scholarly journals Study of the Effectiveness of a Supramolecular Complex Based on Albendazole and Triclabendazole (Altric-Extra) Against Nematodes of the Digestive Tract and Fasciola spp. in Sheep Under Production Conditions

2020 ◽  
Vol 14 (1) ◽  
pp. 89-94
Author(s):  
Ekaterina V. Lagereva ◽  
Vladislav E. Abramov ◽  
Mauldi B. Musaev ◽  
Shahab V. Vatsaev ◽  
Aishat Z. Dzhamalova ◽  
...  
Keyword(s):  
Digestive Tract ◽  
Federal District ◽  
Gastrointestinal Nematodes ◽  
Supramolecular Complex ◽  
Test Method ◽  
Group Method ◽  
North Caucasus ◽  
Mixed Feed ◽  
The North ◽  
Production Conditions

The purpose of the research is to test the effectiveness of the supramolecular complex of albendazole and triclabendazole (Altric-Extra) in case of fasciolosis and nematodoses of the digestive tract of sheep under production conditions. Materials and methods. The test of the effectiveness of Altrik-Extra was carried out in the North Caucasus Federal District of the Chechen Republic in July 2019 on 205 sheep of the Tushino breed, spontaneously infected by gastrointestinal nematodes and Fasciola sp. Sheep infection with helminths was established by fecal examination by Fülleborn using ammonium nitrate. The average number of helminth eggs in 1 g of feces was determined using a VIGIS camera. Altric-Extra was given at a dose of 5 mg/ kg of AS (2.5 mg of albendazole and triclabendazole respectively) or 50 mg/kg in the preparation in a mixture with mixed feed by the group method. The effectiveness of the drug was determined by the results of fecal studies 14 and 25 days after deworming. After giving the drugs for three days, the clinical condition of the experimental sheep was monitored. Altric-Extra effectiveness was evaluated using the “critical test” method according to the Guidelines approved by the World Association for the Progress of Veterinary Parasitology (1995). Results and discussion. The Altric-Extra supramolecular complex in a therapeutic dose of 5.0 mg/kg of AS (for the preparation of 50 mg/kg) was 100% effective against gastrointestinal nematodes and Fasciola sp. of sheep. The sheep ate a mixture of the preparation with mixed feed; it is convenient to set in a group method; side effects after deworming is not observed.

scholarly journals The Efficacy of the Supramolecular Complex of Ivermectin in Production Conditions Against Gastro-intestinal Nematodosis of Herd Horses

2020 ◽  
Vol 14 (3) ◽  
pp. 104-108
Author(s):  
M. B. Musaev ◽  
V. V. Zashchepkina ◽  
S. V. Vatsaev ◽  
A. Z. Dzhamalova ◽  
M. M. Ilyin ◽  
...  
Keyword(s):  
Live Weight ◽  
Physical Exertion ◽  
Federal District ◽  
Supramolecular Complex ◽  
Test Method ◽  
Group Method ◽  
North Caucasus ◽  
The North ◽  
Industrial Injuries ◽  
Production Conditions

The purpose of the research is to test the efficacy of the supramolecular complex of ivermectin against gastro-intestinal nematodes of herd horses under production conditions. Materials and methods. The test of the efficacy of the supramolecular complex of ivermectin was carried out from December 2018 to January 2019 in the North Caucasus Federal District of the Chechen Republic. Two herds of horses of 47 and 54 heads in each of different ages were selected, which were grazed all year round. To determine the infection of horses with nematodes of gastro-intestinal tract, 20 samples of fresh feces from each group were collected from the ground. It was not possible to collect samples from untamed horses to determine the infection by Oxiuris spp. Coproovoscopy was performed using the Fülleborn method. To count eggs in 1 g of faeces, a VIGIS counting chamber was used. The first group was given a 2.0% drug individually in a mixture with food at a dose of 0.15 mg/kg for active substance (AS) (according to the drug 75 mg). The drug was administered to the second group at a dose of 0.2 mg/kg for AS (for the drug 1.0 mg/kg) by the group method in a mixture with food, calculated on a live weight of 500 kg. The efficacy of the drug was determined 2 weeks after deworming according to coproovoscopy data. The efficacy of ivermectin complex was accounted for by the "critical test" method. After deworming, the animals were observed during the experiment. Results and discussion. Dehelminthization of horses with a supramolecular complex of ivermectin at a dose of 0.2 mg/kg for AS in a mixture with mixed feed by a group method for mixed infection of various types of gastro-intestinal nematodes under production conditions showed 100% efficiency. Arabinogalactan in the supramolecular complex helps to eliminate the negative effect of AS (ivermectin) on the animal body. The mixture of the preparation with the food was readily consumed by the horses. Deworming horses of herd keeping with a preparation intended for use in a mixture with feed is technically convenient, practically uncomplicated, and at the same time, physical exertion during fixation of animals and industrial injuries are excluded. We did not observe any side effects after deworming horses.

scholarly journals Commission test of the efficacy of the supramolecular complex of ivermectin against gastrointestinal strongylatoses of horses

2021 ◽  
Vol 15 (2) ◽  
pp. 101-106
Author(s):  
M. B. Musaev ◽  
V. V. Zashchepkina ◽  
Kh. Kh. Gadayev ◽  
Kh. Kh. Shakhbiyev
Keyword(s):  
Active Substance ◽  
Test Group ◽  
Gastrointestinal Nematode ◽  
Federal District ◽  
Supramolecular Complex ◽  
Mixed Feed ◽  
The North ◽  
Egg Number ◽  
Group Feeding ◽  
Fresh Feces

The purpose of the research is a commission test of the efficacy of the supramolecular complex of ivermectin at gastrointestinal strongylatoses of horses.Materials and methods. The commission experiment was performed in June 2019 in the North Caucasian Federal District of the Chechen Republic. The efficacy of the supramolecular complex of ivermectin was evaluated on 20 horses of different breeds in the Seradin Equestrian Center. To determine the rate of gastrointestinal nematode infection in horses, we collected fresh feces in the morning, made tissue imprints from perianal folds and examined them by the Fülleborn's method using a saturated solution of sodium chloride.Results and discussion. The coproovoscopic examination determined a 100% infection of horses with Strongylates and 40.0% infection with Oxyuris sp., with 488.7±24.4 strongylates eggs and 16.9±0.84 Oxyuris sp. eggs found in 1 g of feces, respectively. Seven and 15 days after the supramolecular complex of ivermectin administered to the horses from the first test group at a dose of 0.15 mg/kg for the active substance (7.5 mg/kg for the drug) in a mixture with mixed feed, we did not find any Strongylata eggs or Oxyuris sp. eggs in feces or on tissue imprints. Insufficient efficacy was obtained in the horses from the second test group after being treated with the active substance of ivermectin at a dose of 0.15 mg/kg. The strongylate egg number decreased on average by 244.3±12.21, namely, by 50.1%, and no Oxyuris sp. eggs were found. The efficacy against Oxyuris sp. was 100%. The horses consumed the mixture of drugs with feed readily. There were no side effects after the drugs applied. Thus, we established the high efficacy of the supramolecular complex of ivermectin against gastrointestinal strongylatoses, and the convenience of its use in a mixture with feed to untamed herd horses individually and by group feeding. 

scholarly journals Сommission test of Effectiveness of the supramolecular complex based on triclabendazole and albendazole at Fasciolosis and gastrointestinal strongylatosis of sheep

2020 ◽  
Vol 14 (2) ◽  
pp. 98-102
Author(s):  
E. V. Lagereva ◽  
V. E. Abramov ◽  
M. B. Musayev ◽  
Sh. V. Vatsayev ◽  
A. Z. Dzhamalova ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Side Effects ◽  
Therapeutic Dose ◽  
High Efficiency ◽  
Wide Spectrum ◽  
Gastrointestinal Nematodes ◽  
Supramolecular Complex ◽  
Test Method ◽  
Group Method ◽  
Combined Feed

The purpose of the research is a commission test of the effectiveness of the supramolecular complex based on triclabendazole and albendazole (SMCTA) against gastrointestinal nematodes and fascioles of sheep in a previously calculated therapeutic dose.Materials and methods. The SMCTA effectiveness was tested in the North Caucasus Federal District in July 2019 on Tushin sheep spontaneously infected with gastrointestinal nematodes and fascioles simultaneously. The sheep were owned by an independent entrepreneur. Coproovoscopic examinations were carried out according to the GOST by the Fulleborn’s method using ammonium nitrate at the Republican Veterinary Laboratory of Grozny. Helminthological dissection of 5 control sheep was done to determine the intensity of infection with fascioles and gastrointestinal nematodes, and 3 sheep from each group were dissected at 14 days after dehelminthization to record the effectiveness of the drug. 4 more sheep from each group were dissected on the 25th day. The drug effectiveness was recorded by the critical test method according to the Guidelines approved by the World Association for the Advancement of Veterinary Parasitology (1995).Results and discussion. When conducting clinical trials on sheep spontaneously infected with strongylates of the gastrointestinal tract and lungs, and fascioles, a therapeutic dose was calculated when the drug was administered individually in the form of a suspension of 4.0 mg/kg for the Active Substance (2.0 for ABZ : 2.0 for TCB), 40 mg/kg for the drug, and in a mixture with concentrated feed using the group method of 5.0 mg/kg for the AS (2.5 mg/kg for ABZ : 2.5 mg/kg for TCB), 50 mg/kg for the drug. The commission test of SMCTA at a dose of 5.0 mg/kg for the AS (50 mg/kg for the drug) by the group method in a mixture with combined feed at fasciolosis and strongylatosis of the gastrointestinal tract of sheep showed, according to the coproovoscopy and helminthological dissection of animals, that 100 % efficiency was obtained. A mixture of the drug with combined feed was readily eaten by the sheep; and no side effects were noted after dehelminthization. The Commission noted the absence of side effects, high efficiency and a wide spectrum of the SMKTA effect at a 4-fold reduced therapeutic dose of 5.0 mg/kg as compared with the albendazole (7.5 mg/kg) and triclabendazole (10 mg/kg) substances. 

scholarly journals Аntiparasitic complex of Ivermectin for treatment of herd horses at gastrointestinal Nematodosis

2020 ◽  
Vol 14 (2) ◽  
pp. 114-119
Author(s):  
М. В. Musaev ◽  
V. V. Zashchepkina ◽  
S. S. Khalikov
Keyword(s):  
Federal District ◽  
Preliminary Test ◽  
Gastrointestinal Nematodes ◽  
Supramolecular Complex ◽  
Test Method ◽  
Adhesive Tape ◽  
Russian Scientific ◽  
Russian Scientific Research Institute ◽  
Individual Use ◽  
Combined Feed

The purpose of the research is evaluating the efficacy of the antiparasitic complex based on ivermectin obtained by mechanochemical technology against gastrointestinal nematodosis of herd horses.Materials and methods. The efficacy of the ivermectin-based antiparasitic complex was tested in December-February 2019 in the Southern Federal District of the Chechen Republic in a private farm on 22 stabled foals aged over one year. To diagnose gastrointestinal parascaridosis and strongylatosis, feces of foals were examined using the Fulleborn’s method. Helminth eggs in 1 g of feces were counted in a counting chamber of the All-Russian Scientific Research Institute of Helminthology. In order to diagnose oxyurosis, pieces of transparent adhesive tape with prints from perianal folds were transferred to a glass slide and examined for Oxyuris spp. eggs. The antiparasitic complex of ivermectin 2% was administered in a mixture with food at a dose of 0.1 mg/kg by the drug (0.2 mg/kg by the active substance). After a preliminary test of the ivermectin complex efficacy, the therapeutic dose of the drug was titrated on 46 adult horses (aged 2–4 years) from the same private entrepreneur. The horses spontaneously infected with Strongylata, Parascarids and Oxyurises were divided into 5 groups according to the analogue principle. For animals of groups 1, 2, and 3, the drug was administered at a doses of 0.1, 0.15 and 0.2 mg/kg by the AS respectively. The horses of groups 4 and 5 were given the substance of ivermectin at a doses of 0.1 and 0.2 mg/kg by the AS, mixed with combined feed individually. The efficacy of the supramolecular complex of ivermectin was recorded according to the data of coproovoscopic studies using the critical test method according to the Guidelines approved by the World Association for the Advancement of Veterinary Parasitology (1995). Results and discussion. The rate of infection of the foals with Strongylata, Parascarids and Oxyurises was 100, 40 and 55% respectively as resulted from the coproovoscopic studies. The dissections showed that the intensity of infection with Strongylata was equal to 477.4±23.87 individuals per animal, Parascarids 447.1±55.89, and Oxyurises 22.2±2.02. The 100 % efficacy was determined for the antiparasitic complex of ivermectin at a dose of 0.1 mg/kg by the drug (0.2 mg/kg by the AS) against the main gastrointestinal nematodes. The substance of ivermectin at a dose of 0.2 mg/kg showed 87.5% efficacy against Strongylata and Parascarids, and at a dose of 0.1 mg/kg, it showed a lack of efficacy (50.0 and 25.0% respectively). We recognized the dose of 0.15 mg/kg by the AS of the supramolecular complex of ivermectin with one-time individual use in a mixture with food as therapeutic. 

scholarly journals PROBLEMS AND PROSPECTS OF CROWDSOURCING IMPLEMENTATION IN THE ASSESSMENTS OF RESIDENTS OF THE NCFD MUNICIPALITIES (results of focus groups)

2020 ◽  
pp. 178-182
Author(s):  
С.В. Алиева ◽  
И.В. Долгова ◽  
Н.Н. Киселева
Keyword(s):  
Focus Group ◽  
Focus Groups ◽  
Empirical Data ◽  
Federal District ◽  
Group Method ◽  
North Caucasus ◽  
The North ◽  
Focus Group Method

В статье представлены результаты исследования проблем и перспектив реализации краудсорсинга в муниципальных образованиях СКФО на основе метода фокус-групп. Исследование было нацелено на выявление отношения жителей СКФО к внедрению краудсорсинга в управление муниципальными образованиями, их оценки относительно выбора форм коммуникации, характера мотивов участников и получения эффектов реализации краудсорсинговых проектов. В результате интерпретации полученных эмпирических данных были сделаны обобщения и выполнена систематизация выявленных трендов. The article presents the results of a study of the problems and prospects of crowdsourcing implementation in the municipalities of the North Caucasus Federal District based on the focus group method. The study was aimed at identifying the attitude of residents of the North Caucasus Federal District to the introduction of crowdsourcing in the management of municipalities, their assessment of the choice of forms of communication, the nature of the motives of participants and obtaining the effects of the implementation of crowdsourcing projects. As a result of the interpretation of the obtained empirical data, generalizations were made and the identified trends were systematized.

MODEL OF THE NORTH CAUCASIAN FEDERAL DISTRICT FOOD MARKETS SPATIAL ORGANIZATION

1970 ◽  
pp. 4-9
Author(s):  
А. Kh. Dikinov ◽  
А. А. Eshugaova ◽  
М. М. Abdurakhmanova ◽  
М. А. Sadueva
Keyword(s):  
Economic Development ◽  
Spatial Organization ◽  
Structural Model ◽  
Research Evaluation ◽  
Federal District ◽  
North Caucasus ◽  
Food Markets ◽  
Regional Food ◽  
The North ◽  
Food Market

The most progressive and promising model of spatial organization of food markets of the North Caucasus Russian Theatre is a cluster model. In the proposed methodology of the process approach to develop a structural model of agro-food cluster in the NORTH is cluster analysis. The regional food market as a single system, which combines production, marketing and consumption of foods with a specific hierarchy, is characterized by different relationships and proportions between its components and is an important an indicator of a country's economic development, achieving food security. Disclosure of potential in a market system, its effective use, taking into account regional particularities and specificities of the economy, improvement of the spatial organization and improving the efficiency of such a complex system as the regional food market is impossible without knowledge of its essence, principles of formation and operation. In this connection there was a need to develop modern methods of research, evaluation, analysis, improvement of structure and functional organisation of the regional food markets as an important factor for the socio-economic development the country. The novelty of the research lies in the fact that the clustering of agribusiness implemented taking into account the peculiarities of regional AIC on the basis of strategic management zones: industrial, conventional and organic. To determine the effectiveness of the cluster algorithm of its evaluation, which is based on the criteria of usefulness and survival in the conditions of the cluster in the region, which are defined using evaluation scales and weights the main factors utility and survival in the cluster.

EXPERIENCE OF USING THE CLUSTER APPROACH IN ASSESSING THE SUSTAINABLE DEVELOPMENT OF THE MOUNTAINOUS TERRITORIES OF THE NORTH CAUCASUS

2021 ◽  
Vol 1 (11) ◽  
pp. 37-46
Author(s):  
Rita I. Batyaeva ◽  
◽  
Tat’yana G. Shelkunova ◽  
Irina Yu. Khetagurova ◽  
Tamara G. Khetagurova ◽  
...  
Keyword(s):  
Sustainable Development ◽  
Economic Development ◽  
Social Indicators ◽  
Federal District ◽  
North Caucasus ◽  
Mountain Areas ◽  
The Sustainable Development ◽  
The North ◽  
Technological Level ◽  
National Environmental

The article provides an overview of the effects of the resonant impact of clusters on the ability of mountain areas to adapt to the modern realities of the technological level, as well as the ability to apply innovations, attract investment in the agro-industrial and tourist cluster. A panel of indicators is presented that provides correct comparability of achievements and reflects information for aggregation by various parameters of the economic and geographical indicators of the region: the national environmental rating of the subjects of the North Caucasus Federal District; indicators of sustainable development of the Russian Federation and the North Caucasus Federal District; investment risk of the republics of the North Caucasus Federal District; the main economic and social indicators of the RSO-Alania. It is established that the geoinformation study of the use of a multicomponent indicator of the state of mountain territories is the basis for determining the vector of their further socio-economic development and justifying appropriate management decisions to stabilize economic development. The peculiarity of the approach is the selection of criteria that will be used in the development of mechanisms for the sustainable development of mountain territories according to the target indicators, in accordance with the UN resolution "Transforming our world in the field of sustainable develop-ment for the period up to 2030".

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