scholarly journals THE EFFECT OF RED SESBANIA (SESBANIA GRANDIFLORA L.PERS) LEAVES EXTRACT ADMINISTRATION ON THE DECREASE OF LEUKOCYTE LEVEL IN POST-PARTUM MICE (MUS MUSCULUS) INFECTED WITH STREPTOCOCCUS AGALACTIAE

2018 ◽  
Vol 2 (01) ◽  
pp. 6-11
Author(s):  
HEPPY RINA MARDIANA ◽  
Surya Mustika Sari ◽  
YUFI ARIS LESTARI ◽  
ANIK SUPRIANI ◽  
NANIK NUR ROSYIDAH ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Maternal Mortality ◽  
Mus Musculus ◽  
Streptococcus Agalactiae ◽  
Post Partum ◽  
Organ Injury ◽  
Control Group ◽  
Maternal Mortality Rate ◽  
Treatment Groups ◽  
Infection Incidence

Introduction: Maternal Mortality Rate (MMR) is indicator of public health degree. The cause of maternal mortality is postpartum infection. Streptococcus agalactiae bacterium contributes to postpartum infection incidence through vaginal or reproductive organ injury. Infection incidence is characterized with the increased level of leukocyte. The treatment of post-partum infection is done by administering antibiotics. Red sesbania leaves contains active substance that can inhibit the microbial growth. Objective: This research aimed to find out the effect of red sesbania leaves extract administration as antimicrobial agent to decrease leukocyte level in post partum mice (Mus musculus) infected with Streptococcus agalactiae. Method: The method employed was true experimental one with post test control group design, by dividing postpartum mice into 4 groups: one control group and three treatment groups at doses of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW. All 0-12 hour post partum mice were inoculated with Streptococcus agalactiae bacterium. The administration of 1 ml red sesbania leaves extract in treatment group was conducted 2 hours after the bacterial administration at doses of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW. Result: The result of analysis shows p < 0.05, indicating that the decrease of leukocyte level in all treatment groups (P1, P2, P3). Conclusion: Red sesbania leaves extract has antimicrobial activity that can reduce leukocyte level, thereby can be used as an alternative therapy to decrease maternal mortality rate due to post-partum infectin. KEYWORDS Red sesbania leaves extract, postpartum mice, leukocyte level, Streptococcus agalactiae.

scholarly journals THE EFFECT OF RED SESBANIA (SESBANIA GRANDIFLORA L.PERS) LEAVES EXTRACT ADMINISTRATION ON THE DECREASE OF LEUKOCYTE LEVEL IN POST-PARTUM MICE (MUS MUSCULUS) INFECTED WITH STREPTOCOCCUS AGALACTIAE

2018 ◽  
Vol 2 (01) ◽  
pp. 6-11
Author(s):  
HEPPY RINA MARDIANA ◽  
Surya Mustika Sari ◽  
YUFI ARIS LESTARI ◽  
ANIK SUPRIANI ◽  
NANIK NUR ROSYIDAH ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Maternal Mortality ◽  
Mus Musculus ◽  
Streptococcus Agalactiae ◽  
Post Partum ◽  
Organ Injury ◽  
Control Group ◽  
Maternal Mortality Rate ◽  
Treatment Groups ◽  
Infection Incidence

Introduction: Maternal Mortality Rate (MMR) is indicator of public health degree. The cause of maternal mortality is postpartum infection. Streptococcus agalactiae bacterium contributes to postpartum infection incidence through vaginal or reproductive organ injury. Infection incidence is characterized with the increased level of leukocyte. The treatment of post-partum infection is done by administering antibiotics. Red sesbania leaves contains active substance that can inhibit the microbial growth. Objective: This research aimed to find out the effect of red sesbania leaves extract administration as antimicrobial agent to decrease leukocyte level in post partum mice (Mus musculus) infected with Streptococcus agalactiae. Method: The method employed was true experimental one with post test control group design, by dividing postpartum mice into 4 groups: one control group and three treatment groups at doses of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW. All 0-12 hour post partum mice were inoculated with Streptococcus agalactiae bacterium. The administration of 1 ml red sesbania leaves extract in treatment group was conducted 2 hours after the bacterial administration at doses of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW. Result: The result of analysis shows p < 0.05, indicating that the decrease of leukocyte level in all treatment groups (P1, P2, P3). Conclusion: Red sesbania leaves extract has antimicrobial activity that can reduce leukocyte level, thereby can be used as an alternative therapy to decrease maternal mortality rate due to post-partum infectin. KEYWORDS Red sesbania leaves extract, postpartum mice, leukocyte level, Streptococcus agalactiae.

scholarly journals Bottleneck Pelayanan Nifas pada Upaya Penurunan Risiko Kejadian Kematian Ibu di Wilayah Dinas Kesehatan Kota Semarang

2017 ◽  
Vol 5 (3) ◽  
pp. 28-35
Author(s):  
Ike Johan Prihatini ◽  
Sri Achadi Nugraheni ◽  
Sutopo Patria Jati
Keyword(s):  
Public Health ◽  
Mortality Rate ◽  
Health Services ◽  
Maternal Mortality ◽  
Risk Reduction ◽  
Post Partum ◽  
Scale Up ◽  
Monitoring And Evaluation ◽  
Maternal Mortality Rate

Maternal and child health was a priority of health program in Indonesia. Maternal Mortality Rate in Semarang was ranked second highest in Central Java. The highest proportion of maternal deaths occurred during puerperium. That’s indicates, there was a problem in a process of maternal health services during puerperium period in health facilities. This study was conducted to examine constraints on health systems that limit range of interventions or health services that were important for postpartum, bottlenecks related to postpartum services in Public Health Center (PHC), especially infrastructure, human resources, access to PHC, post partum visits (KF1 and KF3), as well as quality of post partum services on risk reduction of maternal mortality. This case study used a qualitative approach. Data collection through interviews to five midwives as main informants, 5 midwives coordinator and 5 heads of PHC as informant triangulation. Data analsyis used content analysis method, then assigned priority bottleneck through MCUA (Multiple Criteria Utility Assessment) techniques. WHO's scale-up BNA plan to analyze bottleneck causes. Results showed, there was a bottleneck on childbirth services in PHC. The causes of bottleneck risk reduction efforts of maternal mortality incidence in puerperium period has never been analyzed workload of health personnel in PHC, lack of monitoring and evaluation of an availability infrastructure facilities in PHC, there has not been regular training, especially on delivery until puerperium services, and PHC has not received more detailed and operational information about puerperium so their maternal knowledge about puerperium has not increased much and couldn’t raise mother's awareness to do so. Semarang Public Health Office (Dinas Kesehatan Kota Semarang) needs to conduct periodic monitoring and evaluation implementation of postpartum services and improve quality of childbirth services in PHC.Keywords: Bottleneck analysis, health services, post partum, Primary Health Care, Puskesmas, Maternal Mortality Rate

scholarly journals Maternal mortality assessment in a tertiary care hospital in Uttar Pradesh, India

2020 ◽  
Vol 9 (9) ◽  
pp. 3814
Author(s):  
Urvashi Barman Singh ◽  
Shakti Jain ◽  
Yashi Srivastava ◽  
Manisha Gupta ◽  
Meena Dayal
Keyword(s):  
Mortality Rate ◽  
Maternal Mortality ◽  
Post Partum ◽  
Tertiary Care ◽  
Uttar Pradesh ◽  
Care Hospital ◽  
Maternal Deaths ◽  
Maternal Mortality Rate ◽  
Medical College ◽  
Time Period

Background: Objective of this study was to calculate the maternal mortality rate in our hospital and to assess the epidemiological aspects and causes of maternal mortality to further analyse ways to reduce the maternal mortality rate (MMR).Methods: This was a retrospective analytical study done in the department of obstetrics and gynecology, MLN Medical College and District Women Hospital, Prayagraj over a time period of 10 years i.e., October 2009 to October 2019. Retrospective analysis and evaluation of the medical records and statistics was done to find out and collect specific causes of maternal deaths in the give time period.Results: There were 357 maternal deaths from October 2009 to October 2019. Maternal mortality rate in the study was calculated to be 498.42 per 1 lakh live births. Maximum deaths were in 21-30 years age group with multipara, unbooked and illiterate cases. Majority of the deaths reported were from direct causes of maternal mortality i.e., hemorrhage, hypertensive disorders and sepsis.Conclusions: In the selected hospitals, the mean maternal mortality rate in the study period was 498.42/100000 births. 71.4% had direct cause and 21.56% had indirect cause of maternal mortality several factors like regular antenatal visits, early identification of high-risk cases, timely referral, institutional deliveries, adequate post-partum care and follow-up can contribute to decrease the maternal mortality rate effectively.

scholarly journals EXPRESS: Pulmonary arterial hypertension in pregnancy – a systematic review of outcomes in the modern era

2021 ◽  
pp. 204589402110136
Author(s):  
Ting Ting Low ◽  
Nita Guron ◽  
Robin Ducas ◽  
Kenichiro Yamamura ◽  
Pradeepkumar Charla ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Mortality Rate ◽  
Arterial Hypertension ◽  
Maternal Mortality ◽  
Post Partum ◽  
Systolic Pressure ◽  
Pulmonary Artery Systolic Pressure ◽  
Maternal Mortality Rate ◽  
Pulmonary Arterial ◽  
In Pregnancy

Background: Pregnancy is hazardous with pulmonary arterial hypertension (PAH), but the risks may have improved in recent years. We sought to systematically evaluate PAH and pregnancy-related outcomes in the last decade. Methods: We searched for articles describing outcomes in pregnancy cohorts published between 2008-2018. 3658 titles were screened and 13 studies included for analysis. Pooled incidences and percentages of maternal and perinatal outcomes were calculated.  Results: Out of 272 pregnancies, 214 pregnancies advanced beyond 20 gestational weeks. The mean maternal age was 28±2 years, mean pulmonary artery systolic pressure on echocardiogram was 76±19mmHg. Aetiologies include idiopathic PAH 22%, congenital heart disease 64%, and others 15%. Majority (74%) had good functional class I/II. Only 48% of women received PAH-specific therapy. Premature deliveries occur in 58% of pregnancies at mean of 34±1 weeks, most (76%) had caesarean section. Maternal mortality rate was 12% overall (n=26); even higher for idiopathic PAH aetiology alone (20%). Reported causes of death included right heart failure, cardiac arrest, PAH crises, pre-eclampsia and sepsis. 61% of maternal deaths occur at 0-4 days post-partum. Stillbirths rate was 3% and neonatal mortality rate 1%. Conclusions: PAH in pregnancy continues to be perilous with high maternal mortality rate. Continued prospective studies are needed.

The Relationship between the speed of early initiation of breastfeeding with postpartum hemorrhage volume on stage labor

2017 ◽  
Vol 3 (2) ◽  
pp. 99
Author(s):  
Yunarsih Yunarsih ◽  
Dwi Rahayu
Keyword(s):  
Mortality Rate ◽  
Maternal Mortality ◽  
Breast Feeding ◽  
Post Partum ◽  
Early Initiation ◽  
Fourth Stage ◽  
Maternal Mortality Rate ◽  
Post Partum Hemorrhage ◽  
Early Initiation Of Breastfeeding ◽  
Initiation Of Breastfeeding

Maternal mortality rate  in Indonesia is assumed to be high enough; it is 228 per a hundred thousand alive birth case in 2010 with the main factor is a heavy bleeding. The decrease of maternal mortality rate  can be done by decreasing one of its factors that is avoiding a heavy bleeding after the delivery by doing a first breast feeding procedure. The purpose of the study is to find the correlation between the speed of early initiation of breastfeeding with  the volume of blood occur at the fourth stage of the labor (post partum hemorrhage). The method used in the study is an analytical observation (longitudinal prospective). While the population of study is some mothers who experience a vaginal birth in BPM Bunda district Prambon. The number of the sample is 29 mothers using a random sampling technique. The independent variable is the speed of early initiation breastfeeding and the dependent variable is  the volume of blood on the fourth stage (post partum hemorrhage). The datum are analyzed by ( SPSS ) T analyzed on two random sample and match to the meaningful degree of α; 0,05. The result of the study shows that there is a correlation between the speed of first breastfeeding  with   the volume of the blood p = 0,00. Therefore the conclusion of the study is that there is a correlation between the speed of the first breastfeeding and the volume of the blood, so that the researcher hope that the person on duty for the delivery process to encourage the first breastfeeding procedure to the mother and also to enlarge the knowledge of health education of the expecting mother about the essential effect of first breast feeding application.; Keyword : early initiation of breastfeeding, post partum hemorrhage, maternal mortality

scholarly journals HUBUNGAN PARITAS DENGAN KEJADIAN PERDARAHAN PADA IBU POST PARTUM DI BPS NY. N DI DESA KLAGEN SERUT KECAMATAN JIWAN MADIUN

2018 ◽  
Vol 5 (2) ◽  
pp. 29-34
Author(s):  
Etika Desi Yogi ◽  
Sinta Ayu Setiawan ◽  
Sri Dwi Hastuti ◽  
Etika Desi Yogi
Keyword(s):  
Mortality Rate ◽  
Maternal Mortality ◽  
Postpartum Hemorrhage ◽  
Post Partum ◽  
Statistical Test ◽  
Uterine Atony ◽  
Clotting Factor ◽  
P Value ◽  
Chi Square ◽  
Maternal Mortality Rate

Maternal Mortality Rate in East Java 2011 were 101.40 per 100,000 births. The of incidence of maternal mortality in East Java in 2011 was caused by direct obstetric or the bleeding. Factors that lead to postpartum hemorrhage include the presence of uterine atony, retained placenta, lacerations of the birth canal and the blood clotting factor, whereas postpartum hemorrhage predisposing factors that include hydramnios, gemeli, parity and age. Data from the Madiun County Health Department in 2011 found bleeding number 230 of 12 698 maternal. At BPS Ny. Niniek Soelasminingsih, S.ST in 2011 from 58 deliveries got the bleeding as much as 6 patients deliver within 24 hours post partum, 2 people tear the multiparous born 4 cases with uterine atony.            This study aims to determine the relationship of parity with the incidence of post-partum bleeding. Type of study is the correlation with the analytic case-control approach. Collecting data using retrospective data. Samples from this study were all mothers giving birth at BPS Ny Niniek Soelasminingsih, S.ST from the medical records of a total of 61 maternal. The study was conducted in November 2012, the data were analyzed using Chi Square statistical test with a significance level set at p ≤ 0.05. The results showed that the number of women who experience bleeding as many as 12 people, most bleeding is multiparitas mothers by 5 people. Having analyzed by chi-square statistical test results showed no association between parity and incidence of postpartum hemorrhage in BPS Ny. Niniek Soelasminingsih S.ST 0.008 with p value ≤ 0.05 in other words Ha received. Recommended that the delivery assistance by personnel who are competent so that the incidence of postpartum hemorrhage can be treated as good as possible so that the maternal mortality rate in Indonesia could be on tap as well as early detection of high risk pregnant women and maternity over increased.

FAKTOR– FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN ANEMIA PADA IBU HAMIL DI PUSKESMAS TALANG RATU PALEMBANG TAHUN 2014

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Yuhemy Zurizah Yuhemy Zurizah
Keyword(s):  
Mortality Rate ◽  
Health Service ◽  
Maternal Mortality ◽  
Pregnant Women ◽  
Health Center ◽  
Significant Relationship ◽  
World Health ◽  
Chi Square ◽  
Cross Sectional ◽  
Maternal Mortality Rate

  ABSTRACT Maternal Mortality Rate is a barometer of mother health service in a country. At this time maternal mortality rate in Indonesia is still very high. Indonesia Demography Survey on 2007, maternal mortality rate is about 28 per 100.000 of live births. The direct cause of maternal mortality in Indonesia as well as in the other country is hemorraghe (25%), sepsis (15%), eklampsia (12%), abstructed labor (8%). World Health Organization (WHO), 35-37% of pregnant women in developing coutries get anemy. Causing factor’s of anemy on pregnant women is age of pregnant, parity, economi socio, job, education, and nutritional status. Purpose of this research is to know the associated factors with incidence of anemy on pregnant women at the Health Center Talang Ratu Palembang in 2014. This research use analytic survey method with “cross sectional” approach. Population in this research is all of preganant women in medical treatment at Talang Ratu Palembang in 2014. Sample taking in this research with non random samplingmethod and accidental sampling technic. Analysis with univariatly and bivariatlywith Chi Square Statistic test with significant level α 0,05. The result of this research show that from 35 respondent there is (48,6%) respondent with anemy, high–risk age (28,6%), high parity (60,0%) and low economi socio (37,1%). This result show that there is significant relationship between age with incidence of anemy on pregnant women at the health center Talang Ratu Palembang in 2014 with p value0,027, there is significant relationship between parity with incidence of anemy on pregnant women at the health center Talang Ratu Palemabang in 2014 with p value0,023, and there is significant relationship between economi socio with incidence of anemy on pregnant women at the health center Talang Ratu Palembang in 2014 with p value0,026. Of the result, the author hope that health service worker at Talang Ratu health center can improve health service to pregnant women and often giving information about anemy on pregnant and nutritional for pregnant women during pregnancy.     ABSTRAK Angka Kematian Ibu (AKI) merupakan barometer pelayanan kesehatan ibu di suatu negara. Pada saat ini angka kematian ibu di Indonesia masih sangat tinggi. Menurut Survey Demografi dan Kesehatan Indonesia (SDKI) tahun 2007, angka kematian kematian ibu adalah 28 per 100.000 kelahiran hidup. Penyebab langsung kematian ibu di Indonesia seperti halnya Negara lain adalah perdarahan (25%), sepsis (15%), eklampsi (12%), partus lama (8%). Menurut World Health Organization (WHO), 35-37% ibu hamil di negara berkembang dan 18% di negara  maju mengalami anemia. Faktor penyebab terjadinya anemia pada ibu hamil secara tidak langsung adalah umur ibu, paritas, sosial ekonomi, pekerjaan, pendidikan, jarak kehamilan, dan status gizi.Tujuan penelitian ini adalah untuk mengetahui faktor - faktor apa saja yang berhubungan dengan kejadian anemia pada ibu hamil di Puskesmas Talang Ratu Palembang Tahun 2014. Penelitian ini menggunakan metode survey analitikdengan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh ibu hamil yang berobat di Puskesmas Talang Ratu Palembang Tahun 2014. Pengambilan sampel pada penelitian ini dengan metode non random sampling dengan teknik Accidental sampling. Analisis dilakukan secara univariat dan bivariat. Dengan uji statistik chi square tingkat kemaknaan α 0,05. Hasil penelitian menunjukkan dari 35 responden terdapat (48,6%) responden yang anemia, umur yang beresiko  tinggi (28,6%), paritas tinggi (60,0%), dan sosial ekonomi rendah (37,1%). Hasil penelitian ini menunjukkan ada hubungan yang bermakna antara umur dengan kejadian anemia pada ibu hamil di Puskesmas Talang Ratu Palembang Tahun 2014 dengan  p value0,027,  ada hubungan bermakna antara paritas dengan kejadian anemia pada ibu hamil di Puskesmas Talang Ratu Palembang Tahun 2014 dengan p value0,023 dan ada hubungan yang bermakna antara sosial ekonomi dengan kejadian anemia pada ibu hamil di Puskesmas Talang Ratu Palembang Tahun 2014 dengan p value0,026. Dari hasil penelitian ini penulis berharap petugas kesehatan di Puskesmas Talang Ratu Palembang meningkatkan pelayanan kesehatan pada ibu hamil dan lebih sering melaksanakan penyuluhan anemia pada kehamilan dan nutrisi yang baik bagi ibu hamil.    

scholarly journals PERBANDINGAN REGRESI ZERO INFLATED POISSON (ZIP) DAN REGRESI ZERO INFLATED NEGATIVE BINOMIAL (ZINB) PADA DATA OVERDISPERSION (Studi Kasus: Angka Kematian Ibu di Provinsi Bali)

2016 ◽  
Vol 5 (4) ◽  
pp. 133
Author(s):  
NI PUTU PREMA DEWANTI ◽  
MADE SUSILAWATI ◽  
I GUSTI AYU MADE SRINADI
Keyword(s):  
Mortality Rate ◽  
Maternal Mortality ◽  
Regression Models ◽  
Negative Binomial ◽  
Mean Value ◽  
Response Variable ◽  
Maternal Mortality Rate ◽  
Excess Zeros ◽  
Zero Values ◽  
Independent Variable

Poisson regression is a nonlinear regression which is often used for count data and has equidispersion assumption (variance value equal to mean value). However in practice, equidispersion assumption is often violated. One of it violations is overdispersion (variance value greater than the mean value). One of the causes of overdipersion is excessive number of zero values on the response variable (excess zeros). There are many methods to handle overdispersion because of excess zeros. Two of them are Zero Inflated Poisson (ZIP) regression and Zero Inflated Negative Binomial (ZINB) regression. The purpose of this research is to determine which regression models is better in handling overdispersion data. The data that can be analyzed using the ZIP and ZINB regression is maternal mortality rate in the Province of Bali. Maternal mortality rate data has proportion of zeros value more than 50% on the response variable.  In this research, ZINB regression better than ZIP regression for modeling maternal mortality rate. The independent variable that affects the number of maternal mortality rate in the Province of Bali  is the percentage of mothers who carry a pregnancy visit, with ZINB regression models and . 

scholarly journals Two year review of maternal mortality at a tertiary care hospital of GMERS, Valsad, Gujarat, India

2018 ◽  
Vol 7 (6) ◽  
pp. 2283
Author(s):  
Darshna M. Patel ◽  
Mahesh M. Patel ◽  
Vandita K. Salat
Keyword(s):  
Mortality Rate ◽  
Maternal Mortality ◽  
Rural Areas ◽  
Tertiary Care ◽  
Maternal Mortality Ratio ◽  
Care Hospital ◽  
Maternal Deaths ◽  
Maternal Mortality Rate ◽  
Live Births ◽  
Mortality Ratio

Background: According to the WHO, 80 of maternal deaths in developing countries are due to direct maternal causes such as haemorrhage, hypertensive disorders and sepsis. These deaths are largely preventable. Maternal mortality ratio (MMR) in India is 167/100,000 live births.Methods: This retrospective observational study was conducted at GMERS, Valsad. Data regarding maternal deaths from January 2016 to December 2017 were collected and analyzed with respect to epidemiological parameters. The number of live births in the same period was obtained from the labour ward ragister. Maternal mortality rate and Mean maternal mortality ratio for the study period was calculated.Results: The mean Maternal mortality rate in the study period was 413.3/100,000 births. The maternal mortality ratio (MMR) in India is 167/100,000 live births. More than half of maternal deaths were reported in multiparous patients. More maternal deaths were observed in women from rural areas (67.3%), unbooked patients (73.3%) and illiterate women (65.3%). Thirty six (69.3%) maternal death occurred during postpartum period. Most common delay was first delay (60.0%) followed by second delay (40.0%). Postpartum haemorrhage (28.8%), preeclampsia (17.3%), sepsis (13.46%) were the major direct causes of maternal deaths. Indirect causes accounted for one third of maternal deaths in our study. Anemia, hepatitis and heart disease were responsible for 13.4%, 5.7%, and 1.9% of maternal deaths, respectively.Conclusions: Majority of maternal deaths are observed in patients from rural areas, unbooked, and illiterate patients. Hemorrhage, eclampsia and sepsis are leading causes of maternal deaths. Most of these maternal deaths are preventable if patients are given appropriate treatment at periphery and timely referred to higher centers.

scholarly journals Evaluation of maternal and fetal outcome in pregnancies complicated by jaundice-an observational study

2021 ◽  
Author(s):  
Ruchi Kishore ◽  
Neha Thakur ◽  
Mitali Tuwani
Keyword(s):  
Mortality Rate ◽  
Observational Study ◽  
Maternal Mortality ◽  
Viral Hepatitis ◽  
Hellp Syndrome ◽  
Fetal Outcome ◽  
Maternal Outcome ◽  
Fetal Mortality ◽  
Maternal Mortality Rate ◽  
In Pregnancy

Background: The spectrum of jaundice in pregnancy varies from a benign condition with good maternal and fetal outcome to a severe form resulting in liver failure and maternal and fetal mortality. Jaundice may complicate 3-5% of pregnancies. Present study was aimed to analyze the cause, course and impact of jaundice during pregnancy so as to have better understanding and hence better feto-maternal outcome. The present study aimed to analyze the various causes of hepatic dysfunction in pregnancy, maternal and fetal outcome in pregnancies complicated by jaundice and various hematological and liver function variables for predicting maternal and fetal outcome.Methods: The present study was an observational study conducted in the department of obstetrics and gynecology, Pt. JNM medical college and associated Dr. BRAM hospital, Raipur (CG) over period of 2 year from September 2018 to September 2020.Results: Total 0.72% pregnancies were complicated by jaundice. HELLP syndrome was the commonest cause of jaundice in pregnancy (36.7%), followed by viral hepatitis (32.7%). Hepatitis E was the most common type of viral hepatitis (91.8%). Hemolytic jaundice presented with best maternal outcome (maternal mortality rate 8.6%). Worst maternal outcome was seen in AFLP (maternal mortality rate 100%). Best fetal outcome was seen in viral hepatitis (live birth rate 67.6%), whereas worst noted with AFLP (fetal death rate 66.6%). Higher total serum bilirubin, higher serum AST, anemia and deranged INR had significant correlation with maternal mortality.Conclusions: HELLP syndrome and viral hepatitis are preventable causes of jaundice yet it contributed to significant proportion of maternal deaths in 26.5 and 18.5% cases respectively. AFLP is often under diagnosed and had a fulminant course in pregnancy causing maternal and fetal mortality.

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