scholarly journals Metabolic Syndrome in a Population of In-Patients with Schizophrenia in the Western Siberia

Psychiatry ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 52-60
Author(s):  
E. G. Kornetova ◽  
V. I. Gerasimova ◽  
A. A. Goncharova ◽  
V. V. Khamina ◽  
I. A. Mednova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Western Siberia ◽  
Mutual Influence ◽  
Statistical Significance ◽  
Disease Onset ◽  
Antipsychotic Treatment ◽  
Never Married ◽  
Duration Of Illness ◽  
Icd 10

Background. The relevance of this work is due to the incomplete nature of existing studies on risk factors of metabolic syndrome (MS) in patients with schizophrenia. Aim: to study the MS prevalence in schizophrenia in-patients and their clinical, therapeutic and socio-demographic features. Patients and methods: 517 in-patients diagnosed with schizophrenia according to the ICD-10 criteria were examined. All patients underwent a structured clinical interview (SCID); measurement of waist circumference, blood pressure and assessment of biochemical parameters for verification of MS based on the criteria of the IDF (International Diabetes Fediration). An assessment of the severity of clinical and psychopathological symptoms was performed using the PANSS. Results: the prevalence of MS in in-patients with schizophrenia in the Western Siberia is similar to that reported in the literature. It was found that in-patients with schizophrenia and MS are characterized by a predominance of women and older age, as well as a large proportion of divorced, and a smaller proportion of never married. Women with MS were older, got longer duration of illness, and got later onset of disease than men with MS. The age of disease onset was significantly greater in patients with MS than in patients without MS. Atypical antipsychotics were more often used as the basic antipsychotic treatment in the group of patients with MS but this difference between the groups did not reach statistical significance. Conclusions: the main risk factors in patients with schizophrenia and MS coincide with risk factors of MS in general population. A later onset of the disease can act as an independent risk factor. The relationship and mutual influence of risk factors for the development of MS in patients with schizophrenia needs further study.

Assessment of the Risk Factors of MDD Recurrence Based on Deep Learning Approaches

2021 ◽  
Vol 6 (3) ◽  
Author(s):  
Wu Q ◽  
◽  
Zhao W ◽  
Yang X ◽  
Tan H ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Marital Status ◽  
Prediction Accuracy ◽  
Learning Approaches ◽  
Never Married ◽  
Factors Associated ◽  
Diagnosis Codes ◽  
Icd 10 ◽  
And Control

Objective: Explore the risk factors related to the recurrence of MDD and provide a basis for the prevention and control of MDD. Methods: Patients with MDD were extracted from two large, multi-center clinical datasets. The inpatients and outpatients between January 2000 and December 2015 were collected. Eligible patients were 18-90 years-old and had a diagnosis of MDD. The MDD were identified based on the MDD-related ICD-9- CM diagnosis codes; and MDD-related ICD-10-CM diagnosis codes. Eventually, 140,497 patients were qualified for further analysis, including 69.2% female patients. Among of 140,497, 20, 078 patients (14.3%) had no comorbidities. Logistic regression, SVM, and LSTM were employed to predict the key risk factors associated with MDD recurrence. Results: The MDD patients with married /life partners had a lower prevalence rate (9.2%) of MDD recurrence than the patients with single marital status (11.8%). The primary MDD patients had a higher MDD recurrent rate (11.7%) than secondary MDD patients (10.5%). Primary MDD was associated with MDD recurrence (OR 2.49, 95% CI 1.53-3.96) via logistic regression analysis. Insomnia, anxiety and single marital status were also top-ranked risk factors for the MDD recurrence. The prediction accuracy of logistic regression, SVM and LSTM were 0.736, 0.791 and 0.834, respectively. Conclusions: Building statistical models by mining existing EHR data can explore the risk factors associated with MDD recurrence. Our results indicated that primary MDD, never married, anxiety symptoms, and insomnia were risk factors for MDD recurrence. The prediction accuracy of the LSTM model was higher than the other two approaches.

scholarly journals Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms

2016 ◽  
Vol 2016 ◽  
pp. 1-23 ◽  
Author(s):  
Hannu Kankaanranta ◽  
Paula Kauppi ◽  
Leena E. Tuomisto ◽  
Pinja Ilmarinen
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Disease Onset ◽  
Real Life ◽  
Lung Mechanics ◽  
Cross Sectional ◽  
Nitric Oxide Metabolism ◽  
Incident Asthma ◽  
Early Life Exposures ◽  
Clinical Asthma

Asthma is a heterogeneous disease with many phenotypes, and age at disease onset is an important factor in separating the phenotypes. Most studies with asthma have been performed in patients being otherwise healthy. However, in real life, comorbid diseases are very common in adult patients. We review here the emerging comorbid conditions to asthma such as obesity, metabolic syndrome, diabetes mellitus type 2 (DM2), and cardiac and psychiatric diseases. Their role as risk factors for incident asthma and whether they affect clinical asthma are evaluated. Obesity, independently or as a part of metabolic syndrome, DM2, and depression are risk factors for incident asthma. In contrast, the effects of comorbidities on clinical asthma are less well-known and mostly studies are lacking. Cross-sectional studies in obese asthmatics suggest that they may have less well controlled asthma and worse lung function. However, no long-term clinical follow-up studies with these comorbidities and asthma were identified. These emerging comorbidities often occur in the same multimorbid adult patient and may have in common metabolic pathways and inflammatory or other alterations such as early life exposures, systemic inflammation, inflammasome, adipokines, hyperglycemia, hyperinsulinemia, lung mechanics, mitochondrial dysfunction, disturbed nitric oxide metabolism, and leukotrienes.

scholarly journals The role of some risk factors in the development of amyotrophic lateral sclerosis in big industrial city in Western Siberia

2011 ◽  
Vol 10 (2) ◽  
pp. 134-141
Author(s):  
A. V. Lebedev ◽  
B. M. Doronin ◽  
I. A. Gribacheva
Keyword(s):  
Risk Factors ◽  
Amyotrophic Lateral Sclerosis ◽  
Emotional Stress ◽  
Western Siberia ◽  
Disease Onset ◽  
Meat Products ◽  
Industrial City ◽  
Eating Meat ◽  
Lateral Sclerosis

On examination of 78 people with accurate amyotrophic lateral sclerosis the role of some risk factors in the development and the character of the flow of the disease was analyzed. The received findings don't allow excluding the participation of the viruses of herpes and cytomegalovirus in the emergence and development of amyotrophic lateral sclerosis. The most important is the observance of a hypocaloric diet, the prevalence of eating meat products, the availability of guidelines for the transfer of poliomyelitis, rheumatism, herpes infection, acute psycho-emotional stress for the 6 months before disease onset and some others.

scholarly journals Magnitude, components and predictors of metabolic syndrome in Northern Ethiopia: Evidences from regional NCDs STEPS survey, 2016

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0253317
Author(s):  
Kiros Fenta Ajemu ◽  
Abraham Aregay Desta ◽  
Asfawosen Aregay Berhe ◽  
Ataklti Gebretsadik Woldegebriel ◽  
Nega Mamo Bezabih ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Statistical Significance ◽  
Strong Association ◽  
Fasting Blood Glucose ◽  
P Value ◽  
Northern Ethiopia ◽  
Tigray Region ◽  
Steps Survey ◽  
Low Hdl

Background Individuals with metabolic syndrome are five times more susceptible to chronic diseases. Assessment of its magnitude, components, and risk factors is essentials to deploy visible interventions needed to avoid further complications. The study aimed to assess magnitude, components, and predictors of metabolic syndrome in Tigray region northern Ethiopia, 2016. Methods Data were reviewed from Tigray region NCDs STEPs survey data base between May to June 2016. A total of 1476 adults aged 18–64 years were enrolled for the study. Multi-variable regression analysis was performed to estimate the net effect of size to risk factors associated with metabolic syndrome. Statistical significance was declared at p-value of ≤0.05 at 95% confidence interval (CI) for an adjusted odds ratio (AOR). Results The study revealed that unadjusted and adjusted prevalence rate of Metabolic Syndrome (MetS) were (CPR = 33.79%; 95%CI: 31.29%–36.36%) and (APR = 34.2%; 95% CI: 30.31%–38.06%) respectively. The most prevalent MetS component was low HDL concentration (CPR = 70.91%; 95%CI: 68.47%–73.27%) and (APR = 70.61; 95%CI; 67.17–74.05). While; high fasting blood glucose (CPR = 20.01% (95%CI: 18.03–22.12) and (APR = 21.72; 95%CI; 18.41–25.03) was the least ones. Eating vegetables four days a week, (AOR = 3.69, 95%CI; 1.33–10.22), a salt sauce added in the food some times (AOR = 5.06, 95%CI; 2.07–12.34), overweight (AOR = 24.28, 95%CI; 10.08–58.47] and obesity (AOR = 38.81; 12.20–111.04) had strong association with MetS. Conclusion The magnitude of metabolic syndrome was found to be close to the national estimate. Community awareness on life style modification based on identified MetS components and risk factors is needed to avoid further complications.

scholarly journals Cardiometabolic syndrome and associated factors among Ethiopian public servants, Addis Ababa, Ethiopia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zeleke Geto ◽  
Feyissa Challa ◽  
Tadesse Lejisa ◽  
Tigist Getahun ◽  
Meron Sileshi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiovascular Diseases ◽  
Associated Factors ◽  
Preventive Intervention ◽  
Addis Ababa ◽  
Statistical Significance ◽  
World Health ◽  
P Value ◽  
Early Screening

AbstractNon-communicable diseases (NCDs) are increasingly becoming the global cause of premature death encompassing cardiovascular diseases (CVDs), cancer, respiratory diseases and diabetes mellitus. However, cardiometabolic risk factors in the general population, especially among the high-risk groups have rarely been assessed in Ethiopia. The study aimed to assess the prevalence of metabolic syndrome, its components and associated factors among staff in the Ethiopian Public Health Institute (EPHI). An institutional-based cross-section study was conducted from March to June 2018 among EPHI staff members. A total of 450 study participants were involved in the study, and the World Health Organization NCD STEPS survey instrument version 3.1 was used for the assessment. The biochemical parameters were analyzed by using COBAS 6000 analyzer. Statistical package for the social science (SPSS) version 20 was used for data analysis. Both bivariate and multivariate logistic regression analyses were used to identify associated risk factors. p value < 0.05 was considered for statistical significance. The overall prevalence of metabolic syndrome was 27.6% and 16.7% according to IDF and NCEP criteria respectively, with males having greater prevalence than females (35.8% vs 19.4%). Central obesity, low high-density lipoprotein (HDL) and hypertension had a prevalence of 80.2%, 41.3%, and 23.6%, respectively. In multivariate analysis increasing age and having a higher body mass index (25–29.9) were significantly associated with metabolic syndromes. The magnitude of metabolic syndrome was relatively high among public employees. Preventive intervention measures should be designed on the modification of lifestyle, nutrition and physical activities, and early screening for early identification of cardiometabolic risks factors should be practised to reduce the risk of developing cardiovascular diseases.

scholarly journals Prevalence of metabolic syndrome and its associated risk factors among staffs in a Malaysian public university

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mohd Rizal Abdul Manaf ◽  
Azmawati Mohammed Nawi ◽  
Noorlaili Mohd Tauhid ◽  
Hanita Othman ◽  
Mohd Rizam Abdul Rahman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Statistical Significance ◽  
Age Factors ◽  
Cross Sectional Study ◽  
Public University ◽  
Moderate Intensity ◽  
Lifestyle Behaviors ◽  
Cross Sectional ◽  
Associated Risk Factors

AbstractPublic health systems are concerned with the commensurate rise of metabolic syndrome (MetS) incidence across populations worldwide, due to its tendency to amplify greater risk of diabetes and cardiovascular diseases within communities. This study aimed to determine the prevalence of MetS and its associated risk factors among staffs in a Malaysian public university. A cross-sectional study was conducted among 538 staffs from the Universiti Kebangsaan Malaysia (UKM) between April and June 2019. MetS was defined according to JIS “Harmonized” criteria. A questionnaire that consisted of items on socio-demographics, lifestyle risk behaviors and personal medical history information was administered to participants. Subsequently, a series of physical examination and biochemical assessment was conducted at the hall or foyer of selected faculties in the university. Descriptive and inferential statistics were conducted using SPSS version 22.0. Multivariate models were yielded to determine the risk factors associated with MetS. Statistical significance was set at P < 0.05. The overall prevalence of MetS was 20.6%, with men having greater prevalence than women (24.9% vs. 18.3%). Prevalence of MetS increased with age. Factors contributed to MetS in the overall sample were BMI, hypertension, diabetes and physical activity of moderate intensity. Diabetes and hypertension were significantly associated with MetS in men, whereas BMI, diabetes and hyperlipidemia were significantly associated with MetS in women. Lifestyle behaviors and cardio-metabolic risk factors were associated with MetS for the overall sample, and across genders.

Serum Retinol and β-carotene Levels and Risk Factors for Cardiovascular Disease in Morbid Obesity

2010 ◽  
Vol 80 (3) ◽  
pp. 159-167 ◽  
Author(s):  
Gabriela Villaça Chaves ◽  
Gisele Gonçalves de Souza ◽  
Andréa Cardoso de Matos ◽  
Dra. Wilza Abrantes Peres ◽  
Silvia Elaine Pereira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Morbid Obesity ◽  
Serum Levels ◽  
World Health ◽  
Morbidly Obese ◽  
Serum Retinol ◽  
Significant Difference ◽  
Β Carotene

Objective: To evaluate retinol and β-carotene serum levels and their relationship with risk factors for cardiovascular disease in individuals with morbid obesity, resident in Rio de Janeiro. Methodology: Blood serum concentrations of retinol and β-carotene of 189 morbidly obese individuals were assessed. The metabolic syndrome was identified according to the criteria of the National Cholesterol Education Program (NCEP) and World Health Organization (WHO). Lipid profile, insulin resistance, basal insulin, glycemia, blood pressure, and anthropometry and their correlation with retinol and β-carotene serum levels were evaluated. Results: Metabolic syndrome diagnosis was observed in 49.0% of the sample. Within this percentage the levels of β-carotene were significantly lower when body mass index increased. Serum retinol didn't show this behavior. Serum retinol inadequacy in patients with metabolic syndrome (61.3%), according to WHO criterion, was higher (15.8%) than when the whole sample was considered (12.7%). When metabolic syndrome was diagnosed by NCEP criterion, β-carotene inadequacy was higher (42.8%) when compared to the total sample (37.5%). There was a significant difference between average β-carotene values of patients with and without metabolic syndrome (p=0.048) according to the classification of the NCEP. Lower values were found in patients with metabolic syndrome. Conclusion: Considering the vitamin A contribution in antioxidant protection, especially when risk factors for cardiovascular disease are present, it is suggested that great attention be given to morbidly obese. This could aid in prevention and treatment of cardiovascular disease, which affects a significant part of the population.

Correlation of Metabolic Risk Factors with Sessile Serrated Lesions

2020 ◽  
Vol 29 (2) ◽  
pp. 175-179
Author(s):  
Melania Macarie ◽  
Simona Bataga ◽  
Simona Mocan ◽  
Monica Pantea ◽  
Razvan Opaschi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Statistical Significance ◽  
Interval Cancer ◽  
Metabolic Risk Factors ◽  
Control Group ◽  
Anatomical Site ◽  
Metabolic Risk ◽  
Right Colon ◽  
Serrated Lesions ◽  
The Right

Background and Aims: The importance of sessile serrated lesions (SSLs) in the pathogenesis of colorectal carcinoma has been recently established. These are supposed to cause the so-called “interval cancer”, having a rapidly progressive growth and being difficult to detect and to obtain an endoscopic complete resection. We aimed to establish the most important metabolic risk factors for sessile serrated lesions. Methods: We performed a retrospective case-control study, on a series of 2918 consecutive patients who underwent colonoscopy in Gastroenterology and Endoscopy Unit, County Clinical Emergency Hospital, Târgu-Mureș, Romania between 1 st of January 2015-31 th of December 2017. In order to evaluate the metabolic risk factors for polyps’ development, enrolled participants were stratified in two groups, a study group, 33 patients with SSLs lesions, and a control group, 138 patients with adenomatous polyps, selected by systematic sampling for age and anatomical site. Independent variables investigated were: gender, smoking, alcohol consumption, obesity, arterial hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia, hyperuricemia, nonalcoholic liver disease. Results: For SSLs the most common encountered localization was the right colon in 30.55% of cases. By comparative bivariate analysis between SSLs group and control group, it was observed that hypertension (p=0.03, OR 2.33, 95 %CI 1.03-5.24), obesity (p=0.03, OR 2.61, 95 %CI 1.08-6.30), hyperuricemia (p=0.04, OR 2.72, 95 %CI 1.28-7.55), high cholesterol (p=0.002, OR 3.42; 95 %CI 1.48-7.87), and high triglycerides level (p=0.0006, OR 5.75; 95 %CI 1.92-17.2) were statistically associated with SSLs development. By multivariate analysis hypertension and hypertriglyceridemia retained statistical significance. Conclusions: Our study showed that the highest prevalence of SSLs was in the right colon and hypertension and increased triglycerides levels were associated with the risk of SSLs development. These risk factors are easy to detect in clinical practice and may help identifying groups with high risk for colorectal cancer, where screening is recommended.

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