scholarly journals ACID-ALKALINE STATE OF THE ORGANISM AS A REGULATOR OF THE MINERAL STATUS OF RATS’ BLOOD AT CADMIUM POISONING

2020 ◽  
Author(s):  
Natalia Voroshylova ◽  
◽  
Nelia Melnikova ◽  
Keyword(s):  
Metabolic Acidosis ◽  
Mineral Metabolism ◽  
Animal Husbandry ◽  
Experimental Models ◽  
The State ◽  
The Body ◽  
Acid Base ◽  
Before And After ◽  
Acid Base Status ◽  
Livestock Products

The work is devoted to the study of the influence of changes in the acid-base state on the indices of mineral metabolism in the body of cadmium sulphate-poisoned 6 months age-rats. It is known that the entry of cadmium salts into the body causes disorders of protein, lipid, carbohydrate, and mineral metabolism. As well-known, the endotoxicants affect cellular structures and activate lysosomal enzymes, block mitochondrial oxidation and ribosomal synthesis, initiate free radical processes, that are accompanied by disturbance of rheology and blood coagulation, micro- and macro-circulation, water-electrolyte balance. Such caused alterations in macro- and microelement composition of poisoned animals’ organisms disrupt the course of numerous metabolic processes. The research was conducted on the basis of the Department of Biochemistry and Vivarium of the National University of Life and Environmental Sciences of Ukraine using adult 6 months-age outbred rats breeding of the Research and Production Center of Laboratory Animal Husbandry of Educational and Scientific Institute of Veterinary Medicine and Quality and Safety of Livestock Products. Biological models of introduction of rats into the state of experimental metabolic acidosis and alkalosis before and after cadmium sulphate poisoning have been developed, as well as indices of acid-base status and mineral metabolism of the developed experimental models have been studied. The influence of the changes of parameters of acid-base state of the body on the content in the blood of poisoned rats of macronutrients (sodium, potassium, calcium, magnesium, inorganic phosphorus) and trace elements (copper, zinc, and iron). At compare of the changes in parameters of acid-base status of the blood of cadmium sulfate-poisoned animals, it was noted that the state of experimental metabolic acidosis is more expressed than alkalosis, that is more effective for correction and normalization of mineral metabolism in poisoned rats.

scholarly journals Effects of dietary electrolyte balance and calcium supply on mineral and acid−base status of piglets fed a diversified diet

2020 ◽  
Vol 9 ◽  
Author(s):  
M. Bournazel ◽  
M. J. Duclos ◽  
F. Lecompte ◽  
D. Guillou ◽  
C. Peyronnet ◽  
...  
Keyword(s):  
Metabolic Acidosis ◽  
Mineral Metabolism ◽  
Venous Blood ◽  
Electrolyte Balance ◽  
Low Grade ◽  
Acid Base Balance ◽  
Acid Base ◽  
Urine Ph ◽  
Skeletal Health ◽  
Acid Base Status

Abstract Dietary electrolyte balance (dEB) is known to affect acid−base status and mineral metabolism, but is rarely considered in diet formulation for pigs. Yet, the use of a wide variety of local feedstuffs in Europe contributes to lowering the dEB and increasing the fibre content. Hence, mineral requirements may be modified and skeletal health affected. Therefore, the effects of a lower dEB and a higher dietary Ca level on acid−base balance and mineral status were assessed in young pigs fed a diversified diet. A total of twenty-four weaned pigs were fed a control moderate-dEB diet (C) or a diversified moderate-dEB (D), low-dEB (D-A) or low-dEB supplemented with Ca (D-CA) diet. Growth performance, venous blood gas and chemistry, urine pH, mineral balance and femur characteristics were determined. With an equivalent dEB compared with the C diet, the D diet caused an acidification of the urine and increased the excretion of P as a result of a higher dietary content of S. Low-grade metabolic acidosis occurred in piglets fed the D-A diet with changes at systemic and urine levels. A higher excretion of ammonia and P in urine was observed and some bone characteristics tended to be negatively affected. Ca supplementation partially counteracted the effects of low-grade acidosis. Urine excretion of P and ammonia was alleviated and bone characteristics improved. In conclusion, a higher Ca supply must be considered in more diversified diets to counteract the risk of evolving towards low-grade metabolic acidosis which can negatively affect bone.

Studies on the Pathophysiology of Encephalopathy in Reye's Syndrome: Hyperammonemia in Reye's Syndrome

PEDIATRICS ◽  
1975 ◽  
Vol 56 (6) ◽  
pp. 999-1004
Author(s):  
Daniel C. Shannon ◽  
Robert De Long ◽  
Barry Bercu ◽  
Thomas Glick ◽  
John T. Herrin ◽  
...  
Keyword(s):  
Metabolic Acidosis ◽  
Venous Drainage ◽  
Respiratory Alkalosis ◽  
Ammonia Concentration ◽  
Reye's Syndrome ◽  
Acid Base ◽  
Arterial Blood ◽  
Cerebral Venous Drainage ◽  
Acid Base Status ◽  
The Brain

The initial acid-base status of eight survivors of Reye's syndrome was characterized by acute respiratory alkalosis (Pco2=32 mm Hg; Hco3-= 22.0 mEq/liter) while that of eight children who died was associated with metabolic acidosis as well (HCO3-=10.0 mEq/liter). Arterialinternal jugular venous ammonia concentration differences on day 1 (299 mg/100 ml) and day 2 (90 mg/ 100 ml) reflected cerebral uptake of ammonia while those on days 3 and 4 (-43 and -55 mg/100 ml) demonstrated cerebral release. Arterial blood hyperammonemia can be detoxified safely in the brain as long as the levels do not exceed approximately 300µg/100 ml. Beyond that level lactic acidosis is observed, particularly in cerebral venous drainage. Arterial blood hyperammonemia was also related to the extent of alveolar hyperventilation. These findings are very similar to those seen in experimental hyperammonemia and support the concept that neurotoxicity in children with Reye's syndrome is at least partly due to impaired oxidative metabolism secondary to hyperammonemia.

ANALYSIS OF INDICATORS A.Ya. ANIMAL VARIATION PULSE DROP

2021 ◽  
Author(s):  
M. М. Naumov ◽  
Keyword(s):  
Animal Husbandry ◽  
The Body ◽  
Fast Wave ◽  
Functional Changes ◽  
Functional Reserves ◽  
Comprehensive Knowledge ◽  
Modern Economic ◽  
Livestock Products ◽  
The Relationship ◽  
Jersey Cows

The article reveals the possibilities of cardiointervalometry using the modern complex electrophysiological laboratory "CONAN - 4.5". In modern economic conditions, the intensification of animal husbandry requires deep and comprehensive knowledge of many sciences, especially biology and physiology. The body of an animal consistently undergoes interrelated morphological, biochemical and functional changes that provide functional reserves such as energy, metabolic and informational resources. The adaptation mechanisms and the duration of the economic use of cattle in modern conditions of industrial production of livestock products depend on the nature and severity of these reserves. The estimation of the slow and fast-wave components of the variability of the cardiointervals is carried out - the numerical values of A.Ya. Kaplan indicators of heart rate variability (respiratory modulation index (IDM), sympathoadrenal tone index (ISAT), slow wave arrhythmia index (IMA)) of Jersey cows, which reflect the activity of the sympathetic and parasympathetic autonomic nervous system. The work used the mathematical processing of HRV using the method of R.M. Baevsky. In this work, the analysis of the obtained numerical values of the indicators of A.Ya. Kaplan and considered the relationship between the initial vegetative tone of Jersey cows and the obtained values.

Pendrin in the mouse kidney is primarily regulated by Cl− excretion but also by systemic metabolic acidosis

2008 ◽  
Vol 295 (6) ◽  
pp. C1658-C1667 ◽  
Author(s):  
Patricia Hafner ◽  
Rosa Grimaldi ◽  
Paola Capuano ◽  
Giovambattista Capasso ◽  
Carsten A. Wagner
Keyword(s):  
Metabolic Acidosis ◽  
Collecting Duct ◽  
Relative Number ◽  
High Protein ◽  
Acid Excretion ◽  
Acid Base ◽  
Urinary Acidification ◽  
Apical Side ◽  
Acid Base Status ◽  
Net Acid Excretion

The Cl−/anion exchanger pendrin (SLC26A4) is expressed on the apical side of renal non-type A intercalated cells. The abundance of pendrin is reduced during metabolic acidosis induced by oral NH4Cl loading. More recently, it has been shown that pendrin expression is increased during conditions associated with decreased urinary Cl− excretion and decreased upon Cl− loading. Hence, it is unclear if pendrin regulation during NH4Cl-induced acidosis is primarily due the Cl− load or acidosis. Therefore, we treated mice to increase urinary acidification, induce metabolic acidosis, or provide an oral Cl− load and examined the systemic acid-base status, urinary acidification, urinary Cl− excretion, and pendrin abundance in the kidney. NaCl or NH4Cl increased urinary Cl− excretion, whereas (NH4)2SO4, Na2SO4, and acetazolamide treatments decreased urinary Cl− excretion. NH4Cl, (NH4)2SO4, and acetazolamide caused metabolic acidosis and stimulated urinary net acid excretion. Pendrin expression was reduced under NaCl, NH4Cl, and (NH4)2SO4 loading and increased with the other treatments. (NH4)2SO4 and acetazolamide treatments reduced the relative number of pendrin-expressing cells in the collecting duct. In a second series, animals were kept for 1 and 2 wk on a low-protein (20%) diet or a high-protein (50%) diet. The high-protein diet slightly increased urinary Cl− excretion and strongly stimulated net acid excretion but did not alter pendrin expression. Thus, pendrin expression is primarily correlated with urinary Cl− excretion but not blood Cl−. However, metabolic acidosis caused by acetazolamide or (NH4)2SO4 loading prevented the increase or even reduced pendrin expression despite low urinary Cl− excretion, suggesting an independent regulation by acid-base status.

Acid-Base Status Before and After Arterial Clamping

1977 ◽  
Vol 21 (1) ◽  
pp. 62-66 ◽  
Author(s):  
D. B. Stokke ◽  
B. Juhl ◽  
G. Juel
Keyword(s):  
Acid Base ◽  
Before And After ◽  
Acid Base Status

scholarly journals Effect of Diatomite on the Accumulation of Lead and Cadmium in the Body of White Rats

2021 ◽  
Vol 37 ◽  
pp. 00144
Author(s):  
Vasily I. Dorozhkin ◽  
Natalia A. Brichko ◽  
Natalia S. Pavlova ◽  
Galina I. Pavlenko
Keyword(s):  
Heavy Metals ◽  
Animal Husbandry ◽  
Cadmium Accumulation ◽  
The Body ◽  
Feed Additive ◽  
Lead And Cadmium ◽  
White Rats ◽  
Accumulation Of Metals ◽  
Livestock Products ◽  
Cadmium And Lead

Every year, pollution by eco-toxicants of natural and anthropogenic origin is becoming more and more acute. Some of the most toxic among them are heavy metals, especially cadmium and lead. These elements do not decompose. Once released into the environment, these elements continue to circulate in water, soil, and air for a very long time, accumulating in plants and livestock products. Therefore, there is a problem of obtaining safe agricultural products in areas contaminated with heavy metals. In animal husbandry, synthetic and natural enterosorbents are used for obtaining safe products. For example, such enterosorbents are shungites, bentonites, diatomites, clays. We tested diatomite from the Kamyshlovskoye deposit at a dose of 5.0 g/kg of feed to reduce cadmium accumulation and lead during their combined intake. We investigated the feed intake of a combination of cadmium and lead at doses of 5.0 and 50.0 mg/kg feed. The result of this experiment is the accumulation of metals in the liver, kidneys, and bones, and, in addition, in the testes. The use of diatomite to reduce the accumulation of heavy metals has not been successful. There is an increase in lead accumulation in the liver, kidneys, and testes. The content of cadmium in diatomite is 3.86 ± 0.20 mg/kg, lead – 105.0 ± 7.2 mg/kg. The results obtained indicate that diatomite as a feed additive to reduce lead and cadmium intoxication did not show protective properties.

scholarly journals Scientific support and advanced research in dairy farming in the Russian Federation

2021 ◽  
Vol 282 ◽  
pp. 02001
Author(s):  
Tatiana Marinchenko
Keyword(s):  
Research And Development ◽  
Russian Federation ◽  
Animal Husbandry ◽  
Dairy Farming ◽  
Output Growth ◽  
The State ◽  
Scientific Support ◽  
Dairy Cattle Breeding ◽  
The Russian Federation ◽  
Livestock Products

Increasing the output of agricultural products and improving their quality is one of the most important tasks of ensuring the food security of the Russian Federation. The solution to this problem is impossible without the introduction of up-to-date technologies that ensure the competitiveness and output growth, which are the result of scientific research and development. The basis for increasing the efficiency of dairy farming and, as a consequence, increasing milk production is the genetic improvement of the breeding base. The organization of selection and breeding work based on the use of our own genetic resources is a strategic task of the industry, which allows increasing the output of livestock products, reducing the technological import dependence of animal husbandry and minimizing the risk of the introduction of infectious diseases into the country. At the same time, the breeding base of dairy cattle breeding is on average 13.8% of the total livestock in the Russian Federation. The breeding progress is ensured by agricultural organizations, in which less than half of the total head of cows is concentrated. They are also the main consumers of research and development results. The purpose of the study is to analyze the state of the industry and its scientific potential, as well as formulate proposals for improving scientific support to create conditions for solving the tasks set by the state.

scholarly journals Acid base status of prevalent peritoneal dialysis patients

2018 ◽  
Vol 1 (1) ◽  
pp. 21-25
Author(s):  
Raymond Azar ◽  
Vincent Coevoet
Keyword(s):  
Peritoneal Dialysis ◽  
Metabolic Acidosis ◽  
Metabolic Alkalosis ◽  
Lower Probability ◽  
Individual Choice ◽  
Dietary Intakes ◽  
Dialysis Patients ◽  
Acid Base Balance ◽  
Acid Base ◽  
Acid Base Status

Acid-base status of patients on peritoneal dialysis is influenced by multiple factors. Metabolic acidosis is a common feature of chronic renal failure and dialysis treatment provides alkali in the dialysate in order to maintain a normal acid-base balance. This paper reports the prevalence of acid-base disorders in peritoneal dialysis patients and their associations with clinical and laboratory parameters. This is a cross-sectional retrospective study that included all PD patients registered in the RDPLF database. Metabolic acidosis was found in 20.4% of patients while 27.8% of patients had metabolic alkalosis. There is a significant relationship between age, protein intake estimated by nPNA and the level of alkaline reserve pleading in favor of the influence of dietary intakes in the maintenance of metabolic acidosis. Low residual renal function is associated with a lower probability of being in metabolic alkalosis. These results could allow an individual choice of the dialysate buffer in order to permanently obtain stable acid-base status in patients on peritoneal dialysis.

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