scholarly journals Treatment with an intravaginal gel containing siliceous dioxide, selenite, and citric acid to promote regression of ASC-US, LSIL, ASC-H, HSIL, p16/Ki67 status and improve clearance of hr-HPV in cervical specimens

2021 ◽  
Vol 4 ◽  
pp. 48-57
Author(s):  
A. Mueller ◽  
M. Sailer ◽  
P.A. Regidor
Keyword(s):  
Citric Acid ◽  
Tumor Markers ◽  
Sodium Selenite ◽  
Treated Group ◽  
Pap Smears ◽  
Inclusion Criteria ◽  
Pap Testing ◽  
Hpv Status ◽  
Hpv Clearance ◽  
Control Study

Objective: An intravaginal gel containing highly dispersed silicon dioxide (SiO2) and an anti-oxidative combination of citric acid and sodium selenite was tested for its ability to promote regression of abnormal cytological findings and its influence on hr-HPV status and tumor markers p16/Ki67 (CINtec® PLUS test).Patients and methods: A control study was performed, including women (n=100) diagnosed with conspicuous cervical smears (ASC-US, LSIL, ASC-H, or HSIL). The gel was applied for 3x28 days. After three months, participants were analyzed for Pap status, hr-HPV strains, and expression of tumor markers p16/Ki67. Three months later, Pap testing and p16/Ki67 analysis were repeated. The results were compared to those of 106 women who met the same inclusion criteria but did not obtain any treatment.Results: After six months, cytological Pap findings were improved in 80.9% of the participants in the treated group, and the clearing of hr-HPV was observed in 53% of cases. Only 5.3% were tested p16/Ki67 positive after six months in comparison to 75.0% at baseline. In the comparison group, 37.1% of the Pap smears and 18.6% of the CinTec results were improved, but no hr-HPV clearance was observed. The improvements were highly significant for the treatment. Conclutions: The vaginal gel containing SiO2 sodium selenite, and citric acid may support the healing of conspicuous cytological findings and clearance of hr-HPV.

scholarly journals Treating Critically Ill Patients Experiencing SARS-CoV-2 Severe Infection with Ig-M and Ig-A Enriched Ig-G Infusion

Antibiotics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 930
Author(s):  
Alberto Corona ◽  
Giuseppe Richini ◽  
Sara Simoncini ◽  
Marta Zangrandi ◽  
Monica Biasini ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Standard Therapy ◽  
Severe Infection ◽  
Treated Group ◽  
Simplified Acute Physiology Score ◽  
Retrospective Case ◽  
Baseline Characteristics ◽  
Time Of Admission ◽  
Ig G ◽  
Control Study

SARS-CoV-2 in patients who need intensive care unit (ICU) is associated with a mortality rate ranging from 10 to 40–45%, with an increase in morbidity and mortality in presence of sepsis. We hypothesized that IgM and IgA enriched immunoglobulin G may support the sepsis-related phase improving patient outcome. We conducted a retrospective case–control study on 47 consecutive patients admitted to our ICU. At the time of admission, patients received anticoagulants (heparin sodium) together with the standard supportive treatment. We decided to add IgM and IgA enriched immunoglobulin G to the standard therapy. Patients receiving IgM and IgA enriched immunoglobulin G were compared with patients with similar baseline characteristics and treatment, receiving only standard therapy. The mortality resulted significantly higher in patients treated with standard therapy only (56.5 vs. 37.5%, p < 0.01) and, at day 7, the probability of dying was 3 times higher in this group. Variable life adjustment display (VLAD) was 2.4 and -2.2 (in terms of lives saved in relation with those expected and derived from Simplified Acute Physiology Score II) in the treated and not treated group, respectively. The treatment based on IgM and IgA enriched immunoglobulin G infusion seems to give an advantage on survival in SARS-CoV-2 severe infection.

Efficacy of treatment with belladonna in children with severe pallid breath-holding spells

2018 ◽  
Vol 28 (7) ◽  
pp. 922-927 ◽  
Author(s):  
M. Cecilia Gonzalez Corcia ◽  
Adrien Bottosso ◽  
Isabelle Loeckx ◽  
Françoise Mascart ◽  
Guy Dembour ◽  
...  
Keyword(s):  
Positive Response ◽  
Treated Group ◽  
Interquartile Range ◽  
Breath Holding ◽  
Inclusion Criteria ◽  
Before And After ◽  
Single Difference ◽  
Baseline Characteristics ◽  
Receive Treatment

AbstractIntroductionPallid breath-holding spells are common and dramatic forms of recurrent syncope in infancy. They are very stressful despite their harmless nature and sometimes require treatment.ObjectiveThe objective of this study was to evaluate the efficacy of belladonna in severe breath-holding spells.MethodsThis is a multicentric, retrospective series involving 84 children with severe pallid breath-holding spells. Inclusion criteria were >1 pallid breath-holding spell with loss of consciousness, paediatric cardiology evaluation, and follow-up >6 months. In total, 45 patients received belladonna and 39 patients did not receive treatment, according to physician preference.ResultsMean age was 11 months, ranging from 4 to 18 months, with 54% of males. Mean spell duration was 30 seconds (interquartile range 15, 60), and the frequency was four episodes per month (interquartile range 0.5, 6.5). Comparison of baseline characteristics between groups showed similar demographics, with the single difference in the severity of the spells, being more severe in the treated group. When comparing the treated and non-treated groups at 3 months, only two (5%) patients had a complete remission in the first group, whereas 20 (44%) had remission in the belladonna group (p<0.01). When considering the characteristics of the spells before and after the initiation of treatment with belladonna, 75% of the patients presented a positive response, with 44% of the patients presenting with complete resolution of the spells (p<0.01). No major adverse reaction was reported, with only 5% minor adverse events.ConclusionsBelladonna is highly effective to alleviate severe breath-holding spells in young children, without any major adverse effects.

scholarly journals BACKACHE IN PREGNANCY;

2013 ◽  
Vol 20 (04) ◽  
pp. 550-555
Author(s):  
NADEEM SHAHZAD ◽  
FARHAT ASLAM ◽  
AISHA MALIK ◽  
ASIF HANIF
Keyword(s):  
Obese Patients ◽  
Inclusion Criteria ◽  
First Line ◽  
Randomized Control Study ◽  
Pregnant Females ◽  
The Mean ◽  
Randomized Control ◽  
The Difference ◽  
Control Study

Introduction: Backache is a common problem during pregnancy that is faced by almost one quarter of all pregnant womenworldwide. Objectives: To find an association between backache and pregnancy with respect to obesity and to evaluate the effect ofphysiotherapy for relief of pain. Methodology: This longitudinal observational & randomized control study was conducted on pregnantfemales for a period of six months. 150 females fulfilling the inclusion criteria were enrolled into two groups i.e. obese patients (BMI>29.9) and non obese patients (BMI<29.9). All information was recorded on a Performa that was later entered and analyzed usingSPSS-11.5. Results: The mean age of all patients was 33.67±6.73 years with overall average gestational age of 27.47±5.19 weeks.Flexed posture was observed in 90(60%) patients and 60(40%) had very bad sitting habit. There were 80 (53.3%) obese and 70 (46.7%)non-obese patients. Lordosis was observed in 50 cases, straight spine was observed in 90 cases while 60 patients had no straight spine.st Most females reported that pain started during the 1 trimester (110) but only 40 females reported that they developed pain in the 2ndtrimester.100 females reported that pain was continuous while 50 had intermittent. There were 50 (33%) patients who had severebackache while 100 (66.7%) had worse possible pain which was regressed to no pain in 140(93.3%) patients at final follow up visit andonly 10 (6.7%) had moderate pain after physiotherapy. The difference between pre and post physiotherapy was statistically significant.Both obese and non-obese patients were reported to be benefited but better results were found in non-obese patients. Conclusions: Weconclude that physiotherapy is effective in reducing the backache in pregnant females and has no side effects on fetus and mother. Also,more effective results can be achieved through physiotherapy in non-obese patients compared to obese patients. Thus, Physiotherapycan be recommended as the first line treatment for pregnant females.

scholarly journals Risk Factors of Meconium-Stained Amniotic Fluid in Term Pregnancy - A Case Control Study

2021 ◽  
Vol 8 (13) ◽  
pp. 806-810
Author(s):  
Asha P.S ◽  
Sujatha T.L.
Keyword(s):  
Risk Factors ◽  
Caesarean Section ◽  
Amniotic Fluid ◽  
Case Control Study ◽  
Significant Risk ◽  
Case Control ◽  
Inclusion Criteria ◽  
Term Pregnancy ◽  
Meconium Stained Amniotic Fluid ◽  
Control Study

BACKGROUND Meconium stained amniotic fluid is a significant contributor to perinatal and neonatal morbidity and mortality. The study was conducted to determine the risk factors of meconium stained amniotic fluid in term pregnancy. METHODS This study is a prospective case control study done in a tertiary care hospital in South India over a period of one year. 100 women with meconium stained amniotic fluid detected at any time during the course of labour, prior to it or meconium detected in hind waters were enrolled in the study group. The inclusion criteria were term pregnancy, cephalic presentation and singleton pregnancy. 200 women who satisfied the same set of inclusion criteria with clear amniotic fluid, selected on random basis were taken as controls. A standardised pretested proforma was used for data collection. RESULTS In the study, incidence of grade 1, grade 2 and grade 3 meconium were 31 %, 42 % and 27 % respectively. 83 % of cases were in the 20 – 24 year age group and advanced maternal age was not a risk factor in the study. Primiparity (86 % cases vs. 47 % controls) and advanced gestational age (56 % cases and 33 % controls) were significant risk factors. Maternal obesity, socioeconomic status and treatment for infertility were not significant risk factors. Among medical disorders, gestational diabetes mellitus (21 % cases vs. 5 % controls), gestational hypertension (12 % vs. 3.5 %) and hypothyroidism (13 % cases vs. 4.5 % controls) showed statistical significance. Oligoamnios (9 % vs. 1 %), fetal growth restriction (13 % vs. 4.5 %) and maternal infection (12 % vs. 2 %) were significant risk factors. Induced labour and prolonged labour were the significant intrapartum risk factors. Caesarean section rates were nearly doubled in cases (40 %) compared to controls (21.5 %). Babies born to mothers with meconium stained amniotic fluid had low Apgar scores at birth (25 %) and increased neonatal intensive care unit (NICU) admission. CONCLUSIONS Meconium stained amniotic fluid is associated with increased rates of maternal morbidity due to higher rates of operative deliveries and increased incidence of perinatal asphyxia, perinatal morbidity and mortality. Meticulous antenatal care and early identification of risk factors help in reducing the incidence of meconium stained amniotic fluid and preventing adverse maternal and neonatal outcome. KEYWORDS Risk Factors, Meconium, Amniotic Fluid, Term Pregnancy, Caesarean Section, Perinatal Outcome

Progressive Pigmentpurpura: Welche Vorteile Vitamin C oder Rutosid in der Behandlung bieten

2020 ◽  
Vol 8 (3) ◽  
pp. 117-118
Author(s):  
Regina Fölster-Holst
Keyword(s):  
Vitamin C ◽  
Watchful Waiting ◽  
Paediatric Population ◽  
Treated Group ◽  
Inclusion Criteria ◽  
Effective Treatment Option ◽  
Telephone Interviews ◽  
Background Data ◽  
Pigmented Purpuric Dermatoses

Background: Data regarding the course and treatment of pigmented purpuric dermatoses (PPD) in the paediatric population are limited. Although treatments for pigmented purpura are not well established, vitamin C and rutoside have been reported to be an effective treatment option and are widely utilized. Objective: To assess the clinical course and utility of vitamin C and rutoside in paediatric patients with PPD treated at Ann &amp; Robert H. Lurie Children’s Hospital of Chicago between 2008 and 2018. Methods: A retrospective review of all children with PPD managed at our hospital between 2008 and 2018 was performed. Additional follow-up was obtained via telephone interviews. Results: A total of 101 patients met inclusion criteria. The female: male ratio was 1.3 : 1, and the median age at diagnosis was 8.8 years (IQR, 5.7–12.9). Median follow-up was 7.13 months (IQR, 3–17.4). The most common PPD subtypes were lichen aureus (43%) and Schamberg (34%). Fifty-three (52%) patients had evaluable follow-up documentation via their medical record or phone questionnaire. Twenty-eight patients were treated with vitamin C or rutoside or combination therapy. Twenty-five patients received no treatment. Clearance of the rash was noted in 24 (45.3%) patients overall, including 10 (42%) patients in the treated group and 14 (58%) patients in the untreated group. Recurrence was noted in seven (13.2%) patients. Treatment with vitamin C and/or rutoside was well tolerated without side effects. None of the patients were subsequently diagnosed with vasculitis, coagulopathy or cutaneous T-cell lymphoma. Conclusion: Pigmented purpuric dermatosis in children is a benign disorder with high rates of complete resolution. Treatment with vitamin C and rutoside is well tolerated, but in this cohort, there did not appear to be an advantage over watchful waiting without therapy.

scholarly journals Features of Serum Fatty Acids at Acute Ischemic Stroke Onset in Statin-Treated Patients with Hypercholesterolemia

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2833
Author(s):  
Takahisa Mori ◽  
Kazuhiro Yoshioka ◽  
Yuhei Tanno ◽  
Shigen Kasakura
Keyword(s):  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Treated Group ◽  
Diet Therapy ◽  
Seafood Consumption ◽  
Serum Concentrations ◽  
Inclusion Criteria ◽  
Statin Group

In addition to diet therapy, statins are used to prevent cardiovascular disease in patients with hypercholesterolemia (HC). However, acute ischemic stroke (AIS) still occurs in statin-treated patients. How strictly statin-treated patients follow diet therapy before they experience AIS and whether they increase seafood consumption remains unknown. We investigated the serum concentrations and proportions (weight percentages: wt %) of fatty acids (FAs) at AIS onset in statin-treated patients (statin group), compared to those in non-treated patients with HC (6.465 mmol/L or higher) as controls (non-treated group). We included patients with AIS admitted between 2016 and 2019 within 24 h of AIS onset who underwent analysis of serum FAs. During the study period, 188 patients met the inclusion criteria: 133 in the statin group and 55 in the non-treated group. Interestingly, serum FA concentrations in the statin group were lower than those in the non-treated group. However, serum FA wt % in the statin group was almost identical to that in the non-treated group. In conclusion, statin-treated AIS patients had low FA concentrations and identical FA wt %, compared to non-treated AIS patients with HC.

scholarly journals THE ANTI-CATARACT EFFECT OF COENZYME Q10 IN RABBITS

2017 ◽  
Vol 9 (3) ◽  
pp. 13
Author(s):  
Baha'a A. Abdul Hussein ◽  
Ahmed Salim Mahmood
Keyword(s):  
Oxidative Stress ◽  
Coenzyme Q10 ◽  
Sodium Selenite ◽  
Light Transmission ◽  
Treated Group ◽  
Eye Drops ◽  
Distilled Water ◽  
Oxidative Process ◽  
Significant Difference ◽  
The Mean

Objective: cataract is the opacity of the lens which progressively impairs the light transmission to the retina and finally prevents the vision, these opacity result from the oxidative process in the eye. The study aimed to prevent opacity of the lens by using Coenzyme Q10 as eye drops.Methods: Sodium selenite 0.01w/v injected intravitreal to the rabbit's eye to induce the disease, a group of rabbits were receive Coenzyme Q10 eye drop, and another group received distilled water, pre and post induction, cataract maturity was measured to evaluate the opacity deterioration.Results: the group of rabbits that received distilled water after induction of cataract, the opacity occurred within 48-72 h and the mean score of opacity reached to (4±0.00), while Coenzyme Q10 treated group the degree of opacity was (1.5±0.02), and there was a highly significant difference (p<0.01).Conclusion: Coenzyme q10 has an antioxidant activity when use as eye drops and this effect enable Coenzyme Q10 to prevent the opacity which is the major cause of cataract due to oxidative stress.

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