Results of the use of low-intensity laser radiation in the treatment of occupational polyneuropathies of the upper extremities

2021 ◽  
Vol 61 (4) ◽  
pp. 238-242
Author(s):  
Olga A. Kochetova
Keyword(s):  
Comparison Group ◽  
Pulse Velocity ◽  
Nerve Fibers ◽  
Main Group ◽  
Upper Extremities ◽  
Production Factor ◽  
Low Intensity ◽  
Sensory Fibers ◽  
Intensity Laser

Introduction. Effective therapy of occupational polyneuropathy of the upper extremities is a difficult task, because the characteristic clinical and neurophysiological manifestations of this disease persist for many years even after the termination of contact with the etiological harmful production factor - physical overload. Taking into account the low efficiency of existing treatment methods, as well as the peculiarities of the effect of low-intensity laser therapy (LILT), the task of developing a technique for using LILT for the treatment of patients with professional polyneuropathy and assessing its effectiveness during follow-up is very urgent. The aim of the study was to evaluate the effectiveness of LILT for the treatment of occupational polyneuropathy of the upper extremities. Materials and methods. The results of treatment of 236 patients with an established diagnosis of occupational polyneuropathy of the upper extremities are presented. All patients received usual drug therapy, the treatment of patients of the main group differed from the comparison group in that they were additionally treated with LILT according to the developed method. Results. The effectiveness of the therapy was assessed by studying the dynamics of pain in the hands using a visual pain rating scale, pulse velocity along the sensory fibers of the median and ulnar nerves. Changes in each of these parameters in subgroups were assessed at different stages of follow-up (before and immediately after treatment, after 3 and after 6 months). The division of patients into subgroups was carried out by determining type of the nerve fibers' damage. Conclusion: The developed method of LILT of professional polyneuropathy is simple and convenient for use in clinical practice: it is applicable both in a hospital and on an outpatient basis. After treatment, in patients from the main group, in contrast to the comparison group, there was a statistically significant increase in the parameters of pulse velocity along the sensory fibers of the median and ulnar nerves with a simultaneous decrease in the severity of pain. The effect of LILT in patients from the main group decreased after 6 months, which allows us to recommend such courses of LILT 2 times a year. LILT has a limited list of contraindications and is generally well tolerated by patients with minimal local side effects.

ESTIMATION OF THE SAFETY OF LOW-INTENSITY LASER RADIATION IN TREATMENT OF PATIENTS WITH PROFESSIONAL POLYNEUROPATHIES OF THE UPPER LIMBS

2021 ◽  
Author(s):  
S.V. Grebenkov ◽  
◽  
N.Y. Malkova ◽  
O.A. Kochetova ◽  
Keyword(s):  
Laser Radiation ◽  
Side Effects ◽  
Upper Extremities ◽  
Projection Area ◽  
Outpatient Basis ◽  
Short Term ◽  
Low Intensity ◽  
Number Of Patients ◽  
Intensity Laser ◽  
Local Side

Abstract: The inclusion of low-intensity laser radiation in the complex treatment of professional polyneuropathies of the upper extremities, due to its numerous biological effects, contributes to a statistically significant reduction in pain in the hands of patients, and improves the conduction of nerve impulses along the peripheral nerves of the hands. In addition to describing the positive clinical and neurophysiological trends achieved during treatment, the issue of the safety of the developed therapy method is important. The aim of the study is to assess the safety of the proposed method of low-intensity laser therapy (LILT) in patients with professional polyneuropathies of the upper extremities. Material and methods: on the basis of the department of occupational pathology, 116 patients (60 men, 56 women) with occupational polyneuropathies of the upper extremities were treated using LILT. Therapeutic measures were carried out using a semiconductor laser apparatus for red spectrum radiation (650 nm) with fiber-optic light guides for percutaneous therapy "ALP-01-Laton" in the sitting position of patients. Diffuse scattered laser radiation of the red region of the spectrum with an energy illumination of 0.7-1.1 mW / cm2 directly affected the projection area of the exit of the median nerve from the carpal tunnel to the hand. There were 5-10 procedures per course, the energy exposure of laser radiation and the number of sessions were determined individually. Results: To ensure the safety of the therapy, patients were included in the study strictly in accordance with the developed inclusion and non-inclusion criteria. Patients were treated in a specially equipped room with the use of personal protective equipment; safety rules were followed during the operation of the device. During treatment, all 116 patients treated with LILT did not have systemic side effects. A number of patients developed short-term complaints associated with local reactions: short-term tingling sensations and "goose bumps" in the hands, warmth, slight burning sensation, etc. All recorded local side effects occurred directly during LILT-procedures and were completely stopped within 1-5 minutes after their completion. In general, LILT-exposure did not cause serious side effects and was well tolerated by patients. 13.5% of patients noted a decrease in pain in the arms directly during the LILT treatment procedures. Conclusion. The developed method of LILT of professional polyneuropathies of the upper extremities is simple and convenient for use in clinical practice: it is applicable both in a hospital and on an outpatient basis. LILT has a limited list of contraindications, and is generally well tolerated by patients with minimal local side effects.

Prevention of recurrent herpes labialis outbreaks through low-intensity laser therapy: a clinical protocol with 3-year follow-up

2011 ◽  
Vol 27 (5) ◽  
pp. 1077-1083 ◽  
Author(s):  
Carlos de Paula Eduardo ◽  
Letícia Mello Bezinelli ◽  
Fernanda de Paula Eduardo ◽  
Roberta Marques da Graça Lopes ◽  
Karen Müller Ramalho ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Herpes Labialis ◽  
Clinical Protocol ◽  
Low Intensity ◽  
Recurrent Herpes ◽  
Low Intensity Laser Therapy ◽  
Intensity Laser

A new approach to the treatment of dry eye syndrome against the background of chronic peripheral uveitis

2021 ◽  
pp. 154-157
Author(s):  
E.B. Tatarnikova ◽  
◽  
O.I. Krivosheina ◽  
Keyword(s):  
Conservative Treatment ◽  
Dry Eye ◽  
Comparison Group ◽  
Anterior Segment ◽  
Main Group ◽  
Dry Eye Syndrome ◽  
Laser Coagulation ◽  
Complex Method ◽  
Anti Inflammatory

Aim. To study the clinical and functional effectiveness of a complex method of treatment of dry eye syndrome against the background of chronic peripheral uveitis, including local tear-replacement and anti-inflammatory therapy in combination with laser retinal coagulation on the extreme periphery of the fundus. Materials and methods. The study was performed among 98 patients who made up 2 follow-up groups: the main group (78 people) and the comparison group (20 people). All patients underwent OSDI questionnaires, visometry, pneumotonometry, biomicroscopy of the anterior segment of both eyes, binocular ophthalmoscopy with sclerocompression, and the Schirmer I test. In the main group, along with conservative treatment, laser coagulation of the extreme periphery of the retina was performed, in the comparison group - conservative treatment. The follow-up period was 3 months. Results and discussion. The use of a complex method of treatment of «dry eye» syndrome against the background of chronic peripheral uveitis significantly reduces the number of complaints according to the OSDI questionnaire, improves the condition of the eye surface (reducing the overhang of the conjunctival fold, the severity of «sluggish» hyperemia of the conjunctiva of the eyelids and transitional folds, reducing the amount of conjunctival discharge). The indicator of total tear production in the main group after 3 months. it increases by 1,5 times in comparison with the initial data, and in 100% of cases, stable relief of inflammation of the chorioretinal structures on the extreme periphery of the fundus is provided. Conclusion. A new effective method for the treatment of dry eye syndrome against the background of chronic peripheral uveitis, including local tear-replacement and anti-inflammatory therapy in combination with laser retinal coagulation on the extreme periphery of the fundus, has been developed and introduced into clinical practice. The use of this method provides stable clinical and functional results in the long-term period and can be recommended for the treatment of «dry eye» syndrome of mild to moderate severity against the background of chronic peripheral uveitis. Key words: dry eye syndrome, chronic peripheral uveitis, laser coagulation of the extreme periphery of the retina.

scholarly journals Biliary sludge: pathogenesis, etiology and drug therapy

2021 ◽  
Vol 93 (2) ◽  
pp. 179-186
Author(s):  
I. G. Bakulin ◽  
E. B. Avalueva ◽  
M. U. Serkova ◽  
T. E. Skvortsova ◽  
P. V. Seliverstov ◽  
...  
Keyword(s):  
Complete Resolution ◽  
Comparison Group ◽  
Contractile Function ◽  
Generic Drugs ◽  
Main Group ◽  
Therapeutic Effectiveness ◽  
High Effectiveness ◽  
Biliary Sludge ◽  
Number Of Patients

Aim. To evaluate the effectiveness of the use of ursodeoxycholic acid (UDCA) for the treatment of biliary sludge (BS) and to compare the therapeutic effectiveness of the German substance UDCA and generic drugs from other manufacturers. Materials and methods. The study involved 65 patients diagnosed with BS (K80.8). To assess the severity of BS, ultrasound of the gallbladder was performed before treatment, after 1, 3, 6 months during therapy, as well as an assessment of its contractility. All patients were randomized into 2 groups. Patients of the main group received UDCA Ursofalk (Germany) at a dose of 10 mg/kg for at least 6 months. Patients in the comparison group received UDCA (another manufacturer) at a dose of 10 mg/kg for at least 6 months. Results. After 3 months of follow-up, the number of patients with dissolved sludge in the main group was 87.1%, while in the comparison group 50%. In 71% of patients, the normalization of the lean volume of the gallbladder was noted, and in the comparison group only in 47.1%. After 6 months of follow-up, complete resolution of BS in the main group was observed in 93.5% of cases, and in the comparison group in 73.6% of cases. Conclusion. As a result of the study, the high effectiveness of Ursofalk during oral litolysis in patients with stage I GI (BS) in the first 3 months of therapy, as well as the normalization of the contractile function of the gallbladder, were noted.

scholarly journals Evaluation of effectiveness of complex treatment of chronic generalized periodontitis using original splinting design

2021 ◽  
Vol 38 (6) ◽  
pp. 83-93
Author(s):  
N. B. Astashina ◽  
E. P. Rogozhnikova ◽  
A. S. Arutyunov ◽  
N. N. Malginov ◽  
S. V. Kazakov
Keyword(s):  
Quality Of Life ◽  
Comparison Group ◽  
Negative Impact ◽  
Young Patients ◽  
Pathological Process ◽  
Main Group ◽  
Complex Treatment ◽  
Periodontal Tissues

Relevance. The relevance of the study is dictated by the high prevalence of periodontal disease among young people and by the need to search for new approaches to periodontitis treatment in order to increase the effectiveness of treatment at early stages of pathological process. Objective. To evaluate the effectiveness of complex treatment of chronic generalized periodontitis (CGP) of mild severity using a removable splinting construction made according to the author's technique. Materials and methods. At the orthopedic stage of the complex treatment of mild CGP, splinting constructions were used for 47 young patients: in the main group (n = 16) the authors treatment and preventive splint, in the first comparison group (n = 15) a removable metal splint, in the second comparison group (n = 16) a fixed adhesive fiber splint. Periodontal hemodynamics was assessed using ultrasound Doppler analysis 1, 6 and 12 months after the therapeutic measures and tooth immobilization. To identify the possible negative impact of the treatment on the quality of life (QOL) in patients with splint constructions, we used the OHIP-14-Ru questionnaire; the follow-up period was 1.3, 6, and 12 months. Results. Dental immobilization contributed to the improvement of blood flow in the periodontal tissues in the short and long term follow-up, so after 12 months: Vam in the main group increased by 39,8 % and amounted to 0,397 0,004 cm / s, in patients of the comparison groups Vam was 0,329 0,006 cm / s and 0,335 0,003 cm / s, respectively, that is 15,4 % and 18,4 % higher compared with the figures before treatment. The quality of life index for patients using splinting constructions made according to the author's technique, by the OHIP-14-Ru questionnaire was assessed as good 1 year after (3.46 0.59). Conclusions. The use of the proposed original orthopedic design in a complex plan for mild periodontitis treatment helps to improve regional blood circulation and stabilize the pathological process.

scholarly journals The impact of concomitant anemic syndrome on the clinical course of coronary artery disease

Pathologia ◽  
2021 ◽  
Vol 18 (3) ◽  
pp. 263-268
Author(s):  
M. O. Konovalova ◽  
N. S. Mykhailovska
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Iron Deficiency ◽  
Cardiovascular Events ◽  
Comparison Group ◽  
Clinical Course ◽  
Main Group ◽  
Deficiency Anemia ◽  
Artery Disease

The presence of comorbid pathology negatively affects the prognosis of patients with coronary artery disease (CAD). Today it is important to clarify the features of CAD on the background of concomitant anemia and identify the main risk factors for complications to improve the tactics of this category of patients. The aim. To investigate the influence of concomitant anemic syndrome on the clinical course of coronary artery disease, frequency and features of the main cardiovascular events. Materials and methods. The study involved 91 patients with coronary artery disease (42 men and 49 women, age – 70 (49; 93)). All patients were divided into 2 groups: the main group (n = 46) consisted of patients with coronary artery disease with iron-deficiency anemia, the comparison group (n = 45) – patients with coronary artery disease without iron-deficiency anemia. The study of the main cardiovascular events took into account re-hospitalization due to arrhythmic disorders, progression of heart failure (HF), CAD destabilization within the observed period (1 year), as well as death from cardiovascular causes. The data analysis was performed using Statistica 13.0. Results. During the year, 42 non-fatal cardiovascular events were noted in patients of both groups, however in the main group their total number was 30 (67 %) versus 12 (27 %) in the comparison group (χ2 = 13.603; P < 0.05). The presence of concomitant anemia in CAD patients significantly increased the relative risk of re-hospitalizations (RR = 1.9; 95 % CI 1.230–3.112; P < 0.05). Among the reasons for hospitalization in the main group, HF decompensation prevailed – 17 (57 %) patients, unstable angina – 7 (23 %), arrhythmic disorders – 6 (20 %); in the comparison group, among the reasons for re-hospitalization, 7 (57 %) had HF decompensation, 3 (25 %) had unstable angina, and 2 (17 %) cases had arrhythmic disorders. In total, 9 (19.5 %) deaths were recorded in the main group, while in the comparison group 1 (2.2 %) death was recorded during the year (χ2 = 6.995; P < 0.05). The presence of concomitant anemia in patients with CAD increases the risk of fatal outcome by 8.8 times (RR = 8.8; 95 % CI 1.162–66.685; P < 0.05). The presence of moderate anemia in patients with CAD significantly increases the incidence of combined critical events by 39 % during the year of follow-up compared with mild anemia (χ2 = 12.843; P < 0.05). Conclusions. The presence of concomitant anemia is associated with a worsened prognosis for patients having coronary artery disease due to an increased risk of non-fatal cardiovascular events that require re-hospitalization during the year of observation, and an increased incidence of death. Increasing severity of anemia is associated with an increase in the frequency of the combined critical event during 1 year of follow-up.

scholarly journals Clinical and psychopathological peculiarities of suicidal behavior of people who are ill with schizophrenia living in the zone of the Joint Force Operation

2019 ◽  
Vol 27 (3) ◽  
pp. 42
Author(s):  
Pavlo Budonnyi
Keyword(s):  
Suicidal Behavior ◽  
Comparison Group ◽  
Main Group ◽  
Comprehensive Treatment ◽  
Clinical Protocols ◽  
Joint Force ◽  
Treatment And Prevention ◽  
Complex Therapy ◽  
The Future

The relevance and the clinical and social need for this study is due to the fact that, to date, no comprehensive treatment and prevention of suicidal behavior has been developed for patients suff ering from schizophrenia from the zone of the Joint Force Operation (JFO). The aim of our study was to identify the clinical and psychopathological features of suicidal behavior of persons suff ering from schizophrenia and living in the OUF zone. In the process of research, a complex of methods was used: theoretical, socio-demographic, follow-up, clinical-anamnestic, clinicalpsychopathological, psychodiagnostic, statistical (calculations were made using Excel MS Offi ce 2016). Taking into account the principles of bioethics and deontology, in the course of the work, 136 people, aged 22 to 50 years, suffering from schizophrenia (according to IDU-10, code F2 "Schizophrenia, schizotypical states and delusional disorders"), were selected and they all have a tendency to suicidal behavior. All studied were divided into two groups: 71 people with a diagnosis of schizophrenia and suicidal behavior, with whom the author’s complex therapy was subsequently carried out — MG (main group); 65 people, also diagnosed with schizophrenia and suicidal behavior, with whom further therapy was carried out according to standard clinical protocols — CG (comparison group). In the future, each group was divided into subgroups by gender: 38 men included in MG1, 33 women and MG2, respectively, 34 men in CG1, and 31 women in CG2. According to the results of the study, the clinical and psychopathological features of suicidal behavior of persons suff ering from schizophrenia and li ving in the JFO zone were determined. The data obtained in this study later became for us markers for the development and implementation of the author’s methodology of medicalpsychological support.

scholarly journals Effect of low-intensity laser radiation on hemostasis in patients with chronic obstructive pulmonary disease

2019 ◽  
Vol 18 (3) ◽  
pp. 586-592
Author(s):  
Natalya M Balabina ◽  
Alexey N Kalyagin ◽  
Tatyana M Maksikova ◽  
Vadim A Dulskiy ◽  
Valentina A Haptanova ◽  
...  
Keyword(s):  
Laser Radiation ◽  
Respiratory Function ◽  
Medical Science ◽  
Main Group ◽  
Stable Phase ◽  
Control Group ◽  
Thrombin Time ◽  
Standard Drug ◽  
Low Intensity ◽  
Intensity Laser

Objective. The study presents results of the low-intensity intravenous (IV) laser radiation effect on some indicators of the hemostasis system and respiratory function of 83 patients with a chronic lung disease (COPD), stable phase, II-III (after GOLD scale), including 51 men and 32 women. The average COPD duration was 9.6±4.4 years. Materials and methods. All patients with COPD were randomly divided into 2 groups - comparison (30 people) and main (53 people). The control group consisted of 20 practically healthy people, matched by sex and age. Patients in the control group received only standard drug therapy with IGCC/DBA combination (budesonide/formoterol, salmeterol/fluticasone propionate inhalation at a therapeutic dose corresponding to the COPD clinical symptoms severity). Result and Discussion. In addition to the basic treatment, the main group received a course of intravenous lowintensity laser radiation. As established before the treatment initiation, patients with COPD experienced a decrease in FEV1, Tiffno index, SaO2. Conclusion. The respiratory function disruption was accompanied by a significant activation of plasma hemostasis ( prothrombin time shortening, thrombin time, activated partial thromboplastin time) and a significant increase in platelet aggregation (increase in the aggregation degree, aggregation rate, decrease in the aggregation time). At the same time, in patients with COPD, a significant decrease in anticoagulant activity was observed before treatment, particularly antithrombin III decrease when compared with the control group (p <0.05) and CRP (main group: 0.86±0.02; control group: 0.85±0.02). The introduction of low-intensity laser radiation into the patients complex with COPD led to the these parameters normalization. Bangladesh Journal of Medical Science Vol.18(3) 2019 p.586-592

scholarly journals Effect of high-intensity versus low-intensity praziquantel treatment on HIV disease progression in HIV and Schistosoma mansoni co-infected patients: a randomised controlled trial

2019 ◽  
Vol 3 ◽  
pp. 81
Author(s):  
Andrew Abaasa ◽  
Gershim Asiki ◽  
Andrew Obuku Ekii ◽  
Josephine Wanyenze ◽  
Pietro Pala ◽  
...  
Keyword(s):  
Viral Load ◽  
High Intensity ◽  
Comparison Group ◽  
Controlled Trial ◽  
Hiv Disease ◽  
Low Intensity ◽  
Hiv Progression ◽  
Praziquantel Treatment ◽  
Randomised Controlled

Background: It has been hypothesised that Schistosoma co-infection exacerbates HIV progression, and hence anthelminthic intervention in co-infected individuals will delay it. We evaluated effects of high-intensity versus low-intensity praziquantel treatment of schistosomiasis on HIV disease progression among co-infected patients from fishing populations around Lake Victoria, Uganda. Methods: Between August 2012 and September 2015, we conducted an open-label randomised, controlled trial. Adults, antiretroviral therapy-naïve, CD4 counts ≥350 cells/μl, HIV and S. mansoni co-infected, were randomised 1:1 to praziquantel (40mg/kg) given quarterly (starting at enrolment) or annually (starting 12 weeks after enrolment; such that low-intensity participants were still untreated when sampled at 12 weeks). A non-randomised HIV-positive S. mansoni-negative comparison group was recruited. The primary outcome was mean change in plasma viral load at 12 and 60 weeks. Results: In total 363 participants (high-intensity 113, low-intensity 113, comparison group 137) were recruited; 96 (85.0%), 97 (85.8%) and 107 (78.1%) completed 60 weeks of follow up, respectively. Adjusting for baseline age and viral load, the geometric mean ratio (aGMR [95%CI]) viral load for high-intensity vs low-intensity groups at 12 weeks was 0.90 [0.65, 1.25] p=0.55 and at 60 weeks 1.88 [0.78, 4.53] p=0.16. Results in the comparison group were similar to trial arms. High-intensity, compared to low-intensity, treatment resulted in substantially lower S. mansoni prevalence at all follow up visits (p<0.05). Conclusions: In communities with a high burden of both S. mansoni and HIV infection, high-intensity treatment of S. mansoni does not delay HIV progression despite relevant benefit for parasite clearance. Trial registration: ISRCTN15371662 (17/11/2016)

scholarly journals Mechanistic modeling suggests that low-intensity focused ultrasound can selectively recruit myelinated or unmyelinated nerve fibers

2020 ◽  
Author(s):  
Théo Lemaire ◽  
Elena Vicari ◽  
Esra Neufeld ◽  
Niels Kuster ◽  
Silvestro Micera
Keyword(s):  
Electromechanical Coupling ◽  
Focused Ultrasound ◽  
Nerve Fibers ◽  
Mechanistic Modeling ◽  
Exposure Limits ◽  
Computational Framework ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Spatially Varying ◽  
Sensory Fibers

AbstractLow-Intensity Focused Ultrasound Stimulation (LIFUS) holds promise for the remote modulation of neuronal activity, but an incomplete mechanistic characterization hinders its clinical maturation. Here, we developed a computational framework to model intramembrane cavitation in multi-compartmental, morphologically-realistic neuronal representations, and used it to investigate ultrasound neuromodulation of peripheral nerves by spatially-varying pressure fields. Our findings show that LIFUS offers distinct parametric sub-spaces to selectively recruit myelinated or unmyelinated axons and modulate their spiking activity over physiologically relevant regimes and within safe exposure limits. This singular feature, explained by fiber-specific differences in membrane electromechanical coupling, consistently explains recent empirical findings and suggests that LIFUS can preferentially target nociceptive and sensory fibers to enable peripheral therapeutic applications not addressable by electric stimulation. These results open up new opportunities for the development of more selective and effective peripheral neuroprostheses. Our framework can be readily applied to other neural targets to establish application-specific LIFUS protocols.

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