There was studied the distribution of postpartum pathology of cows and disease of calves in early postnatal period in conditions of Nizhny Novgorod region. It was established, that the new tissue drug "bio-tec" has positive influence on reproductive function, safety and live weight gain of calves. The postpartum pathology of cows gained wide spread among nizhnynovgorod farms up to 80%, e.g. Endometritis and subinvolution of uterus 37,4 and 23,9 respectively. By clinical examination of newborn calves it was established, that in the first month of life 50,3% fall ill with gastrointestinal diseases of various etiologies. The die-off of calves reached 29%. Using "bio-tec" drug to dry cows decreased the percentage of postpartum pathology by 35% and reduced the time of involution of uterus for 11,2 days; the service period reduced by 21,2 days and the diseases of newborn calves was twice less, that increased the energy of growth and in 16 month age heifers went over animals of the control group by 10%, that allowed their earlier use for reproduction. So, the results of conducted research showed, that twice a day injection of tissue drug "bio-tec" to dry cows in 10ml dose 60-55 and 40-35 days to calving contributes reducing of obstetric pathology. Subsequent use to calves in 4ml dose in 5-8 days age increases the safety of calves and positively influences the live weight gain, that in fact gives abilities of more effective cattle breeding.