EPIDEMIOLOGICAL CHARACTERISTICS OF BREAST CANCER IN THE REPUBLIC OF MORDOVIA

The article analyzes the main epidemiological characteristics of breast cancer in the Republic of Mordovia in comparison with the Russian Federation. Based on the official accounting and reporting documentation for 2011-2019. the territorial and age-specific features of the incidence were determined, the structure of pathomorphological forms of breast cancer was assessed, the weighted average cost of providing specialized medical care for breast neoplasms in a hospital in the Republic of Mordovia was calculated. It has been shown that the incidence of breast cancer in the Republic of Mordovia for 2011-2019 increased, which corresponds to the all-Russian laws: 6.11 per 100 thousand women in the age group of women 25-29 years old to 213.14 in the age group 60-64 years. Infiltrating ductal carcinoma prevailed in the structure of the pathomorphological form of breast cancer among the inhabitants of the Republic - 58.8%. It has been shown that the cost of providing specialized hospital care for stage III breast cancer is 8 times higher than for stages I-II of breast cancer. Thus, the analysis showed that breast cancer is a serious medical and social problem, and effective treatment of the disease requires costly treatment in a specialized hospital, and the cost of drug therapy for the disease increases significantly at advanced stages.

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CLINICAL AND SUBCLINICAL CHARACTERISTICS ON BREAST CANCER PATIENTS TREATED WITH ANTHRACYCLINES

Tạp chí Y học Cộng đồng ◽

10.52163/vjcm.v62i5.131 ◽

2021 ◽

Vol 62 (5) ◽

Author(s):

Bui Dang Minh Tri ◽

Doan Thanh Truc ◽

Tri Kim Ngoc ◽

Vo Van Cuong

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Ductal Carcinoma ◽

Nipple Discharge ◽

Medullary Carcinoma ◽

Unknown Boundary ◽

Age Group ◽

Breast Cancer Patients ◽

Research Subjects ◽

Tubular Carcinoma

Objective: Describing the clinical and subclinical characteristics on breast cancer patients treated with Anthracyclines at Thong Nhat hospital.Subjects and methods: a prospective descriptive study on 43 patients with breast cancer was treated with Anthracyclines with 4 to 6 cycles as determined by clinical doctor at Thong Nhat hospital. Results: Average age: 49.2 ± 3.2 years old. The age group accounted for the largest proportion in the study object was the 50-60 age group (48.84%). The percentage of patients who self-examined the tumor was the highest with 79.07%. There were 9.30% of patients with pain symptoms, 11.63% of patients with nipple discharge. Tumor position in the upper-external quadrant accounted for the largest percentage with 55.81%. The average size of tumors was 2.56 ± 1.2 (cm). The main form of lesions detected on ultrasound was the local lesion with over 80% with an unknown boundaryfeature (81.40%) and predominantly invasive (76.74%). The histopathological type accounted for the highest percentage was the invasive tubular carcinoma (79.07%), the medullary carcinoma andmucinous carcinoma body accounted for the lowest rate with 2.33% and 0%, respectively. The histological degree accounted for the highest percentage among the research subjects was degree 2with 50.18%. Stage III accounted for the highest rate with 46.51%.Conclusion: The most common age group for breast cancer was 50-60 years old, the main symptom was self-examination with breast tumors, breast cancer were mainly local tumor at the upper-externalposition. On ultrasound, the lesions were the local, unknown boundary, and invasive lesions. Breast cancer was mainly invasive ductal carcinoma, histologic degree 2.

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Role of Ag NORs in Improve Diagnosis of Breast Cancer with Different grades and Subtypes’ among Sudanese women

Science Progress and Research ◽

10.52152/spr/2021.166 ◽

2021 ◽

Vol 1 (4) ◽

pp. 443-448

Author(s):

Doaa Ibrahim Ahmed

Keyword(s):

Breast Cancer ◽

Invasive Carcinoma ◽

Ductal Carcinoma ◽

Lobular Carcinoma ◽

Age Group ◽

Lobular Carcinoma In Situ ◽

Tissue Sections ◽

In Situ Carcinoma

This study aimed to evaluate the role of Ag NORs in improves diagnosis of Breast cancer with different subtypes’ among Sudanese Patients. This study include tissue sections of breast cancer diagnosed women, they were 30, ductal and lobular invasive carcinoma were 10 for each, while ductal and lobular in-situ carcinoma were 5 each. Found correlation between subtypes of breast cancer and Ag NOR , Invasive ductal carcinoma had more NOR while the lobular carcinoma in situ was less one , Stage III most frequency than the other stage. Silver staining were performed and Ag-NOR were detected in ductal and lobular invasive carcinoma more than ductal and lobular in-situ carcinoma, grade III has more frequency of Ag-NOR than other stages, and no correlation found between Ag-NOR and age group

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Comparison of ultrasound and histopatological findings breast cancer between women aged below and above 40 years.

Psychology and Education Journal ◽

10.17762/pae.v58i1.2207 ◽

2021 ◽

Vol 58 (1) ◽

pp. 5713-5722

Author(s):

Suraini Mohamad Saini Et al.

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Ductal Carcinoma ◽

Tumour Size ◽

Breast Cancer Incidence ◽

Age Group ◽

Her2 Receptor ◽

Cross Sectional ◽

Common Features ◽

Ultrasound Findings

Breast cancer is the most common cancer among females, but breast cancer incidence in young women is low. There are limited studies of breast cancer in this age group in Malaysia, while there are conflicting data regarding these women's prognosis compared to older patients. This study describes the common features presented by breast carcinoma on histopathological and ultrasound findings. Objective: To compare the ultrasound findings and histopathological characteristics of breast cancer for women aged below 40 years and those aged 40 years and above. Methodology: This was a retrospective, cross-sectional study using secondary data, in which the data was collected respectively from patient's clinical histories, radiology findings, and histopathology reports of patients with breast cancer in Hospital Serdang from 1 January 2009 until 31 December 2018. Patients were divided into two age groups (ages below 40, ages 40 and above). Results: 205 patients were included in this study. The most common type of breast carcinoma is invasive ductal carcinoma. Common features are grade II breast cancer cells, DCIS high grade, stage 2 (TNM), tumour size of T2 and lymph node invasion. The majority of tumours are positive with oestrogen receptor, progesterone receptor, and HER2 receptor. Conclusion: Younger age group has a similar feature with the older age group, except they have late stage and progesterone negativity. There is no significant association between age group, ultrasound, histological features, and breast carcinoma receptors. Keywords: ultrasound breast, histopathological, breast cancer

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Epidemiological profile of aged women with breast cancer in a private clinic in Criciúma/sc

Mastology ◽

10.29289/259453942020v30s1041 ◽

2020 ◽

Vol 30 (Suppl 1) ◽

Author(s):

Maristela Harder Peters ◽

Giorgia Emilia Klering ◽

Thamyra Manenti Bonfante

Keyword(s):

Breast Cancer ◽

Hormone Therapy ◽

Elderly Women ◽

Ductal Carcinoma ◽

Private Clinic ◽

The Body ◽

Luminal A ◽

Aged Patients ◽

The Mean ◽

Epidemiological Characteristics

Objectives: Breast cancer is the most common cancer among women, gradually increasing its incidence in the aged population. This study aims to analyze the epidemiological characteristics of patients over 60 years of age with breast cancer in a private clinic in the city of Criciúma, Santa Catarina. Methods: This is a retrospective observational study, with collection of primary and secondary data and a quantitative approach. The sample was obtained through the analysis of 76 medical records and questionnaires, between 2014 and 2018. Results: The mean age of the patients was 70.39 years. The mean age of menarche and menopause was 13.23 and 49.48 years, respectively. Regarding the body mass index, 38.4% had some degree of obesity. Most elderly women (81.8%) were non-smokers. Evenly, 92.3% were non-alcoholics. Most cancers were detected by mammography (39.3%). Conservative surgery was predominant (74.2%). The association between radiotherapy and hormone therapy was the predominant adjuvant therapy (48.7%). Neoadjuvance was performed in 15 patients, 9 of whom underwent neoadjuvant chemotherapy (60.0%). The most used hormone therapy was anastrozole (88.9%). The most common side effects related to hormone therapy were isolated muscle pain (35.7%) and associated hot flushes (21.4%). There was a predominance of invasive ductal carcinoma (59.2%) and Luminal A subtype (43.6%). Conclusion: Aged patients usually present with smaller and less aggressive tumors, mostly submitted to less aggressive treatments.

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Qatar experience of standard risk breast cancer screening program (BCSP).

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.26_suppl.18 ◽

2014 ◽

Vol 32 (26_suppl) ◽

pp. 18-18

Author(s):

Salha M. Bujassoum ◽

Reena Alassam ◽

Hekmat Bugrein

Keyword(s):

Breast Cancer ◽

Ductal Carcinoma ◽

Screening Program ◽

Arab World ◽

Breast Cancer Incidence ◽

Incidence Rates ◽

Distributed Model ◽

Age Group ◽

Detection Rates ◽

Triple Assessment

18 Background: Qatar has one of the highest age-adjusted breast cancer incidences in the Arab world. Although this is much lower than the incidence in the West. Breast-cancer incidence in Qatar was 45 per 100,000 in 2003 to 2007.These higher incidence rates in Qatar are mainly due to the growing population. The prevalent age group, for Qatari and non-Qatari patients, was age 40 to 50. This suggests that the age-specific incidence of breast cancer in Qatari women is unlike the pattern usually seen in Western nations where median age at diagnosis is 61 years, moreover the diagnosis is often at advanced stages of breast cancer. These factors led to establishment the first hospital based (BCSP) in Qatar. It uses a distributed model of mammography service. The program launched 2008, accepts eligible asymptomatic women at ages 40 to 69. Methods: Retrospective study was done during the period from April 2008 to December 2013. Our aim is to describe our experience of (BCSP) in Qatar and to monitor performance indicators. Our (BCSP) includes an office call and recall as well as triple assessment. We also discuss positive cases in multidisciplinary meeting. Results: Total number of screened women was 4,264 with an increasing participation, year by year. Out of these, Qatari patient’s accounts for 1,145, and non Qatari for 3,119. The age group of cases was (43 to 51). Total breast biopsies were 82, of which 45 were positive of breast carcinomas, (37) invasive ductal carcinoma, (8) noninvasive ductal carcinoma. The invasive cancer detection rate was 8.2 %. The positive predictive value (PPV) was 46%. Sensitivity value has improved from 51% in 2008 to 70% in 2012 as well as specificity value that has increased from 77% in 2008 to 83% in 2012. Conclusions: Public acceptance of (BCSP) in Qatar gradually increased and detection rates are higher than western countries. We’re detecting biologically aggressive tumors at younger age groups. We’ve a unique population and we need to utilize our data and evidence based medicine to guide policy makers and women to make the correct decision towards (BCSP).

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Breast cancer pathology patterns in Armenia.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.e12586 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. e12586-e12586

Author(s):

Davit Zohrabyan ◽

Samvel Bardakhchyan ◽

Sergo Mkhitaryan ◽

Liana Safaryan ◽

Jemma Arakelyan ◽

...

Keyword(s):

Breast Cancer ◽

Ductal Carcinoma ◽

Lobular Carcinoma ◽

Medullary Carcinoma ◽

Her2 Status ◽

Leukocyte Infiltration ◽

Luminal A ◽

Luminal B ◽

Epidemiological Characteristics ◽

Armenian Women

e12586 Background: Breast cancer (BC) is the most common malignancy among the women in Armenia (AM). Currently there is a knowledge gap regarding the morphology distribution of the BC in AM. Methods: The data on patients with BC diagnosed in 2015-2016 in the pathology lab “Davidyants Labs” in AM were retrospectively reviewed. Pts with Her2+ results by IHC were excluded from the study, due to unavailability to perform FISH or CISH analyses. Overall 361 pathology reports were evaluated. Results: The median age was 54 years; range [19-82]. Histopathological subtypes were defined for 305 pts, from which lobular carcinoma 57.4% of cases (175/305), ductal carcinoma 26.9% (82/305), mucinous carcinoma 2.6% (8/305), mixed type carcinoma (lobular and ductal) 2.6% (8/305), DCIS 2% (n = 6/305), non specified carcinoma 2% (6/305), medullary carcinoma 1% (n = 3/305) and others 5.6% (17/305). Within the cohort 8.5% (23/270) were grade 1, 65.9% grade 2 (178/270); 25.6% grade 3 (n = 69/270). Vascular or lymphatic invasion was present in 59.5% (50/84) and 64.7% (55/85), respectively. Staging distribution, based on pT pN data for 92 pts who went to primary surgery, was: 0 stage 7.6% (7/92), I stage 22.8% (21/92), II stage 41.3% (38/92), III stage 28.3% (26/92). Staging distribution based on ypT ypN data for 27 pts who went to surgery after neoadjuvant chemo was 0 stage 25.9% (7/27), I stage 18.5% (5/27), II stage 29.6% (8/27), III stage 25.9% (7/27). ER and PR were defined for 244 patients. ER positive 89.8% (219/244) of cases, PR pos. 73% (178/244), ER/PR pos. 72.5% (177/244) cases. Her receptor was defined for 237 patients. Her3+ 16.9% (40/237); Her2+ 12.7% (30/237); Her1+ 38% (90/237); Her0 32.5% (n = 77/237). We could not evaluate Her2+ status by FISH or CISH, so these results were excluded from the analysis. Ki67 was low (≤20) in 42.1% (101/240) of cases and high ( > 20) in 57.9% (139/240). Within the group Luminal A type was 41.4% (84/203); Luminal B 32.5% (66/203); Her positive 19.7% (40/203) and triple negative 6.4% (13/203). p53 and perineural invasion (Pn) was present in 32% (16/50) and 52% (26/50), respectively. Tumor leukocyte infiltration was determined for 16 patients. Leukocyte infiltration was positive in 43.7% (7/16) cases, negative in 25% (4/16) cases, minimal in 31.3% cases (5/16). Conclusions: BC in Armenian women presents with different epidemiological characteristics in comparison with other ethnicities. Lobular type BC is the most frequent type among Armenian women, however, differential diagnosis between lobular/ductal carcinomas was done without IHC (E-Cadherin), which rises the need for further studies on that regard.

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Clinical pathological and epidemiological study of triple negative breast cancer

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20172465 ◽

2017 ◽

Vol 5 (6) ◽

pp. 2657

Author(s):

Arun Ajay ◽

Priya Radhakrishnan

Keyword(s):

Breast Cancer ◽

Triple Negative ◽

Ductal Carcinoma ◽

Tertiary Care ◽

High Rate ◽

Care Hospital ◽

Breast Carcinomas ◽

Significant Difference ◽

Her 2 ◽

Epidemiological Characteristics

Background: Worldwide breast cancer is the most frequently diagnosed life threatening cancer in women and a leading cause of cancer death among women. In Kerala, India around 30% of cancer-affected women have carcinoma breast. Breast carcinomas which do not express estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER-2/neu) receptors are known as triple negative breast carcinomas (TNBC). They are extremely aggressive with poor prognosis. Here the authors described the clinical pathological and epidemiological characters of triple negative breast carcinomas in a tertiary care hospital in Kerala, India and compare with non-TNBC.Methods: It was a cross sectional comparative study. Clinical, pathological and epidemiological characteristics of 75 cases of TNBC were compared with that of 225 cases of non-TNBC presented in Department of General Surgery, Government medical college, Kozhikode, Kerala, India between a period from March 2014 to October 2015 (20 months). Patients were recruited after obtaining an informed consent. ER, PR, HER-2/neu status were determined by immunohistochemical staining. Data obtained were statistically analyzed using SPSS software.Results: Triple negative breast carcinoma was significantly associated with a younger age (mean age 43.67 years), early age of menarche. Commonly seen in premenopausal age group (78.7%). Patients with the triple-negative carcinoma had relatively large tumors (mean size 4.45cm compared to 3.14cm) and a high rate of node positivity (86.67%). More advanced stage at diagnosis with high grade tumor characteristics. Most common histopathology was invasive ductal carcinoma (98.7%) but no statistical difference was noted with non-TNBC.Conclusions: No significant difference was noted between TNBC and non TNBC on comparing family history, parity, age at 1st child birth, OCP use. The outcome of the disease following treatment was unable to study due to short time frame of the study.

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Prøveprosjekt med mammografiscreeening i fire fylker; organisering og gjennomføring

Norsk Epidemiologi ◽

10.5324/nje.v7i2.399 ◽

2009 ◽

Vol 7 (2) ◽

Author(s):

Steinar Østerbø Thoresen

Keyword(s):

Breast Cancer ◽

Cost Benefit ◽

Pilot Project ◽

English Summary ◽

Age Group ◽

Breast Cancers ◽

Nodal Involvement ◽

Attendance Rate ◽

Font Size ◽

The Cost

SAMMENDRAGRandomiserte kontrollerte studier har vist at systematisk mammografiscreening i aldersgruppen 50 til 69 årreduserer dødeligheten av brystkreft med omlag 30%. I 1994 ble det av Sosial- og helsedepartementetbesluttet å iverksette et prøveprosjekt med mammografi i fire fylker. Prosjektet omfatter kvinner i alderen50-69 år og skal pågå i fire år med to screeningrunder. Utvalgte fylker er Akershus, Hordaland, Oslo ogRogaland. Det er valgt en fylkeskommunal modell i samarbeid med Kreftregisteret, Statens helseundersøkelser(SHUS) og Statens strålevern. Kreftregisteret har den nasjonale prosjektledelse, mens SHUS haransvar for invitasjoner, svarbrev samt innkjøp og drift av busser. Prosjektet skal evalueres både frakostnadsiden og informasjonsvirksomheten. Det utføres to-bilde mammografi med dobbelt tyding. Detførste driftsåret var 1996. Oppmøte før purring ligger på omlag 77%. Det er påvist 337 krefttilfeller.Svulstene er overveiende meget små og uten spredning til lymfeknuter i armhulen. Det har vært få driftsproblemer,og tiltaket er svært godt mottatt blant de inviterte kvinner.Thoresen SØ. Mammography screening in four Norwegian counties: a pilot project.Nor J Epidemiol ENGLISH SUMMARYOrganised breast cancer screening by mammography can reduce mortality from breast cancer substantially.In Norway a pilot project in four counties was startet in 1996, including 160 000 women in the age group50 to 69 years. Two-view mammography and double reading are performed. So far the attendance rate is77%, before reminders are sent to the women. The attendance rate in the mobile units are high. A total of337 breast cancers have been identified, which is seven out of 1000 screened. The positive predictive valueis 13%. The majority of the invasive tumors are small and without nodal involvement. The pilot project isscheduled for four years and will also be evaluated form the cost/benefit side.1997; 7 (2): 179-182.

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A Retrospective Analysis of Breast Cancer at BPKMCH, Nepal

Nepalese Journal of Cancer ◽

10.3126/njc.v4i1.31852 ◽

2020 ◽

Vol 4 (1) ◽

pp. 98-101

Author(s):

Chin Bahadur Pun ◽

Sadina Shrestha ◽

Ranjan Raj Bhatta ◽

Greta Pandey ◽

Suraj Uprety ◽

...

Keyword(s):

Breast Cancer ◽

Retrospective Study ◽

Invasive Ductal Carcinoma ◽

Ductal Carcinoma ◽

Grading System ◽

Age Group ◽

Common Cancer ◽

Grade Ii ◽

Common Histological Type ◽

Related Mortality

Introduction: Breast cancer is the most common cancer and also the leading cause of cancer related mortality in women worldwide which impact 2.1 million women each year. Breast cancer rates are increasing in nearly every region globally. Methods: This was retrospective study at Department of Pathology in B P Koirala Memorial Cancer Hospital effective from 15 April 2018 to 14 April 2019. All the data were retrieved and analyzed. Results: Total 205 breast cancer cases were analyzed, among them 198 cases were females accounting 96.5 %and 7 cases were males accounting 3.5 %.Among 205 cases, 181 (88.6%) cases were invasive ductal Carcinoma No Special Type. Majority of cases 111(54%) were diagnosed with Nottingham grading system grade II of breast cancer. According to our study breast cancer was most common in the age group 41-50 years (32.2%). Conclusion: Breast cancer is more common in females than in males. Most common affected age group was 41-50 years. Most common histological type was invasive ductal carcinoma NST. Similarly, left sided breast cancer was more common than right.

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Clinicopathological pattern and risk factors of carcinoma breast in younger age group

Bangabandhu Sheikh Mujib Medical University Journal ◽

10.3329/bsmmuj.v9i2.29197 ◽

2016 ◽

Vol 9 (2) ◽

pp. 92

Author(s):

Sadia Sharmin ◽

Sarwar Alam ◽

Md. Zillur Rahman Bhuiyan ◽

Md. Nazir Uddin Mollah ◽

Md. Mamun-Or-Rasheed

Keyword(s):

Breast Cancer ◽

Clinical Presentation ◽

Ductal Carcinoma ◽

Oral Contraceptive Pill ◽

Young Age ◽

Age Group ◽

Breast Cancer Patients ◽

Cross Sectional ◽

Pathological Characteristics ◽

History Of

Worldwide, breast cancer is the most frequently diagnosed life-threatening cancer and the leading cause of cancer death among women. Approximately 7% of all breast cancers are diagnosed in women <40 years of age. Young age at diagnosis influences prognosis negatively as they present with more advanced disease at diagnosis and a poorer 5-year survival than older patients. The present study includes breast cancer patients in the age group of 18 to 40 years to enrich our knowledge about clinical presentation and pathological characteristics of breast cancer. To find out the clinical presentation and pathological characteristics of breast cancer among the young age group. This cross-sectional study was done over 100 cases of histopathologically proven breast cancer from structured Questionnaire was used as data collection tool. Mean age was 33.89 years. Among the respondents 88% are married. Among the total studied population 61 respondents had the history of oral contraceptive pill use. Family history of cancer presents in 13.0% respondents and absent in 87.0% respondents. Among the respondents 95% patients presented with lump in the breast. 97.0% had invasive carcinoma 90% were invasive ductal carcinoma in which 46.0% were moderately differentiated. 51.0% patients were in the stage IIa and stage IIb.

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