scholarly journals Cenerentola entra a palazzo: il nuovo ruolo della pronuncia nell’insegnamento linguistico

EL LE ◽  
2021 ◽  
Author(s):  
Maria Grazia Busà
Keyword(s):  
Speech Intelligibility ◽  
Foreign Accent ◽  
Current Status ◽  
The Past ◽  
Theoretical Approaches ◽  
L2 Pronunciation

This paper provides an overview of the current status of L2 pronunciation teaching and shows that there is a greater appreciation for L2 pronunciation teaching today than there was in the past. The paper starts by reviewing the main theoretical approaches in pronunciation teaching of the past 70 years and introduces today’s approach focusing on ‘speech intelligibility’ rather than on the achievement of native-like pronun-ciation. It then addresses the following issues: what we mean by foreign accent and speech intelligibility; how foreign accent can affect communication and speakers’ integration in society; what challenges present-day L2 pronunciation teachers; how technology can help.

Advances In Asthma Care

2003 ◽  
Vol 1 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Chris Garvey
Keyword(s):  
Healthcare Costs ◽  
Professional Organizations ◽  
Current Status ◽  
Asthma Care ◽  
Advanced Level ◽  
Clinical Criteria ◽  
Asthma Knowledge ◽  
The Past ◽  
The Us ◽  
Examination Process

Asthma rates in the US have risen during the past 25 years, as have asthma-related morbidity and healthcare costs. Professional organizations involved in asthma care have identified the need to assure that an advanced level of asthma knowledge and skill is available to patients with asthma, their families, and insurers. This need led to development of the certification for asthma educators. The Certified Asthma Educator (AE-C) must meet specific clinical criteria and pass a standardized examination designed to evaluate knowledge and skill for providing competent asthma education and coordination. The development and current status of the Certified Asthma Educator examination process and content are discussed, as are goals of the certification

Water resources management in Greece: current status and prospective outlook

1995 ◽  
Vol 32 (9-10) ◽  
pp. 267-272 ◽  
Author(s):  
A. Angelakis ◽  
E. Diamadopoulos
Keyword(s):  
Water Resources ◽  
Water Resources Management ◽  
Water Demand ◽  
Treatment Plant ◽  
Current Status ◽  
Reclaimed Wastewater ◽  
Resources Management ◽  
The Past ◽  
Precipitation Water ◽  
Pollution Loads

The basic aim of this paper is to present the existing conditions and problems of water resources management in Greece. Water demand has increased tremendously over the past 30 years. Despite adequate precipitation, water imbalance is often experienced, due to temporal and regional variations of the precipitation, the increased water demand during the summer months and the difficulty of transporting water due to the mountainous terrain. Integration of reclaimed wastewater originating from the wastewater treatment plant effluents into the water resources management is proposed. This plan exhibits the potential for reducing the pollution loads entering sea or inland waters, while at the same time providing water for irrigation.

Upcoming Drifts In Bio-Similars

2020 ◽  
Vol 15 ◽  
Author(s):  
Geeta Aggarwal ◽  
Manju Nagpal ◽  
Ameya Sharma ◽  
Vivek Puri ◽  
Gitika Arora Dhingra
Keyword(s):  
Metabolic Diseases ◽  
Market Competition ◽  
Current Status ◽  
Medicinal Products ◽  
The Past ◽  
Biologic Activity ◽  
Emerging Trends ◽  
Regulatory Guidelines ◽  
Food Drug Administration ◽  
Insight Into

Background: Biopharmaceuticals such as Biologic medicinal products have been in clinical use over the past three decades and have benefited towards the therapy of degenerative and critical metabolic diseases. It is forecasted that market of biologics will be going to increase at a rate of 20% per year, and by 2025, more than ˃ 50% of new drug approvals may be biological products. The increasing utilization of the biologics necessitates for cost control, especially for innovators products that have enjoyed a lengthy period of exclusive use. As the first wave of biopharmaceuticals is expired or set to expire, it has led to various opportunities for the expansion of bio-similars i.e. copied versions of original biologics with same biologic activity. Development of biosimilars is expected to promote market competition, meet worldwide demand, sustain the healthcare systems and maintain the incentives for innovation. Methods: Appraisal of published articles from peer reviewed journals, PubMed literature, latest news and guidelines from European Medicine Agency, US Food Drug Administration (FDA) and India are used to identify data for review. Results: Main insight into the quality requirements concerning biologics, current status of regulation of biosimilars and upcoming challenges lying ahead for the upgrading of marketing authorization of bio-similars has been incorporated. Compiled literature on therapeutic status, regulatory guidelines and the emerging trends and opportunities of biosimilars has been thoroughly stated. Conclusion: Updates on biosimilars will support to investigate the possible impact of bio-similars on healthcare market.

scholarly journals Research Trends of Acupuncture Therapy on Cancer Over the Past Two Decades: A Bibliometric Analysis

2020 ◽  
Vol 19 ◽  
pp. 153473542095944
Author(s):  
Jing Guo ◽  
Lixia Pei ◽  
Lu Chen ◽  
Hao Chen ◽  
Dongmei Gu ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Acupuncture Therapy ◽  
Supportive Care ◽  
Bibliometric Analysis ◽  
Integrative Medicine ◽  
Clinical Studies ◽  
Current Status ◽  
Cancer Center ◽  
Future Research ◽  
The Past

Purpose: Acupuncture has been used for managing cancer-related symptoms. However, there are still few studies concerning the overall trends in acupuncture therapy on cancer based on bibliometric analysis. This study aims to demonstrate the current status and trends in this field over the past 2 decades. Methods: Articles were retrieved from the Web of Science from 2000 to 2019. CiteSpace was used for co-authorship network of countries/institutions, dual-map analysis, and detecting the keywords with citation bursts. VOSviewer was used to construct networks based on co-authorship and co-citation analysis of authors, and co-occurrence of keywords. Results: A total of 927 articles and reviews were included in the final analysis. The number of publications has steadily increased with some fluctuations among years. The country and institution contributing most to this field are the USA and Memorial Sloan Kettering Cancer Center. Mao JJ was the most productive author and Molassiotis A ranked first in the cited authors. The co-occurrence analysis revealed 5 clusters (including “clinical trials,” “clinical studies on chemotherapy/radiation-induced symptoms,” “CAM therapy for cancer,” “clinical studies on vasomotor symptoms,” and “systematic reviews”). Most recent keyword bursts were “neuropathic pain,” “arthralgia,” “prevention,” “supportive care,” and “integrative medicine”. Conclusions: The annual publication output would increase rapidly in the next decade, which shows a promising future in this research field. Future research hotspots would focus on the role of acupuncture in neuropathic pain, arthralgia, prevention, supportive care, and integrative medicine.

scholarly journals What is the prospect of indoleamine 2,3-dioxygenase 1 inhibition in cancer? Extrapolation from the past

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Yu Yao ◽  
Heng Liang ◽  
Xin Fang ◽  
Shengnan Zhang ◽  
Zikang Xing ◽  
...  
Keyword(s):  
Predictive Biomarkers ◽  
Kynurenine Pathway ◽  
Phase Iii ◽  
Current Status ◽  
The Past ◽  
Indoleamine 2,3 Dioxygenase ◽  
Negative Results ◽  
Rate Limiting Step ◽  
Pharmacodynamic Markers ◽  
Tumor Types

AbstractIndoleamine 2,3-dioxygenase 1 (IDO1), a monomeric heme-containing enzyme, catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan metabolism, which plays an important role in immunity and neuronal function. Its implication in different pathophysiologic processes including cancer and neurodegenerative diseases has inspired the development of IDO1 inhibitors in the past decades. However, the negative results of the phase III clinical trial of the would-be first-in-class IDO1 inhibitor (epacadostat) in combination with an anti-PD1 antibody (pembrolizumab) in patients with advanced malignant melanoma call for a better understanding of the role of IDO1 inhibition. In this review, the current status of the clinical development of IDO1 inhibitors will be introduced and the key pre-clinical and clinical data of epacadostat will be summarized. Moreover, based on the cautionary notes obtained from the clinical readout of epacadostat, strategies for the identification of reliable predictive biomarkers and pharmacodynamic markers as well as for the selection of the tumor types to be treated with IDO1inhibitors will be discussed.

scholarly journals Applications of Smart Helmet in Applied Sciences: A Systematic Review

2021 ◽  
Vol 11 (11) ◽  
pp. 5039
Author(s):  
Yosoon Choi ◽  
Yeanjae Kim
Keyword(s):  
Applied Sciences ◽  
Wireless Communication ◽  
Communication Technology ◽  
Academic Research ◽  
Current Status ◽  
Smart Devices ◽  
The Past ◽  
Modular Concept ◽  
Research Questions ◽  
Cloud Servers

A smart helmet is a wearable device that has attracted attention in various fields, especially in applied sciences, where extensive studies have been conducted in the past decade. In this study, the current status and trends of smart helmet research were systematically reviewed. Five research questions were set to investigate the research status of smart helmets according to the year and application field, as well as the trend of smart helmet development in terms of types of sensors, microcontrollers, and wireless communication technology. A total of 103 academic research articles published in the past 11 years (2009–2020) were analyzed to address the research questions. The results showed that the number of smart helmet applications reported in literature has been increasing rapidly since 2018. The applications have focused mostly on ensuring the safety of motorcyclists. A single-board-based modular concept unit, such as the Arduino board, and sensor for monitoring human health have been used the most for developing smart helmets. Approximately 85% of smart helmets have been developed to date using wireless communication technology to transmit data obtained from smart helmets to other smart devices or cloud servers.

Virus Decline of Strawberry in California and the Role of Insect Vectors and Associated Viruses

2015 ◽  
Vol 16 (4) ◽  
pp. 211-215 ◽  
Author(s):  
Surendra K. Dara
Keyword(s):  
Frankliniella Occidentalis ◽  
Western Flower Thrips ◽  
Trialeurodes Vaporariorum ◽  
Current Status ◽  
Insect Vectors ◽  
The Past ◽  
Disease Vector ◽  
Flower Thrips ◽  
Purple Coloration

Greenhouse white fly, Trialeurodes vaporariorum (Westwood); western flower thrips, Frankliniella occidentalis (Pergande); and strawberry aphid, Chaetosiphon fragaefolii (Cockerell), are common pests of strawberries in California and are vectors of one or more viruses. Most of the viruses transmitted by these vectors do not cause symptoms on strawberry when the infection occurs individually. However, when one of the viruses (Beet pseudoyellows virus or Strawberry pallidosis-associated virus) transmitted by T. vaporariorum is present along with one of the viruses transmitted by F. occidentalis, C. fragaefolii, or other sources, it results in a virus decline of strawberry, which can cause significant crop losses. Stunted root and plant growth, purple coloration of foliage, and dieback of the plant are some of the symptoms associated with virus decline. Increases in T. vaporariorum infestations during the past few years significantly elevated the risk of whitefly as a crop pest and a disease vector. This article reviews virus decline of strawberry, symptoms of infection, and the current status of insect vectors in California strawberries. Accepted for publication 17 November 2015. Published 20 November 2015.

Reimbursement as a Legitimizing Strategy for Health Education

2009 ◽  
Vol 10 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Virginia J. Noland Dodd ◽  
Ying Li
Keyword(s):  
Health Education ◽  
Third Party ◽  
Current Status ◽  
The Past ◽  
Education Profession ◽  
Third Party Reimbursement

The health education profession has made significant advances throughout the past few decades. However, health education is still described as an emerging profession. This article suggests strategies to move health education from its status as an emerging profession into that of an acknowledged profession. The authors assert that actively seeking direct third-party reimbursement will advance health education's emergence as a profession as well as increase its legitimacy in the eyes of other professions. The benefits of direct third-party reimbursement, experiences of the nursing profession's pursuit of direct third-party reimbursement, and the current status of health education are discussed. The article concludes by offering strategies for pursuing direct third-party reimbursement.

scholarly journals Application of EIA/SEA system in land use planning: Experience from Serbia

Spatium ◽  
2005 ◽  
pp. 18-21 ◽  
Author(s):  
Bozidar Stojanovic
Keyword(s):  
Decision Making ◽  
Land Use Planning ◽  
Spatial Planning ◽  
Current Status ◽  
Scientific Validity ◽  
The Past ◽  
Current Assessment ◽  
Eu Directives ◽  
Assessment Procedures ◽  
Effective Integration

This paper discusses the experience and current status of EIA/SEA procedures and assessment methodologies in Serbia, aiming to propose strategies that can lead to effective integration of the SEA in spatial planning. Institutional and practical problems with regard to the regulations of EIA/SEA were considered. Experience from the past decade shows that implementation of EIA system in Serbia has not been effective as expected. New legislation on EIA and SEA is harmonized with corresponding EU Directives. First steps in the application of the SEA show that the main issues are screening, scooping and decision making. According to the research results, it is suggested that extra evaluation processes should be incorporated into current assessment procedures to improve their scientific validity and integrity.

scholarly journals Evaluation of Substituted Pyrazole-Based Kinase Inhibitors in One Decade (2011–2020): Current Status and Future Prospects

Molecules ◽  
2022 ◽  
Vol 27 (1) ◽  
pp. 330
Author(s):  
Mohammed I. El-Gamal ◽  
Seyed-Omar Zaraei ◽  
Moustafa M. Madkour ◽  
Hanan S. Anbar
Keyword(s):  
Kinase Inhibitors ◽  
Therapeutic Agents ◽  
Current Status ◽  
Pyrazole Derivatives ◽  
Chronological Order ◽  
Pharmacological Activities ◽  
The Past ◽  
Cancer Types ◽  
Privileged Scaffold ◽  
Almost All

Pyrazole has been recognized as a pharmacologically important privileged scaffold whose derivatives produce almost all types of pharmacological activities and have attracted much attention in the last decades. Of the various pyrazole derivatives reported as potential therapeutic agents, this article focuses on pyrazole-based kinase inhibitors. Pyrazole-possessing kinase inhibitors play a crucial role in various disease areas, especially in many cancer types such as lymphoma, breast cancer, melanoma, cervical cancer, and others in addition to inflammation and neurodegenerative disorders. In this article, we reviewed the structural and biological characteristics of the pyrazole derivatives recently reported as kinase inhibitors and classified them according to their target kinases in a chronological order. We reviewed the reports including pyrazole derivatives as kinase inhibitors published during the past decade (2011–2020).

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