scholarly journals EFFECT OF “SITTAMATTI (SIDA CORDIFOLIA LINN.) KUDINEER (DECOCTION)” IN RESPIRATORY COMPLAINT - COUGH

2020 ◽  
Vol 8 (8) ◽  
pp. 24-36
Author(s):  
S. R. Pholtan Rajeev
Keyword(s):  
Medicinal Plants ◽  
Control Group ◽  
Treatment Level ◽  
Herbal Products ◽  
Cns Depressant ◽  
Group I ◽  
Anti Inflammatory ◽  
Group Ii ◽  
Sida Cordifolia ◽  
Emerging And Developing Countries

Background: The world is fulfilled by various medicinal plants which are widely have been used in treatment of various diseases since ancient time. Medicinal plants still play an important role in emerging and developing countries. Herbs are staging a comeback and herbal ‘renaissance’ is happening all over the globe. The herbal products today symbolize safety in contrast to the synthetics that are regarded as unsafe to human and environment. Although herbs had been priced for their medicinal, flavoring and aromatic qualities. In this research, sittamatti (Sida cordifolia) has been reported to possess analgesic, anti-inflammatory and hypoglycemic activities as well as hepato-protective activity. Traditionally the plant Sida cordifolia (Linn) has been used as CNS depressant, fat lose, analgesics, anti-inflammatory, hypotensive, hepato protective. Presence of ephedrine has highlighted the utility of this plant. various Ayurvedic preparation of this plant used in asthma diseases, etc. Methods: This plant spread in Mullaitivu commonly therefore utilize that as Cough decoction. First authentication of plant with experts from University of Jaffna and collecting, washing, drying and grinded for decoction preparation size. Then packing and labeling and distribute to selected 60 research samples of two groups to clinical trial and collected data through questionnaire and result analyzing in statistical way. Result: Group-I & Group-II 1st Week (AFTER treatment) level of the samples. The test is significant at 0.0001 (adjusted for ties) Comparing the HT (Group-I), Research Decoction (Group-II) was shown Significant (p<0.05) reduction in symptom of cough. One-month (04 Weeks) of treatment with research decoction significantly (p<0.05) change symptom of cough with the control group- hospital internal treatment (HT) (group-I). Conclusion: effectiveness of research drugs – Sittamati Kudineer, Three months (04 Weeks) of treatment with research decoction significantly (p<0.05) change symptom of cough with the control group- normal hospital internal treatment (HT) (group-I).

scholarly journals GAMBARAN HISTOPATOLOGIK LAMBUNG TIKUS WISTAR SETELAH DIINDUKSI DENGAN ASPIRIN

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Poppy M Lintong ◽  
Lily L. Loho ◽  
Herman Anggran
Keyword(s):  
Lamina Propria ◽  
Food Pellet ◽  
Wistar Rat ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Microscopic Features ◽  
Anti Inflammatory ◽  
Group Ii ◽  
Normal Stomach

Abstract: Aspirin is one of the non-steroid-anti-inflammatory drugs. Its pharmacodynamic effects are as an analgesic, antipyretic, anti-inflammatory, anti-thrombotic, and uricosuric agent. The side effects of aspirin are on the respiratory tract, the gastrointestinal tract, blood, metabolic processes, endocrine functions, pregnancy, hypersensitivity, and drug interaction. The purpose of this study was to evaluate the macroscopic and microscopic features of wistar rat stomachs after the administration of aspirin. This was an experimental study, using nine wistar rats divided into three groups equally. Group I, the control group, was given a food pellet only. Group II was given the pellet, added with aspirin 21 mg daily for 10 days. Group I and Group II were terminated on day 11. Group III was given the pellet, added with aspirin 21 mg/day for 10 days, and was terminated on day 14. All the wistar rat stomachs were examined macroscopically and microscopically. The results showed that the control group had a macroscopically normal stomach architecture, and the mucosa layers and rugae were intact and looked pinkish white. The groups treated with aspirin still showed normal stomach architecture, and the mucosa layers and rugae were intact but looked more palid than that of the control group. Microscopically, the stomach walls of the control group were normal, but groups treated with aspirin for 10 days revealed edema of the lamina propria, dilatation of capillaries; and predominantly neutrophilic infiltration in the lamina propria. Ceasing of aspirin administration showed a resolution of the inflammatory process, marked by diminished infiltration of PMN cells and tisuue edema. Conclusion: Aspirin treatment of 21 mg a day for 10 days revealed histopathologically acute gastritis of the wistar rat stomach walls. The inflammatory reaction was diminished after the cessation of aspirin. Keywords: aspirin, histopathology, stomach.   Abstrak: Aspirin tergolong obat anti-inflamasi non-steroid (AINS) yang secara farmakodinamika mempunyai efek analgesik, anti-piretik, anti-inflamasi, anti-trombotik, dan urikosurik, namun mempunyai efek samping pada saluran  cerna terutama lambung. Penelitian ini bertujuan untuk mendapatkan gambaran histopatologik (makroskopik dan mikroskopik) lambung tikus Wistar setelah pemberian aspirin. Penelitian ini bersifat eksperimental dengan menggunakan sampel sembilan ekor tikus Wistar yang dibagi atas tiga kelompok. Kelompok I (kontrol) terdiri dari tiga ekor tikus yang diberi pelet biasa dan air minum. Kelompok II terdiri dari tiga ekor tikus yang diberi pelet biasa, air minum, dan aspirin dosis 21 mg/hari  selama 10 hari. Pada hari ke-11 kelompok I dan II diterminasi. Kelompok III terdiri dari tiga ekor tikus yang diberikan pelet biasa, air minum, dan aspirin dosis 21 mg/hari selama 10 hari, kemudian aspirin dihentikan dan tikus diterminasi pada hari ke-14. Setelah diterminasi, kelompok I-III diotopsi, diambil organ lambungnya, kemudian dilakukan pemeriksaan histopatologik. Hasil penelitian memperlihatkan makroskopik mukosa lambung tampak lebih pucat sedangkan mikroskopik menunjukkan tanda-tanda radang akut. Penghentian pemberian aspirin diikuti dengan resolusi reaksi inflamasi yang ditandai oleh penurunan infiltrasi sel-sel radang PMN dan edema jaringan. Sinpulan: Pemberian aspirin 21 mg/hari selama 10 hari mengakibatkan terjadinya gambaran histopatologik gastritis akut pada lambung tikus Wistar. Reaksi inflamasi menurun setelah penghentian pemberian aspirin. Kata kunci: aspirin, histopatologi, lambung.

scholarly journals Comparison of Ellagic Acid and NSAI Agents in the Treatment of Achilles Tendon Lacerations: An Experimental Study in Rabbits

2019 ◽  
Vol 104 (11-12) ◽  
pp. 575-581
Author(s):  
Ertuğrul Allahverdi ◽  
Tülay Diken Allahverdi ◽  
Sevil Vural
Keyword(s):  
Achilles Tendon ◽  
Ellagic Acid ◽  
Diclofenac Sodium ◽  
Tendon Healing ◽  
Control Group ◽  
Group I ◽  
Significant Difference ◽  
Tendon Ruptures ◽  
Anti Inflammatory ◽  
Group Ii

Objective Although Achilles tendon ruptures can have many causes, they are known to develop most commonly with trauma. Nonsteroidal anti-inflammatory drugs (NSAID) and low doses of corticosteroids are used in the medical treatment of tendon ruptures. Ellagic acid (EA), which also has an anti-inflammatory effect, has been reported to show its effect via cyclooxygenase 2 (COX2) inhibition as well. The effects of EA and diclofenac sodium on tendon healing were compared in this study. Methods We used a total of 18 male New Zealand rabbits in 3 groups with 6 in each. The study was performed under general anesthesia with a xylazine-ketamine combination. After a defect was created in the right Achilles tendon of all the rabbits, group I was administered diclofenac sodium and group II was administered EA for 1 week, whereas the control group (group III) was not administered anything. Postoperative follow-up was provided for all groups. Results Euthanasia was performed in all subjects at the end of the eighth week, and the tendons were compared in terms of macroscopic and histopathologic features and tensile resistance. Although there was no statistically significant difference in the tensile resistance Newton values of group I and group II, these values were higher than in the control group, and the NSAI group values were statistically significantly higher than in the control group. Conclusions We concluded that EA and NSAIs could be effective in the recovery of tendon integrity and tensile strength and increasing the movement capacity in pathology caused by tendon damage because of their anti-inflammatory features.

scholarly journals Rat dental pulp tissue reaction after capped with propolis derived nonflavonoid extract

2011 ◽  
Vol 23 (1) ◽  
Author(s):  
Ardo Sabir
Keyword(s):  
Dental Pulp ◽  
Chemical Substance ◽  
Tissue Reaction ◽  
Control Group ◽  
Pulp Tissue ◽  
Group I ◽  
Pulp Inflammation ◽  
Dental Pulp Tissue ◽  
Anti Inflammatory ◽  
Group Ii

Propolis is a resinous material collected by honey bees from various plants. Many types of research have shown that it has antibacterial and anti-inflammation activities. Flavonoid is the main chemical substance in propolis that inhibits bacterial growth and reduces the release of free radicals, suggesting that this component has anti-bacterial and anti-inflammatory properties. However, there is another chemical substance in propolis that shows antibacterial dan anti-inflammatory activities. The purpose of the present study was to assess the rat dental pulp tissue reaction after capped with propolis derived non-flavonoids extract. Non-flavonoids substances were purified from an ethanol extract of propolis obtained from South Sulawesi, Indonesia. A Class I cavity was prepared on the occlusal surface of the right maxillary first molar in Spraque-Dawley rats. The dental pulp was exposed and then capped with a zinc oxide-based filler as a control (Group I), or non-flavonoids propolis (Group II). Then, each cavity was filled with glass ionomer cement. The animals were sacrificed at week 1, 2, or 4. Biopsy samples were obtained, and these were stained and viewed by light microscopy. The histological examination was based on the presence of polymorph nuclear leukocytes and macrophages. The results showed that pulp inflammation occurred in both groups as early as week 1. However, the inflammation occurred in Group II was relatively milder compared to Group I at all time period. Therefore, present results suggest that application of non-flavonoids propolis extract on rat's dental pulp tissue might inhibit inflammatory process.

Features of the cervix uteri in women of reproductive age with endometrial polyps and micropolyps

2016 ◽  
pp. 108-111
Author(s):  
T.F. Tatarchuk ◽  
◽  
D.G. German ◽  
Keyword(s):  
Reproductive Age ◽  
Cervix Uteri ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Endometrial Polyps ◽  
Group Iii ◽  
Aggressive Form ◽  
Group I ◽  
Group Ii ◽  
Control Group Group

The article presents the comparative analysis of the state of the cervix in women with endometrial polyps and micropolyps. Patients and methods. The study involved 130 patients aged 18-35 years: 70 patients with endometrial polyps (group I), 30 patients with micropolyps (group II) and 30 patients of the control group (group III). Results. According to the anamnesis of women in the I group were significantly more frequent diseases of the cervix, which corrected physical surgery methods, in particular cryodestruction. In group II, the representatives of these indicators were similar to healthy. Normal colposcopic picture met significantly less frequently in patients and I, and II group. The differences in the incidence of HPV high oncogenic risk in all groups were not statistically significant. Conclusion. Destructive methods used in the detection of any changes in the cervix are often overly aggressive, form scars and contributing to inflamaciones process. In the chain of events leading to the formation of PE, cervical pathology and its correction can take the basic place. Key words: endometrial polyp, micropolyps, chronic endometritis, uterine cervix, colposcopy.

scholarly journals Irisin levels in relation to metabolic and liver functions in Egyptian patients with metabolic syndrome

2016 ◽  
Vol 94 (4) ◽  
pp. 359-362 ◽  
Author(s):  
Fatma H. Rizk ◽  
Samah A. Elshweikh ◽  
Amira Y. Abd El-Naby
Keyword(s):  
Metabolic Syndrome ◽  
Liver Enzymes ◽  
Resistance Index ◽  
Control Group ◽  
Model Assessment ◽  
Group Iii ◽  
Group I ◽  
Elevated Liver Enzymes ◽  
Liver Functions ◽  
Group Ii

Irisin is a new myokine that is suspected to influence metabolic syndrome (MetS). However, there is a great controversy with respect to its level in cases of MetS and its correlation with different metabolic parameters. The present study assesses irisin levels in MetS patients and studies its relationship to metabolic and liver functions to evaluate the possible role of the liver in regulation of this level. Sixty subjects were included in this experiment, who were divided into 3 groups: group I (normal control), group II (MetS patients with normal liver enzymes), and group III (MetS with elevated liver enzymes and fatty liver disease). Serum irisin levels showed significant increases in groups II and III compared with group I, and significant increases in group III compared with group II. Also, irisin levels were positively correlated with body mass index, serum triglycerides, homeostatic model assessment of insulin resistance index (HOMA-IR), and liver enzymes. We concluded that serum irisin levels increased in patients with MetS, especially those with elevated liver enzymes, and had a positive correlation with parameters of lipid metabolism and glucose homeostasis with the possibility of hepatic clearance to irisin.

Comparison of the parameters of retinal sensitivity after vitrectomy due to rhegmatogenous retinal detachment

2021 ◽  
pp. 349-354
Author(s):  
R.R. Fayzrakhmanov ◽  
◽  
A.V. Sukhanova ◽  
O.A. Pavlovsky ◽  
E.D. Bosov ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Rhegmatogenous Retinal Detachment ◽  
Silicone Oil ◽  
Light Sensitivity ◽  
Control Group ◽  
Strong Positive Correlation ◽  
Gas Tamponade ◽  
Group I ◽  
Silicone Oil Tamponade ◽  
Group Ii

Purpose. To compare the parameters of a light sensitivity (LS) of the central zone of a retina after vitrectomy due to reghmatogenous retinal detachment (RRD) with a silicone oil tamponade (SOT) and gas tamponade (GT). Material and methods. The study included 20 eyes after pars plana vitrectomy due to macula-off rhegmatogenous retinal detachment (RRD) by 25G. All patients were divided in 2 groups depending on the choice of the tamponade. The group I (10 eyes) included cases with the silicone oil tamponade (SOT) (1300 cSt), in the group II (10 eyes) – the gas tamponade (GT) (C2F6). The control group included contralateral eyes without ophthalmic pathology. All patients underwent standard ophthalmological examination and fundus- microperimetry (FMP) on the 30th day after removal of the SOT for the group I, or on the 30th day after the C2F6 tamponade for the group II. Results. According to FMP data, the parameter of average light sensitivity (LS) in the group I was significantly reduced, both in comparison with the group II (p=0.007) and the control group (p=0.003). Differentiation by zones in the group I revealed a decrease in each analyzed parameter in comparison with the control group (p<0.05) and a decrease in the 2nd zone (p=0.031) and the 4th zone (p=0.038) in comparison with the group II. In the 1st zone of the group I the formation of a relative scotoma was revealed in 4 cases out of 10 (40%). The parameters of light sensitivity (LS) in comparison with the control in the group II were significantly reduced when analyzed in each zone (p<0.05). A strong positive correlation was found between the Best Corrected Visual Acuity (BCVA) and the average LS in the group II (r=0.87). Conclusion. There is a decrease in the functional parameters of the retina with SOT compared with GT in the form of a decrease in the LS parameter in the 10° zone according to FMP data. Key words: retinal detachment, photosensitivity, microperimetry, silicone tamponade.

To Compare Frequency of Sore Throat in Early Postop period in General Anesthesia and Endotracheal Intubation for Abdominal Surgeries who are given Dexamethasone and Normal Saline

2021 ◽  
Vol 15 (6) ◽  
pp. 1227-1229
Author(s):  
R. Farooqi ◽  
T. Iqbal ◽  
M. S. Mehmood ◽  
Z. Y. Bhatti ◽  
F. Liaquat
Keyword(s):  
General Anesthesia ◽  
Sore Throat ◽  
Endotracheal Intubation ◽  
Normal Saline ◽  
Controlled Study ◽  
Control Group ◽  
Chi Square ◽  
Group I ◽  
Chi Square Test ◽  
Group Ii

Aim: To Compare frequency of sore throat in early post operative period among patients undergoing general anaesthesia and endotracheal intubation for abdominal surgeries who are given dexamethasone and normal saline. Study Design: Randomized controlled study Setting: Department of Anesthesia/ ICU, Sheikh Zayed Hospital, Lahore Duration of study: Six months i.e. 25-09-2009 to 25-03-2010. Methodology: 120 patients undergoing elective general surgery on abdomen were selected. They were divided into two groups. Group I received dexamethasone 8mg (2ml) I/V pre-operatively and group II received 2ml normal saline I/V pre-operatively. Chi square test was used. Visual analogue (VAS) scale was used for recording sore throat. The VAS score ≤4 was considered as no sore throat and VAS scores>4 were considered as the sore throat. Results: Frequency of post-operative sore throat after the first 24 hours following GA and endotracheal intubation was lower in group (I) as compared to the control group (II). Eleven (20%) patients with dexamethasone had post-operative sore throat compared to thirty one (56.3%) patients in control group. (p<0.01). Conclusion: Pre-operative use of dexamethasone was associated with decreased incidence of post-operative sore throat. Keywords: Visual analogue scale (VAS), Post-operative sore throat, general anesthesia

scholarly journals Effect of Fiber Rich Product on Childhood Obesity and Lipid Profile Aged 10-12 Years

2021 ◽  
Vol 9 (3) ◽  
pp. 87-90
Author(s):  
A. Jyoth ◽  
Keyword(s):  
Exercise Group ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Diet Survey ◽  
Group Ii ◽  
And Control ◽  
Experimental Group ◽  
Positive Results ◽  
Green Peas

The effect of fiber rich product on child hood obesity studied with 60 sample which were collected randomly among 10-12 years and categorized into 2 groups i.e, experimental group and control group. Experimental group further categorized into three groups i.e, supplementation with exercise (n=15), only supplementation group (n=15), only exercise group (n=15) and control group consists of (n=15).Anthropometric, and diet survey conducted as parameters. A fiber rich product was prepared and supplemented for 2 months to the selected subjects and it consists of whole Bengal gram, whole green gram, green peas, barley and jaggery. Positive results were obtained in three experimental groups. Significant decrease observed inweight, and BMI, Total cholesterol, Triglycerides, LDL, VLDL significant increase observed in HDL in group I II and III. The results were (51.60-48.26kg, 24.7-23.1, 195.2-152.3 mg/dl, 168.2-145.0 mg/dl, 52.2-54.13 mg/dl, 109.4- 69.4mg/dl, 33.6-28.7mg/dl) in group I, In group II the results are (50.3-49.86kg, 23.7-23.4, 168.6-161.0mg/dl, 145.4-129.6mg/dl, 44.2-45.2 mg/dl, 95.3-90.0mg/dl, 29.1-28.3mg/dl).In group III the tesults aere (50.7-49.6kg, 24.5-23.9, 143.2-139.3mg/dl, 139-134.5mg/dl, 38.2-38.7mg/dl 76.8-74.1 mg/dl, 25.6-28.1mg/dl) .From the results it was clear that when compared to group II and III group I has shown better results.

scholarly journals Relationships between urinary neural and immune factors in the patients with interstitial cystitis/ bladder painful syndrome

2020 ◽  
Vol 22 (5) ◽  
pp. 879-886
Author(s):  
R. F. Sholan
Keyword(s):  
Mast Cells ◽  
Interstitial Cystitis ◽  
Pearson Correlation ◽  
Control Level ◽  
Clinical Manifestations ◽  
Control Group ◽  
Bladder Tissue ◽  
Bladder Pain ◽  
Group I ◽  
Group Ii

The purpose of this work was to study the relationships between urinary cytokines, mast cells and nerve growth factor (NGF) in the patients with interstitial cystitis/bladder pain syndrome (IC/BPS). Sixty-eight women with clinically diagnosed IC/BPS were under study. Their mean age was 54.2±12.4 years. Urinary concentrations of interleukins (IL-1β, IL-6, IL-8), tumor necrosis factor-α (TNFα), and NGF were determined by ELISA technique. Mast cells were identified in biopsies of mucous membranes from urinary bladder harvested during cystoscopy. Statistical evaluation was performed by Statistica program in Microsoft Excel. Pearson correlation quotients were calculated. Depending on the type of IC/BPS, the patients were divided into 2 groups: group I included 36 patients with classic type of disease; group II comprised 32 patients with non-ulcer type of IC/BPS. No significant differences were revealed between the groups. In 13.9% of patients from group I, the onset of clinical manifestations of the disease was observed at the age of less than 40 years; in group II, 28.1% of the examined mentioned appearance of the disease symptoms at this age. The levels of IL-1β in the patients from group I was 2.4 times higher than in controls (p < 0.05). IL-6, IL-8 and TNFα concentrations exceeded control values by 2.0 (p < 0.05), 2.5 (p < 0.05) and 2.0 times (p < 0.05), respectively. In the patients from group II, the content of IL-1β, IL-6, IL-8 and TNFα was 2.4 (p < 0.05), 2.0 (p < 0.05), 2.0 (p < 0.05) and 1.9 (p < 0.05) times higher than in the control group, respectively. There were no significant differences between groups I and II, in IL-1β, IL-6, and TNFα levels, except of IL-8 in women of group I that was 20.3% higher than in group II. The urinary NGF level in the patients with IC/BPS exceeded the control level 1.6 times (p < 0.05) for group I, and 1.5 times (p < 0.05) for group II. The number of mast cells in the patients of group I was significantly higher than in controls and in group II, i.e., 1.6 (p < 0.05) and 1.4 times (p < 0.05), respectively. In most cases, a direct weak correlation was revealed between the indices. Only in group I, a moderate correlation (r = + 0.508) could be detected between IL-1β and mast cells. Determination of cytokine levels allows to detect activation of inflammatory cells in bladder tissue and provides an opportunity for developing diagnostic strategies. Increased numbers of mast cells may indicate the importance of these cells in the disease progression, whereas elevated levels of NGF in urine suggests that IC/BPS may be caused by chronic inflammation.

scholarly journals The Influence of Highly Dispersed Metal Forms on Calcium and Phosphorus Metabolism in Polygastric Animals

2022 ◽  
Author(s):  
Makaeva Ayna Maratovna ◽  
Sizova Elena Anatolevna ◽  
Atlanderova Ksenya Nikolaevna
Keyword(s):  
Feed Additives ◽  
The Body ◽  
Feed Additive ◽  
Utilization Rate ◽  
Control Group ◽  
Ruminal Fluid ◽  
Group I ◽  
Calcium And Phosphorus ◽  
Group Ii ◽  
Experimental Group

Determining which forms of mineral feed additives can increase farm animal productivity is a key area of research. This study assessed the mineral composition of ruminal fluid and the effectiveness of calcium and phosphorus used by animals after the introduction of finely dispersed particles (FDP) of SiO2 (group I) and FeCo (group II) with a hydrodynamic radius of 109.6 ± 16.6 and 265 ± 25 nm, respectively. The deposition and use of calcium and phosphorus in the body of the experimental animals exceeded the control values. In group I, 30.8% more calcium was deposited (p ≥ 0.05), and in group II, the value was 30.3% (p ≥ 0.01). In the experimental groups, the calcium utilization rate was 27.3% higher in group I (p ≥ 0.05), and 28.2% higher in group II (p ≥ 0.01) compared to in the control. Phosphorus deposition was 34% higher (p ≤ 0.01) in experimental group I and 6% higher in experimental group II, compared with the control. Group I had a high utilization rate of phosphorus from the feed (with a 29% difference compared to the control). Comparison of the experimental groups revealed that the introduction of SiO2 FDP promoted an increase in the concentration of silicon, phosphorus, and calcium in the ruminal fluid. The introduction of FeCo FDP was accompanied by a decrease in the concentration of iron and cobalt in the ruminal fluid. Thus, the use of feed additive in finely dispersed form in the diet of animals was accompanied by an increase in the use of calcium and phosphorus by the animal’s body, which is advisable when intensifying milk and meat productivity. The obtained results require further research. Keywords: finely dispersed forms of microelements, ruminants, calcium and phosphorus exchange, feeding

Sign in / Sign up

Export Citation Format

Share Document