scholarly journals BIOMARKERS OF OXIDATIVE STRESS AND ANTIOXIDANT SYSTEM IN EXPERIMENTAL GINGIVITIS AND ITS` CORRECTION WITH PLANT ANTIOXIDANTS

2017 ◽  
Vol 1 (4) ◽  
pp. 28-30
Author(s):  
O. I. Zalyubovska ◽  
T. I. Tiupka ◽  
V. V. Zlenko ◽  
A. O. Minaieva
Keyword(s):  
Oxidative Stress ◽  
Antioxidant System ◽  
Experimental Gingivitis ◽  
Plant Antioxidants ◽  
Biomarkers Of Oxidative Stress

BIOMARKERS OF OXIDATIVE STRESS AND ANTIOXIDANT SYSTEM IN EXPERI- MENTAL GINGIVITIS AND ITS` CORRECTION WITH PLANT ANTIOXIDANTS

scholarly journals Effect of sodium chloride on oxidative stress biomarkers of the freshwater bivalve Anodonta cygnea

2018 ◽  
Vol 9 (2) ◽  
pp. 135-140
Author(s):  
D. S. Pesnya ◽  
A. V. Romanovsky ◽  
Y. S. Klimova ◽  
R. A. Fedorov ◽  
E. S. Ivanova
Keyword(s):  
Oxidative Stress ◽  
Sodium Chloride ◽  
River Water ◽  
Antioxidant System ◽  
Malonic Dialdehyde ◽  
Water Soluble ◽  
Freshwater Bivalve ◽  
Anodonta Cygnea ◽  
Nacl Concentration ◽  
Biomarkers Of Oxidative Stress

For the first time a study was conducted of the effects of the change in the concentration of sodium chloride in water on the biomarkers of oxidative stress (enzymes: catalase (CAT), glutathione reductase (GR), glutathione-S-transferase (GST), and the levels of reduced glutathione (GSH), and a marker of peroxidation lipids (LPO) – malonic dialdehyde (MDA)) in the gills of the freshwater mollusc Anodonta cygnea. Adult specimens of A. cygnea of both sexes with a shell length of 70–100 mm were selected for the study, a total of 36 individuals. The molluscs were collected in one of the bays on the southwestern coast of the Volga reaches of the Rybinsk Reservoir (reservoir of the cascade of the upper Volga). The molluscs were kept in the laboratory in aquariums with river water and sand collected from the place of the molluscs' collection. During the experiment, a solution of NaCl 3 g/l in river water was introduced into the container with molluscs. Samples of molluscs’ tissues were taken before application of the saline solution, 40 and 120 min after changing the salt concentration to 3 g/l, and 20 and 60 min after changing the NaCl solution to river water. The change in the concentration of NaCl in water (0–3 g/l) did not affect the content of water-soluble protein in the gills of molluscs during short-term exposure. The change in NaCl concentration in water caused the intensification of LPO processes in the gills of A. cygnea. The change in the activity of the enzymes of the antioxidant system and the increase in the concentration of GSH in A. cygnea gills, indicates their involvement in protecting freshwater molluscs from NaCl-induced oxidative stress. The change in the functioning of the glutathione system may be a compensatory mechanism for changing the NaCl concentration in water. Such biomarkers of oxidative stress as malonic dialdehyde and enzymes of the antioxidant system are sensitive indicators of changes in NaCl concentration in water in freshwater bivalve molluscs, for example A. cygnea.

scholarly journals Isoprostanes in Veterinary Medicine: Beyond a Biomarker

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 145
Author(s):  
Ashley K. Putman ◽  
G. Andres Contreras ◽  
Lorraine M. Sordillo
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Veterinary Medicine ◽  
Biological Fluids ◽  
Biological Action ◽  
Clinical Applications ◽  
Animal Medicine ◽  
Inflammatory Processes ◽  
Oxidized Products ◽  
Biomarkers Of Oxidative Stress

Oxidative stress has been associated with many pathologies, in both human and animal medicine. Damage to tissue components such as lipids is a defining feature of oxidative stress and can lead to the generation of many oxidized products, including isoprostanes (IsoP). First recognized in the early 1990s, IsoP are formed in numerous biological fluids and tissues, chemically stable, and easily measured by noninvasive means. Additionally, IsoP are highly specific indicators of lipid peroxidation and thereby are regarded as excellent biomarkers of oxidative stress. Although there have been many advancements in the detection and use of IsoP as a biomarker, there is still a paucity of knowledge regarding the biological activity of these molecules and their potential roles in pathology of oxidative stress. Furthermore, the use of IsoP has been limited in veterinary species thus far and represents an avenue of opportunity for clinical applications in veterinary practice. Examples of clinical applications of IsoP in veterinary medicine include use as a novel biomarker to guide treatment recommendations or as a target to mitigate inflammatory processes. This review will discuss the history, biosynthesis, measurement, use as a biomarker, and biological action of IsoP, particularly in the context of veterinary medicine.

scholarly journals PSX-3 Antioxidant system characteristics in Saanen goats depending on performance

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 461-462
Author(s):  
Polina D Bokhan ◽  
Alesya A Bakhta ◽  
Larisa Y Karpenko ◽  
Anna I Kozitcyna ◽  
Anna B Balykina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Milk Yield ◽  
Antioxidant System ◽  
Free Radical Oxidation ◽  
Dairy Goat ◽  
Blood Levels ◽  
Lactation Performance ◽  
Radical Oxidation ◽  
System Characteristics

Abstract Dairy goat breeding is widespread worldwide. Goat milk and other derivative products are an important part of nutrition. Dairy products are the most important part of goat breeding; therefore, lactation performance is a relevant issue. The purpose of this study was to evaluate antioxidant system characteristics in Saanen goats depending on lactation performance. The experiment was conducted in the north-western region of Russian Federation, in the laboratories of the biochemistry and physiology departments at FSBEI of Higher Education «SPbSAVM». The three experimental groups included 30 Saanen goats each, 2nd–3rd lactations, selected using matched pairs method. 1st group included low milk producing ability goats (< 600 kg of milk yield per year), 2nd group included average milk producing ability goats (600–800 kg of milk yield per year), 3rd group included high milk producing ability goats (>800 kg of milk yield per year). The blood samples were taken once: at peak lactation performance (45 days after parturition). The blood levels of lipid peroxygenation markers (malondialdehyde, dienketone and conjugated dienes) and superoxide dismutase and catalase activity were assessed by standard methods. Results presented as mean±standard error of the mean. Student’s t-test was used after proving normal distribution. Level of significance is labeled as P < 0.05. The results are displayed in table 1 and 2. After analyzing the received data of antioxidant system characteristics, we found a high intensity of free-radical oxidation in high milk producing ability goats. This results in oxidative stress development. Activity of anti-oxidizing enzymes was elevated; therefore, free-radical oxidation is intensive. Consequently, these data allow us to take into consideration exogenous anti-oxidizing agents administration in high milk producing ability goats in order to reduce oxidative stress.

scholarly journals Effects of Desiccation on Metamorphic Climax in Bombina variegata: Changes in Levels and Patterns of Oxidative Stress Parameters

Animals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 953
Author(s):  
Tamara G. Petrović ◽  
Ana Kijanović ◽  
Nataša Kolarov Kolarov Tomašević ◽  
Jelena P. Gavrić ◽  
Svetlana G. Despotović ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Antioxidant System ◽  
Water Availability ◽  
System Control ◽  
Glutathione S Transferase ◽  
Oxidative Stress Parameters ◽  
Metamorphic Climax ◽  
Bombina Variegata ◽  
Stress Parameters

In this paper, we examined how the oxidative status (antioxidant system and oxidative damage) of Bombina variegata larvae changed during the metamorphic climax (Gosner stages: 42—beginning, 44—middle and 46—end) and compared the patterns and levels of oxidative stress parameters between individuals developing under constant water availability (control) and those developing under decreasing water availability (desiccation group). Our results revealed that larvae developing under decreasing water availability exhibited increased oxidative damage in the middle and end stages. This was followed by lower levels of glutathione in stages 44 and 46, as well as lower values of catalase, glutathione peroxidase, glutathione S-transferase and sulfhydryl groups in stage 46 (all in relation to control animals). Comparison between stages 42, 44 and 46 within treatments showed that individuals in the last stage demonstrated the highest intensities of lipid oxidative damage in both the control and desiccation groups. As for the parameters of the antioxidant system, control individuals displayed greater variety in response to changes induced by metamorphic climax than individuals exposed to desiccation treatment. The overall decrease in water availability during development led to increased oxidative stress and modifications in the pattern of AOS response to changes induced by metamorphic climax in larvae of B. variegata.

A manganese oxide nanozyme prevents the oxidative damage of biomolecules without affecting the endogenous antioxidant system

Nanoscale ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 3855-3863 ◽  
Author(s):  
Namrata Singh ◽  
Mohammed Azharuddin Savanur ◽  
Shubhi Srivastava ◽  
Patrick D'Silva ◽  
Govindasamy Mugesh
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Manganese Oxide ◽  
Antioxidant System ◽  
Mammalian Cells ◽  
Redox State ◽  
Stress Conditions ◽  
System P ◽  
Endogenous Antioxidant ◽  
Antioxidant Machinery

Multi-enzyme mimetic Mn3O4 nanoflowers (Mp) modulate the redox state of mammalian cells without altering the cellular antioxidant machinery under oxidative stress conditions.

scholarly journals Oxidative Stress Biomarkers, Nut-Related Antioxidants, and Cardiovascular Disease

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 682 ◽  
Author(s):  
Julia Lorenzon dos Santos ◽  
Alexandre Schaan de Quadros ◽  
Camila Weschenfelder ◽  
Silvia Bueno Garofallo ◽  
Aline Marcadenti
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease ◽  
Cardiovascular Prevention ◽  
Food Sources ◽  
Dietary Antioxidants ◽  
Oxidative Stress Biomarkers ◽  
Atherosclerosis Progression ◽  
Coronary Syndrome ◽  
Biomarkers Of Oxidative Stress

Atherosclerosis is related to fat accumulation in the arterial walls and vascular stiffening, and results in acute coronary syndrome which is commonly associated with acute myocardial infarction. Oxidative stress participates in the pathogenesis of atherosclerosis. Thus, the inclusion of food sources of dietary antioxidants, such as different kinds of nuts, may improve biomarkers related to oxidative stress, contributing to a possible reduction in atherosclerosis progression. This article has briefly highlighted the interaction between oxidative stress, atherosclerosis, and cardiovascular disease, in addition to the effect of the consumption of different nuts and related dietary antioxidants—like polyphenols and vitamin E—on biomarkers of oxidative stress in primary and secondary cardiovascular prevention. Studies in vitro suggest that nuts may exert antioxidant effects by DNA repair mechanisms, lipid peroxidation prevention, modulation of the signaling pathways, and inhibition of the MAPK pathways through the suppression of NF-κB and activation of the Nrf2 pathways. Studies conducted in animal models showed the ability of dietary nuts in improving biomarkers of oxidative stress, such as oxLDL and GPx. However, clinical trials in humans have not been conclusive, especially with regards to the secondary prevention of cardiovascular disease.

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