To the question of the therapeutic value of overfeeding nephrotic proteins

1937 ◽  
Vol 33 (2) ◽  
pp. 132-142
Author(s):  
A. I. Golikov ◽  
M. M. Grigorieva

The study of the problem of water exchange and issues of the pathogenesis of edema (Starling, Krog, Beilis, Schade, Gover, Shabanier, Kilin, etc.) made it possible to establish the colossal significance in the pathogenesis of nephrosis of a number of factors associated with the state of the body's proteins. To one degree or another, depletion of blood plasma proteins, sharp changes in the ratio of protein fractions with a shift towards the coarse-dispersed phase (globulins), an increase in the hydrophilicity of tissue colloids (McClure and Aldrich test) characterize pathological shifts in the protein economy of the body. The osmotic pressure of nephrotic plasma proteins drops sharply due to an increase in osmotically much less active globulins and fibrinogen (Schade, Shabanier, Gover, Kilin, Malkin, etc.). This decrease can in some cases reach a value of 10-14 cm of water column in comparison with the normal value of 30-40 cm (Gover, Golikov). According to modern views, these violations of the protein constant due to changes in the salt balance, in the state of permeability of the capillary wall and the state of tissue colloids are a common cause of the hydropic state of the body. Along with the violation of protein metabolism, changes in the state of lipoid-cholesterol metabolism occur in the body with nephrosis. The absence of contraindications for giving nephrotic protein is well known.

2014 ◽  
Vol 17 (1) ◽  
pp. 45-58 ◽  
Author(s):  
Daniele Marano ◽  
Silvana Granado Nogueira da Gama ◽  
Rosa Maria Soares Madeira Domingues ◽  
Paulo Roberto Borges de Souza Junior

OBJECTIVE: To assess the prevalence and potential factors associated with pre-pregnancy nutritional status of women. METHODS: This is a cross-sectional study carried out between December 2007 and November 2008 with 1,535 women in the first trimester of pregnancy and randomly selected in health units of the Brazilian public health system (SUS) in the municipalities of Queimados and Petrópolis in the State of Rio de Janeiro. The diagnosis of nutritional deviations was based on the Body Mass Index, according to the classification of the Institute of Medicine, and the following categories were obtained: underweight, normal weight, overweight and obesity. In the statistical analysis, the multinomial logistic regression model was used and an odds ratio and confidence interval of 95% were estimated. RESULTS: The sample included women between 13 and 45 years. The prevalence of underweight, overweight and obesity were 10, 18 and 11%, respectively. Women living in Queimados, adolescents, women who did not live with a partner and smokers had a higher proportion of low pre-pregnancy weight. There was an association between hypertension, overweight and obesity. Adolescents presented lower chance to overweight and obesity. Living in Queimados reduced the odds of overweight. CONCLUSION: The proportion of pre-pregnancy nutritional deviations was high, and recognizing factors that lead to them is very important for an early identification of women at nutritional risk, with view to interventions to reduce the adverse effects of malnutrition on maternal and child health.


2013 ◽  
Vol 45 (5) ◽  
pp. 627-641 ◽  
Author(s):  
NEETA RAO ◽  
L. JEYASEELAN ◽  
ANNA JOY ◽  
V. SAMPATH KUMAR ◽  
M. THENMOZHI ◽  
...  

SummaryStudies among migrants show that they are more susceptible to HIV infection than the general population and thereby spread the epidemic from high prevalence to low prevalence areas. It is therefore critical to enhance the body of knowledge on factors associated with condom use among migrants. This study, conducted in 2009 in the State of Maharashtra, covers 4595 single in-migrants aged 15–49 years and aims at understanding the factors associated with non-use of condoms consistently. Information was collected using a Structured Interview Schedule covering demographic, socioeconomic profile, sexual history, knowledge, behaviour and stigma and discrimination indicators. Logistic regression analysis was used to understand the association between unprotected sex and various socio-demographic and environmental factors. The models were run using the Enter method. The goodness-of-fit of the model was assessed using Hosmer and Lemeshow chi-squared statistics. A significant association is observed between sex with sex workers and older migrants (>24 years), the literate, those who are mobile, unmarried, employed in the textile, quarry and construction industries, who often consume alcohol and who watch pornographic films. The factors associated with unprotected sex are age between 30 and 34 years and no literacy. Migrants who are mobile and consume alcohol show a significant association with unprotected sex. The findings suggest a need for a comprehensive HIV prevention programme including strategies to address the stressful work conditions. The prevention programmes should focus not only on skills for safer sex practices, but also on alcohol use reduction.


1987 ◽  
Vol 252 (3) ◽  
pp. R457-R461
Author(s):  
E. Regoeczi

Unlike in the case of some other species, the plasma curve of iodine-labeled antithrombin III (I-AT-III) in rabbits requires fitting with a three-term exponential function for obtaining reliable estimates of the catabolic rate and distribution of I-AT-III among various body compartments (Carlson, Atencio, and Simon. J. Clin. Invest. 74: 191-199, 1984). To decide whether this phenomenon is referable to the host or the protein, the behavior of rabbit and human I-AT-III was comparatively analyzed in rabbits. Data obtained with rabbit I-AT-III confirmed the findings by Carlson and co-workers. Human I-AT-III assumed a distribution that closely paralleled that of homologous I-AT-III, thus suggesting that the pattern of distribution is determined by the host species rather than its AT-III. Rabbits metabolized human I-AT-III 1.61 times faster than homologous I-AT-III by an unknown mechanism not involving immune response; a facet that may prove useful for the identification of the sites of catabolism of AT-III. The exponent of the body weight was calculated for the relationship between species size and AT-III turnover. A value of 0.5 was obtained that is distinctly lower than the exponents found earlier for some other plasma proteins.


1937 ◽  
Vol 33 (2) ◽  
pp. 126-132
Author(s):  
A. G. Teregulov

Clinically, with nephrosis, we observe edema, albuminuria, lipoiduria, which, as follows from the data of modern clinics, along with changes in the kidneys, largely depend on the general suffering of the body disorders of protein and lipid metabolism. Indeed, studies have established that with nephrosis there are deep biochemical shifts - a decrease in blood plasma proteins, a change in the ratio of the protein fraction of the blood towards globulins, an increase in the content of fibrinogen, uric acid, a decrease in osmotic pressure and, finally, in parallel with a change in protein metabolism and changes in fat-lipoid metabolism - hypercholesterolemia.


2017 ◽  
pp. 65-70
Author(s):  
N.A. Shcherbina ◽  
◽  
L.A. Vygovskaya ◽  

The objective: to study the effect of immunocorrecting therapy on the state of blood lipid spectrum in pregnant with intrauterine infection. Patients and methods. The study involved examination of three groups of pregnant with viral, bacterial and mixed infection. Each of the groups was divided into 2 subgroups: with subsequent implementation of infection in newborns and without it. Control group included patients with physiological pregnancy. The pregnant received immunocorrecting therapy. Blood serum was assessed to determine the levels of total cholesterol (TC), triglycerides (TG), high, low and very low density lipoproteins (HDL, LDL, VLDL). Results. The study implied the assessment of the effect of the elaborated immunocorrecting complex on the state of blood lipid spectrum in pregnant with intrauterine infection. In the group of patients with viral infections, regardless of its subsequent implementation, the use of the developed therapeutic complex triggered activation of cholesterol metabolism and reduction of hypertriglyceridemia to normal TG content in blood. In patients with bacterial infection, regardless of its implementation, the performed treatment resulted in cholesterol metabolism normalization. In the subgroup with mixed infection in its implementation, the treatment neutralized triglyceridemia and normalized TG level. In the subgroup with mixed infection without its implementation, the treatment allowed to normalize the level of TG and VLDL and increase HDL. Conclusions. The use of the elaborated immunocorrecting therapy has a positive effect on the metabolism of lipids, which reflects the lipid profile of blood. The main effect of the treatment is the normalization of the levels of triglycerides in pregnant and their carriers VLDL, and this effect is manifested with all the variants of infection under investigation. The detected increase in the level of HDL is indicative of an increase in the reverse transport of cholesterol and activation of its metabolism. This allows us to consider that the use of this therapeutic complex stimulates compensatory metabolic processes in the body of pregnant women, despite the presence of infection. Key words: intrauterine infection, lipid spectrum, immunocorrecting therapy.


2017 ◽  
Vol 4 (4) ◽  
pp. 180-209 ◽  
Author(s):  
Sarah L. Desmarais ◽  
Joseph Simons-Rudolph ◽  
Christine Shahan Brugh ◽  
Eileen Schilling ◽  
Chad Hoggan

Author(s):  
Iryna Butyrska

The author proves that the successful stability of independent Slovenia contributed to a number of factors, existing since its being incorporated in the SFRY. The factor, uniting the state has become the common goal – the aspiration to join the EU. The process of the European integration contributed to the modernization of a number of spheres, in particular social, cultural and economic ones. The global financial and economic crisis has revealed the turmoil in the economy of the state and its leadership was forced to gradually reduce a significant part of social privileges for the population. This caused the tension in the society and reduced the level of the national unity, having a negative impact on people’s wellbeing. However, since 2014, the Prime Minister M. Cherar has been trying to restore people’s trust in the state. The situation is getting better; indicators of trust in government are increasing, which also points to state capacity and political regime stability in Slovenia. Keywords: Slovenia, state stability, social sphere, government


2006 ◽  
Vol 157 (7) ◽  
pp. 283-286
Author(s):  
Guido Bernasconi

The silvicultural principles of a forest management plan for Canton Neuchâtel reveals itself as steeped in a systemic approach that allows us to consider the forest as a truly living system. In this context, it seems judicious to the author to conceive of the body forest personnel as a group of responsible people who share certain common ethics and who, in their work, promote the emergence of collective services recognised as beneficial to the state and which would be supported by public funding for the good of the entire community.


Author(s):  
Dr.Saurabh Parauha ◽  
Hullur M. A. ◽  
Prashanth A. S.

In Ayurveda, Jwara is not merely the concept of raised body temperature, but as is said in Charaka Samhita, 'Deha- Indriya- Manah- Santap' is the cardinal symptoms of Jwara. This can be defined as the state where the body, mind as well as sense oragans suffer due to the high temperature. Vishamajwara is a type of fever, which is described in all Ayurvedic texts. Charaka mentioned Vishamajwara and Chakrapani have commented on Vishamajwara as Bhutanubanda, Susruta affirmed that Aagantuchhanubhandohi praysho Vishamajware. Madhavakara has also recognised Vishamajwara as Bhutabhishangajanya (infected by microorganism). Vishamajwara is irregular (inconsistent) in it's Arambha (nature of onset commitment), Kriya (action production of symptoms) and Kala (time of appearance) and possesses Anushanga (persistence for long periods). The treatment of this disease depends upon Vegavastha and Avegavastha of Jwara. Various Shodhana and Shamana procedures are mentioned in classics to treat Visham Jwara.


2020 ◽  
Vol 46 (5) ◽  
pp. 531-539
Author(s):  
I. M. Larina ◽  
A. G. Brzhzovsky ◽  
A. M. Nosovsky ◽  
A. S. Kononikhin ◽  
O. I. Orlov

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