scholarly journals Moderate alcohol consumption and depressive symptoms: A marginal structural model approach promoting causal inference

2021 ◽  
Author(s):  
Rachel Visontay ◽  
Louise Mewton ◽  
Tim Slade ◽  
Izzuddin M. Aris ◽  
Matthew Sunderland
Keyword(s):  
Depressive Symptoms ◽  
Alcohol Consumption ◽  
Structural Model ◽  
Short Form ◽  
Secondary Analysis ◽  
Moderate Alcohol Consumption ◽  
Marginal Structural Model ◽  
Middle Adulthood ◽  
Linear Contrasts ◽  
Model Approach

Importance: Prevention of depressive symptoms and disorders is a key public health priority but requires an improved understanding of modifiable risk and protective factors. A salient unanswered question in this context is whether the apparent protective effect of alcohol against depression may be causal.Objective: To compare the effects of consistent abstinence, occasional, moderate, and heavy alcohol consumption throughout early-to-middle adulthood on depressive symptoms at age 50.Design: This secondary analysis of the National Longitudinal Survey of Youth (NLSY79) cohort employed a marginal structural model approach in assessing the relationship between alcohol consumption in early-to-middle adulthood (29-37 through 41-49) and depressive symptoms at age 50. Alcohol consumption was based on measurements at 1994, 2002, and 2006, covariates at 1992, 1994, and age 40 (1998-2006), and outcome at age 50 (2008-2016). Setting: The NLSY79 is a nationally representative, population-based cohort study.Participants: 5,667 eligible participants at baseline provided valid data on alcohol consumption, depressive symptoms, and covariates of interest. Exposure: Alcohol consumption was categorised as either abstinence, occasional, moderate, or heavy drinking in 1994, 2002, and 2006.Main Outcome and Measure: Depressive symptoms at age 50 as measured by the Centre for Epidemiological Studies-Depression Scale short form (CES-D-SF).Results: Of the 5,667 eligible participants at baseline, 2,862 [50.50%] were female and the mean age was 30.81 [2.24], with 3,593 participants providing valid outcome data for analysis. Results of linear contrasts from marginal structural models were consistent with a J-shaped relationship, where both consistent occasional (b=-0.84, CI= -1.47, -.11) and consistent moderate (b=-1.08, CI=-1.88, -.20) drinkers had significantly reduced predicted CES-D-SF scores at age 50 compared to consistent abstainers. Consistent heavy drinkers were predicted to have increased depressive symptoms, but this was not statistically significant (b=0.34, CI=-0.62, 1.25). In sex-stratified analyses, results were similar for females and males.Conclusions and Relevance: In this secondary analysis of longitudinal data accounting for time-varying exposure and confounding, consistent low-to-moderate alcohol consumption in early-to-middle adulthood predicted lower depressive symptoms at age 50, compared with those abstaining from alcohol. This work offers preliminary evidence that such protective effects may be causal.

scholarly journals Relationship between alcohol consumption and myocardial infarction among ageing men using a marginal structural model

2011 ◽  
Vol 22 (6) ◽  
pp. 825-830 ◽  
Author(s):  
Jenni Ilomäki ◽  
Anjum Hajat ◽  
Jussi Kauhanen ◽  
Sudhir Kurl ◽  
Jay S. Kaufman ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Alcohol Consumption ◽  
Structural Model ◽  
Marginal Structural Model

scholarly journals Moderate Alcohol Consumption and Depressive Symptoms Among Permanent Supportive Housing Residents

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 527-527
Author(s):  
Esther Holmes ◽  
Scott Walters
Keyword(s):  
Social Support ◽  
Depressive Symptoms ◽  
Alcohol Consumption ◽  
Leisure Activities ◽  
Supportive Housing ◽  
Moderate Alcohol Consumption ◽  
Lifestyle Behaviors ◽  
Permanent Supportive Housing ◽  
Significant Difference ◽  
Patient Health

Abstract Objectives The objective of this analysis was to evaluate the influence of alcohol consumption on depressive symptoms among permanent supportive housing (PSH) residents within the context of other lifestyle factors. Methods A longitudinal analysis was conducted among 420 PSH residents participating in a technology-assisted health coaching program. Three timepoints were included: baseline, six-month, and twelve-month assessment visits. The independent variable was alcohol use, measured by the Timeline Follow-Back (TLFB). The dependent variable was depressive symptoms, measured by the 9-item Patient Health Questionnaire (PHQ-9). Covariates included total vegetable and fruit intake, tobacco use, social support, satisfaction with leisure activities, race, sex, age, and visit. The interaction of social support with the lifestyle behaviors was evaluated. Results Heavy alcohol consumers had greater depressive symptoms compared with moderate alcohol consumers (b = 1.54, P = 0.01). However, there was not a statistically significant difference in depressive symptoms between non-consumers of alcohol and moderate alcohol consumers (b = 0.77, P = 0.19). Social support was not a statistically significant effect modifier. Conclusions Moderate alcohol consumption may reduce the risk of having depressive symptoms among PSH residents. Funding Sources Funding for the program was provided through a Medicaid 1115 Waiver to the State of Texas.

Effect of an in-home, family-inclusive rehabilitation programme on depressive symptoms in veterans with traumatic brain injury and its mediation by activity engagement

2020 ◽  
Vol 27 (11) ◽  
pp. 1-13
Author(s):  
Laraine Winter ◽  
Helene J Moriarty ◽  
Keith M Robinson
Keyword(s):  
Traumatic Brain Injury ◽  
Depressive Symptoms ◽  
Brain Injury ◽  
Short Form ◽  
Secondary Analysis ◽  
Depression Scale ◽  
The United States ◽  
Rehabilitation Programme ◽  
Community Reintegration ◽  
Activity Engagement

Background/Aims Depression, the most common psychiatric sequela of traumatic brain injury in both civilians and veterans, produces serious and wide-ranging problems. Although medication and cognitive behavioural therapy are the most common treatments, some rehabilitation approaches designed to enhance functioning and/or community reintegration may decrease depression by facilitating active engagement in life – the key component of some depression therapies. The present secondary analysis of a community reintegration-focused rehabilitation programme for veterans with traumatic brain injury posed two questions: Did the programme affect depressive symptoms? If so, was this effect mediated by engagement in activities? Methods A secondary analysis was undertaken of an intervention study of 83 former members of the United States Armed Forces (veterans) with traumatic brain injury, who were interviewed in their homes. Depressive symptoms were assessed using the short-form Centre for Epidemiological Studies-Depression Scale, activity engagement using an 8-item subscale derived from the Community Reintegration of Injured Service Members Scale, and physical and emotional functioning using the SF-36V. Sociodemographic, medical and military characteristics were elicited during the first interview, and medical and military characteristics were identified through a medical chart review. Results Depressive symptoms significantly decreased among the veterans in the treatment group. That effect was mediated by activity engagement. Thus, the intervention's impact on depressive symptoms was attributable to the increased activity that it produced. Conclusions Research on rehabilitation that enhances engagement in activities should examine its possible benefits for improving mood.

Symptoms of Alcohol Dependence Predict Suicide Ideation Among Alaskan Undergraduates

Crisis ◽  
2016 ◽  
Vol 37 (3) ◽  
pp. 232-235 ◽  
Author(s):  
Christopher R. DeCou ◽  
Monica C. Skewes
Keyword(s):  
Depressive Symptoms ◽  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Suicide Ideation ◽  
Alcohol Problems ◽  
Future Research ◽  
Causal Mechanism ◽  
Students At Risk ◽  
The Relationship ◽  
Alcohol Related Problems

Abstract. Background: Previous research has demonstrated an association between alcohol-related problems and suicidal ideation (SI). Aims: The present study evaluated, simultaneously, alcohol consequences and symptoms of alcohol dependence as predictors of SI after adjusting for depressive symptoms and alcohol consumption. Method: A sample of 298 Alaskan undergraduates completed survey measures, including the Young Adult Alcohol Consequences Questionnaire, the Short Alcohol Dependence Data Questionnaire, and the Beck Depression Inventory – II. The association between alcohol problems and SI status was evaluated using sequential logistic regression. Results: Symptoms of alcohol dependence (OR = 1.88, p < .05), but not alcohol-related consequences (OR = 1.01, p = .95), emerged as an independent predictor of SI status above and beyond depressive symptoms (OR = 2.39, p < .001) and alcohol consumption (OR = 1.08, p = .39). Conclusion: Alcohol dependence symptoms represented a unique risk for SI relative to alcohol-related consequences and alcohol consumption. Future research should examine the causal mechanism behind the relationship between alcohol dependence and suicidality among university students. Assessing the presence of dependence symptoms may improve the accuracy of identifying students at risk of SI.

Effects of Moderate Alcohol Consumption on Platelet Function, Tissue-Type Plasminogen Activator and Plasminogen Activator Inhibitor

1990 ◽  
Vol 63 (03) ◽  
pp. 345-348 ◽  
Author(s):  
J Veenastra ◽  
C Kluft ◽  
Th Ockhuizen ◽  
H v d Pol ◽  
M Wedel ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Plasminogen Activator ◽  
Platelet Function ◽  
Plasminogen Activator Inhibitor ◽  
Tissue Type ◽  
Moderate Alcohol Consumption ◽  
Tissue Type Plasminogen Activator ◽  
Postprandial Phase ◽  
Type Plasminogen Activator ◽  
Activator Inhibitor

SummaryShort-term effects of moderate alcohol consumption on platelet function, tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) were studied in two age groups of volunteers (20–30 and 45–55 years), each consisting of eight healthy males. The alcohol (30 g in red port and wine) was consumed during a standard dinner. Two blood samples were drawn: one in the postprandial phase, and one the next morning after fasting overnight. Alcohol consumption tended to increase platelet aggregation and production of hydroxy fatty acids, reduced plasma t-PA activity and increased PAI activity in the postprandial phase. After the overnight fast the effects on t-PA and PAI had disappeared whereas at that time alcohol consumption tended to decrease platelet function. The effects of alcohol on t-PA and PAI activity appeared mainly in the older age group, whereas the t-PA activity in this group was already much lower, irrespective of alcohol consumption.

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