Significant reduction in depressive symptoms among patients with at least moderately severe depressive symptoms after participation in a therapist-supported, evidence-based program delivered via a smartphone app
Depression is a debilitating disorder associated with many poor health outcomes, including increased comorbidity and early mortality. Despite the advent of new digital health interventions, few have been tested among patients with more severe forms of depression. As such, we examined whether 150 patients with at least moderately severe depressive symptoms (PHQ-9>=15) experienced significant reductions in depressive symptoms after participation in a therapist-supported, evidence-based program delivered via smartphone app. An-intent-to-treat analysis showed that patients with at least moderately severe depressive symptoms at pre-program assessment experienced significant decreases in depressive symptoms at end-of treatment (mean PHQ-9 reduction=7.3, Hedges’ g = 1.7]) that were maintained at 1-, 3-, 6-, and 12-months post-program. Also, 40% of patients with at least moderately severe depressive symptoms at baseline and 32% of patients with severe depressive symptoms (PHQ-9>=20) at baseline responded to the intervention at end-of-treatment, defined as experiencing >= 50% reduction in PHQ-9 score and a post-program PHQ-9 score lower than 10. Future randomized trials are warranted to test the Meru Health Program as a scalable solution for patients with more severe symptoms of depression.