scholarly journals Ozonetherapy vs SARS-COV-2 in gut: the fountainhead

2020 ◽  
Author(s):  
Giovanni Tommaso Ranaldi ◽  
Emanuele Rocco Villani ◽  
Laura Franza ◽  
Giulia Motola
Keyword(s):  
Antioxidant Activity ◽  
Microvascular Complications ◽  
Clinical Manifestations ◽  
Severe Respiratory Failure ◽  
Cytokine Storm ◽  
Clinical Observations ◽  
Wide Range ◽  
Obvious Benefit ◽  
Life Threatening ◽  
Medical Ozone

COVID-19 is the disease caused by the new coronavirus SARS-CoV-2 and is characterized by clinical manifestations ranging from mild, flu-like symptoms, to severe respiratory failure and multi-organ failure. Patients with more severe symptoms may require intensive care treatments and face a high risk of mortality.COVID 19 is characterized by an abnormal inflammatory response similar to a cytokine storm, which is associated with endothelial dysfunction and microvascular complications. To date, no specific treatments are available for COVID-19 and its potentially life-threatening complications.Numerous experimental and clinical observations have suggested that the gut microbiota plays a key role in sepsis and ARDS pathogenesis. The incidence of diarrhea in COVID-19 patients and the high mortality rate in elderly patients, considered together, indicate a possible involvement of the intestine-lung axis in COVID-19 with association of dysbiosis.Ozonetherapy is the administration of a mixture of ozone and oxygen, or Medical Ozone (MO), which produces a series of benefits capable of counteracting a wide range of pathologies, in use for over a century as an unconventional medicine practice.MO is fundamental to inhibit the activation of the inflammatory reaction and to obtain an antioxidant activity both in the tissue and in the blood. Oxidative ozone preconditioning causes an increase in SOD, GSH-Px values.MO, using large auto-hemo-infusion or rectal insufflation technique or ozonized water, could help oxygenate the tissues better, decrease gut inflammation and regulate immune response, help slow down viral growth, regulate circulation and avoid or slow down vascular hypertrophy and consequent hyperemia , especially in the early stages, with obvious benefit at microbiome level.

scholarly journals Devils and Angels: Ozonetherapy for microcirculation in covid-19

2020 ◽  
Author(s):  
Giovanni Tommaso Ranaldi ◽  
Emanuele Rocco Villani ◽  
Laura Franza ◽  
Giulia Motola
Keyword(s):  
Lung Inflammation ◽  
Microvascular Complications ◽  
Clinical Manifestations ◽  
Severe Respiratory Failure ◽  
Ozone Therapy ◽  
Risk Of Mortality ◽  
Wide Range ◽  
Life Threatening ◽  
Medical Ozone ◽  
Infusion Technique

COVID-19 is the respiratory disease caused by the new coronavirus SARS-CoV-2 and is characterized by clinical manifestations ranging from mild, flu-like symptoms, to severe respiratory failure and multi-organ failure. Patients with more severe symptoms may require intensive care treatments and have a high risk of mortality. COVID 19 is characterized by an abnormal inflammatory response similar to a cytokine storm, which is associated with endothelial dysfunction and microvascular complications. To date, no specific treatments are available for COVID-19 and its potentially life-threatening complications.Ozone therapy is the administration of a mixture of ozone and oxygen, or Medical Ozone (MO), which produces a series of benefits capable of counteracting a wide range of pathologies, in use for over a century as an unconventional medicine practice.The use of Ozone therapy with the large auto-hemo-infusion technique could help oxygenate the tissues better, decrease lung inflammation and regulate the immune response, help slow down viral growth, regulate lung circulation and avoid or slow down vascular hypertrophy and consequent hyperemia, especially in the early stages

scholarly journals Ozonetherapy: a multirole weapon, topical pathway against SARS-COV-2

2020 ◽  
Author(s):  
Giovanni Tommaso Ranaldi ◽  
Emanuele Rocco Villani ◽  
Laura Franza ◽  
Giulia Motola
Keyword(s):  
Immune Response ◽  
Intensive Care ◽  
Viral Load ◽  
Microvascular Complications ◽  
Clinical Manifestations ◽  
Innate Immune ◽  
Cytokine Storm ◽  
Risk Of Mortality ◽  
Wide Range ◽  
Life Threatening

COVID-19 is the respiratory disease caused by the new coronavirus SARS-CoV-2 and is characterized by clinical manifestations ranging from mild, flu-like symptoms to severe respiratory and multi-organ failure. Patients with more severe symptoms may require intensive care treatments and face a high risk of mortality. COVID 19 is characterized by an abnormal inflammatory response similar to a cytokine storm, which is associated with endothelial dysfunction and microvascular complications. To date, no specific treatments are available for COVID-19 and its potentially life-threatening complications.Ozonetherapy is the administration of a mixture of ozone and oxygen (MO), which produces a series of benefits capable of counteracting a wide range of pathologies, in use for over a century as an unconventional medicine practice.Ozonetherapy using the techniques of small self-emo-infusion, and the topical application of ozonated oils or irrigation with ozonated water at the nasal level, could help to enhance the innate immune response at the level of the entrance ports in order to decrease the viral load and slow viral growth, especially in the early stages. In fact, recent studies show that nasal transport is likely to be a key feature of transmission, and drugs / vaccines administered intranasally could be highly effective in limiting spread.

scholarly journals Ankle edema after administration of selective serotonin reuptake inhibitors

2018 ◽  
Vol 10 (1) ◽  
pp. 25-26
Author(s):  
Konstantinos Kontoangelos ◽  
Marina Ecomomou ◽  
Charalambos Papageorgiou
Keyword(s):  
Psychotropic Medication ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Clinical Manifestations ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Drug Induced ◽  
Skin Reactions ◽  
Wide Range ◽  
Life Threatening

Clinical manifestations of drug-induced skin reactions include a wide range of symptoms, from mild drug-induced exanthemas to dangerous and life-threatening generalized systematic reactions. Drug-induced skin reactions to psychotropic medication are usually associated with antiepileptic drugs. However, a significant role can be assigned to selective serotonin reuptake inhibitors. We report a case of a female patient, who after approximately one month therapy with escitalopram developed a bilateral ankle edema, which resolved completely within the first week following its discontinuation. Although serious complications are rare, clinicians should be aware of severe skin complications in patients treated with antidepressants, which necessitate careful clinical monitoring and management. Individualization of pharmacotherapy is crucial, together with regular evaluation of safety and tolerance of the treatment.

scholarly journals Computed tomography angiography findings of abdominal aortic disease: A review of emergencies

2020 ◽  
Vol 73 (11-12) ◽  
pp. 393-400
Author(s):  
Mirela Jukovic ◽  
Aleksandra Mijatovic ◽  
Ivana Stojic ◽  
Ljiljana Drazetin ◽  
Maja Stankov ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Abdominal Aorta ◽  
Computed Tomography Angiography ◽  
Clinical Manifestations ◽  
Aortic Disease ◽  
Occlusive Disease ◽  
Tunica Media ◽  
Abdominal Aortic ◽  
Wide Range ◽  
Life Threatening

Introduction. The aorta is a major blood vessel that supplies all segments of the human body. Acute aortic syndrome is a term that implies a life-threatening aortic disease. Due to the speed of examination and widespread availability, computed tomography angiography is a front-line diagnostic modality for emergencies and diseases of the abdominal aorta. The aim of this study was to provide a wide range of potentially life-threatening abnormalities of the abdominal aorta in daily clinical and radiological practice through a series of computed tomography angiography images and three-dimensional virtual reconstruction. Abdominal aortic aneurysm is defined as a 50% increase in diameter more than the normal arterial diameter. One of the most important complications of an aneurysm is a rupture that can be acute or chronic, presenting with various clinical manifestations. Aortic dissections are caused by abnormality of the tunica media layer, forming an intimal-medial flap and two types of lumen. A penetrating aortic ulcer may erode through the internal elastic lamina of the aortic wall and allow formation of hematoma within the tunica media. Occlusive disease of the abdominal aorta may refer to the late stage of chronic aortoiliac occlusive disease, whereas the acute and/or subacute form occurs due to sudden thrombosis or occlusion. Conclusion. The recognition of specific radiological signs of abdominal aortic disease using computed tomography angiography contributes to optimal treatment of patients and reduces mortality.

scholarly journals COVID-19 DIAGNOSTICS: CURRENT STATE OF THE PROBLEM AND PROSPECTS IN THE BRANCH

2020 ◽  
Vol 10 (2) ◽  
pp. 69-77
Author(s):  
A. A. Gorbunov ◽  
L. E. Sorokina ◽  
D. V. Chegodar ◽  
A. V. Kubyshkin ◽  
I. I. Fomochkina
Keyword(s):  
Distress Syndrome ◽  
Viral Pathogenesis ◽  
Diagnostic Methods ◽  
Severe Respiratory Failure ◽  
Cytokine Storm ◽  
Rt Pcr ◽  
Current State ◽  
Wide Range ◽  
The World ◽  
Coronavirus Infection

SARS-CoV-2 is a new representative of the world of virology related to coronaviruses and can cause a wide range of diseases of the respiratory system: from colds to acute respiratory distress-syndrome with severe respiratory failure. The pathogenesis of a new coronavirus infection (COVID-19) is associated with the ability of SARS-CoV-2 to bind to ACE receptors and subsequently activate IL-6, the main stimulator of the “cytokine storm”. Due to such features of the viral pathogenesis, early and accurate detection of active forms, as well as virus carriage are needed. In review, the whole spectrum of the main diagnostic methods is represented, with a comparison of the effectiveness and con- ditional indication of COVID-19: from the currently used methods (RT-PCR, ELISA) to potentially possible (OT-LAMP, CRISPR), as well as those still under development (chemiluminescence).

Hereditary afibrinogenemia: A literature review and clinical observations

2016 ◽  
Vol 88 (12) ◽  
pp. 120-125
Author(s):  
E V Yakovleva ◽  
V L Surin ◽  
D S Selivanova ◽  
A M Sergeeva ◽  
M V Gonсharova ◽  
...  
Keyword(s):  
Literature Review ◽  
Clinical Manifestations ◽  
Plasma Fibrinogen ◽  
Clinical Phenotypes ◽  
Consanguineous Marriages ◽  
Clinical Observations ◽  
Genealogical Analysis ◽  
Life Threatening ◽  
Homozygous Mutations

Afibrinogenemia is a rare congenital coagulopathy that leads to life-threatening bleeding. In afibrinogenemia, plasma fibrinogen levels are less than 0.1 g/L. The clinical manifestations of the disease can be both bleeding and thromboses of different localizations, which is determined by the multifunctional role of fibrinogen in hemostasis. The described cases demonstrate different clinical phenotypes of the disease. In both cases the diagnosis was confirmed by genetic examinations that revealed homozygous mutations in the fibrinogen A genes. The nature of the mutations assumes consanguineous marriages, as confirmed by the results of a genealogical analysis. Fibrinogen preparations are promising in treating afibrinogenemia in Russia.

scholarly journals ECMO Rescues Patients With Acute Respiratory Failure Related to GPA

2021 ◽  
Vol 8 ◽  
Author(s):  
Rongjun Wan ◽  
Wenzhe Yang ◽  
Xinhua Ma ◽  
Wei Yang ◽  
Pinhua Pan ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Granulomatosis With Polyangiitis ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Systemic Involvement ◽  
Online Databases ◽  
Appropriate Treatment ◽  
Wide Range ◽  
Life Threatening

Granulomatosis with polyangiitis (GPA) is a subtype of anti-neutrophil cytoplasmic antibody-associated vasculitis with a wide range of clinical symptoms related to the systemic involvement of small blood vessels. The respiratory system is one of the most frequently involved, and life-threatening acute respiratory failure could occur due to diffusive alveolar hemorrhage and tracheal stenosis. When maximum mechanical ventilation is unable to maintain oxygenation, extracorporeal membrane oxygenation (ECMO) should be considered as the final respiratory supportive method, if available. Here we present a 32-year-old male patient with acute respiratory failure (ARF) related to GPA, who was rescued by winning time for accurate diagnosis and appropriate treatment. Additionally, we reviewed more than 60 GPA-related ARF cases on multiple online databases, summarized the clinical manifestations of these patients, and concluded that ECMO plays an important role in further respiratory support for ARF patients with GPA and assists in accurate and timely diagnosis and appropriate treatment, thus helping them recuperate.

scholarly journals Meningococcal infection in modern conditions: clinical, microbiological and preventive aspects

2020 ◽  
Vol 11 (3) ◽  
pp. 81-92
Author(s):  
Кsenija V. Markova ◽  
Natalia V. Skripchenko ◽  
Yuriy V. Lobzin ◽  
Vadim E. Karev ◽  
Alla A. Vilnits ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Meningococcal Infection ◽  
Social Significance ◽  
Genetic Characteristics ◽  
Age Related ◽  
Wide Range ◽  
Atypical Manifestations ◽  
Analytical Review ◽  
Life Threatening ◽  
Epidemiological Characteristics

The problem of meningococcal infection remains relevant due to the high epidemiological and social significance throughout the world, the unpredictability of the course, a wide range of clinical manifestations (from asymptomatic carriage to extremely severe generalized forms) with a high risk of life-threatening conditions and deaths, and a significant incidence of disability after past illness (loss of limbs, deafness, mental inferiority, and more). The changing serogroup landscape of meningococcal infection with an increase in the incidence of diseases caused by Neisseria meningitidis serogroup W, Y and others is noteworthy. The article presents an analytical review of literature and reflects current clinical, epidemiological, diagnostic and preventive trends in the Russian Federation and abroad. The review focuses on the epidemiological features of meningococcal infection, depending on the serogroup affiliation of meningococcus, the variety of clinical manifestations of the generalized form of meningococcal infection, including atypical manifestations, age-related features, depending on the serogroup of the pathogen. New diagnostic approaches and the possibilities of specific prophylaxis are highlighted. Attention is focused on the importance of monitoring the clinical and epidemiological characteristics of meningococcal infection depending on the genetic characteristics of the pathogen, and the need for further in-depth studies of this problem.

scholarly journals Clinical cases of meningococcal infection caused by Neisseria meningitidis serogroup W

2019 ◽  
Vol 64 (5) ◽  
pp. 114-122
Author(s):  
N. V. Skripchenko ◽  
V. E. Karev ◽  
K. V. Markova ◽  
A. A. Vilnits ◽  
N. F. Pulman
Keyword(s):  
Neisseria Meningitidis ◽  
Fatal Outcome ◽  
Clinical Manifestations ◽  
Meningococcal Infection ◽  
Hemorrhagic Infarction ◽  
Heart Damage ◽  
Clinical Observations ◽  
Wide Range ◽  
Significant Disease ◽  
The Brain

Meningococcal infection remains a socially significant disease due to a wide range of clinical manifestations, severe course with high mortality, reaching 40-80% for certain forms. In recent years we observe a change in the serogroup picture of meningococcal infection, in particular, an increase in the proportion of meningococcal serogroup W, characterized by polymorphism of clinical manifestations. The authors present two their own clinical observations of a generalized form of meningococcal infection with a severe course in adolescents caused by Neisseria meningitidis of W serogroup with fatal outcome. They describe the peculiarities of the cases, namely, inconsistency of the clinical picture at the beginning of the disease and post-mortem changes. The article describes heart damage in the form of focal purulent septic myocarditis and purulent foci of destruction in the brain stem, hemorrhagic infarction of the choroid plexus with hemotamponade of the lateral ventricles of the brain, the predominance of septicopia over septicemia. The revealed changes are likely to reflect clinical and morphological features of meningococcal infection caused by N. meningitidis of serogroup W.

scholarly journals The modern view of congenital cytomegalovirus infection: clinical observations

2020 ◽  
Vol 19 (4) ◽  
pp. 58-63
Author(s):  
N. V. Kholodnova ◽  
L. N. Mazankova ◽  
A. A. Volter ◽  
I. E. Turina ◽  
A. L. Rossina ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Modern View ◽  
Clinical Observations ◽  
Wide Range ◽  
Newborn Child ◽  
Intrauterine Infections

Тhis work is a continuation of the literature review «The modern view of congenital cytomegalovirus infection» and is devoted to the clinical cases. Particular attention is paid to the severity of congenital cytomegalovirus infection (CCMVI), as well as the its clinical variability, including developmental anomalies. The variety of clinical forms requires a wide range of examinations to identify all this infection manifestations in a newborn child and children in the first months of life, as well as the doctors alertness regarding the timely diagnosis of intrauterine infections based on the existing clinical features. The presented cases demonstrate the CCMVI clinical manifestations: the «classical» generalized manifest form, with a specific clinical, laboratory and instrumental findings, the severe generalized CCMVI with kidney congenital malformation and postnatal development of congenital cataract.

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