scholarly journals Сommission test of Effectiveness of the supramolecular complex based on triclabendazole and albendazole at Fasciolosis and gastrointestinal strongylatosis of sheep

2020 ◽  
Vol 14 (2) ◽  
pp. 98-102
Author(s):  
E. V. Lagereva ◽  
V. E. Abramov ◽  
M. B. Musayev ◽  
Sh. V. Vatsayev ◽  
A. Z. Dzhamalova ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Side Effects ◽  
Therapeutic Dose ◽  
High Efficiency ◽  
Wide Spectrum ◽  
Gastrointestinal Nematodes ◽  
Supramolecular Complex ◽  
Test Method ◽  
Group Method ◽  
Combined Feed

The purpose of the research is a commission test of the effectiveness of the supramolecular complex based on triclabendazole and albendazole (SMCTA) against gastrointestinal nematodes and fascioles of sheep in a previously calculated therapeutic dose.Materials and methods. The SMCTA effectiveness was tested in the North Caucasus Federal District in July 2019 on Tushin sheep spontaneously infected with gastrointestinal nematodes and fascioles simultaneously. The sheep were owned by an independent entrepreneur. Coproovoscopic examinations were carried out according to the GOST by the Fulleborn’s method using ammonium nitrate at the Republican Veterinary Laboratory of Grozny. Helminthological dissection of 5 control sheep was done to determine the intensity of infection with fascioles and gastrointestinal nematodes, and 3 sheep from each group were dissected at 14 days after dehelminthization to record the effectiveness of the drug. 4 more sheep from each group were dissected on the 25th day. The drug effectiveness was recorded by the critical test method according to the Guidelines approved by the World Association for the Advancement of Veterinary Parasitology (1995).Results and discussion. When conducting clinical trials on sheep spontaneously infected with strongylates of the gastrointestinal tract and lungs, and fascioles, a therapeutic dose was calculated when the drug was administered individually in the form of a suspension of 4.0 mg/kg for the Active Substance (2.0 for ABZ : 2.0 for TCB), 40 mg/kg for the drug, and in a mixture with concentrated feed using the group method of 5.0 mg/kg for the AS (2.5 mg/kg for ABZ : 2.5 mg/kg for TCB), 50 mg/kg for the drug. The commission test of SMCTA at a dose of 5.0 mg/kg for the AS (50 mg/kg for the drug) by the group method in a mixture with combined feed at fasciolosis and strongylatosis of the gastrointestinal tract of sheep showed, according to the coproovoscopy and helminthological dissection of animals, that 100 % efficiency was obtained. A mixture of the drug with combined feed was readily eaten by the sheep; and no side effects were noted after dehelminthization. The Commission noted the absence of side effects, high efficiency and a wide spectrum of the SMKTA effect at a 4-fold reduced therapeutic dose of 5.0 mg/kg as compared with the albendazole (7.5 mg/kg) and triclabendazole (10 mg/kg) substances. 

scholarly journals Аntiparasitic complex of Ivermectin for treatment of herd horses at gastrointestinal Nematodosis

2020 ◽  
Vol 14 (2) ◽  
pp. 114-119
Author(s):  
М. В. Musaev ◽  
V. V. Zashchepkina ◽  
S. S. Khalikov
Keyword(s):  
Federal District ◽  
Preliminary Test ◽  
Gastrointestinal Nematodes ◽  
Supramolecular Complex ◽  
Test Method ◽  
Adhesive Tape ◽  
Russian Scientific ◽  
Russian Scientific Research Institute ◽  
Individual Use ◽  
Combined Feed

The purpose of the research is evaluating the efficacy of the antiparasitic complex based on ivermectin obtained by mechanochemical technology against gastrointestinal nematodosis of herd horses.Materials and methods. The efficacy of the ivermectin-based antiparasitic complex was tested in December-February 2019 in the Southern Federal District of the Chechen Republic in a private farm on 22 stabled foals aged over one year. To diagnose gastrointestinal parascaridosis and strongylatosis, feces of foals were examined using the Fulleborn’s method. Helminth eggs in 1 g of feces were counted in a counting chamber of the All-Russian Scientific Research Institute of Helminthology. In order to diagnose oxyurosis, pieces of transparent adhesive tape with prints from perianal folds were transferred to a glass slide and examined for Oxyuris spp. eggs. The antiparasitic complex of ivermectin 2% was administered in a mixture with food at a dose of 0.1 mg/kg by the drug (0.2 mg/kg by the active substance). After a preliminary test of the ivermectin complex efficacy, the therapeutic dose of the drug was titrated on 46 adult horses (aged 2–4 years) from the same private entrepreneur. The horses spontaneously infected with Strongylata, Parascarids and Oxyurises were divided into 5 groups according to the analogue principle. For animals of groups 1, 2, and 3, the drug was administered at a doses of 0.1, 0.15 and 0.2 mg/kg by the AS respectively. The horses of groups 4 and 5 were given the substance of ivermectin at a doses of 0.1 and 0.2 mg/kg by the AS, mixed with combined feed individually. The efficacy of the supramolecular complex of ivermectin was recorded according to the data of coproovoscopic studies using the critical test method according to the Guidelines approved by the World Association for the Advancement of Veterinary Parasitology (1995). Results and discussion. The rate of infection of the foals with Strongylata, Parascarids and Oxyurises was 100, 40 and 55% respectively as resulted from the coproovoscopic studies. The dissections showed that the intensity of infection with Strongylata was equal to 477.4±23.87 individuals per animal, Parascarids 447.1±55.89, and Oxyurises 22.2±2.02. The 100 % efficacy was determined for the antiparasitic complex of ivermectin at a dose of 0.1 mg/kg by the drug (0.2 mg/kg by the AS) against the main gastrointestinal nematodes. The substance of ivermectin at a dose of 0.2 mg/kg showed 87.5% efficacy against Strongylata and Parascarids, and at a dose of 0.1 mg/kg, it showed a lack of efficacy (50.0 and 25.0% respectively). We recognized the dose of 0.15 mg/kg by the AS of the supramolecular complex of ivermectin with one-time individual use in a mixture with food as therapeutic. 

scholarly journals Study of the Effectiveness of a Supramolecular Complex Based on Albendazole and Triclabendazole (Altric-Extra) Against Nematodes of the Digestive Tract and Fasciola spp. in Sheep Under Production Conditions

2020 ◽  
Vol 14 (1) ◽  
pp. 89-94
Author(s):  
Ekaterina V. Lagereva ◽  
Vladislav E. Abramov ◽  
Mauldi B. Musaev ◽  
Shahab V. Vatsaev ◽  
Aishat Z. Dzhamalova ◽  
...  
Keyword(s):  
Digestive Tract ◽  
Federal District ◽  
Gastrointestinal Nematodes ◽  
Supramolecular Complex ◽  
Test Method ◽  
Group Method ◽  
North Caucasus ◽  
Mixed Feed ◽  
The North ◽  
Production Conditions

The purpose of the research is to test the effectiveness of the supramolecular complex of albendazole and triclabendazole (Altric-Extra) in case of fasciolosis and nematodoses of the digestive tract of sheep under production conditions. Materials and methods. The test of the effectiveness of Altrik-Extra was carried out in the North Caucasus Federal District of the Chechen Republic in July 2019 on 205 sheep of the Tushino breed, spontaneously infected by gastrointestinal nematodes and Fasciola sp. Sheep infection with helminths was established by fecal examination by Fülleborn using ammonium nitrate. The average number of helminth eggs in 1 g of feces was determined using a VIGIS camera. Altric-Extra was given at a dose of 5 mg/ kg of AS (2.5 mg of albendazole and triclabendazole respectively) or 50 mg/kg in the preparation in a mixture with mixed feed by the group method. The effectiveness of the drug was determined by the results of fecal studies 14 and 25 days after deworming. After giving the drugs for three days, the clinical condition of the experimental sheep was monitored. Altric-Extra effectiveness was evaluated using the “critical test” method according to the Guidelines approved by the World Association for the Progress of Veterinary Parasitology (1995). Results and discussion. The Altric-Extra supramolecular complex in a therapeutic dose of 5.0 mg/kg of AS (for the preparation of 50 mg/kg) was 100% effective against gastrointestinal nematodes and Fasciola sp. of sheep. The sheep ate a mixture of the preparation with mixed feed; it is convenient to set in a group method; side effects after deworming is not observed.

scholarly journals The Efficacy of the Supramolecular Complex of Ivermectin in Production Conditions Against Gastro-intestinal Nematodosis of Herd Horses

2020 ◽  
Vol 14 (3) ◽  
pp. 104-108
Author(s):  
M. B. Musaev ◽  
V. V. Zashchepkina ◽  
S. V. Vatsaev ◽  
A. Z. Dzhamalova ◽  
M. M. Ilyin ◽  
...  
Keyword(s):  
Live Weight ◽  
Physical Exertion ◽  
Federal District ◽  
Supramolecular Complex ◽  
Test Method ◽  
Group Method ◽  
North Caucasus ◽  
The North ◽  
Industrial Injuries ◽  
Production Conditions

The purpose of the research is to test the efficacy of the supramolecular complex of ivermectin against gastro-intestinal nematodes of herd horses under production conditions. Materials and methods. The test of the efficacy of the supramolecular complex of ivermectin was carried out from December 2018 to January 2019 in the North Caucasus Federal District of the Chechen Republic. Two herds of horses of 47 and 54 heads in each of different ages were selected, which were grazed all year round. To determine the infection of horses with nematodes of gastro-intestinal tract, 20 samples of fresh feces from each group were collected from the ground. It was not possible to collect samples from untamed horses to determine the infection by Oxiuris spp. Coproovoscopy was performed using the Fülleborn method. To count eggs in 1 g of faeces, a VIGIS counting chamber was used. The first group was given a 2.0% drug individually in a mixture with food at a dose of 0.15 mg/kg for active substance (AS) (according to the drug 75 mg). The drug was administered to the second group at a dose of 0.2 mg/kg for AS (for the drug 1.0 mg/kg) by the group method in a mixture with food, calculated on a live weight of 500 kg. The efficacy of the drug was determined 2 weeks after deworming according to coproovoscopy data. The efficacy of ivermectin complex was accounted for by the "critical test" method. After deworming, the animals were observed during the experiment. Results and discussion. Dehelminthization of horses with a supramolecular complex of ivermectin at a dose of 0.2 mg/kg for AS in a mixture with mixed feed by a group method for mixed infection of various types of gastro-intestinal nematodes under production conditions showed 100% efficiency. Arabinogalactan in the supramolecular complex helps to eliminate the negative effect of AS (ivermectin) on the animal body. The mixture of the preparation with the food was readily consumed by the horses. Deworming horses of herd keeping with a preparation intended for use in a mixture with feed is technically convenient, practically uncomplicated, and at the same time, physical exertion during fixation of animals and industrial injuries are excluded. We did not observe any side effects after deworming horses.

scholarly journals Comprehensive Parameters Identification and Dynamic Model Validation of Interior-Mount Line-Start Permanent Magnet Synchronous Motors

Machines ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 4 ◽  
Author(s):  
Luqman S. Maraaba ◽  
Zakariya M. Al-Hamouz ◽  
Abdulaziz S. Milhem ◽  
Ssennoga Twaha
Keyword(s):  
Mathematical Model ◽  
Permanent Magnet ◽  
High Efficiency ◽  
Experimental Tests ◽  
Induction Machines ◽  
Test Methods ◽  
Operating Conditions ◽  
Test Method ◽  
Permanent Magnet Synchronous Motors ◽  
Synchronous Motors

The application of line-start permanent magnet synchronous motors (LSPMSMs) is rapidly spreading due to their advantages of high efficiency, high operational power factor, being self-starting, rendering them as highly needed in many applications in recent years. Although there have been standard methods for the identification of parameters of synchronous and induction machines, most of them do not apply to LSPMSMs. This paper presents a study and analysis of different parameter identification methods for interior mount LSPMSM. Experimental tests have been performed in the laboratory on a 1-hp interior mount LSPMSM. The measurements have been validated by investigating the performance of the machine under different operating conditions using a developed qd0 mathematical model and an experimental setup. The dynamic and steady-state performance analyses have been performed using the determined parameters. It is found that the experimental results are close to the mathematical model results, confirming the accuracy of the studied test methods. Therefore, the output of this study will help in selecting the proper test method for LSPMSM.

New opportunities of halotherapy in the prevention and medical rehabilitation of children

2021 ◽  
pp. 37-47
Author(s):  
Alina Vyacheslavovna Chervinskaya ◽  
Irena Vladimirovna Pogonchenkova ◽  
Maya Alekseevna Khan ◽  
Natalya Anatolievna Mikitchenko ◽  
Natalya Anatolievna Lyan
Keyword(s):  
Sodium Chloride ◽  
Bronchial Asthma ◽  
Respiratory Diseases ◽  
High Efficiency ◽  
Medical Rehabilitation ◽  
Favorable Effect ◽  
Group Method ◽  
Biophysical Properties ◽  
Pediatric Practice ◽  
Highly Dispersed

The article is devoted to new possibilities of using halotherapy in the prevention, treatment and medical rehabilitation of children. In recent years, active work has been carried out to develop new effective methods of reproducing the aerodispersed medium in the form of haloingalation therapy or by group method — in the conditions of a halochamber. The therapeutic effect of halotherapy is determined by the biophysical properties of a dry highly dispersed aerosol of sodium chloride. The paper presents the biophysical properties of the main active factor of halotherapy, i.e. a dry highly dispersed aerosol of sodium chloride, and reveals some aspects of the formation of the mechanism of therapeutic action. The anti-inflammatory, draining, mucolytic, immunomodulatory, sanogenetic effect of haloaerosol is shown. In pediatric practice, haloaerosol therapy is used for medical rehabilitation of children with respiratory diseases (bronchial asthma, bronchitis), ENT pathology (rhinosinusitis, tonsillitis, pharyngitis), skin diseases. Halotherapy is the method of choice in the prevention of acute respiratory diseases and improving the health of children in general education institutions. The high efficiency of the complex application of halotherapy in various diseases in children has been established. A promising direction for the development of halotherapy is the development of combined exposure technologies. The high efficiency of the use of haloingalation therapy in combination with magnetic therapy in the treatment of acute rhinosinusitis in children has been proven. Based on the conducted studies, a favorable effect of the use of halotherapy and flutter therapy on clinical and functional parameters in children with bronchial asthma was revealed. The data on the possibility of combined use of halotherapy with a pulsed low-frequency electrostatic field in the medical rehabilitation of children suffering from bronchial asthma are presented. Simplicity, safety, the possibility of personalization of exposure and good tolerability by children expands the possibilities for using halotherapy in pediatric practice.

Dr. Shannon Replies

PEDIATRICS ◽  
1975 ◽  
Vol 56 (4) ◽  
pp. 619-619
Author(s):  
Daniel C. Shannon
Keyword(s):  
Gastrointestinal Tract ◽  
Side Effects ◽  
Intravenous Administration ◽  
Ductus Arteriosus ◽  
Oral Feeding ◽  
Blood Levels ◽  
Severe Toxicity ◽  
Potential Toxicity ◽  
Nasojejunal Tube ◽  
Rectal Route

Dr. Morens raises questions of potential toxicity of theophylline in the gastrointestinal tract, kidney and ductus arteriosus. Except for vomiting, which has occurred in some infants when blood levels have been excessive (mainly 2Oµg/ml), we have not observed any of these side effects in treating 93 infants. In all infants, treatment was given through a nasogastric or nasojejunal tube until oral feeding was possible. Because acute severe toxicity in children and adults has been related to intravenous administration, we have used this route only when necessary. Because of erratic absorption, we have avoided the rectal route.

scholarly journals Engineering and experimental testing of two-wavelength laser-assisted device for photocoagulation of eye tissue

2013 ◽  
Vol 6 (2) ◽  
pp. 10-15
Author(s):  
Yury Sergeevich Astakhov ◽  
Yevgeny Leonidovich Akopov ◽  
Aleksandr Anatolevich Ivanov ◽  
Mariya Alexeevna Smirnova ◽  
Leonid Nikolaevich Panteleev ◽  
...  
Keyword(s):  
High Efficiency ◽  
Experimental Testing ◽  
Wide Spectrum ◽  
Retinal Disease ◽  
Primary Objective ◽  
3D Analysis ◽  
Potential Candidate ◽  
Living Tissue ◽  
Wide Range ◽  
Retinal Photocoagulation

Retinal photocoagulation is believed to be one of most efficient methods to treat many retinal abnormalities. By now, a number of lasers operating at different wavelengths, irradiation intensities, and exposure times have been tested in search of optimal parameters for each type of retinal photocoagulation. Taking into consideration a wide range of such parameters, the primary objective of the present study was to develop a device that would combine the potentials of different lasers into a single universal laser-assisted coagulator (ULAC) equally suitable for a wide diversity of retinal disease. Important issue would be the creation of an experimental model allowing an operative evaluation of the coagulating effect induced by the ULAC. The sources of coherent irradiation to be combined were DPSS and diode lasers (532 and 810 nm, respectively). Through two individual fibers, irradiation generated by each of the lasers entered the optical blender to be further directed to the target, now via a single fiber. The target termed the “surrogate of living tissue” was a mixture of donor human blood and chicken egg white, which corresponded, respectively, to the chromophore and thermocoagulating agent, both sensitive to laser beams at 532 and 810 nm. As a result, irradiation of surrogate of living tissue by a laser under the trial caused the formation of a coagulate and its firm adhesion to the coverslip, after that the coagulate was separated from the unaffected surrogate of living tissue followed by its 3D-analysis. In conclusion, the whole procedure, while being relatively non-expensive and easy to perform, has proved to be simple enough for testing of a wide spectrum of coagulation-inducing parameters, whatever laser was used. Moreover, even the initial experiments have shown the high efficiency of the ULAC as a potential candidate for the application in ophthalmological practice.

scholarly journals Effectiveness of the new Iverlong prolonged-release drug for gastrointestinal nematodoses in sheep

2020 ◽  
Vol 210 ◽  
pp. 06011
Author(s):  
Sergey Engashev ◽  
Ekaterina Engasheva ◽  
Vladimir Kolesnikov ◽  
Natalia Koshkina ◽  
Maria Lopteva ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Drug Administration ◽  
Live Weight ◽  
Gastrointestinal Nematodes ◽  
Recommended Dose ◽  
Prolonged Release ◽  
The Third ◽  
Release Drug ◽  
Anthelmintic Effect

The article presents the results of experiment on testing a prolonged form of the Iverlong drug against gastrointestinal nematodes in sheep. The work was carried out on 30 lambs. The lambs of the first group were subcutaneously injected with the Iverlong preparation at a dose of 1 ml/50 kg of live weight (in 1 ml of 50 mg of Ivermectin plus PLGA prolongator), the lambs of the second group were treated with the same preparation, but at a dose of 0.5 ml/50 kg of live weight. The lambs of the third group served as a control, which were subcutaneously injected with the well-known Ivomek drug in the recommended dose (1 ml/50 kg of live weight). The effectiveness from the prolonged form of Iverlong in 2 doses against nematodes of the gastrointestinal tract was taken into account by means of coprological studies before drug administration and every 15 days for three months. According to the results of coprological studies, it was found that the Iverlong drug in a dose of 1ml/50 kg of the animal’s live weight showed a high prolonged anthelmintic effect and for 60 days protected animals from infection by nematodes of the gastrointestinal tract.

scholarly journals Novel T7-modified pH-responsive targeted nanosystem for co-delivery of docetaxel and curcumin in the treatment of esophageal cancer

2020 ◽  
Author(s):  
Lian Deng ◽  
Xiongjie Zhu ◽  
Zhongjian Yu ◽  
Ying Li ◽  
Lingyu Qin ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Side Effects ◽  
High Efficiency ◽  
In Vivo Studies ◽  
Ph Responsive ◽  
Therapeutic Platform ◽  
Multiple Drugs ◽  
Esophageal Cancer Cells

Abstract Although single-drug chemotherapy is still an effective treatment for esophageal cancer, its long-term application is limited by severe side effects. Nanomedicines have increasingly attracted attention because of their good biological safety, targeting and high-efficiency loading of multiple drugs. Herein, we have developed a pH-responsive nanocarrier that has high affinity for the transferrin receptor, which is overexpressed by tumor cells. The system is capable of simultaneous delivery of the chemotherapy drug, docetaxel, and the Chinese Medicine, curcumin, for treatment of esophageal cancer. This novel T7-modified targeting nanosystem releases loaded drugs when exposed to the acidic microenvironment of the tumor, and exerts a synergistic anti-tumor effect, and T7-NP-DC with docetaxel and curcumin loading of 10% and 6.1%, respectively. In vitro and in vivo studies showed that improved anti-tumor efficacy could be obtained by loading docetaxel and curcumin into the T7-modified nanocarrierwithout obvious toxicity or side effects, compared to drug without nanocarrier. Furthermore, the nanocarriers conjugated with T7 short peptides were more readily taken up by esophageal cancer cells compared with normal cells.Together, our findings indicate that the materials can safely exert synergistic anti-tumor effects and provide an excellent therapeutic platform for combination therapy of esophageal cancer.

scholarly journals CURCUMIN, A NATURAL GOLDEN DRUG AND ITS ANTICANCER ASPECTS FROM SYNTHESIS TO DELIVERY: A REVIEW

2020 ◽  
pp. 70-84
Author(s):  
GEETA KRISHNAMURTHY ◽  
DEEPTI ROY ◽  
JYOTSNA KUMAR
Keyword(s):  
Side Effects ◽  
Anticancer Activity ◽  
Review Paper ◽  
Chemotherapeutic Agent ◽  
Wide Spectrum ◽  
Curcuma Longa ◽  
Structure Modification ◽  
Synthetic Drugs ◽  
Effective Drugs ◽  
Novel Delivery Systems

Cancer is a dreadful disease and, in most cases, leads to death even when it is being treated. Even though synthetic drugs are still in use for the treatment of cancer, the seriousness of the side effects of these drugs has boggled researcher’s mind to find more effective drugs which will help to overcome the side effects and have greater potency in trying to make the patient completely free of the disease. Recently, researchers turned their attention towards bio-components present in natural products. Curcumin, a polyphenol and the main constituent of a rhizome Curcuma longa, has geared significant interest due to its wide spectrum of therapeutics values, especially anticancer activity. Paper summarizes the chemistry and bio-metabolism of curcumin in the human body. Aim of this review article is to gather the dispersed efforts of researchers predominantly in improving the bioavailability of curcumin. In the present review, comprehensive literature on anticancer activity of Curcumin via combination therapy, structure modification, synthesis of analogues, novel delivery systems have been highlighted. Besides, the review paper explicated several challenges associated with Curcumin as an adjuvant chemotherapeutic agent and emphasizes more on clinical studies.

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