Aplikasi Berbasis Mobile untuk Diabetisi dalam Menunjang Ibadah Puasa, Haji dan Umroh Kerja Sama Persadia Unit RSI Sultan Agung

Dari data Kementerian Kesehatan dari Sampel Registration Survey 2014 menyebutkan bahwa diabetes telah menjadi penyebab kematian terbesar nomor 3 di Indonesia, dengan presentase sebesar 6,7%, setelah stroke (21,1%) dan penyakit jantung koroner (12,9%), Berdasarkan data Riskesdas 2013 (Kemenkes RI, 2013), 90% dari total kasus diabetes merupakan diabetes tipe 2, yang umumnya terjadi pada orang dewasa. Namun beberapa tahun terakhir makin banyak ditemukan pada usia dewasa muda kurang dari 30 tahun bahkan pada anak-anak dan remaja. Indonesia merupakan negara muslim terbesar di dunia. Jumlah penduduk Indonesia 258 juta 87,2% adalah warga muslim. Sebagai warga muslim disyariatkan untuk melaksanakan berbagai ibadah antara lain ibadah puasa di bulan ramadan, haji dan umroh. Pada saat puasa pasien diabetes tidak makan selama siang hari yang berpeluang menimbulkan kecenderungan makan berlebih pada malam hari. Hal ini berpotensi menyebabkan pasien 5 kali lebih berisiko mengalami hiperglikemia dan sebanyak 7 kali lebih berisiko mengalami hipoglikemia. Kegiatan edukasi program aplikasi berbasis mobile untuk diabetesi sebagai bekal dalam menjalankan ibadah puasa haji dan umroh telah dilaksanakan dengan yang diikuti oleh 348 peserta dengan berbagai unsur peserta antara lain dokter, mahasiswa kesehatan, perawat dan ibu rumah tangga. Aplikasi juga telah didistribusikan di google playstore sehingga masyarakat luas akan lebih mudah mengunduh, memasang dan memakai aplikasi tersebut dimana saja, kapan saja dengan melalui koneksi internet.Data from the Ministry of Health from the 2014 Sample Registration Survey states that diabetes has become the 3rd largest cause of death in Indonesia, with a percentage of 6.7%, after stroke (21.1%) and coronary heart disease (12.9%). Data from Riskesdas 2013 (Kemenkes RI, 2013), 90% of total diabetes cases are type 2 diabetes, which generally occurs in adults. However, in recent years, it is increasingly found in adults less than 30 years, even in children and adolescents. Indonesia is the largest Muslim country in the world. The total population of Indonesia 258 million 87.2% are Muslims. As Muslim citizens, they are obliged to carry out various acts of worship, including fasting in the month of Ramadan, Hajj and Umrah. During fasting, diabetic patients do not eat during the day which may lead to a tendency to overeat at night. This puts the patient 5 times more likely to develop hyperglycemia and 7 times more likely to develop hypoglycemia. Educational activities for mobile-based application programs for diabetes as a provision for carrying out the Hajj and Umrah fasting services have been carried out by 348 participants with various participants including doctors, health students, nurses and housewives. Applications have also been distributed on the Google Play Store so that the wider community will find it easier to download, install and use the application anywhere, anytime via an internet connection.

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The Effect and Mechanism of Trimethylamine-N-oxide, a Metabolite of Intestinal Flora, on Coronary Heart Disease in Type 2 Diabetic Patients

10.21203/rs.3.rs-123785/v1 ◽

2020 ◽

Author(s):

jie li ◽

Xiaoqin Ha ◽

Xiaoling Cai ◽

Chenyuan Yan ◽

Caixia Jia ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

Western Blot ◽

Mrna Level ◽

Elevated Serum ◽

Intestinal Flora ◽

Diabetic Patients ◽

Rrna Gene

Abstract BackgroundTrimethylamine N-Oxide (TMAO) has been shown to be an independent risk factor for cardiovascular disease. Our aim is to study the effects of TMAO on type 2 diabetes mellitus-coronary heart disease and to explore its mechanism.MethodsA total of 50 healthy controls , 50 T2DM patients and 50 T2DM combined with CHD patients were enrolled. Serum samples were collected to detect glucose, myocardial enzyme spectrum and TMAO level. The 16S rRNA gene sequencing analyzed the diversity of intestinal flora. Taking the ZDF rat as the experimental object, the model of T2DM combined with CHD was established in rats. Blood samples were taken to detect glucose, myocardial enzyme spectrum and TMAO level. The inflammatory protein and mRNA expression of TLR4, NLRP3, Caspase-1 and IL-1β were detected by Western blot and RT-qPCR. In vitro culture of H9c2(2-1) for experiments. The CCK-8 method was used to detect the survival rate of cells after glucose and TMAO treatment. After the cells were treated with selected glucose and TMAO, the cells were treated with selected glucose, TMAO and BAY11-7082, Western blot detected the presence of pyroptosis and the pathway of TLR4/NF-κB/NLRP3. RT-qPCR was used to determine the mRNA level of inflammatory factor.DiscussionChanges in the composition of intestinal flora in patients with type 2 diabetes can lead to elevated serum TMAO levels. Animal and cell experiments have confirmed that elevated TMAO level may lead to inflammatory myocardial injury in rats and is related to the mechanism of TLR4/NF-κB/NLRP3.

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Prevalence and Risk Factors of Coronary Heart Disease in Chinese Patients with type 2 Diabetes Mellitus, 2013-2018

10.21203/rs.3.rs-42382/v1 ◽

2020 ◽

Author(s):

Chenchen Wang ◽

Zuoling Xie ◽

Xi Huang ◽

Zheng Wang ◽

Haiyan Shangguan ◽

...

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Regression Analysis ◽

Heart Disease ◽

Diabetic Patients ◽

Population Census ◽

Chd Risk ◽

Chd Risk Factors

Abstract Background: Coronary heart disease (CHD) is the most common cause of death in patients with type 2 diabetes (T2DM). We aim to estimate the prevalence of CHD and cardiovascular risk factors in Chinese diabetic inpatients.Methods: A total of 66536 diabetic inpatients from 2013 to 2018 were investigated, demographic and clinical data were gathered from 30693 patients with T2DM. The age-standardized prevalence of CHD was calculated on the basis of data from Chinese population census in 2010. Multiple imputation was used to impute missing values and logistic regression analysis was used to analyze the risk factors.Results: The crude prevalence of CHD was estimated to be 23.5% and a standardized prevalence was 13.9% (16.0% in men and 11.9% in women). More than half of diabetic patients with CHD have 4 or above of the 5 traditional risk factors, which is much higher than 38.96% of diabetic patients (p<0.01). Multivariate regression analysis showed that diabetes duration, hypertension, smoking, underweight, overweight, obesity, hypoglycemia were significantly associated with a higher risk of CHD (all p<0.05). The odds ratio of CHD in patients having 3, 4, or 5 CHD risk factors were 2.35 (95%CI 1.81- 3.04), 2.96 (95%CI 2.28- 3.85), and 5.29 (95%CI 4.04- 6.93), compared with diabetes patients without any other risk factors.Conclusions: The prevalence of CHD was rather high in Chinese T2DM inpatients, aggregation of CHD risk factors was more seriously, hierarchical CHD prevention strategies based on risk factors are needed for them.

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Retinol Binding Protein-4 Is Associated with TNF-αand Not Insulin Resistance in Subjects with Type 2 Diabetes Mellitus and Coronary Heart Disease

Disease Markers ◽

10.1155/2009/725948 ◽

2009 ◽

Vol 26 (3) ◽

pp. 135-140 ◽

Cited By ~ 13

Author(s):

Nasser M. Al-Daghri ◽

Omar S. Al-Attas ◽

Majed Alokail ◽

Hossam M. Draz ◽

Ahmed Bamakhramah ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

Hypoglycemic Agents ◽

Control Group ◽

Diabetic Patients ◽

Oral Hypoglycemic Agents ◽

Low Carbohydrate Diet

We studied the association between RBP4 and various markers related to insulin resistance and diabetic complications as well as inflammatory markers in Saudi population suffering from type 2 diabetes and coronary heart disease. Patients with type 2 diabetes were divided into 3 groups according to the type of treatment and involvement of coronary artery disease. Serum RBP4, TNF-α, insulin, CRP, resistin, leptin and adiponectin were analysed in all samples. RBP4 levels increased significantly in the group of diabetic subjects treated with oral hypoglycemic agents and diabetic patients with coronary heart disease (30.2 ± 11.8; 33.4 ± 13.6 respectively), while there was no significant change in the other group for diabetic subjects on low-carbohydrate diet (25.1 ± 10.9) compared to control group (22.6 ± 9.5). RPB4 levels were positively correlated with TNF-α in the group of diabetic subjects on oral hypoglycemic agents and diabetic patients with coronary heart disease (r= 0.52,P< 0.05;r= 0.58,P< 0.05 respectively). No correlations were found between RBP4 levels and insulin resistance in all studied groups. Our findings suggest that serum RBP4 levels is associated with pro-inflammatory cytokine (TNF-α) and is not associated with insulin resistance among patients with type 2 diabetes and coronary heart disease.

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Flow Mediated Dilatation Is Reduced with the Progressive Stages of Glomerular Filtration Rate and Albuminuria in Type 2 Diabetic Patients without Coronary Heart Disease

Journal of Diabetes Research ◽

10.1155/2015/728127 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 12

Author(s):

Hiroyuki Ito ◽

Mina Nakashima ◽

Kentaro Meguro ◽

Haruki Furukawa ◽

Hitomi Yamashita ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

Glomerular Filtration Rate ◽

Glomerular Filtration ◽

Filtration Rate ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Flow Mediated Dilatation

We aimed to clarify the usefulness of measuring the flow mediated dilatation (FMD) in patients with type 2 diabetes mellitus without and with coronary heart disease (CHD). The FMD was measured in 480 patients with type 2 diabetes and in 240 nondiabetic subjects. The FMD was significantly lower in the subjects with CHD (n= 145,5.4±3.2%) than in those without CHD (n= 95,6.9±3.5%) among the nondiabetic subjects. The FMD was also lower in the subjects both with CHD (n= 161,5.6±2.8%) and without CHD (n= 319,6.1±3.3%) among the patients with diabetes compared to those without both diabetes and CHD. The FMD showed a significant positive correlation with the estimated glomerular filtration rate (eGFR) in the diabetic patients without CHD, while there was no significant association in those with CHD. The FMD was significantly lower with the progressive stages of the GFR or albuminuria in the patients without CHD among those with diabetes, although the FMD was not different in those with CHD. In conclusion, the FMD is considered to be useful for the detection of atherosclerosis in patients with type 2 diabetes, even if overt macroangiopathy is not diagnosed.

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The Complications of Bariatric Surgery Patients with Type 2 Diabetes in the World: A Systematic Review and Meta-Analysis

Current Diabetes Reviews ◽

10.2174/1573399814666180403164529 ◽

2018 ◽

Vol 15 (1) ◽

pp. 49-61 ◽

Cited By ~ 4

Author(s):

Ali Kabir ◽

Sara Mousavi ◽

Abdolreza Pazouki

Keyword(s):

Type 2 Diabetes ◽

Bariatric Surgery ◽

Meta Analysis ◽

Late Complications ◽

Diabetic Patients ◽

Restrictive Procedures ◽

The World ◽

Diabetic Population ◽

Mortality Percentage

Background: In this Meta-analysis, we aimed to quantify the incidence of complications of different methods of bariatric surgery on diabetic patients. Introduction: Type 2 Diabetes Mellitus (T2DM) is increasing worldwide specifically in obese cases. Additionally, obesity worsens T2DM. Complications of each bariatric surgery method were assessed separately; but, a meta-analysis of these complications and comparison between procedures in T2DM patients have not been investigated previously. The result of this study will help surgeons to choose the most appropriate surgical technique, considering individual conditions for a diabetic patient. Methods: We searched PubMed, Scopus, and ISI for original papers including bariatric surgical procedures for diabetic population and the reported consequences. Data analyses were done using Stata software. Results: Mortality percentage between diabetic and non-diabetic patients was statistically nonsignificant (P = 0.987). Early and late complications were higher in diabetic group in comparison with non-diabetic (6.0% vs. 1.8%, P = 0.024 and 0.6% vs. 0.3%, P = 0.04, respectively). Most prevalent findings in malabsorptive (7.8%, P < 0.001) and restrictive procedures (80%, P < 0.001) were major complications and hypoglycemic episodes, respectively. Conclusion: As our study showed, most of the complications are not necessarily higher in diabetic population but dependent on the method of surgery.

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Metformin Role in Diabetic Patients with Tuberculosis: a Review

Journal Of Tropical Pharmacy And Chemistry ◽

10.25026/jtpc.v5i3.275 ◽

2021 ◽

Vol 5 (3) ◽

Author(s):

Esravila Ariya Wibisono

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Immune Response ◽

Type 2 Diabetes Mellitus ◽

Bacterial Resistance ◽

Diabetic Patients ◽

The World ◽

Sputum Conversion ◽

Global Health Challenge

Tuberculosis (TB) epidemic is a global health challenge, and WHO estimated the incidence of the new cases reaching 11.1 million people in 2017. Indonesia is classified as a high TB burden country, with 8% of its population infected by TB and ranks third in the world. Type-2 diabetes mellitus (T2DM) is known comorbidity for TB patients. TB-T2DM patients have a higher chance of morbidity, mortality, relapse, bacterial resistance, treatment failure, and slower sputum conversion than TB patients without T2DM. Recent studies suggest that metformin may have a potential synergistic role for TB-T2DM patients. Metformin has immunomodulator properties that can improve the body's immune response and inflammatory response against TB in individuals with T2-DM.

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PERBANDINGAN NILAI AGREGASI TROMBOSIT PADA PASIEN DIABETES MELITUS TIPE 2 DENGAN KOMPLIKASI VASKULAR DAN TANPA KOMPLIKASI VASKULAR DI RSUP PROF. DR. R. D KANDOU MANADO

Jurnal e-Biomedik ◽

10.35790/ebm.2.1.2014.4393 ◽

2014 ◽

Vol 2 (1) ◽

Author(s):

Gratia Tangkuman

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Platelet Aggregation ◽

Platelet Function ◽

Vascular Complications ◽

Diabetic Patients ◽

Significant Difference ◽

The World ◽

Diabetes Melitus

Abstract: Diabetes melitus is a main medical problem around the world. WHO estimated that in 2000 there were 171 milion people with diabetes around the world and in 2030 there will be 366 million people. In diabetic patients, there are dysfunctions of platelet function caused microangiopati, macroangiopati, and platelet reactivity. Dysfunction of platelet function are associated with vascular complications of diabetes melitus. This study used an observational analytic method using comparative hypothesis test. This study was conducted to 30 diabetic patients, 15 patients have vascular complications while the other 15 have no vascular complications. Those patients are registered in Poliklinik Endokrin Metabolik RSUP Prof. Dr. R. D. Kandou Manado. The samples were processed in Prokita Laboratorium in Malalayang, Manado. Data analysis showed that there are significant difference between platelet aggregation value examined using ADP 5 µm agonist in diabetic patient with vascular complications and diabetic patients without vascular compications (p = 0.004). The same result were obtained from comparing the platelet agggregation value examined using ADP 10 µm agonist (p = 0.000). There are significant difference between platelet aggregation value in type 2 diabetes melitus patients with vascular complications and without complications. Keywords: Platelet aggregation, type 2 diabetes melitus, vascular complications. Abstrak: : Diabetes Melitus menjadi masalah kesehatan di dunia. WHO memperkirakan ada 171 juta orang di dunia dengan diabetes pada tahun 2000 dan diproyeksikan meningkat menjadi 366 juta pada tahun 2030. Pada diabetes melitus terjadi disfungsi dari trombosit sehingga menyebabkan mikroangiopati, makrongiopati dan hiperaktivitas trombosit. Gangguan fungsi trombosit ini dihubungkan dengan berbagai komplikasi vaskuler. Penelitian ini menggunakan observasional analitik dengan menggunakan metode uji hipotesis komparatif. Subjek dalam penelitian ini berjumlah 30 orang, 15 orang pasien diabetes mellitus tipe 2 dengan komplikasi vaskular dan tanpa komplikasi vaskular yang terdaftar di Poliklinik Endokrin Metabolik RSUP Prof. Dr. R. D. Kandou Manado. Pembuatan sampel dilakukan di Laboratorium Prokita Malalayang Manado. Dari hasil analisis, didapatkan adanya perbedaan yang bermakna antara nilai agregasi trombosit yang diperiksa menggunakan agonis ADP 5 µm pada pasien dengan komplikasi vaskuler dan pasien diabetes tanpa komplikasi vaskuler (p = 0,004). Hasil yang sama juga didapatkan pada nilai agregasi trombosit yang diperiksa menggunakan agonis ADP 10 µm (p = 0,000). Kesimpulan dari penelitian ini didapatkan terdapat perbedaan signifikan antara nilai agregasi trombosit pada pasien diabetes mellitus tipe 2 dengan komplikasi vaskular dan tanpa komplikasi vaskular. Kata Kunci: Agregasi trombosit, diabetes melitus tipe 2, komplikasi vaskular.

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Association of Major Dietary Patterns with General and Abdominal Obesity in Iranian Patients with Type 2 Diabetes Mellitus

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000233 ◽

2015 ◽

Vol 85 (3-4) ◽

pp. 145-155 ◽

Cited By ~ 9

Author(s):

Marjan Ghane Basiri ◽

Gity Sotoudeh ◽

Mahmood Djalali ◽

Mohammad Reza Eshraghian ◽

Neda Noorshahi ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Abdominal Obesity ◽

Dietary Patterns ◽

Dietary Pattern ◽

Diabetic Patients ◽

General Obesity ◽

Healthy Dietary Pattern

Abstract. Background: The aim of this study was to identify dietary patterns associated with general and abdominal obesity in type 2 diabetic patients. Methods: We included 728 patients (35 - 65 years) with type 2 diabetes mellitus in this cross-sectional study. The usual dietary intake of individuals over 1 year was collected using a validated semi-quantitative food frequency questionnaire. Weight, height, and waist circumference were measured according to standard protocol. Results: The two major dietary patterns identified by factor analysis were healthy and unhealthy dietary patterns. After adjustment for potential confounders, subjects in the highest quintile of the healthy dietary pattern scores had a lower odds ratio for the general obesity when compared to the lowest quintile (OR = 0.45, 95 % CI = 0.26 - 0.79, P for trend = 0.02), while patients in the highest quintile of the unhealthy dietary pattern scores had greater odds for the general obesity (OR = 3.2, 95 % CI = 1.8 - 5.9, P for trend < 0.001). There were no significant associations between major dietary patterns and abdominal obesity, even after adjusting for confounding factors. Conclusion: This study shows that in patients with type 2 diabetes mellitus, a healthy dietary pattern is inversely associated and an unhealthy dietary pattern is directly associated with general obesity.

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ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i8.456 ◽

2019 ◽

Vol 3 (8) ◽

Author(s):

Shah Namrata Vinubhai ◽

Pardeep Agarwal ◽

Bushra Fiza ◽

Ramkishan Jat

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Sugar ◽

Serum Ferritin ◽

Inflammatory Marker ◽

Control Group ◽

Diabetic Patients ◽

Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

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