The Impact of PER3 VNTR Polymorphism on the Development of Schizophrenia in a Turkish Population

2021 ◽  
Vol 55 (2) ◽  
pp. 188-193
Author(s):  
Filiz Ozsoy ◽  
Serbulent Yigit ◽  
Ayse Feyda Nursal ◽  
Muberra Kulu ◽  
Nevin Karakus
Keyword(s):  
Turkish Population ◽  
Vntr Polymorphism ◽  
The Impact

scholarly journals Dopamine D4 receptor gene polymorphism (DRD4 VNTR) moderates real-world behavioural response to the food retail environment in children

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Catherine Paquet ◽  
Andre Krumel Portella ◽  
Spencer Moore ◽  
Yu Ma ◽  
Alain Dagher ◽  
...  
Keyword(s):  
Energy Density ◽  
Food Environment ◽  
Local Food ◽  
Receptor Gene ◽  
Environment Interaction ◽  
Dopamine D4 Receptor ◽  
Vntr Polymorphism ◽  
Food Retailers ◽  
D4 Receptor ◽  
The Impact

Abstract Background Evidence for the impact of the food retailing environment on food-related and obesity outcomes remains equivocal, but only a few studies have attempted to identify sub-populations for whom this relationship might be stronger than others. Genetic polymorphisms related to dopamine signalling have been associated with differences in responses to rewards such as food and may be candidate markers to identify such sub-populations. This study sought to investigate whether genetic variation of the dopamine D4 receptor gene (DRD4 exon III 48 bp VNTR polymorphism) moderated the association between local exposure to food retailers on BMI and diet in a sample of 4 to12-year-old children. Methods Data collected from a birth cohort and a community cross-sectional study conducted in Montreal, Canada, were combined to provide DRD4 VNTR polymorphism data in terms of presence of the 7-repeat allele (DRD4-7R) for 322 children aged between 4 and 12 (M (SD): 6.8(2.8) y). Outcomes were Body Mass Index (BMI) for age and energy density derived from a Food Frequency Questionnaire. Food environment was expressed as the proportion of local food retailers classified as healthful within 3 km of participants’ residence. Linear regression models adjusted for age, sex, income, cohort, and geographic clustering were used to test gene*environment interactions. Results A significant gene*food environment interaction was found for energy density with results indicating that DRD4-7R carriers had more energy dense diets than non-carriers, with this effect being more pronounced in children living in areas with proportionally more unhealthy food retailers. No evidence of main or interactive effects of DRD4 VNTR and food environment was found for BMI. Conclusions Results of the present study suggest that a genetic marker related to dopamine pathways can identify children with potentially greater responsiveness to unhealthy local food environment. Future studies should investigate additional elements of the food environment and test whether results hold across different populations.

Association of interleukin (IL)-4 gene intron 3 VNTR polymorphism with multiple sclerosis in Turkish population

2013 ◽  
Vol 74 (9) ◽  
pp. 1157-1160 ◽  
Author(s):  
Nevin Karakus ◽  
Serbulent Yigit ◽  
Gulsum Semiha Kurt ◽  
Betul Cevik ◽  
Osman Demir ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Turkish Population ◽  
Vntr Polymorphism

The association between Interleukin (IL)-4 gene intron 3 VNTR polymorphism and alopecia areata (AA) in Turkish population

Gene ◽  
2013 ◽  
Vol 527 (2) ◽  
pp. 565-569 ◽  
Author(s):  
Göknur Kalkan ◽  
Nevin Karakus ◽  
Yalçın Baş ◽  
Zennure Takçı ◽  
Pınar Özuğuz ◽  
...  
Keyword(s):  
Alopecia Areata ◽  
Turkish Population ◽  
Vntr Polymorphism

Comparison of Head and Neck Cancer Distribution in Turkish and Syrian Populations

2020 ◽  
Author(s):  
Gozde SERİNDERE ◽  
Behiye BOLGUL ◽  
Didar GURSOY ◽  
Sibel HAKVERDİ ◽  
Nazan SAVAS
Keyword(s):  
Head And Neck ◽  
Turkish Population ◽  
Developed Countries ◽  
University Hospital ◽  
High Rate ◽  
Pathology Report ◽  
Increased Risk ◽  
Turkish Patients ◽  
Risk Of Cancer ◽  
The Impact

Background: Although oral health improves in several countries, global problems are still present. Predictably, the disadvantaged and poor population groups in both developing and developed countries have high rate of malign disease. The aim of this study was to evaluate the prevalence of head and neck cancers (HNCs) and to compare them between Syrian and Turkish population. Methods: A total of 4570 patients confirmed to have HNC histopathologically from Hatay Mustafa Kemal University Hospital Pathology report archive were retrospectively evaluated. Among them, 452 were Syrian patients while 4118 were Turkish patients. Data were collected from 2010 to 2017. Gender and age information were taken from medical records. According to the pathological results, HNCs were classified. Results: In 474 patients, HNCs were inscriptived, of which 317 were in males and 157 in females aged 23–80 years with histologically approved cancer of head and neck area. Overall, 100 were Syrian patients while 374 were Turkish patients. In both Syrian and Turkish patients, the most observed HNC was squamous cell carcinoma (SCC). Conclusion: Nowadays, the prevalence of cancer is higher because of the excessive consumption of alcohol, tobacco, chewing, and smoking. For the higher cancer incidence in Syrian refugees, we thought that the impact of war such as stress may have been effective as well as the known several etiologic factors of cancer. For the increased risk of cancer, the early diagnosis of this become more important.  

scholarly journals Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Elifcan Aladag ◽  
Zahit Tas ◽  
Bilgesu Safak Ozdemir ◽  
Tayfun Hilmi Akbaba ◽  
Meltem Gulsun Akpınar ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Essential Element ◽  
Renin Angiotensin System ◽  
Severe Pneumonia ◽  
Turkish Population ◽  
Control Group ◽  
Converting Enzyme ◽  
Ace Gene ◽  
And Control ◽  
The Impact

Introduction. The coronavirus disease 2019 (COVID-19), that is caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has spread rapidly worldwide since December 2019. The SARS-CoV-2 virus has a great affinity for the angiotensin-converting enzyme-2 (ACE-2) receptor, which is an essential element of the renin-angiotensin system (RAS). This study is aimed at assessing the impact of the angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphisms, on the susceptibility and clinical outcomes of the COVID-19 immunoinflammatory syndrome. Patients and Methods. A total of 112 patients diagnosed with COVID-19 between 1 and 15 May 2020 were enrolled in the study. ACE gene allele frequencies were compared to the previously reported Turkish population comprised of 300 people. Results. The most common genotype in the patients and control group was DI with 53% and II with 42%, respectively. The difference in the presence of the D allele between the patient and control groups was statistically significant (67% vs. 42%, respectively, p < 0.0001 ). Severe pneumonia was observed more in patients with DI allele (31%) than DD (8%) and II (0%) ( p = 0.021 ). The mortality rate, time to defervescence, and the hospitalization duration were not different between the genotype groups. Conclusion. Genotype DI of ACE I/D polymorphism is associated with the infectious rate particularly severe pneumonia in this study conducted in the Turkish population. Therefore, ACE D/I polymorphism could affect the clinical course of COVID-19.

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements in an adult Turkish population

2010 ◽  
Vol 25 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Nihat Ozer ◽  
Nese Cam ◽  
Burak Tangurek ◽  
Songul Ozer ◽  
Huseyin Uyarel ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Warfarin Dose ◽  
Patient Characteristics ◽  
Turkish Population ◽  
The Impact

scholarly journals Eating Habits and Lifestyle Changes Among Turkish Population During Covid-19 Pandemic Period

2021 ◽  
Vol 9 (12) ◽  
pp. 2206-2212
Author(s):  
Sibel Karakaya ◽  
Merve Eda Eker ◽  
Sedef Nehir El ◽  
Beste Özsezen
Keyword(s):  
Physical Activity ◽  
Dietary Habits ◽  
Eating Habits ◽  
Turkish Population ◽  
Lifestyle Changes ◽  
Smoking Habits ◽  
Mailing Lists ◽  
Significant Difference ◽  
Age Range ◽  
The Impact

This study aimed to investigate the impact of the Covid-19 pandemic on eating habits, and lifestyles including sleeping and smoking habits, and physical activity of the Turkish population aged >15 years using a web-survey. The survey was conducted from the 5th of August to the 4th of October 2020 by using an online platform and disseminated through institutional and private social networks (Facebook and WhatsApp) and institutional mailing lists. The questionnaire consisted of demographic information, anthropometric data, changes in dietary habits, and changes in lifestyle habits. The total number of participants was 1020 in the study and 71.1% of them are female, and 80% of the participants were in the 20-59 age range. More than half of the participants (67.42%) declared that their eating habits and lifestyles changed during the Covid-19 pandemic. Most of the participants (63%) declared that there is no special food that can improve their immunity against the Covid-19. Contrary to them, most of those who added certain foods to their diets or increased the consumption of certain foods to improve the immunity (39.8%), declared that they got that information from social media such as Twitter, Facebook, and WhatsApp. In particular smoking habits did not change and sleep hours increased during the Covid-19 period. Concerning physical activity, no significant difference was found between the percentage of people before and during the Covid-19 period.

Exophthalmometry Values of Turkish Adult Population and the Effect of Age, Sex, Refractive Status, and Hertel Base Values on Hertel Readings

2008 ◽  
Vol 18 (2) ◽  
pp. 165-171 ◽  
Author(s):  
Ü. Beden ◽  
Y. Özarslan ◽  
H.E. Öztürk ◽  
B. Sönmez ◽  
D. Erkan ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Adult Population ◽  
Linear Regression Analysis ◽  
Turkish Population ◽  
Multiple Linear Regression Analysis ◽  
Interpupillary Distance ◽  
Refractive Status ◽  
The Impact

Purpose To establish normal exophthalmometry values in the adult Turkish population, and the impact of age, gender, interpupillary distance, Hertel base selection, and refractive status on globe position. Methods Exophthalmometry measurements and refractive status of 2477 subjects were conducted in one tertiary and five primary health care centers. Change of globe position by age, intersex differences in terms of globe position, correlations of Hertel base with exophthalmometry results, and interpupillary distance (IPD) were evaluated. Multiple linear regression analysis was performed to test determination effect of each variable on final Hertel reading. Results Median Hertel reading was 13 mm, and 95% of the population had an upper limit of 17 mm for both eyes. There was a negative correlation between spherical equivalent of refractive status and exophthalmometry results and a weak positive correlation between IPD and exophthalmometry result. Mean Hertel value was found to decrease significantly after the third decade. Hertel base value was found to have moderate linear correlation with Hertel results. A weak correlation was detected with Hertel base/IPD ratio with final Hertel results. Multiple linear regression analysis was performed and only 13% and 20% of change in Hertel values bilaterally were found to be determined by other variables (age, IPD, refractive status, and Hertel base value) for females and males. Conclusions Normative dataset for exophthalmometry results of the Turkish population is established to be used in clinical practice and research. Only 13% to 20% of change in Hertel values was detected to be determined by age, IPD and Hertel base values.

scholarly journals Association between the Interleukin-1 Receptor Antagonist (IL1RN) Variable Number of Tandem Repeats (VNTR) Polymorphism and Lymphoma

2021 ◽  
Author(s):  
Hosna Sarani ◽  
Behrouz Molashahi ◽  
Mohsen Taheri ◽  
Gholamreza Bahari ◽  
Seyed Mahdi Hashemi ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Tandem Repeats ◽  
Interleukin 1 ◽  
Population Sample ◽  
Variable Number ◽  
Vntr Polymorphism ◽  
Non Hodgkin Lymphoma ◽  
Polymerase Chain ◽  
The Impact ◽  
Hematopoietic Cancer

Introduction: Lymphoma is a common hematopoietic cancer. Immunosuppression is one of the main risk factors for the development of lymphoma. The interleukin (IL)-1 receptor antagonist IL1RN, which binds to the IL-1 receptor, moderates a variety of immune responses related to IL-1. We aimed to assess the impact of IL1RN variable number of tandem repeats (VNTR) polymorphism on lymphoma risk in an Iranian population sample. Materials and Methods: DNA was extracted from peripheral blood of 120 subjects with non-Hodgkin Lymphoma (NHL), 50 subjects with Hodgkin’s lymphoma (HL), and 186 unrelated healthy individuals. IL1RN VNTR polymorphism was detected using polymerase chain reaction. Results: Our findings revealed that the IL1RN VNTR polymorphism was associated with protection against NHL (P≤0.001, OR: 0.30, 95% CI: 0.18-0.53). The IL1RN 2 allele significantly decreased the risk of NHL (p = 0.023, OR = 0.66, 95%CI = 0.46–0.93). In addition, we found that IL1RN 1/2 was associated with a lower risk of HL (p ≤0.001, OR = 0.24, 95%CI = 0.12–0.50). Conclusion: Our results suggest that the presence of IL1RN VNTR polymorphism is associated with a decreased risk of lymphoma in an Iranian subpopulation in southeast Iran.

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