scholarly journals The prevalence of acute erosive-ulcerative gastroduodenal lesions in patients with cardiovascular diseases, taking anticoagulants and antiplatelet agents

Author(s):  
A. A. Poliantsev ◽  
D. V. Frolov ◽  
D. V. Linchenko ◽  
S. N. Karpenko ◽  
A. A. Chernovolenko ◽  
...  

Aims: to draw attention to the lack of recommendations for the prevention and treatment of acute erosive-ulcerative gastroduodenal lesions and their complications associated with the severity of the patient’s condition, the massiveness of antiplatelet and anticoagulant therapy and the degree of risk of bleeding.Materials and methods: a literature review was conducted of domestic and foreign authors on the problem of pathogenesis, clinical manifestations, diagnosis, treatment and prevention of lesions of the upper gastrointestinal tract in cardiovascular diseases.Results: there are no standardized recommendations for the prevention and treatment of OEGP and their complications, taking into account the individual characteristics of the patient, based on evidence.Conclusion: it is necessary to develop a scale that assesses the risk of OEGP and gastrointestinal bleeding in cardiovascular diseases, methods of treatment and prevention of these conditions, taking into account the specific parameters of the patient.

2021 ◽  
pp. 159101992110150
Author(s):  
Robin J Borchert ◽  
Davide Simonato ◽  
Charlotte R Hickman ◽  
Maurizio Fuschi ◽  
Lucie Thibault ◽  
...  

The use of antiplatelets is widespread in clinical practice. However, for neurointerventional procedures, protocols for antiplatelet use are scarce and practice varies between individuals and institutions. This is further complicated by the quantity of antiplatelet agents which differ in route of administration, dosage, onset of action, efficacy and ischemic and hemorrhagic complications. Clarifying the individual characteristics for each antiplatelet agent, and their associated risks, will increasingly become relevant as the practice of mechanical thrombectomy, stenting, coiling and flow diversion procedures grows. The aim of this review is to summarize the existing literature for the use of P2Y12 inhibitors in neurointerventional procedures, examine the quality of the evidence, and highlight areas in need of further research.


2021 ◽  
Vol 21 (3) ◽  
pp. 63-72
Author(s):  
Igor M. Ulyukin ◽  
Nataliya V. Kiseleva ◽  
Vadim V. Rassokhin ◽  
Elena S. Orlova ◽  
Alekcey A. Sechin

AIM: The mission is to assess possible psychosomatic disorders (in particular, stress as a nervous breakdown, an acute temporal phase of a specific disorder, which is manifested primarily by signs of depression and neurosis) in young patients who have had COVID-19, in the course of rehabilitation, to improve medical and psychological support after their discharge from the hospital. MATERIALS AND METHODS: 60 convalescents who have had COVID-19 and had practically been healthy before (men aged 19.87 1.64 years) were examined. The main clinical variants and manifestations of COVID-19 in our study were inapparent infection (II) in 19 cases (31.67%), acute respiratory viral infection (ARVI) in 21 cases (35.0%), pneumonia without respiratory failure (P) in 20 cases (33.33%). These are clinical variants and manifestations of mild-to-moderate of COVID-19 severity. The diagnosis of all clinical variants and manifestations of COVID-19, the patients examination, treatment and discharge from the hospital were carried out in accordance with regulatory documents. The patients were examined 68 month after discharge from the hospital. Psychometric examination of these individuals to separate their clinical manifestations of distress and somatization and manifestations of depression and anxiety was carried out according to the questionnaire The Four-Dimensional Symptom Questionnaire, 4DSQ), developed in 1996 by the Dutch specialists B. Terluin. This questionnaire was translation into Russian and adapted by A.B. Smulevich et al. [2014]. Voluntary informed consent was obtained from each of the patients before their participating the study. RESULTS: Indicators of distress, anxiety, somatization after all the clinical variants and manifestations of COVID-19 have a moderately increased level, which indicates a serious illness that has been suffered, in some cases with an unfavorable outcome. The strongly increased level of depression in our study is probably due to the presence of astheno-neurotic syndrome due to the previous COVID-19 disease. The data on the correlation between the scales of methods indicate the direction of possible psychoprophylactic work with convalescents. CONCLUSIONS: The results of the study showed that young patients without concomitant diseases who have had COVID-19, even with a mild and low-symptom course, may develop psychosomatic consequences such as distress, anxiety, somatization and some others. The reasons, duration, potential risk factors for their development require further study, however, timely developed preventive and therapeutic and diagnostic measures, taking into account the individual characteristics of the patient, can have a positive effect.


2020 ◽  
Vol 75 (3) ◽  
pp. 60-64
Author(s):  
N.F. Aleshina ◽  
◽  
N.V. Piterskaya ◽  
I.V. Starikova ◽  
◽  
...  

52 patients aged 26 to 54 years (39 women and 13 men) with hypersensitivity of the teeth were examined. Taking into account the individual approach to the examination of patients, the dental status was determined, etiological factors, body features, the presence of somatic pathology, clinical manifestations of hypersensitivity of the teeth were determined, with the determination of the degree, prevalence and intensity of hyperesthesia. The study made it possible to make a rational choice of treatment and prevention measures, taking into account individual General and local manifestations of this pathology.


Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 537
Author(s):  
Rachel Hair ◽  
Junichi R. Sakaki ◽  
Ock K. Chun

The percentage of individuals over the age of 60 is projected to reach 22% by 2050; chronic diseases associated with aging can present challenges for these individuals. Anthocyanins and the gut microbiome have each been studied as independent influencers of health. Both these factors have shown to have a positive effect on cardiovascular and bone health in individuals, as well as on the prevention or treatment of certain forms of cancers. Anthocyanins have shown to modulate the composition of the gut microbiome and may have overlapping mechanisms in the prevention and treatment of cardiovascular disease, cancer, neurodegenerative disorders and aging-associated bone loss. These health outcomes are responsible for the hospitalization and deaths of millions of Americans every year and they cost the United States billions of dollars each year to maintain, prevent and treat. Alternative methods of treatment and prevention are desired since conventional methods (surgical and pharmacological methods, physical therapy, etc.) can be costly and have significant side effects; evidence suggests that anthocyanins and the gut microbiome may be potential avenues for this. This review evaluates the findings of existing literature on the role of anthocyanins and the gut microbiome on health and their potential as a natural therapeutic agent or a target organ to provide an alternative to the conventional methods of disease prevention and treatment.


Author(s):  
M. A. Kachkovsky ◽  
I. P. Vvedenskaya ◽  
V. Yu. Vvedensky ◽  
A. A. Supilnikov ◽  
J. V. Ponomareva ◽  
...  

Many questions remain in the diagnosis, treatment, and prevention of dyslipidemia, despite the available clinical recommendations. Among these issues is the cause of cardiovascular diseases, when achieving and maintaining the target values of lipid metabolism. We need to change the existing paradigm. Apolipoproteins as protein components of lipoproteins can significantly more accurately characterize the dyslipidemic status of a patient, since their structure and composition are unique. A personalized strategy for the prevention and treatment of dyslipidemia is possible based on the apolipoprotein profile. At present, new data on the functions of apolipoproteins, their genetic polymorphisms, and molecular preparations for correcting their content and lipid metabolism have been proposed.


2018 ◽  
Vol 17 (6) ◽  
pp. 77-85
Author(s):  
M. D. Smirnova ◽  
I. V. Barinova ◽  
T. V. Fofanova ◽  
Z. N. Blankova ◽  
O. N. Svirida ◽  
...  

One of the causes of high mortality from cardiovascular diseases is the lack of effective measures for the primary and secondary prevention of cardiovascular complications (CCO), due to the difficulty of timely identification risk factors (RF) and individuals with a high individual risk of CCO. This is especially true for patients from low/mean risk. This group is heterogeneous. Often, clinical manifestations of atherosclerosis occur for the first time without “classical” RF. Possible factors that increase the risk of developing cardiovascular diseases and CCO, are: heart rate, increased formation of advanced glycation endproducts, disorders of bone mineral metabolism, thyroid function, low adherence to therapy, psychosocial factors and climatic features. This review is devoted to the analysis of the evidence base of the influence of these “new” CCO RF and the individual patient prognosis.


2021 ◽  
Vol 19 (4) ◽  
Author(s):  
Jacek Meller

Life and health as fundamental matters are major concerns for every human being. To this end, he / she should be assisted by the community in which they live. If the foundation of social life is the personalistic principle, the recognition of the primacy of the dignity of the person, among other values, is constructed on the principles of subsidiarity and solidarity. It is the role of the healthcare institution to create such conditions, in which the safest and the most effective methods of treatment and prevention are available, and the individual can consciously select which of these realises his or her good to the greatest extent, in accordance with the recognised hierarchy of values, the accepted worldview, and life goals. The aim of this article is to analyse the relationship between the community and the individual, in the field of healthcare, under normal conditions and during epidemics. The existence of specific threats may suggest that exceptions to the fundamental rules of social life: autonomy, subsidiarity, and social solidarity, are permissible. However, the recognition of the fundamental value of the dignity of the person, requires the community to apply the same rules as in normal times, although many activities of public institutions are intensified in times of more serious danger.


2020 ◽  
Vol 12 (3-1) ◽  
pp. 134-151
Author(s):  
Svetlana Khmelevskaya ◽  
◽  
Elena Ocheredko ◽  

The subject of the research is the philosophical (ontological, epistemological, philosophical-anthropological and social-philosophical) foundations of personalized medicine, the biomedical foundations of which are methods of therapy and prevention of diseases based on the individual characteristics of the patient. The authors highlight the preventive nature of personalized medicine - to prevent the patient's diseases based on certain diagnostic methods and using a system of preventive measures, as well as its focus on improving the effectiveness of treatment for a specific patient. The value of personalized medicine is that it allows to determine precisely the causes of a particular disease or to assess a person's predisposition to certain diseases, to apply preventive measures to minimize the risks of diseases; to use personalized methods of treatment and correction of the conditions of a particular patient, as well as biomarkers for monitoring the effectiveness of therapy. The philosophical foundations of personalized medicine, on the one hand, contain certain philosophical attitudes related to medicine in general, and on the other hand, reflect specific features determined by new technologies that modern medicine possesses. In particular, the article points to a change in the concept of personalization in connection with the disclosure of its content at the genomic level. The authors emphasize that personalized medicine raises a number of new problems of a philosophical nature: the approach to a person as a set of data about his or her body, the possible increase in social inequality due to the lack of general availability of the results of personalized medicine, and so on. The article substantiates the idea that improving and reducing the cost of sequencing technologies will help make new methods of treating diseases more accessible to the general population. Further personification of medicine will occur due to obtaining more and more objective information about patients, increasing the number of subgroups in the typology of patients, offering them variable methods of treatment, as well as due to the increasing involvement of a patient in the treatment processes, based on a better understanding of his/her “existential presence analytics”.


2018 ◽  
Vol 25 (16) ◽  
pp. 1909-1919 ◽  
Author(s):  
Elisabetta Calamelli ◽  
Paolo Bottau ◽  
Marcello Lanari

Background: Asthma represents a worldwide health problem with a strong morbidity and a major impact on the health care system. Multiple efforts have been made towards the development of new strategies for the prevention and treatment of this disorder. In the light of this the present review of the literature aimed at summarizing the latest advances in prevention and treatment of pediatric asthma with a focus on the most effective options of interventions during the first stages of life. Methods: References were identified by searches of PubMed. Search terms used in the search were “pediatric asthma”, “treatment” and “prevention”. We included only meta-analysis, randomized controlled trials, reviews and systematic review articles pertaining to humans and subjects aged 0-18 years. All the interventions have been classified as “non-pharmacological” and “pharmacological”. Results: Non-pharmacological interventions have been focused in identifying the genetic and environmental factors underlying the pathogenesis of this disease, including the individual genetic susceptibility, the early allergic sensitization, the role of the environmental microbiome and the exposure to infections and to pollutants. Moreover, the optimization of the existing pharmacological strategies and the development of new treatment options have improved markedly the management of this disease, thereby reducing the health care costs and ameliorating the quality of life of patients. Conclusion: Childhood asthma prevention and treatment still represents a worldwide challenge. Future efforts should be aimed at identifying high risk target populations, minimizing the costs of each policy of intervention and increasing adherence to treatment strategies.


Author(s):  
Е.В. Филиппова ◽  
Ю.К. Кондрашова ◽  
Ю.Ш. Тагоев

В статье представлен анализ информации из литературных источников, посвященной изучению хронофармакологии алкоголизма. Для лечения алкоголизма используется комплексный подход, определяющийся тяжестью состояния больного и индивидуальными особенностями симптоматики. В связи со способностью фармакологических соединений вмешиваться в течение ритмических процессов на всех уровнях организации биосистемы хронофармакологический эффект лекарственных средств может быть полезным или нежелательным. Высокой степенью осложнений со стороны сердечно-сосудистой и нервной систем, а также печени и желудочно-кишечного тракта характеризуется хроническая алкогольная интоксикация. Надежного средства патогенетической фармакотерапии алкоголизма до настоящего времени не разработано. При этом лекарственные препараты используют в основном для купирования явлений абстиненции. Одно из первых мест в терапии алкогольного абстинентного синдрома, сопровождающегося тревогой, страхом и беспокойством, занимают депримирующие средства. Однако расширение их применения в Российской Федерации для лечения алкоголизма остается необоснованным. Так как алкоголизм вызывает крайне разнообразные по своим клиническим проявлениям и по степени тяжести психические расстройства, то для их лечения используется широкий спектр психотропных препаратов. Для проведения противогипоксической и детоксифицирующей терапии используются энергокорригирующие средства. Алкогольный абстинентный синдром с преобладанием неврозоподобных и вегетативнососудистых расстройств является показанием к применению препаратов из класса антиоксидантов. Они сочетают в себе свойства транквилизаторов и ноотропов, не оказывая токсического воздействия на сердце и защищая миокард в условиях гипоксии. Однако на данный момент существует дефицит информации об эффективности их применения при алкогольной абстиненции. The article presents an analysis of information from literary sources devoted to the study of the chronopharmacology of alcoholism. For the treatment of alcoholism, an integrated approach is used, which is determined by the severity of the patient's condition and the individual characteristics of the symptoms. Due to the ability of pharmacological compounds to interfere during rhythmic processes at all levels of the organization of the biosystem, the chronopharmacological effect of drugs may be useful or undesirable. Chronic alcohol intoxication is characterized by a high degree of complications from the cardiovascular, nervous systems, liver and gastrointestinal tract. A reliable means of pathogenetic pharmacotherapy of alcoholism has not yet been developed. At the same time, medications are used mainly for the relief of withdrawal symptoms. One of the first places in the treatment of alcohol withdrawal syndrome, accompanied by anxiety, fear and anxiety, is occupied by depressants. However, the expansion of their use in the Russian Federation for the treatment of alcoholism remains unfounded. Since alcoholism causes extremely diverse mental disorders in their clinical manifestations and severity, a wide range of psychotropic drugs is used for their treatment. For antihypoxic and detoxifying therapy, energy-correcting agents are also used. Alcohol withdrawal syndrome with a predominance of neurosis-like and vegetative-vascular disorders is an indication for the use of drugs from the class of antioxidants. They combine the properties of tranquilizers and nootropics, without having a toxic effect on the heart and protecting the myocardium in hypoxia. However, at the moment there is a lack of information about the effectiveness of their use in alcohol withdrawal.


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