scholarly journals Caring Cancer Patients While Living With COVID-19: An Experience of a Tertiary Cancer Care Center

2020 ◽  
Vol 4 (1) ◽  
pp. 51-60
Author(s):  
Murari Man Shrestha ◽  
Hari Prasad Dhakal ◽  
Banita Gurung ◽  
Sajin Rajbhandary ◽  
Sachin Shakya ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Human Life ◽  
Care Center ◽  
Control Measures ◽  
The Novel ◽  
Health Crisis ◽  
Treatment Services ◽  
Rapid Spread ◽  
Novel Virus ◽  
The Government

COVID-19 has emerged as a serious public health crisis of 21st century affecting millions of people around the world. First identified in Wuhan China, COVID-19 has spread globally claiming millions of human life and suffering. The Government of Nepal (GoN) has accelerated control measures through mass media, laboratory testing, quarantine, isolation and treatment of COVID patients in designated hospitals. With rapid spread of COVID-19, the government owned as well as the private hospitals and health institutions across the nation face a great challenge to contain the spread of the novel virus. Nepal Cancer Hospital and Research Center (NCHRC) has been managing uninterrupted treatment services to cancer patients since the beginning of spread of COVID-19 in Nepal. Early planning and preparedness has been crucial to ensure patient care in the midst of COVID-19 pandemic.

Coronavirus: Towards controlling of the pandemic - Indian scenario

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 462-468
Author(s):  
Latika kothari ◽  
Sanskruti Wadatkar ◽  
Roshni Taori ◽  
Pavan Bajaj ◽  
Diksha Agrawal
Keyword(s):  
Control Measures ◽  
The Novel ◽  
Medical Treatments ◽  
Health Crisis ◽  
The Public ◽  
Infection Control Measures ◽  
The Social ◽  
Asking Questions ◽  
The Government ◽  
Novel Coronavirus

Coronavirus disease 2019 (COVID-19) is a communicable infection caused by the novel coronavirus resulting in severe acute respiratory syndrome coronavirus 2 (SARS-CoV). It was recognized to be a health crisis for the general population of international concern on 30th January 2020 and conceded as a pandemic on 11th March 2020. India is taking various measures to fight this invisible enemy by adopting different strategies and policies. To stop the COVID-19 from spreading, the Home Affairs Ministry and the health ministry, of India, has issued the nCoV 19 guidelines on travel. Screening for COVID-19 by asking questions about any symptoms, recent travel history, and exposure. India has been trying to get testing kits available. The government of India has enforced various laws like the social distancing, Janata curfew, strict lockdowns, screening door to door to control the spread of novel coronavirus. In this pandemic, innovative medical treatments are being explored, and a proper vaccine is being hunted to deal with the situation. Infection control measures are necessary to prevent the virus from further spreading and to help control the current situation. Thus, this review illustrates and explains the criteria provided by the government of India to the awareness of the public to prevent the spread of COVID-19.

scholarly journals COVID-19 and the Heart

2020 ◽  
pp. 1-5 ◽  
Author(s):  
Chaitanya Rojulpote ◽  
Karthik Gonuguntla ◽  
Shivaraj Patil ◽  
Abhijit Bhattaru ◽  
Paco Bravo
Keyword(s):  
Cardiovascular System ◽  
The Novel ◽  
Health Crisis ◽  
Risk Of Death ◽  
Increased Risk ◽  
The World ◽  
Significant Burden ◽  
Coronary Syndromes ◽  
Novel Virus ◽  
Underlying Mechanisms

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus disease 2019 (COVID-19) has resulted in a global health crisis. Prior to the arrival of this viral pandemic, the world was already plagued with a significant burden of cardiovascular disease. With the introduction of the novel virus, the world now faces a double jeapordy. Early reports have suggested an increased risk of death in individuals with underlying cardio-metabolic disorders. The exact effects of COVID-19 on the cardiovascular system are not well determined, however lessons from prior viral epidemics suggest that such infections can trigger acute coronary syndromes, arrhythmias and heart failure via direct and indirect mechanisms. In this article, we aimed to discuss the effects and potential underlying mechanisms of COVID -19 as well as potential implications of treatments targeted against this virus on the cardiovascular system.

scholarly journals Inflammatory pathways and potential therapies for COVID-19: A mini review

2021 ◽  
Vol 19 ◽  
pp. 205873922110029
Author(s):  
Areeg M Dabbish ◽  
Nouran Yonis ◽  
Mohamed Salama ◽  
Musthafa M Essa ◽  
M Walid Qoronfleh
Keyword(s):  
Immune Response ◽  
Proinflammatory Cytokines ◽  
Interferon Response ◽  
The Novel ◽  
Health Crisis ◽  
The Public ◽  
Repurposed Drugs ◽  
Novel Virus ◽  
Novel Coronavirus

The public health crisis of the novel coronavirus disease (COVID-19) is alarming since January 2020. COVID-19 genome (SARS-CoV-2) is related to other highly pathogenic coronaviruses SARS-CoV (severe acute respiratory syndrome coronavirus) and MERS-CoV (Middle East respiratory syndrome coronavirus). Amino acid substitutions in some of SARS-CoV-2 proteins resulted in mutations proposing more virulent and contagious properties for this novel virus. Coronavirus penetrates the host cell via endocytosis and once infected, immune responses are triggered to fight against the pathogen. Innate immune response activates major transcription factors to secrete proinflammatory cytokines and type 1 interferon response (T1INF) to induce antiviral immunity. While adaptive immunity initiates cascade of B-cells antibody mediated and T-cells cellular mediate immunities, several mechanisms are raised by SARS-CoV-2 to evade host immune response. Consequently, a surge of proinflammatory cytokines, known as cytokine storm (CS) are released. Failure to manage CS results in several pathological complications as acute respiratory distress syndrome (ARDS). Although researches have not discovered an effective treatment against SARS-CoV-2, recent therapeutic approaches recommending the use of anti-inflammatories in combination with antivirals and some repurposed drugs for COVID-19 patients. Future medications should be designed to target essential hallmarks in the CS to improve clinical outcomes.

scholarly journals Making Sense of Pandemic COVID-19 and its Affect(abilities) in the Indian Context

2021 ◽  
Vol 20 (1) ◽  
pp. 115-133
Author(s):  
Abhisek Ghosal
Keyword(s):  
The Novel ◽  
Self Monitoring ◽  
The Third ◽  
Making Sense ◽  
Indian Context ◽  
Rapid Spread ◽  
The Government ◽  
To Come ◽  
Novel Coronavirus ◽  
Restrictive Measures

This article seeks to reflect on pandemic COVID-19 and its diverse affect(abilities) in the context of India. After the outbreak of the novel coronavirus in India, the government resorted to a number of restrictive measures including quarantine, lockdown, self-isolation, and self-monitoring in order to contain the rapid spread of the new virus. This article argues that the pandemic has rendered “historical ruptures” to the world at large, and seeks to examine how it has affected the ‘usual’ ways of living of marginalised people in India, including how migrant labourers have had to strive to come to terms with the dreadful consequences of the pandemic. Furthermore, this article puts into focus how certain governmental measures are brought into effect to check the affect(abilities) of COVID-19. In order to elaborate on these affect(abilities) certain critical philosophical standpoints are drawn. In the opening section, bio-philosophical nuances of illness are expounded. These are followed, in the second section, by a discussion of neuroeconomical aspects of these affect(abilities). In the third section, theoretical notions of potentiality, singularity, and transpolitical becomings are examined through Continental philosophies. Finally, particularities of the Indian context are critically elucidated in the context of affect(abilities) of pandemic COVID-19.

scholarly journals COVID-19 denial in Turkmenistan veiling the real situation

2022 ◽  
Vol 80 (1) ◽  
Author(s):  
Hashim Talib Hashim ◽  
Ahed El Abed El Rassoul ◽  
John Bchara ◽  
Attaullah Ahmadi ◽  
Don Eliseo Lucero-Prisno
Keyword(s):  
Human Life ◽  
The Novel ◽  
Real Situation ◽  
The Real ◽  
The Public ◽  
Unethical Practices ◽  
First Case ◽  
Media Reports ◽  
The Government ◽  
Novel Coronavirus

AbstractCoronavirus disease 2019 (COVID-19) emerged in late 2019, with the first case identified in Wuhan City, Hubei Province, China, on 12 December 2019. In order to perceive the comprehensive impact of this pandemic, we have to know that misinformation and denials about COVID-19 have surely exacerbated its diffusion and hindered the response against it. Turkmenistan remains one of the very few countries in the world that lacks reports about emerging cases of the novel coronavirus. Turkmen authorities claim that they have adopted all attainable measures required in order to combat the virus, asserting that COVID-19 has yet to reach their country. Despite the government’s reported absence of COVID-19 in the country, rumors, media reports and independent sources suggest the spread of the pandemic in Turkmenistan. By mid-June 2020, the outbreak was referred to as being serious with patients suffering extreme health risks, and following its state of disrepair and unethical practices, many of those anticipated to be COVID-19 infected tend to suffer at home, discouraging any interaction with the healthcare system. The civil society in Turkmenistan, for the time being, takes full part of the government’s duty in the process of informing and educating the public regarding the COVID-19 pandemic, and endeavors to keep the government and WHO accountable for behaving in such repressive ways that could lead to rather preventable loss of human life in Turkmenistan. Yet, efforts hang fire before unveiling the real situation, and Turkmenistan’s government owning up to the negations and roaming speculations, not only regarding the coronavirus crisis, but every public-related issue itself.

scholarly journals Molecular Docking Studies of some Antiviral and Antimalarial Drugs Via Bindings to 3CL-Protease and Polymerase Enzymes of the Novel Coronavirus (SARS-CoV-2)

2020 ◽  
Vol 10 (5) ◽  
pp. 6444-6459 ◽  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Antimalarial Drugs ◽  
The Novel ◽  
Rapid Spread ◽  
Novel Virus ◽  
Novel Coronavirus ◽  
3Cl Protease ◽  
Insight Into

The rapid spread of the novel coronavirus (SARS-CoV-2) as a serious threat to the world public health is in dire need of finding potential therapeutic agents. Chinese have tested several antiviral and antimalarial drugs as potent inhibitors for the novel virus, such as remdesivir, chloroquine, hydroxychloroquine, umifenovir and favipiravir. In this study, we used the molecular docking models to study the binding interactions between these pharmaceuticals, as well as our proposed remdesivir analogue (AZCV-20) with the 3CLpro and RNA-dependent RNA polymerase (RdRp) of the SARS-CoV-2, using MEO and Autodock4 methods. Our study provides insight into the possible role of structural flexibility and efficacy during interactions between 3CLpro, RdRp and the drugs.

scholarly journals COVID-19 Pandemic in Nigeria: Misconception Among Individuals, Impact on Animals and the Role of Mathematical Epidemiologists

2021 ◽  
Author(s):  
Oluwasegun Micheal Ibrahim ◽  
Damilola Daniel Ekundayo
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
World Health ◽  
The Novel ◽  
Good People ◽  
The World ◽  
Novel Virus ◽  
The Government ◽  
Health Organization ◽  
The Impact

In March 2020, the World Health Organization declared coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2, to be a pandemic. Since the declaration, Nigeria economy has been greatly impacted thus resulting in a recession. This paper considers a couple of misconceptions among Nigerian people in the COVID-19 pandemic era thereby causing the spread of the novel virus and hence making the situation difficult for the government to handle. In particular, we discuss the first and second waves of the pandemic as it affects the Nigerian people. The impact of the pandemic on animals and the role of mathematical epidemiologists in combatting the spread is discussed herein. We give some recommendations that could be adopted by the government and the good people of Nigeria to reduce the further spread of the virus.

scholarly journals COVID-19, a Pandemic Situation: Symptoms and its Prevention Scenario

2021 ◽  
pp. 150-157
Author(s):  
Daksh Hardaswani
Keyword(s):  
Virus Disease ◽  
The Novel ◽  
Physical And Mental Health ◽  
Health Crisis ◽  
Animal Virus ◽  
Therapeutic Drugs ◽  
Corona Virus ◽  
Rapid Spread ◽  
The World ◽  
Day By Day

The corona virus COVID-19 is the pandemic due to global health crisis among the world and greatest challenge that we have faced in 21ST century. The novel corona virus disease COVID-19 has become the 5th pandemic which is reported in Wuhan, China and gradually spread into worldwide. This virus is a spillover of an animal virus and then also adapted the ability of transferring human to human. This virus is highly contagious due to rapid spread and constantly evolves in the human population. This virus has spread to every continent of the world and the death ratio is staggering. The COVID-19 pandemic is a lot more than just a health calamity, but it is also socio-economic because people are losing jobs and income. The COVID-19 disease affects physical and mental health due to isolation. Moreover, more and more countries are affecting the cases of COVID-19 which are rising very rapidly day by day. Therefore, every country needs to several actions which accelerates their safety health, balance between the protection of health, prevent economic and social disruption due to this pandemic. In the spirit of the solidarity, we all need to be contributing our self to protect this situation. However, every country is equally responsible for determining the measures to prevent or decrease the viral transmission. Government authorizes also trying to act for reduce disease’s trajectory and they focus on develop the vaccination and therapeutic drugs.  

scholarly journals In defense of the Unified Health System in the context of SARS-CoV-2 pandemic

2020 ◽  
Vol 73 (suppl 2) ◽  
Author(s):  
Janieiry Lima de Araújo ◽  
Kalyane Kelly Duarte de Oliveira ◽  
Rodrigo Jácob Moreira de Freitas
Keyword(s):  
Health System ◽  
Political Action ◽  
Human Life ◽  
Response Strategy ◽  
The Political ◽  
Health Crisis ◽  
Ethical Attitude ◽  
Unified Health System ◽  
Study Results ◽  
The Government

ABSTRACT Objective: To discuss the political and structural conditions for establishing the Unified Health System (UHS – Sistema Único de Saúde, SUS) in coping with the SARS-CoV-2 pandemic. Methods: Theoretical-reflection study. Results: At the first moment named “The global and the local in facing the SARS-CoV-2 pandemic” is presented the health crisis that took place worldwide and the government actions to combat COVID-19. A second moment named “Between dismantling actions and resistance, the UHS is the best way to face the SARS-CoV-2 pandemic”, reflects on the neoliberal attacks on the health system and how it resists, remaining the main pandemic response strategy. Conclusion: The strengthening of democracy and the defense of the UHS are the way out of the crisis. It is believed that this reflection generates - in everyone who deals with caretaking - the political action, the ethical attitude, the desire for valorization and the spirit of struggle in defense of the UHS and human life.

Tackling COVID-19 Using Blockchain Technology

2021 ◽  
pp. 75-93
Author(s):  
Padmavathi U. ◽  
Narendran Rajagopalan
Keyword(s):  
Virus Disease ◽  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Health Crisis ◽  
Record Keeping ◽  
The Public ◽  
Blockchain Technology ◽  
Novel Virus ◽  
Novel Coronavirus

In December 2019, the outbreak of novel coronavirus disease was first reported in Wuhan City, the capital of Hubei Province, China, and the virus started to exacerbate throughout the world. This new world health crisis threatens the public with its ongoing pandemic across the globe. This chapter first discusses the novel coronavirus disease (COVID-19) pandemic, symptoms and its preventive measures. A timeline of this virus disease by World Health Organisation (WHO) is depicted in this chapter. The authors enlighten the global impact of coronavirus on healthcare systems and the need for technology-empowered solutions to control the spread of this novel virus. In particular, this chapter focuses on the pioneering blockchain technology that has the potential to mitigate and fight against this pandemic outbreak. In addition, this chapter manifests how this distributed record keeping technology and its enriched features could help the healthcare professionals to combat the crisis.

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