Adrenergic storm-induced Warburg effect in COVID-19: A hypothesis.
Keyword(s):
At present, there is no treatment option available for COVID-19 condition and most importantly the underlying pathophysiology in COVID-19 is not known. No theory at present explains all the clinical features in COVID-19. In this article, I had proposed a hypothesis that explains the underlying pathophysiology in COVID-19 and based on it proposed treatment options for COVID-19. I propose that the adrenergic storm-induced Warburg effect (aerobic glycolysis) may be the underlying mechanism in the COVID-19 condition. I propose alpha1 adrenergic blockers in the early phase and beta-adrenergic blockers in the late phase of COVID-19 to inhibit the adrenergic storm and reverse the Warburg effect in COVID-19 condition.
2018 ◽
Vol 18
(6)
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pp. 454-466
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Aerobic Glycolysis and the Warburg Effect. An Unexplored Realm in the Search for Fibrosis Therapies?
2015 ◽
Vol 192
(12)
◽
pp. 1407-1409
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Keyword(s):