scholarly journals Fato e maledizione nell’Antigone di Sofocle

2021 ◽  
Author(s):  
Marco Dorati
Keyword(s):  
Significant Role ◽  
Semantic Level ◽  
And Function

The paper analyses the presence and function of curses in Sophocles’ Antigone. In particular, it explores the interaction that the introduction of predetermined elements into the plot of the tragedy creates with the pre-existing fate. Scarcely relevant on the level of the actual development of events, the curse nevertheless plays a significant role on the semantic level.

Pathophysiology of Involuntary Emotional Expression Disorder

CNS Spectrums ◽  
2007 ◽  
Vol 12 (S5) ◽  
pp. 17-22 ◽  
Author(s):  
Peter V. Rabins ◽  
David B. Arciniegas
Keyword(s):  
Clinical Experience ◽  
Significant Role ◽  
Emotional Expression ◽  
Symptom Control ◽  
Structure And Function ◽  
Sigma Receptor ◽  
Expression Systems ◽  
Inhibitory Mechanisms ◽  
And Function ◽  
Extensive Clinical Experience

AbstractExtensive clinical experience and research suggest that a cortico-limbic-subcortico-thalamic-ponto-cerebellar network plays a significant role in the expression of human emotions. This network includes specific cerebral, cerebellar, and brainstem areas and their multiple projections/pathways, with activity modulated through serotonergic, dopaminergic, glutamatergic, and possibly sigma receptor neurotransmitter systems. Disruptions of regulatory and inhibitory mechanisms in the structure and function of this network likely constitute a pathophysiological basis for the crying and laughing episodes characteristic of involuntary emotional expression disorder. Pharmacologic interventions targeting the neurochemical modulators of the emotional expression systems may afford opportunities for symptom control among persons affected by this disorder.

scholarly journals Evolving Functional and Structural Dynamism in Coupled Boolean Networks

2014 ◽  
Vol 20 (4) ◽  
pp. 441-455 ◽  
Author(s):  
Larry Bull
Keyword(s):  
Network Model ◽  
Significant Role ◽  
Regulatory Network ◽  
Boolean Networks ◽  
Network Node ◽  
Mobile Dna ◽  
Natural Systems ◽  
Node Connectivity ◽  
And Function

This article uses a recently presented abstract, tunable Boolean regulatory network model to further explore aspects of mobile DNA, such as transposons. The significant role of mobile DNA in the evolution of natural systems is becoming increasingly clear. This article shows how dynamically controlling network node connectivity and function via transposon-inspired mechanisms can be selected for to significant degrees under coupled regulatory network scenarios, including when such changes are heritable. Simple multicellular and coevolutionary versions of the model are considered.

The Spirit in 1 Corinthians

Pneuma ◽  
2021 ◽  
Vol 43 (3-4) ◽  
pp. 485-495
Author(s):  
J. Ayodeji Adewuya
Keyword(s):  
Significant Role ◽  
Holy Spirit ◽  
Community Formation ◽  
Personal Lives ◽  
The Holy Spirit ◽  
And Function

Abstract The Holy Spirit plays a significant role in 1 Corinthians. Paul discusses the role of the Spirit in personal lives, community formation, and worship, among other aspects of Christian living. Paul’s teaching about the Holy Spirit in 1 Corinthians cannot be understood apart from the situation of the congregation in Corinth. It is not possible to address every issue related to the Holy Spirit in an essay of this length. However, Paul highlights and sometimes elaborates on different aspects of the ministry and function of the Holy Spirit among believers in several passages. Therefore, the approach in this essay is to look at some of the passages and see how much they foster the understanding of the Holy Spirit’s work in 1 Corinthians.

scholarly journals A review of emerging innovations in COVID-19

2021 ◽  
Author(s):  
Sakshi Saggi
Keyword(s):  
Literature Review ◽  
Human Health ◽  
Significant Role ◽  
Social Life ◽  
Emerging Technologies ◽  
Future Application ◽  
Innovative Technologies ◽  
Disruptive Technologies ◽  
Disruptive Innovations ◽  
And Function

The COVID-19 pandemic has globally impacted humanity. Human health, productivity, social life and function is affected. Every country has felt effects, domestic as well as international. Emerging technologies also known as disruptive technologies have played a significant role in the pandemic. This literature review is a manifest overview on the utilization of existing technologies during the COVID-19 pandemic. The strengths, weakness, opportunities and threats of the innovative technologies under review have been summarized. Their benefits and further scope of disruptive innovations have been reviewed. The review aims to identify and highlight approaches/gaps for improvement and future application.

scholarly journals Role ofβ2 Integrins in the Binding of Thymocytes to Rat Thymic Macrophages

1994 ◽  
Vol 4 (1) ◽  
pp. 65-77 ◽  
Author(s):  
Miodrag Čolić ◽  
Vesna Ilić ◽  
Takuya Tamatani ◽  
Masayuki Miyasaka ◽  
Miloš D. Pavlović
Keyword(s):  
Significant Role ◽  
Inhibitory Effect ◽  
Adherent Cells ◽  
Experimental Conditions ◽  
Tnf Α ◽  
Significant Difference ◽  
Ifn Γ ◽  
And Function

A role of β2 integrins and one of their ligands, ICAM-1, in thymic macrophage (TMF)/thymocyte interactions was studied. TMF were isolated as adherent cells from 4-day old culture of thymic-cell suspensions either from normal or hydrocortisone-treated rats. Adherent cells were 94-98% positive with ED1 (a pan-macrophage marker). The majority of them (75-95%) expressed the CD11b and CD18 molecules, and 60-70% expressed CD54 (ICAM-1). A low proportion of TMF (10-20%) expressed CDlla (LFA-1). The expression of all these antigens was upregulated by IFN-α and TNF-α. The effect of these mAbs on TMF/thymocyte binding was studied using a simple rosette assay by incubating unstimulated or IFN-γ or TNF-α stimulated TMF, grown on microscopic slides with resting or ConA +IL-2 activated thymocytes. It was found that LFA-1/CD18 and ICAM-1 play a significant role in the TMF/thymocyte adhesion. In addition, a LFA-l-dependent/ICAM- 1-independent adhesion pathway was observed, suggesting that LFA-1 might use another ligand. The inhibitory effect of anti-CD18 mAb (WT-3) was higher than the effect of anti-LFA-1 mAb (WT-1) and was a consequence of blocking the CD18 chain both on thymocytes and TMF. No significant difference in the expression and function of adhesion molecules was found between TMF obtained from normal or hydrocortisone-treated rats. The involvement of CD1 1b in these processes was of lesser importance than the role of the CD11a molecule. By using mAbs to different epitopes of the CD11b molecule, such as OX-42 (anti-CD11b/CD11c), ED7, and ED8 (anti-CD11b), it was found that they were either slightly or moderately inhibitory under certain experimental conditions or did not significantly modulate TMF/thymocyte binding. Oχ-42 was slightly stimulatory in some experiments. Cumulatively, these results show that 2 integrins play a significant role in TMF/thymocyte interactions and probably contribute to T-cell development in vivo.

scholarly journals Hypothetical Protein Predicted to Be Tumor Suppressor: A protein Functional Analysis

2021 ◽  
Author(s):  
Md. Abdul Kader ◽  
Md. Akash Ahmed ◽  
Md. Sharif Khan ◽  
Sheikh Abdullah Al Ashik ◽  
Md. Shariful Islam ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Significant Role ◽  
Hypothetical Protein ◽  
Future Research ◽  
Suppressor Activity ◽  
Von Hippel Lindau ◽  
Cancer Breast ◽  
Novel Bacterium ◽  
Tumor Suppressor Activity ◽  
And Function

Abstract BackgroundLitorilituus sediminis is a Gram-negative, aerobic, novel bacterium under the family of Colwelliaceae, has a stunning hypothetical protein containing domain called von Hippel–Lindau (pVHL) that has significant tumor suppressor activity. Therefore, this study was designed to elucidate the structure and function of the biologically important hypothetical protein EMK97_00595 (QBG34344.1) using several bioinformatics tools. ResultsThe functional annotation exposed that the hypothetical protein is an extracellular secretory soluble signal peptide and containing the VHL (VHL beta) domain that has a significant role in tumor suppression. This domain is conserved throughout evolution, as its homologs are available in various types of the organism like mammals, insects, and nematode. The gene product of VHL has a critical regulatory activity in the ubiquitous oxygen-sensing pathway. This domain has a significant role to inhibit cell proliferation, angiogenesis progression, kidney cancer, breast cancer, and colon cancer. ConclusionAt last, the current study depicts that the annotated hypothetical protein is linked with tumor suppressor activity which might be of great interest to future research in the higher organism.

Phra Payutto and Debates ‘On the Very Idea of the Pali Canon’ in Thai Buddhism

2009 ◽  
Vol 26 (1) ◽  
pp. 1-31 ◽  
Author(s):  
Martin Seeger
Keyword(s):  
Significant Role ◽  
Religious Beliefs ◽  
Focal Point ◽  
Public Intellectual ◽  
Theravada Buddhism ◽  
Beliefs And Practices ◽  
Pali Canon ◽  
And Function ◽  
Meaning And Function ◽  
Pāli Canon

In this paper I investigate a number of public intellectual debates in current Thai Theravada Buddhism that are related to several fundamental questions regarding the meaning and function of the Pali canon. The focal point of this investigation will be debates in which the Thai scholar monk Phra Payutto (b. 1939) has been playing a significant role. In these debates, the Pali canon is regarded as a central text endowed with special normative and formative authority. I will look at contestations that concern Theravada-ness and, at the same time, and inextricably linked with this, at concepts of demarcation to systems of religious beliefs and practices that are believed to be ‘outside’ Theravada. This, of course, engages the question of inclusivism, exclusivism and pluralism within Theravada. In so doing, I explore and posit concepts on the meanings and functions of the Pali canon that position it either as the or an authoritative reference.

A lysosome-targeting viscosity-sensitive fluorescent probe based on a novel functionalised near-infrared xanthene-indolium dye and its application in living cells

2020 ◽  
Vol 8 (38) ◽  
pp. 8838-8844
Author(s):  
Chang Liu ◽  
Tong Zhao ◽  
Song He ◽  
Liancheng Zhao ◽  
Xianshun Zeng
Keyword(s):  
Fluorescent Probe ◽  
Significant Role ◽  
Near Infrared ◽  
Living Cells ◽  
Biological Processes ◽  
The Status ◽  
And Function

The viscosity of lysosomes plays a significant role in modulating biological processes and reflects the status and function of this kind of organelle, e.g., locations, morphologies, and components.

scholarly journals Discussion on the Position and Function of Statistical Methods in Modern Economics

2020 ◽  
Vol 218 ◽  
pp. 02041
Author(s):  
Yulu Liu
Keyword(s):  
Economic Development ◽  
Statistical Methods ◽  
Significant Role ◽  
Economic Situation ◽  
Living Standards ◽  
Modern Economic ◽  
Important Position ◽  
And Function

With the improvement of people’s living standards, the structure of society has gradually become more complex, and modern economics is even more unpredictable. No matter how the economic situation in China and internationally changes, we must adhere to the method of viewing problems through the perspective of modern economics. Skilled use of statistical methods in modern economics. Now, in view of the use of modern economic statistical methods in China, this paper analyzes the important position and significant role of statistical methods, and gradually strengthens the important position of statistical methods in China’s economic development.

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