Bacterial nanoparticles can deliver proteins, medications, enzymes, and genes to diagnose and cure numerous illnesses
Bacterial nanoparticles can transport proteins, medicines, enzymes, and genes for the detection and treatment of several diseases, including gastrointestinal illnesses, diabetes, cancer, and infections. The key problem of bacteria-derived nanoparticles is the dose-limiting toxicity of bacterial cells. This intrinsic bacterial toxicity hampers further therapeutic use of these nanoparticles, since they contain persistent toxicity even when toxin-encoding is removed. A multi-particle membrane vesicle-based vaccine produced from a Neisseria meningitidis virulent strain was approved for clinical use under the brand name Bexsero. The adaptability of nanoparticles based on bacteria and the utilization of synthetic biotechnologies allows for further research and potential therapeutic uses. Using sophisticated and specialized features of engineering materials can overcome the problems facing bacteria-based medication delivery systems. The creation of genetically and chemically altered gut microorganisms is a potential approach to illness prevention and therapy. While the various preparation processes and arduous separation procedures needed make them unsuitable for large-scale production, they should still be devised.