose in the Heart and Liver of C57BL Mice

1970 ◽  
Vol 28 ◽  
pp. 208-209
Author(s):  
K.K. SEKHRI ◽  
C.S. ALEXANDER ◽  
H.T. NAGASAWA
Keyword(s):  
Osmium Tetroxide ◽  
Male Mice ◽  
Alcohol Group ◽  
Group Iii ◽  
Group I ◽  
C57bl Mice ◽  
Group Ii

C57BL male mice (Jackson Lab., Bar Harbor, Maine) weighing about 18 gms were randomly divided into three groups: group I was fed sweetened liquid alcohol diet (modified Schenkl) in which 36% of the calories were derived from alcohol; group II was maintained on a similar diet but alcohol was isocalorically substituted by sucrose; group III was fed regular mouse chow ad lib for five months. Liver and heart tissues were fixed in 2.5% cacodylate buffered glutaraldehyde, post-fixed in 2% osmium tetroxide and embedded in Epon-araldite.

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