scholarly journals Systematically investigating the role of context on effect replicability in reinstatement of fear in humans

2021 ◽  
Author(s):  
Tina B Lonsdorf ◽  
Rachel Sjouwerman
Keyword(s):  
Human Subjects ◽  
Contextual Information ◽  
Response Patterns ◽  
Control Groups ◽  
Conditioning Paradigm ◽  
Psychophysiological Measures ◽  
Return Of Fear ◽  
And Control ◽  
Conditioned Responding

Context is crucial in guiding behavior in an ever changing world and contextual information plays a crucial role in associative learning processes. For instance, the return of fear (RoF) after reinstatement (i.e, re-exposure the unconditioned stimulus (US) after successful fear extinction) is context dependent and is suggested to occur only when either extinction and test, or extinction and reinstatement context are identical, not when US re-exposure (i.e., reinstatement) occurs in a context different from extinction and test. Human adaptions of reinstatement paradigms have resulted in mixed findings: CS specific as well as unspecific RoF or unexpected “reinstated” conditioned responding in no reinstatement US control groups. Here, we systematically investigate the role of context on reinstatement-induced RoF in a human differential fear conditioning paradigm using subjective and psychophysiological measures in a large sample (N=212) including reinstatement and control groups. Overall, response patterns in reinstatement-groups mirrored results from single-cue rodent work. Yet, only generalized, not differential RoF was observed. Remarkably, depending on outcome measure RoF was also observed under identical experimental context conditions without US-re-exposure, underlining effects of contextual change beyond the reinstatement-US and challenging reinstatement research in human subjects and what we think we know about the mechanisms behind the reinstatement-phenomenon.

scholarly journals DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk

2021 ◽  
Vol 18 (14) ◽  
pp. 7486
Author(s):  
Mirosław Śnit ◽  
Maciej Misiołek ◽  
Wojciech Ścierski ◽  
Anna Koniewska ◽  
Grażyna Stryjewska-Makuch ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Laryngeal Cancer ◽  
Basic Research ◽  
Control Groups ◽  
Allele Distribution ◽  
Study Results ◽  
Risk Patients ◽  
And Control ◽  
The Relationship

AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk. PATIENTS AND METHODS: This study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer. RESULTS: The results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically significant differences in allele distribution of rs6620138 DIAPH2 and rs9901806 HIC1 in the case and control groups subgroups. CONCLUSIONS: This study results suggested that genetic variation of rs6620138 DIAPH2 polymorphism is related to the susceptibility to laryngeal cancer. Our results provide a basis to begin basic research on the role of DIAPH2 gene in the pathogenesis of laryngeal cancer.

THE ROLE OF WHATSAPP IN TEACHING VOCABULARY TO THE STAFFS OF UMBUL PONGGOK KLATEN

2021 ◽  
Vol 5 (2) ◽  
pp. 773
Author(s):  
Lia Ardiana Safitri
Keyword(s):  
Experimental Design ◽  
Foreign Language ◽  
Random Sampling ◽  
Sampling Procedure ◽  
Assessment Instrument ◽  
Vocabulary Test ◽  
Control Groups ◽  
Post Test ◽  
And Control

This study was conducted with the aim of knowing the significant role of WhatsApp in teaching vocabulary, especially staff learning achievement which was limited to vocabulary achievement as measured by a vocabulary test at Umbul Ponggok Klaten. Participants in this study amounted to 30 people consisting of 15 men and 15 women. All participants will learn English as a foreign language using WhatsApp to learn new vocabulary items via their mobile, tablet or laptop. Participants' English level will be measured. Random sampling procedure was carried out. To carry out the research, a true experimental design was used. The participants were assigned to two experimental and control groups. The assessment instrument in this study used a pre-test and post-test. The results showed that the use of the WhatsApp application in teaching vocabulary to the Umbul Ponggok Klaten staff was able to improve the achievement of new English vocabulary mastery of the Umbul Ponggok Klaten staff which was getting better.

scholarly journals Clinical Impact of Estradiol/Testosterone Ratio in Patients with Acute Ischemic Stroke

2020 ◽  
Author(s):  
Jung-Won Choi ◽  
In Woo Ryoo ◽  
Jun Yeong Hong ◽  
Kyung-Yul Lee ◽  
Hyo Suk Nam ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Sex Hormones ◽  
Control Group ◽  
Control Groups ◽  
Sexual Hormones ◽  
Stroke Group ◽  
Male Patients ◽  
And Control

Abstract Background: Sex hormones may be associated with a higher incidence of ischemic stroke or stroke-related events. In observational studies, lower testosterone concentrations are associated with infirmity, vascular disease, and adverse cardiovascular risk factors. Currently, female sexual hormones are considered neuroprotective agents. The purpose of this study was to assess the role of sex hormones and the ratio of estradiol/testosterone (E/T) in patients with acute ischemic stroke (AIS).Methods: Between January 2011 and December 2016, 146 male patients with AIS and 152 age- and sex-matched control subjects were included in this study. Sex hormones, including estradiol, progesterone, and testosterone, were evaluated in the AIS patient and control groups. We analyzed the clinical and physiological levels of sex hormones and hormone ratios in these patients.Results: The E/T ratio was significantly elevated among patients in the stroke group compared to those in the control group (P = 0.001). Categorization of data into tertiles revealed that patients with the highest E/T ratio were more likely to have AIS [odds ratio (OR) 3.084; 95% Confidence interval (CI): 1.616-5.886; P < 0.001) compared with those in the first tertile. The E/T ratio was also an independent unfavorable outcome predictor with an adjusted OR of 1.167 (95% CI: 1.053-1.294; P = 0.003).Conclusions: These findings support the hypothesis that increased estradiol and reduced testosterone levels are associated with AIS in men.

Investigating ADAMTS7 and ADAMTS12 levels in prediabetic and Type 2 diabetic patients

2021 ◽  
Author(s):  
Mercan Taştemur ◽  
Selvihan Beysel ◽  
Sema Hepşen ◽  
Sanem Öztekin ◽  
Erman Çakal ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Diabetic Patients ◽  
Control Groups ◽  
Type 2 Diabetic Patients ◽  
Human Enzyme ◽  
Significant Difference ◽  
And Control ◽  
Type 2 Diabetic

Background: This study aims to investigate the role of ADAMTS7 and ADAMTS12 on atherosclerosis and inflammation in prediabetic and diabetic patients. Patients & methods: Serum ADAMTS7 and ADAMTS12 levels were compared with the atherosclerotic and inflammatory markers in diabetic (n = 65, female 30.9%, mean age = 53 years), prediabetic (n = 55, female 36.6%, mean age = 49 years) and control groups (n = 55, females 32.5%, mean age = 49 years). Serum ADAMTS levels were determined by a human enzyme-liked immunoassay. Results: In terms of ADAMTS7, there was no significant difference between diabetic, prediabetic and control groups (50.93, 44.34, 59.07, respectively; p > 0.05). ADAMTS12 is lower in diabetics (p < 0.05), whereas it is similar in prediabetics and controls (14.53, 20.76, 25.05, respectively; p > 0.05). ADAMTS7 and ADAMTS12 levels did not differ in diabetic nephropathy, retinopathy and neuropathy (p > 0.05). Conclusion: While ADAMTS12 was significantly lower in diabetics and prediabetics, ADAMTS7 and ADAMTS12 were not related to diabetic complications (nephropathy, retinopathy and neuropathy).

Appropriate Control Groups in Feminist Research

1981 ◽  
Vol 5 (4) ◽  
pp. 637-644 ◽  
Author(s):  
Mary Brown Parlee
Keyword(s):  
Causal Relationship ◽  
Methodological Issue ◽  
Psychological Research ◽  
Feminist Research ◽  
Control Groups ◽  
Psychology Of Women ◽  
Theoretical Perspectives ◽  
And Control ◽  
Theoretical Issues

Control groups in psychological research reveal the outlines of the investigator's theoretical framework. They identify variables which are assumed to affect the causal relationship between independent and dependent variable and, by implication, those which are not. This role of control groups is implicitly denied when they are discussed simply as a methodological issue. Feminist psychologists can use the inevitable interpenetration of methodological and theoretical issues to promote new theoretical perspectives under the guise of sounder methodology. One result may be to move the psychology of women outside (beyond-?) a conceptualization of science in which the notions of experimentation and control are central.

Role of Anticipation in Schizophrenia-Related Pursuit Initiation Deficits

2006 ◽  
Vol 95 (2) ◽  
pp. 593-601 ◽  
Author(s):  
Matthew T. Avila ◽  
L. Elliot Hong ◽  
Amanda Moates ◽  
Kathleen A. Turano ◽  
Gunvant K. Thaker
Keyword(s):  
Target Motion ◽  
Motion Information ◽  
Control Groups ◽  
Pursuit Initiation ◽  
Information Studies ◽  
Pursuit System ◽  
Velocity Information ◽  
And Control ◽  
Eye Velocity

Schizophrenia patients exhibit several smooth pursuit abnormalities including poor pursuit initiation. Velocity discrimination is also impaired and is correlated with pursuit initiation performance—suggesting that pursuit deficits are related to impairments in processing velocity information. Studies suggest that pursuit initiation is influenced by prior target motion information and/or expectations and that this is likely caused by expectation-based changes in the perceptual inputs to the pursuit system. We examined whether poor pursuit initiation in schizophrenia results from inaccurate encoding of immediate velocity signals, or whether these deficits reflect a failure to use prior target motion information to “optimize” the response. Twenty-eight patients and 24 controls performed an adapted version of a “remembered pursuit task.” Trials consisted of a series of target motions, the first of which occurred unexpectedly, followed by four to seven identical targets each preceded by an auditory cue and a “catch target” in which a cue was given followed by target extinction. Initiation eye velocity in response to unexpected, first targets was similar in the patient and control groups. In contrast, patients showed lower eye velocity in response to repeated, cued targets compared with controls. Patients also showed reduced eye velocity in response to catch targets. Reduction in pursuit latency across repeated targets was less robust in patients. Results suggest that processing of immediate velocity information is unaffected in schizophrenia and that pursuit initiation deficits reflect an inability to accurately generate, store, and/or access “remembered” velocity signals.

scholarly journals THE ROLE OF ANTIBIOTIC PROPHYLAXIS IN PREVENTION OF INTESTINAL STOMAS CLOSURE

2016 ◽  
pp. 25-31
Author(s):  
Y. A. Shelygin ◽  
S. I. Achkasov ◽  
D. V. Piliev ◽  
O. I. Sushkov
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prophylactic Antibiotics ◽  
Control Group ◽  
Control Groups ◽  
Single Intravenous Injection ◽  
Group I ◽  
Intestinal Stoma ◽  
Operation Results ◽  
And Control

AIM. To evaluate the effectiveness of antibiotic prophylaxis in closure of preventive intestinal stomas. MATERIALS AND METHODS. In a main (I-first) group included 99 patients who did not undergo antibiotic prophylaxis (ABP). In the control (II-second) group were 96 patients who underwent ABP by a single intravenous injection of 1,2 g of amoxycillin / clavulanic acid in 30 minutes before the operation. RESULTS. The overall incidence of complications in the main and control groups was 23 (23,3 %) and 27 (27,9 %), respectively (p=0,53). Among them, the surgical site infection (SSI) was the first place in the frequency of complications: in group I in 12 (12,2 %) in group II in 11 (11,4 %) patients (p=0,35 ). Postoperative diarrhea with frequency of stools 5 or more times per day in second place infrequency, but has evolved into two less in the main than in the control group - in 4 (4,0 %), and 8 (8.3 %) patients, respectively (p=0,212). Febrile fever was detected more frequently in the first group than in the second - 6 (6,1 %) and 1 (1,0 %) cases, respectively (p=0,06). Other complications were the paresis of gastrointestinal tract (p=0,76), bleeding from the formed anastomosis area (p=0,149), pneumothorax (p=0,324), cystitis (p=0,309) and lobar pneumonia (p=0,309). There were no statistically significant complications associated with one of two groups. CONCLUSION. The results of the study not prove the effectiveness of the ABP in patients undergoing closure preventive intestinal stoma. This does not allow us to recommend its routine use. The question of prophylactic antibiotics should be taken individually, considering all the possible risks.

scholarly journals Induction of the Mice Model Regarding the Endometriosis and Assessment of Antioxidant Treatment Effectiveness: An Experimental Protocol

2020 ◽  
Vol 8 (2) ◽  
pp. 133-141
Author(s):  
Hayedeh Hoorsan ◽  
Masoumeh Simbar ◽  
Fahimeh Ramezani Tehrani ◽  
Fardin Fathi ◽  
Nariman Mosaffa ◽  
...  
Keyword(s):  
Experimental Study ◽  
Vitamin C ◽  
First Generation ◽  
Treatment Effectiveness ◽  
Second Phase ◽  
Mice Model ◽  
Control Groups ◽  
Ovarian Endometriosis ◽  
And Control

Objectives: Over the past twenty years, the role of inflammatory, immunologic, and stress oxidative factors in the pathogenesis of endometriosis has been emphasized in the literature. Endometrial induced lesions in the surgical endometriosis model of mice are similar to those observed in women. Therefore, the present study evaluated the effects of vitamin C treatment on the endometriosis mice model. More precisely, it aimed to induce an optimum model of endometriosis using both peritoneal and ovarian approaches and to compare the histological and fertility changes in the first-generation infants of endometriosis induced, sham, and control groups. Finally, the study assessed the influence of vitamin C administration treatment on the induced endometriosis mice model and its first-generation infants. Methods: This experimental study was done in three phases. In the first phase, 32 mice were randomly divided into four groups receiving induced endometriosis through peritoneal approach, induced endometriosis through an ovarian approach, as well as sham and control groups. The histological and fertility characteristics of the first generation of ovarian endometriosis, sham, and control groups were compared in the second phase. Then, the histological and fertility characteristics of those endometriosis induced models receiving vitamin C were compared with the controls, and the first generation of these groups was compared as well. Results: This experimental study began in April 2017 and will be finished in 2020. Conclusions: The results of this study improve our knowledge about the mechanisms involved in endometriosis progressions. The results further provide a comprehensive animal model for further research and assess the therapeutic role of antioxidants.

scholarly journals Defects in the interventricular and atrial septa: the contribution of the transcription factor GATA6 and the signal molecule NOTCH1

2020 ◽  
pp. 64-70
Author(s):  
А.В. Цепокина ◽  
А.В. Понасенко ◽  
Н.С. Деева ◽  
А.В. Шабалдин
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Modern Medicine ◽  
Gene Interactions ◽  
Congenital Heart Diseases ◽  
Control Groups ◽  
Signal Molecule ◽  
Exogenous Factors ◽  
And Control

Актуальность: Поиск биологических маркёров, вовлеченных в патогенез врожденных пороков сердца (ВПС), остается актуальным вопросом современной медицины и биологии. Врожденные пороки - мультифакторное заболевание, причинами развития которого является взаимовлияющее действие эндогенных и экзогенных факторов. В настоящее время показана роль генов семейства GATA и NOTCH1 в формировании предрасположенности к развитию врожденных пороков сердца. Материалы и методы: Группу исследования составили 58 детей с диагнозом дефекта межжелудочковой и межпредсердной перегородок, в контрольную группу включены 103 ребенка без данной патологии. Генотипирование проводили полимеразной цепной реакцией в режиме реального времени с использованием TaqMan-зондов. Результаты: Исследование встречаемости генотипов генов GATA6 и NOTCH1 в исследуемой и контрольной группах не показало статистически значимых различий. Однако, анализ межгенных взаимодействий при помощи программы MDR 3.0.2. позволил выделить ряд протективных и рисковых генотипов. Заключение: Несмотря на отсутствие статистически значимых различий по частоте встречаемости генотипов, полученные в ходе анализа межгенных связей сочетания генотипов могут быть связаны с предрасположенностью к развитию ВПС. Background: The search for biological markers involved in the congenital heart diseases pathogenesis remains a topical problem in modern medicine and biology. Congenital heart diseases are a multifactorial disease caused by the mutually affecting effects of endogenous and exogenous factors. Currently, the role of GATA and NOTCH1 gene family in the predisposition to development of congenital heart diseases is shown. Materials and methods: 58 children with a diagnosis of congenital heart diseases (defects in the interventricular and atrial septa) and 103 children without this pathology were included in the study and the control groups, respectively. Genotyping was performed by real-time polymerase chain reaction using TaqMan probes Results: A study of the frequencies of the genotypes in the GATA6 and NOTCH1 genes in the study and control groups showed no statistically significant differences. At the same time, the analysis of gene-gene interactions using MDR 3.0.2 software allows to determine a number of protective and risk genotypes. Conclusion: Despite the absence of significant differences in the frequency of genotypes, combinations of genotypes obtained during the analysis of gene-gene interactions may be associated with a predisposition to the development of congenital heart diseases.

The Haemostatic Mechanism and Menstruation: The Role of Intra-Uterine Contraceptive Devices

1979 ◽  
Vol 42 (05) ◽  
pp. 1548-1556 ◽  
Author(s):  
S M Rajah ◽  
M E Foley ◽  
J K Clayton ◽  
S R Aparicio ◽  
C C Bird ◽  
...  
Keyword(s):  
Survival Time ◽  
Survival Times ◽  
Platelet Function Tests ◽  
Control Groups ◽  
Contraceptive Devices ◽  
Platelet Survival ◽  
Before And After ◽  
And Control ◽  
Platelet Functions

SummaryThe haemostatic mechanism of 40 female patients undergoing menstruation, 20 with intra-uterine devices (IUCD) and 20 without (Control), were studied. The patients’ coagulation profiles, fibrinolytic system and platelet functions were studied before and after hysterectomy. Platelet survival times and platelet consumption was determined using 51Cr. labelled autologous platelets. Patients who menstruated during the study had their pads collected and radioactivity measured. Histology, autoradiography and scintillation counting was performed on uteri obtained from a hysterectomy performed towards the end of the platelet survival study period. There were no significant differences in the coagulation, fibrinolytic and platelet function tests in these 2 groups, though in each group there were the expected changes after operation.Platelet survival time, consumption and radioactivity in the tampons showed no significant differences between the IUCD and control groups, although there were 6 patients with low platelet survival times in the IUCD group. Resected uteri showed surprising lack of concentration of platelets which may have been due in part to loss of blood at operation and handling of the uterus. Surprisingly, in the control patients, platelet survival time in response to the severe haemosatic challenge of menstruation were normal. However in the IUCD group, 6 patients showed shortening of platelet survival. Also surprisingly and equally in both control and IUCD groups, was the small amount of platelet related radioactivity in the menstruating fluid.

Sign in / Sign up

Export Citation Format

Share Document