scholarly journals ОПІОЇДНІ РЕЦЕПТОРИ

World Science ◽  
2020 ◽  
Vol 1 (1(53)) ◽  
pp. 48-50
Author(s):  
Паньків М. В. ◽  
Пальтов Е. В. ◽  
Кривко Ю. Я. ◽  
Жуковський В. С.
Keyword(s):  
Opioid Receptors ◽  
Chemical Structure ◽  
Scientific Information ◽  
The Body ◽  
Huge Number ◽  
Duration Of Action ◽  
Opioid Medication ◽  
Number Of Factors ◽  
Withdrawal Effects ◽  
Primary Action

The aim of our work was to study scientific information and to systematize data of domestic and foreign literature concerning the study of opioid receptors. The study of receptors localization and action is a promising and very complex task. Evidence of the complex effect of each group of receptors on the body is the fact that even those drugs that have a chemical structure in common with morphine, each have their own characteristics in the spectrum of action, side effects, the ability to pass the blood-brain barrier, efficacy and duration of anesthesia, addictive properties and other. This is eplained due to that the effect on receptors depends not only on the primary action of the drug, but also on the particular metabolism of a particular drug, since metabolites can be just the main factors influencing opioid receptors. In this context, it is important to note the huge number of factors that can change the duration and effectiveness of opioids, which involves a deep knowledge of this issue.Such differences partly explain th epecularity and characteristics of each opioid medication in terms of efficacy and duration of action, toxic inflance on the body, risk of complications and the occurrence of withdrawal effects, as well as particularities of use in patients with hepatic and renal impairment.

scholarly journals THE ROLE OF THE HIF1A GENE IN THE DEVELOPMENT OF ENDURANCE ATHLETES

2021 ◽  
Author(s):  
A.O. Zaitseva ◽  
◽  
M.O. Aksenov
Keyword(s):  
Gene Polymorphism ◽  
High Intensity ◽  
The Body ◽  
Endurance Athletes ◽  
Frequency Of Occurrence ◽  
Huge Number ◽  
Electronic Resource ◽  
Number Of Factors ◽  
Hif1a Gene

The sports phenotype is extremely complex, it includes a huge number of factors that depend on a combination of various traits and characteristics. The article contains information on one of the important genes involved in the adaptation of the body to hypoxia, which occurs during high-intensity aerobic loads. An analysis of the Ensemble electronic resource is presented, during which the frequency of occurrence of the HIF1A gene polymorphism was determined in various population groups. The results of the study of sports training of athletes, specializing in middle distance running, are shown.

Determination of Antioxidant Activities and Bioactive Components of Foeniculum vulgare Mill. (Samonsabar)

2019 ◽  
Vol 30 (3) ◽  
pp. 16-22
Keyword(s):  
Antioxidant Activities ◽  
Biological Activities ◽  
Scientific Information ◽  
Ethanolic Extract ◽  
The Body ◽  
World Health ◽  
Gas Chromatography Mass Spectrometry ◽  
Molecular Formula ◽  
Bioactive Components ◽  
Foeniculum Vulgare

World Health Organization (WHO) estimated that 80% of the population of developing countries use traditional medicines, mostly natural plant products, for their primary health care needs. In the past few decades, the medicinal value of plants has been assumed more important dimension owing largely to the discovery that extracts from plants contain not only primary metabolites but also a diverse array of secondary metabolites with antioxidant potential. Medicinal plants are potential sources of natural compounds with biological activities and therefore attract the attention of researchers worldwide. Antioxidants are vital substances which possess ability to protect the body from damage due to free radical-induced oxidative stress. The purpose of current study was to determine the antioxidant activities and bioactive components of Foeniculum vulgare (fennel) (Samonsabar) seeds by using UV Visible Spectrophotometer (UV-Vis) and Gas Chromatography-Mass Spectrometry (GC-MS). Aqueous extract of fennel seeds showed more antioxidant activity (IC50: 0.28 ug/ml) than ethanolic extract (IC50: 0.83 ug/ml) and comparable to standard antioxidant, ascorbic acid (IC50: 0.59 ug/ml). GC-MS analysis was fruitful in identification of compounds based on peak area, retention time, molecular formula, molecular weight, MS Fragmentions and pharmacological actions. Ten bioactive phytochemical compounds from aqueous extracts and 11 from ethanolic extract of fennel seeds were identified. These findings indicated that fennel seeds are potential to provide preventive properties against oxidative damage. These results will give scientific information for quality control of indigenous drug to herbal medicine users and local practitioners using fennel for different types of ailments

Nitrite and Nitrate Levels in Groundwater, Water Distribution Network, Bottled Water and Juices in Iran : A systematic Review

2020 ◽  
Vol 21 ◽  
Author(s):  
Maasoumeh Marhamati ◽  
Asma Afshari ◽  
Behzad Kiani ◽  
Behrooz Jannat ◽  
Mohammad Hashemi
Keyword(s):  
Drinking Water ◽  
Water Distribution ◽  
Scientific Information ◽  
Distribution Network ◽  
Water Distribution Network ◽  
The Body ◽  
International Standards ◽  
Nitrogen Fertilizers ◽  
Nitrate Content ◽  
Nitrate And Nitrite

Background: Nitrate and nitrite can get into the body through the consumption of contaminated water either directly or indirectly. The accumulation of these compounds in the body, in the long run, leads to health problems, for example, digestive disorders, cancers, and even death threats in children. The aim of this review is to investigate nitrate and nitrite pollution levels in drinking water and fruit juices in Iran. Methods: In this review data were collected through searching the Scientific Information Database, Science-Direct, Scopus, PubMed, Google Scholar, and Magiran databases using the keywords Nitrate, Nitrite, Drinking water, Drinking Water Resources, Juice and Iran. Finally, the location of the studies was geocoded through the Google My Maps (https://www.google.com/mymaps) software. Results: Studies clearly indicated that the juices are safe in terms of nitrate. Nitrate and nitrite values were less than the national and international standards in all samples of bottled drinking water except for a few of the studies. The results of the reviewed studies also indicated that the nitrate content was higher than that written on the label in 96% of the samples, and nitrite was not labeled in 80% of them. The nitrate quantity was higher than the permissible limit, in the water distribution network of Bushehr, Gilan and Mazandaran Provinces. Talesh, Ardabil, Hashtgerd, Divandareh, and Kerman cities had high nitrate levels in more than 50% of wells. Conclusion: Using nitrogen fertilizers and lack of a wastewater treatment system were the main reasons for the presence of nitrate and nitrite.

Detection of psychotropic substances in the blood by LC/MS/MS

2014 ◽  
Vol 284 ◽  
pp. 60-69
Author(s):  
Mariola Wicka ◽  
◽  
Piotr Chołbiński ◽  
Dorota Kwiatkowska ◽  
Andrzej Pokrywka ◽  
...  
Keyword(s):  
Human Body ◽  
Chemical Structure ◽  
Drugs Of Abuse ◽  
Point Of View ◽  
The Body ◽  
Psychoactive Substances ◽  
Psychotropic Substances ◽  
Road Users ◽  
Conducting Research ◽  
Proper Interpretation

Year on year, one can observe an increase in the use of addictive substances. This leads to occurring the problem of addiction as well as the use of psychoactive substances as a serious hazard to road users. The Regulation of the Minister of Health on agents acting similarly to alcohol and the conditions and manner of conducting research on their presence in the human body, requires adequate benchmarks for performing these tests. An importantfactor, from consultative point of view, is the knowledge of the chemical structure of substances belonging to different groups of drugs of abuse, their metabolic transformations that occur in the body as well as their influence on the body. This is to aid in the proper interpretation of the results of the analytical tests.

LIKE TRAJECTORIES OF THE BODY MOTION IN THE MEDIUM, THE RESISTANCE OF WHICH IS PROPORTIONAL TO THE SQUARE OF RELATIVE VELOCITY

2020 ◽  
pp. 77-83
Author(s):  
A.Y. Peretyatko ◽  
Keyword(s):  
Relative Velocity ◽  
The Body ◽  
Body Motion ◽  
Huge Number ◽  
History Of ◽  
Number Of Publications

For the pre-revolutionary Don historiography, complaints about the lack of a full-fledged generalizing work of the history of the Cossacks were extremely characteristic. As shown in the article, a similar situation is observed in our time: the article has again become the main genre of Cossack historiography, and the understanding of a huge number of publications on the history of various Cossack troops is extremely difficult. The author proves that in these conditions, works that claim to generalize become especially important, but it is extremely difficult to summarize all the facts, developments and research concepts on any broad topic of Cossack history. In his opinion, the search for other methods of scientific generalization and perception by historians of the developments of their colleagues looks promising. One of these ways he sees the organization of round tables on specifically Cossack topics, especially dedicated to new discoveries.

scholarly journals Distribution of birds in Colombia

2021 ◽  
Vol 9 ◽  
Author(s):  
Danny Vélez ◽  
Edwin Tamayo ◽  
Fernando Ayerbe-Quiñones ◽  
Julián Torres ◽  
Juan Rey ◽  
...  
Keyword(s):  
Decision Making ◽  
Species Richness ◽  
Land Use Planning ◽  
Scientific Information ◽  
Sustainable Use ◽  
Bird Species ◽  
Geographic Information ◽  
Huge Number ◽  
Bird Species Richness ◽  
Taxonomic Groups

1. Colombia with 1941 known recorded bird species is one of the most species rich countries in the world. Efforts are necessary to conserve, study and promote sustainable use of this important taxonomic group throughout Colombia’s vast territory. 2. In an ideal world, informed decisions that are based on sound scientific information should be likelier to have successful outcomes. Nevertheless, there are barriers that make it difficult to access and use information in a timely fashion. Those same barriers impede the study, conservation and sustainable use of bird species in Colombia. On the other hand, given that there is good documentation about the ecology of a large number of species, information about the distribution of birds can be easily incorporated into decision-making processes, once this information becomes readily available in a consumable format using Geographic Information Sciences tools. 3. In this context, the main objective of this paper is to present the first compilation of the current distribution of 1889 (97%) species of birds in Colombia, using expert criteria. The shapefiles were used to show the distribution and diversity of bird species in Colombia under both geopolitical and conservation geographic units. 4. The information provided in this paper can be used as a baseline for a huge number of initiatives that aim to strengthen conservation efforts and improve knowledge about one the most unique taxonomic groups in the country. These range from land use planning strategies at the municipal or department scale to sustainable use of bird species - such as those initiatives related to bird watching - in Colombia. This study has considered three key aspects: 1) the importance of birds for Colombia’s ecosystems, 2) the privileged place of Colombia in bird species richness and 3) the importance of data mobilisation in formats easily consumable by Geographic Information Systems (GIS) to facilitate the processes of informed decision-making. We present the first compilation - in shapefile format - for 1889 of the 1941 bird species recorded from Colombia. Using this novel collection, we showed the species richness of birds in Colombia’s 33 Departments plus its Captial District (DPs), 1122 Municipalities (MNs), 58 protected areas (PAs), 39 Regional Autonomous Corporations (the authorities responsible within their respective jurisdictions for regulating the environment and renewable natural resources in Colombia; CARs) and 916 Collectively Titled Territories (including both indigenous reservations and afro-descendant communities; CTTs). In addition, we provide a list of known bird species richness for the above geographic units found in the available literature. The information provided here can be used as a baseline for a huge number of initiatives concerning the study, conservation and sustainable use of bird species present in Colombia, providing access to key features of bird distribution that should facilitate decision-making.

scholarly journals Reviewing Effective Factors of Alimentary Deficiency in Animals Reproductive Functions

2021 ◽  
Vol 11 (2) ◽  
pp. 157-169
Author(s):  
Pavlo Skliarov ◽  
Serhiy Fedorenko ◽  
Svitlana Naumenko ◽  
Oleksandr Onyshchenko ◽  
Alina Pasternak ◽  
...  
Keyword(s):  
Reproductive Function ◽  
Optimal Level ◽  
The Body ◽  
Reproductive Capacity ◽  
Toxic Substances ◽  
Prevention Measures ◽  
Animal Reproduction ◽  
Number Of Factors ◽  
Wide Range ◽  
Negative Impacts

Animal reproduction is one of the main factors limiting the efficiency of livestock production. Its optimal level is possibly achieved when certain conditions are created for animals. As reproduction is a complex reflex process depending on neuroendocrine regulatory mechanisms, the character and strength of stimuli, which, in turn, is due to a number of factors. Under normal conditions, the body of animals is affected by many different factors, which are appropriately transformed and specified by positive or negative reactions. Inhibitory factors include air pool, saturated with harmful substances and gases, ionizing radiation, poor water quality along with altered redox properties, hypokinesia combined with poor unbalanced feeding, systematic chronic stress, presence of toxic substances in feed, and the deficiency of vitamins and other bioantioxidants in feed or their excessive spending. Of the wide range of genetic and paratypic factors of negative impacts on reproductive capacity, the most common one is alimentary, which causes impaired reproductive function due to deficiencies in the rules, regulations, and feeding regime of animals. In particular, the alimentary can be associated with both general malnutrition (starvation) and overfeeding (obesity). However, the alimentary form of infertility mostly occurs due to low-quality diets when the diet lacks vital components (mainly vitamins, macro-, and micronutrients) or the quantitative ratios of the ingredients are violated. This is possible even if the total nutritional value of the diet meets the established requirements for the physiological needs of the body. Vitamins, micro-, and macronutrients are ecologically deficient factors of disturbance of animal reproductive function, the influence of which is observed on all processes of reproduction, from fertilization to the postpartum period and the preservation of young animals. The pathogenesis of their insufficiency is associated with the violation of steroido-, gameto-, and embryogenesis and the emergence of ante-, intra-, neo- and postnatal pathologies, respectively. Therefore, treatments and prevention measures should be aimed at providing animals with biologically complete balanced feeding and replenishment of the body with vitamins and minerals. However, all these issues remain incompletely studied and need further research.

To the question of the therapeutic value of overfeeding nephrotic proteins

1937 ◽  
Vol 33 (2) ◽  
pp. 132-142
Author(s):  
A. I. Golikov ◽  
M. M. Grigorieva
Keyword(s):  
Plasma Proteins ◽  
Water Exchange ◽  
Cholesterol Metabolism ◽  
The State ◽  
The Body ◽  
Factors Associated ◽  
A Value ◽  
Number Of Factors ◽  
Therapeutic Value ◽  
Blood Plasma Proteins

The study of the problem of water exchange and issues of the pathogenesis of edema (Starling, Krog, Beilis, Schade, Gover, Shabanier, Kilin, etc.) made it possible to establish the colossal significance in the pathogenesis of nephrosis of a number of factors associated with the state of the body's proteins. To one degree or another, depletion of blood plasma proteins, sharp changes in the ratio of protein fractions with a shift towards the coarse-dispersed phase (globulins), an increase in the hydrophilicity of tissue colloids (McClure and Aldrich test) characterize pathological shifts in the protein economy of the body. The osmotic pressure of nephrotic plasma proteins drops sharply due to an increase in osmotically much less active globulins and fibrinogen (Schade, Shabanier, Gover, Kilin, Malkin, etc.). This decrease can in some cases reach a value of 10-14 cm of water column in comparison with the normal value of 30-40 cm (Gover, Golikov). According to modern views, these violations of the protein constant due to changes in the salt balance, in the state of permeability of the capillary wall and the state of tissue colloids are a common cause of the hydropic state of the body. Along with the violation of protein metabolism, changes in the state of lipoid-cholesterol metabolism occur in the body with nephrosis. The absence of contraindications for giving nephrotic protein is well known.

Making an Exhibition of Ourselves: Using the Dead to Fight the Battles of the Living

2016 ◽  
Author(s):  
Tiffany Jenkins
Keyword(s):  
Cultural Context ◽  
The Body ◽  
Dead Body ◽  
American Military ◽  
Number Of Factors ◽  
Dead Bodies ◽  
The Dead ◽  
Osama Bin Laden ◽  
The Individual ◽  
Nuremberg Trials

In October 2011, graphic images of a blood-stained and dead Muammar Gaddafi were sent around the internet. For some time after his death, his dead body was displayed at a house in Misrat, where masses of people queued to see it. His corpse provided a focus for the Libyan people, as proof that he really was dead and could finally be dominated. When Osama bin Laden was killed by the American military in May that same year, unlike Gaddafi, the body was absent, but the absence was significant. Shortly after he was killed a decision was taken not to show pictures of the dead body and it was buried at sea. The American military appear to have been concerned it would become a physical site for his supporters to congregate, and the photographs used by different sides in a propaganda war. Both cases reflect an aim to control the dead body and associated meanings with the person; that is not unusual: after the Nuremberg trials, the Allied authorities cremated Hermann Göring—who committed suicide prior to his scheduled hanging—so that his grave would not become a place of worship for Nazi sympathizers. These examples should remind us that dead bodies have longer lives than is at first obvious. They are central to rituals of mourning, but beyond this, throughout history, they have also played a role in political battles and provided a—sometimes contested—focus for reconciliation and remembrance. They have political and social capital and are objects with symbolic potential. In The Political Lives of Dead Bodies the anthropologist Katherine Verdery explores the way the dead body has been used in this way and why it is particularly effective. Firstly, she observes, human remains are effective symbolic objects because their meaning is ambiguous; that is whilst their associated meanings are contingent on a number of factors, including the individual and the cultural context, they are not fixed and are open to interpretation and manipulation: ‘Remains are concrete, yet protean; they do not have a single meaning but are open to many different readings’ (Verdery 1999: 28).

Endogenous opioids and related peptides: from molecular biology to clinical medicine The Sir Henry Dale Lecture for 1985

1985 ◽  
Vol 107 (2) ◽  
pp. 147-157 ◽  
Author(s):  
H. Imura ◽  
Y. Kato ◽  
Y. Nakai ◽  
K. Nakao ◽  
I. Tanaka ◽  
...  
Keyword(s):  
Molecular Biology ◽  
Opioid Receptors ◽  
Clinical Medicine ◽  
Biological Activities ◽  
Opioid Peptide ◽  
Endogenous Opioids ◽  
The Body ◽  
Molecular Forms ◽  
Protein Chemistry ◽  
Precursor Proteins

ABSTRACT Advances in techniques in molecular biology have facilitated the research into endogenous opioids and related peptides in several ways. The organization and expression of genes and the primary structure of three precursor proteins of opioid peptides have been elucidated. These studies predicted the presence of potentially bioactive peptides, which has been confirmed by later studies. Advances in techniques in protein chemistry have helped to elucidate the distribution and molecular forms of endogenous opioids and related peptides in the body, and the processing of precursor proteins. Studies on the function of these peptides have shown a broad spectrum of actions. Leumorphin, a newly identified peptide, has been shown to exhibit unique biological activities. In spite of extensive studies, the physiological and pathophysiological significance of opioid peptide systems are not yet completely understood. This is mainly due to the paucity of our knowledge about opioid receptors. Further studies on the subtypes of opioid receptors will help to elucidate all aspects of the function of endogenous opioids and related peptides. J. Endocr. (1985) 107, 147–157

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