Lipid profile in obese children with and without insulin resistance

Obesity in adults and children is characterized by epidemiological prevalence with a tendency to increase. Purpose of the study- to analyze the lipid profile in overweight children, depending on the presence of insulin resistance. 247 overweight and obese children aged 2 to 18 were examined, including 160 boys and 87 girls. Obesity was diagnosed if the BMI exceeded 97 percentile, according to gender and age. Assessment of the lipid profile included measurements of total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein. To evaluate the parameters of the lipid profile, we used the National Cholesterol Education Program (NCEP) according to the latest edition (2006). We analyzed lipid values depending on the presence or absence of insulin resistance. BMI was also evaluated according to Z-BMI. Insulin resistance was detected in 69.9% of children. Hyperlipidemia was detected in 24.9% of children and dyslipidemia in 83% of the children examined. A change was found in all indicators of the lipid profile, depending on the presence of insulin resistance. A significant increase in Z-BMI was revealed depending on the presence of insulin resistance. Conclusions: Most overweight children have insulin resistance and dyslipidemia; the type of dyslipidemia in children with obesity directly depends on the presence of insulin resistance.

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169 BODY MASS INDEX, INSULIN RESISTANCE INDICES AND LIPID PROFILE THEIR RELATIONSHIP WITH HIGHLY SENSITIVE C - REACTIVE PROTEIN IN OBESE CHILDREN

Journal of Investigative Medicine ◽

10.2310/6650.2005.00005.168 ◽

2005 ◽

Vol 53 (1) ◽

pp. S107.4-S107

Author(s):

W. N. Evans ◽

G. A. Mayman ◽

R. J. Acherman ◽

K. A Cass ◽

K. T. Kip ◽

...

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Lipid Profile ◽

Body Mass ◽

Obese Children ◽

C Reactive Protein ◽

Reactive Protein ◽

Highly Sensitive

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Leptin Levels, Basal Metabolic Rates, and Insulin Resistance in Obese Pubertal Children

International Journal of Nutrology ◽

10.1055/s-0040-1713796 ◽

2020 ◽

Vol 13 (01) ◽

pp. 017-023

Author(s):

Elisabete Vieira Conterato ◽

Tania Diniz Machado ◽

Carlos Alberto Nogueira-de-Almeida ◽

Elza Daniel Mello

Keyword(s):

Insulin Resistance ◽

Blood Pressure ◽

Body Composition ◽

Metabolic Rate ◽

Lipid Profile ◽

Fat Mass ◽

Basal Metabolic Rate ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Obese Children

Abstract Introduction Obesity in children and adolescents is considered a serious public health problem. The consequences of overweight can last for life. It is extremely important to have formulas to calculate the basal metabolic rate (BMR) that are truly reliable in relation to the individual caloric expenditure. Objectives To investigate the association of serum levels of leptin, lipid profile, and insulin resistance (insuline resistance by Homeostatic Model Assessment [HOMA] index) with the body mass index (BMI) z-score of pubertal obese children. In addition, to compare the basal metabolic rate (BMR) evaluation carried out using bioimpedance (BIA) with the Food and Agricultural Organization/World Health Organization (FAO/WHO) equation. Methods Cross-sectional study including 37 pubertal obese children (aged 7 to 12 years old) seen for the first time in the outpatient care unit specialized in child obesity between June 2013 and April 2014. The participants were assessed regarding anthropometric data, body composition (fat mass) by BIA 310 bioimpedance analyzer (Biodynamic Body Composition Analyser, model 310 - Biodynamics Corporation, Seattle, EUA), and blood pressure. Blood samples were collected to measure glucose, insulin, lipid profile, triglycerides, and leptin. The stage of sexual maturity was determined by self-assessment according to the Tanner scale. Results Higher leptin levels were found in the severe obesity group (p = 0.007) and, as expected, higher BMI (p < 0.001), and fat mass (p = 0.029). The groups did not differ in relation to insulin, insulin resistance (HOMA-IR), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and blood pressure. The BMR measured by bioimpedance was lower as compared to the measure by the FAO/WHO equation (p < 0.001). Conclusions These results suggest that severely obese children may present leptin resistance in this early stage of life, (since this hormone is higher in these children). It is suggested that health professionals prioritize the calculation of BMR by bioimpedance, since the FAO/WHO equation seems to overestimate the caloric values.

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Non-Alcoholic Fatty Liver Disease in Overweight Children and its Relationship with Retinol Serum Levels

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.78.1.27 ◽

2008 ◽

Vol 78 (1) ◽

pp. 27-32 ◽

Cited By ~ 15

Author(s):

Suano de Souza ◽

Silverio Amancio ◽

Saccardo Sarni ◽

Sacchi Pitta ◽

Fernandes ◽

...

Keyword(s):

Insulin Resistance ◽

Liver Disease ◽

Fatty Liver ◽

Lipid Profile ◽

Fatty Liver Disease ◽

Thiobarbituric Acid ◽

Serum Levels ◽

Control Group ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Objectives: To evaluate the frequency of non-alcoholic fatty liver disease, the retinol serum levels, lipid profile, and insulin resistance in overweight/obese children. To relate these biochemical variables with the risk of this disease in the population studied. Methods: The study was cross-sectional and prospective, with 46 overweight/obese school children (28 female, 18 male; mean age 8.6 years). The control group consisted of 45 children, paired by age and gender. Hepatic steatosis, evaluated by ultrasound, was classified as normal, mild, moderate, or severe. Also evaluated were serum retinol levels; thiobarbituric acid reactive substances; lipid profile; and fasting glucose and serum insulin levels, used for the calculation of the Homeostasis Model Assessment. Results: Hepatic ultrasound alterations were found in 56.5% and 48,9% of the overweight/obese and control group children, respectively. Presence of obesity was associated with high levels of triglycerides (OR = 4.6; P = 0.002). In the studied children, the risk of steatosis was related to a trend to a higher percentage of retinol inadequacy (OR = 2.8; p = 0.051); there was no association with thiobarbituric acid reactive substances, lipid profile, or insulin resistance. Conclusions: The high frequency of non-alcoholic fatty liver disease in both groups, evaluated by hepatic ultrasound, in low-socioeconomic level children, independent of nutritional condition and without significant association with insulin resistance, emphasizes that especially in developing countries, other risk factors such as micronutrient deficiencies (e.g. vitamin A) are involved.

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Association of serum lipid profile and insulin resistance in polycystic ovary syndrome (PCOs) women in Ahvaz, Iran

Endocrine Abstracts ◽

10.1530/endoabs.63.p132 ◽

2019 ◽

Author(s):

Homeira Rashidi ◽

Mina Tafazoli ◽

Mohammad Taha Jalali ◽

Armaghan Moravej Aleali

Keyword(s):

Insulin Resistance ◽

Polycystic Ovary Syndrome ◽

Lipid Profile ◽

Serum Lipid ◽

Polycystic Ovary ◽

Serum Lipid Profile ◽

Ovary Syndrome

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Association Analysis Indicates That a Variant GATA-Binding Site in the PIK3CB Promoter Is a Cis-Acting Expression Quantitative Trait Locus for This Gene and Attenuates Insulin Resistance in Obese Children

Diabetes ◽

10.2337/db07-1273 ◽

2007 ◽

Vol 57 (2) ◽

pp. 494-502 ◽

Cited By ~ 18

Author(s):

C. Le Stunff ◽

A. Dechartres ◽

V. Mariot ◽

C. Lotton ◽

C. Trainor ◽

...

Keyword(s):

Insulin Resistance ◽

Quantitative Trait Locus ◽

Binding Site ◽

Association Analysis ◽

Quantitative Trait ◽

Expression Quantitative Trait Locus ◽

Obese Children ◽

Cis Acting ◽

Trait Locus

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Is Active Lifestyle Related to Autonomic Nervous System Function and Lipid Profile in People with Overweight? A Study Pilot

Sustainability ◽

10.3390/su13052439 ◽

2021 ◽

Vol 13 (5) ◽

pp. 2439

Author(s):

Alexis Espinoza-Salinas ◽

Edgardo Molina-Sotomayor ◽

Johnattan Cano-Montoya ◽

Jose Antonio Gonzalez-Jurado

Keyword(s):

Physical Activity ◽

Insulin Resistance ◽

Nervous System ◽

Autonomic Nervous System ◽

Lipid Profile ◽

Model Assessment ◽

System Function ◽

Autonomic Nervous System Function ◽

Autonomic Nervous ◽

Nervous System Function

Autonomic nervous system function is an important predictor of physical fitness. The objective of this study was to find out the associations of autonomic activity parameters, lipid profile, insulin concentrations, and insulin resistance in overweight men with the level of physical activity. A descriptive and correlational study was carried out in 28 overweight men: 14 physically active (PA) and 14 physically inactive (PI). The following variables were assessed: Level of physical activity, HRV (heart rate variability), basal insulin, HOMA-IR index (Homeostasis Model Assessment Insulin-Resistance), and lipid profile. The main results show a positive correlation between the spectral parameters of the HRV and total cholesterol (r = 0.24), LDL (r = 0.59), VLDL (r = 0.86), and insulin (r = 0.88) of sedentary people, evidencing a directly proportional correlation with BMI. We conclude that weight gain and a sedentary lifestyle are associated with an increase in sympathetic discharge, which, in turn, is associated with an increase in lipid profile and insulin levels.

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Advanced Lipoprotein Analysis Shows Atherogenic Lipid Profile That Improves After Metreleptin in Patients with Lipodystrophy

Journal of the Endocrine Society ◽

10.1210/js.2019-00103 ◽

2019 ◽

Vol 3 (8) ◽

pp. 1503-1517 ◽

Cited By ~ 6

Author(s):

Alexandra B Kinzer ◽

Robert D Shamburek ◽

Marissa Lightbourne ◽

Ranganath Muniyappa ◽

Rebecca J Brown

Keyword(s):

Insulin Resistance ◽

High Density Lipoprotein ◽

Lipid Profile ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Profile ◽

Cvd Risk ◽

Lipoprotein Particles ◽

Atherogenic Lipid Profile ◽

Atherogenic Lipid

Abstract Context Patients with lipodystrophy have dyslipidemia and insulin resistance. Leptin treatment with metreleptin in lipodystrophy decreases insulin resistance and lowers triglycerides without changing high-density lipoprotein. Detailed measurement of lipoprotein particles with nuclear magnetic resonance (NMR) spectroscopy can offer insights into cardiovascular disease (CVD) risk and lipid metabolism beyond a standard lipid panel. We hypothesized that patients with lipodystrophy would have a more atherogenic lipid profile than controls at baseline, which would be ameliorated with metreleptin treatment. Objective To characterize the lipoprotein profile in patients with lipodystrophy compared with controls and to evaluate effects of metreleptin treatment. Design, Setting, Patients, and Intervention Patients with lipodystrophy (N = 17) were studied before and after metreleptin for 2 weeks and 6 months and compared with 51 insulin-sensitive sex-matched controls. Main Outcome Measures Lipoprotein profiles were measured by NMR with the LP4 deconvolution algorithm, which reports triglyceride-rich lipoprotein particles (TRLPs), high-density lipoprotein particles (HDLPs), and low-density lipoprotein particles (LDLPs). Results Patients with lipodystrophy had elevated large TRLPs and smaller HDLPs and LDLPs compared with controls. Five patients with lipodystrophy had chylomicrons, compared with zero controls. Metreleptin decreased the size and concentration of TRLPs, eliminated chylomicrons in all but one patient, decreased LDLPs, and increased LDLP size. Metreleptin treatment did not have major effects on HDLPs. Conclusions Patients with lipodystrophy had an atherogenic lipoprotein profile at baseline consistent with elevated CVD risk, which improved after metreleptin treatment. The presence of fasting chylomicrons in a subset of patients with lipodystrophy suggests saturation of chylomicron clearance by lipoprotein lipase.

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