scholarly journals Etiological structure of infectious agents in the urinary tract among children

2021 ◽  
Vol 101 (1) ◽  
pp. 38-44
Author(s):  
Sh.K. Yeleupayeva ◽  
◽  
A.S. Dinmukhamedova ◽  
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Staphylococcus Epidermidis ◽  
Urban Areas ◽  
Inflammatory Diseases ◽  
Urinary System ◽  
Number Of Children ◽  
Acute Respiratory Diseases ◽  
Sick Children ◽  
Etiological Agents

The article presents the results of the research of etiological structure of urinary tract infection among children. Out of the total number of urological and nephrological sick children`s research, it is defined that 283 microorganisms selected from the urine were found. 63.2 % of the total number of children in nephrological department is related to only urological diseases. In recent, there has been an open trend to increase a frequency of diseases of the urinary system. Over the past five years, the number of diseases of the genitourinary system in urban children in Kazakhstan has increased to 65 %.The review shows that inflammatory diseases of kidneys and urinary tract take the second place after acute respiratory diseases of upper breathing tract. In this work, it is established that a causative agent of urinary system infection among children is pathogenic, as well as relative-pathogenic microorganisms. As it is shown, the leading etiological agent of uroinfection is Staphylococcus epidermidis (13.9 %), Escherichia coli (12.2 %), Enterobacter cloacae (7.8 %). In some cases, streptococcus are excreted. Also, there were dominant pathogens of nephroinfection among children such as Escherichia coli (21.1 %), Enterococcus faecalis (9.6 %), Staphylococcus epidermidis (20.1 %). Some types of Candida fungi in the formation of the urinary tract and kidney infection (mostly C.albicans (9.5 %), C.kruseae (8.1 %), C.glabrata (5.6 %) pathogens) are observed in the study of urine in children. During the general research, it was found that the etiological agents of urinary system among children consist of a huge microbiological spectrum, especially among children living in urban areas.

Evaluation of the Antimicrobial Efficacy of Urinary Catheters Impregnated With Antiseptics in an In Vitro Urinary Tract Model

2003 ◽  
Vol 24 (7) ◽  
pp. 506-513 ◽  
Author(s):  
Trupti A. Gaonkar ◽  
Lester A. Sampath ◽  
Shanta M. Modak
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Urinary Tract ◽  
Staphylococcus Epidermidis ◽  
Bacterial Colonization ◽  
Silver Sulfadiazine ◽  
Antimicrobial Spectrum

AbstractObjectives:To evaluate the long-term efficacy of urinary Foley catheters (latex and silicone) impregnated with (1) chlorhexidine and silver sulfadiazine (CXS) and (2) chlorhexidine, silver sulfadiazine, and triclosan (CXST) in inhibiting extra-luminal bacterial adherence and to compare their efficacy with that of silver hydrogel latex (SH) and nitrofurazone-treated silicone (NF) catheters.Design:The antimicrobial spectrum of these catheters was evaluated using a zone of inhibition assay. A novel in vitro urinary tract model was developed to study the potential in vivo efficacy of antimicrobial catheters in preventing extraluminal bacterial colonization. The “meatus” was inoculated daily with Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, and Candida albicans. The “bladder” portion of the model was cultured daily to determine bacterial growth.Results:Both CXS and CXST catheters had a broader antimicrobial spectrum than SH and NF catheters. In the in vitro model, CXST latex and silicone catheters exhibited significantly better efficacy (3 to 25 days) against uropathogens, compared with CXS (1 to 14 days) and control (0 to 5 days) catheters (P = .01). CXST latex catheters exhibited significantly longer protection against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa, compared with SH catheters (P = .01). CXST silicone catheters resisted colonization with Staphylococcus aureus and Staphylococcus epidermidis for a significantly longer period (23 to 24 days) than did NF catheters (9 to 11 days) (P = .01).Conclusion:Catheters impregnated with synergistic combinations of chlorhexidine, silver sulfadiazine, and triclosan exhibited broad-spectrum, long-term resistance against microbial colonization on their outer surfaces (Infect Control Hosp Epidemiol 2003;24:506-513)

scholarly journals Urinary Tract Infections with Non-Escherichia coli Pathogens in Children: An Observational Study

2020 ◽  
Vol 12 (4) ◽  
Author(s):  
Mitra Naseri ◽  
Gholam Reza Sarvari ◽  
Niayesh Tafazoli ◽  
Nooshin Tafazoli
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Vesicoureteral Reflux ◽  
Neurogenic Bladder ◽  
Bladder Dysfunction ◽  
Urinary System ◽  
Neurogenic Bladder Dysfunction ◽  
E Coli ◽  
Pseudomonas Species ◽  
Tract Infections

Background: Urinary tract infections (UTIs) with non-Escherichia coli (E. coli) species are associate with urological abnormalities. Objectives: To compare the prevalence of non-E. coli infections in patients with urological anomalies, neurogenic bladder dysfunction, and those with apparently normal urinary systems. Methods: Pediatric nephrology clinic at a tertiary-care center in east of Iran. Children affected by UTI enrolled from 2003 to 2016. The results of urine culture were noted at enrolment. Cases with nephrolithiasis who had normal voiding cystourethrogram were excluded. After the implementation of imaging and urodynamic examinations, 832 patients enrolled according to the following inclusion criteria: cases with vesicoureteral reflux, urinary obstruction, neurogenic bladder, and patients with apparently normal urinary tract. The prevalence of infections with E. coli vs. non-E. coli pathogens were compared between different groups of enrolled cases. Results: In this study, 62.26% of the subjects had a normal urinary system, while 33.77%, 3.97%, and 2.4% of whom had vesicoureteral reflux, neurogenic bladder, and obstruction, respectively. Non-E. coli pathogens were responsible for infections in 17.29%, 19.39%, 33.74%, and 17.15% of these cases, respectively. Infections with non-E. coli pathogens were significantly more prevalent in cases with neurogenic bladder (P = 0.003). Pseudomonas species were responsible for 4/125, 5/118, 5/28, and 0/6 episodes of non-E. coli infections in cases with apparently normal urinary system, patients with vesicoureteral reflux, cases with neurogenic bladder, and those with urinary obstruction, respectively (P = 0.004). Conclusions: Infections with non-E. coli and also Pseudomonas species are significantly more prevalent in patients with neurogenic bladder dysfunction rather than those with urological abnormalities and/or cases with apparently normal urinary system.

scholarly journals UJI SENSITIVITAS BAKTERI PENYEBAB INFEKSI SALURAN KEMIH PADA PASIEN DIABETES MELITUS TERHADAP SEFTRIAKSON, LEVOFLOKSASIN, DAN GENTAMISIN

2016 ◽  
Vol 12 (2) ◽  
pp. 205
Author(s):  
Nova Octavianty Rachman ◽  
Muhamad Darwin Prenggono ◽  
Lia Yuli Budiarti
Keyword(s):  
Diabetes Mellitus ◽  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Staphylococcus Epidermidis ◽  
Sensitivity Test ◽  
Cross Sectional ◽  
Diabetes Melitus

Abstract: Urinary Tract Infection (UTI) is a general term that indicates the presences or propagation of microorganism in urine. The urinary tract infection is a very common condition that occurs in both women and men of all ages. Diabetes Mellitus (DM) can lead to the development of bacteriuria. Bacterial resistance to antibiotics prolongs the UTI recover. The aim of this research was to find out bacterial sensitivity urinary tract infection in patients diabetes mellitus to selected antibiotic during July-September 2015. It was a descriptional study with cross-sectional. The subject of this research is all patients diabetes mellitus with urinary tract infection in internal medicine wards Ulin General Hospital Banjarmasin. The sampling technique in this research was a total sampling. The sensitivity test to antibiotic test in the research used Kirby Bauer method and analyzed according to CLSI 2013 standard.This type of bacteria found in this research are Escherichia coli, Pseudomonas aerugenosa, Staphylococcus epidermidis, and Staphylococcus aureus. The sensitivity test result the percentage type of bacteria are sensitive to ceftriaxone 73%, levofloxaxin 84,6%, and gentamicin 73%. The conclution is that most sensitive antibiotic is levofloxaxin (84,6%) Keywords: diabetes mellitus (DM), urinary tract infection (UTI), ceftriaxone, levofloxaxin, gentamicin. Abstrak: Infeksi Saluran Kemih (ISK) didefinisikan sebagai adanya infeksi bakteri dalam urin yang ditandai dengan bakteriuria bermakna. Infeksi saluran kemih merupakan kondisi yang sangat umum terjadi baik pada wanita maupun pria pada semua usia. Diabetes Melitus (DM) dapat menyebabkan perkembangan bakteriuria. Resistensi bakteri terhadap antibiotik menyebabkan lamanya penyembuhan dari ISK. Penelitian ini bertujuan mengetahui sensitivitas bakteri penyebab ISK pada pasien DM terhadap antibiotik terpilih periode Juli-September 2015. Penelitian ini merupakan penelitian deskriptif dengan pendekatan Cross Sectional. Subjek penelitian ini adalah seluruh pasien DM dengan ISK Rawat Inap di Bangsal Penyakit Dalam RSUD Ulin Banjarmasin. Teknik pengambilan sampel pada penelitian ini adalah Total Sampling. Uji sensitivitas bakteriuria terhadap antibiotik uji pada penelitian ini menggunakan metode Kirby-Bauer dan dianalisis secara deskriptif sesuai dengan standar CLSI 2013. Jenis bakteri yang ditemukan pada penelitian ini adalah Escherichia coli, Pseudomonas aerugenosa, Staphylococcus epidermidis, Staphylococcus aureus. Hasil uji sensitivitas menunjukkan bahwa presentase jenis bakteri yang sensitif terhadap Seftriakson 73%, Levofloksasin 84,6%, dan Gentamisin 73%. Persentase isolat bakteri yang resisten terhadap Seftriakson 15,3%, Levofloksasin 3,8%, dan Gentamisin 3,8%. Kesimpulan antibiotik yang paling sensitif terhadap bakteri penyebab ISK pada penilitian ini adalah Levofloksasin (84,6%). Kata-Kata kunci: diabetes melitus (DM), infeksi saluran kemih (ISK), seftriaxon, levofloksasin, gentamisin

scholarly journals POLA BAKTERI PADA URIN PASIEN YANG MENGGUNAKAN KATETER URETRA DI INSTALASI RAWAT INAP RSUP PROF. DR. R. D. KANDOU MANADO

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Jemmy C. Sie
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Nosocomial Infection ◽  
Prospective Study ◽  
Staphylococcus Epidermidis ◽  
Urethral Catheter ◽  
Age Group ◽  
Enterobacter Species

Abstract: One of the most common nosocomial infection is urinary tract infection (UTI); 80% of cases are associated with the use of urethral catheters. The most common pathogens are Escherichia coli, Enterococcus, Klebsiella, Pseudomonas, Proteus, and Enterobacter species. Bacteria patterns could change from time to time and from area to area. This study aimed to obtain the bacteria pattern in urine of patients using urethral catheter.This was a descriptive prospective study. There were 20 urine samples from November 2013 until January 2014 in IRINA RSUP Prof Dr RD Kandous Manado. The results showed that age >60 years was the most common age group (41.8%). Males (84.9%) were predominantly affected in this study. Staphylococcus epidermidis was found in 20% of samples, followed by several other bacteria. Conclusion: The most affected age group using urethral catheter with bacteriuria was over 60 years, more frequent in males, and the most common pathogen was Staphylococcus epidermidis.Keywords: bacteria, bacteria pattern, urinary tract infection, nosocomial infection, urethral catheterAbstrak: Salah satu infeksi nosokomial yang sering terjadi adalah infeksi saluran kemih (ISK), 80% kasus ISK diasosiasikan dengan penggunaan kateter uretra. Patogen yang paling sering ditemukan adalah Escherichia coli, Enterococcus, Klebsiella, Pseudomonas, Proteus, dan Enterobacter. Pola bakteri dapat berbeda dari waktu ke waktu dan dari daerah ke daerah. Penelitian ini bertujuan untuk mengetahui pola bakteri pada urin pasien yang menggunakan kateter.Penelitian ini menggunakan desain penelitian deskriptif prospektif pada 20 sampel urin selama bulan November 2013 hingga Januari 2014 di instalasi rawat inap RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian memperlihatkan umur 61-70 tahun merupakan insidensi tertinggi. Jumlah sampel laki-laki dengan bakteriuria lebih banyak dibandingkan perempuan. Simpulan: Kelompok umur tersering yang menggunakan kateter uretra dengan bakteriuria ialah umur di atas 60 tahun, lebih sering pada laki-laki, dan bakteri yang paling banyak ditemukan Staphylococcus epidermidis.Kata kunci: bakteri, pola bakteri, infeksi saluran kemih, infeksi nosokomial, kateter uretra

scholarly journals Pathogen profile of urinary tract infections in Nephrology Unit

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Dariusz Chojeta ◽  
Iwona Smarz-Widelska ◽  
Malgorzata M. Koziol
Keyword(s):  
Escherichia Coli ◽  
Drug Resistance ◽  
Urinary Tract ◽  
Drug Susceptibility ◽  
Noticeable Increase ◽  
Therapeutic Decisions ◽  
Resistance Patterns ◽  
Etiological Agents ◽  
Tract Infections ◽  
Outpatient Settings

Abstract Introduction. Urinary tract infection (UTI) is one of the most common types of infection in both hospitalized and outpatient settings. The etiology is mostly bacterial, and the typical causative agent is uropathogenic Escherichia coli. There is a noticeable increase in drug resistance of pathogenic microorganisms. The aim of the study was retrospective analyses of etiological agents of UTI and their antibiotic resistance patterns in Nephrology Unit patients. Material and methods. An infection was diagnosed based on the patient’s symptoms and positive results of urine culture, carried out over 26 months. The clinical material was tested by using the VITEK system, the drug susceptibility of the emerged pathogens was identified. Results. The most common etiological agents of UTI were Gram-negative rods: Escherichia coli (51.23%), Klebsiella spp. (19.3%) and Proteus spp. (13.68%). The analysis of drug resistance profiles of these pathogens showed a high percentage of strains resistant to broad-spectrum penicillins and fluoroquinolones. At the same time, it seems that E. coli isolates presented the most favorable pattern of drug susceptibility in this comparison. Conclusions. The alarming tendency of increasing drug resistance among pathogens causing UTIs to antibiotics such as penicillins or fluoroquinolones prompts a careful choice of drugs in empirical therapies. The most appropriate practice in this regard seems to be meticulous control of nosocomial infections and making therapeutic decisions based on the knowledge of local microbiological data.

Infectious and Inflammatory Diseases of the Urinary System

2020 ◽  
pp. 27-34
Author(s):  
Georgiy Rubenovich Petrosyan
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Spinal Cord Injuries ◽  
Inflammatory Diseases ◽  
The Elderly ◽  
Winter Period ◽  
Urinary System ◽  
Increased Risk ◽  
Causative Agents ◽  
Tract Infections

Urinary tract infections are the most common bacterial lesions of humans. About 150 million cases of these diseases are registered annually in the world. About 95 % of urinary tract infections occur when bacteria migrate ascending from the urethra to the bladder, and in acute uncomplicated pyelonephritis, from the ureter to the kidney. An increased risk of developing urinary tract infections is observed in infants, the elderly, pregnant women, patients with spinal cord injuries, diabetes mellitus, multiple sclerosis, immunodeficiency diseases, structural abnormalities of the kidneys and urinary tract. The autumn-winter period is a traditional season of development and exacerbation of diseases of the urinary system. This is facilitated by a high risk of hypothermia, a relative decrease in physical activity, a change in the drinking regime and a partial decrease in the body's defenses against colds. The main and most common inflammatory diseases of the urinary system include urethritis, cystitis, pyelonephritis. Due to the anatomical features of the structure of the urethra (the urethra of men is longer and narrower than that of women), urethritis of various etiologies are more common in the stronger sex. Women, for the most part, suffer from cystitis, since the causative agents of infection easily bypass the short and relatively wide urethra and immediately enter the bladder, where they find fairly favorable conditions for reproduction [5].

scholarly journals Medical and Social Component of Medical Management: Improving the Model of Providing Medical Aid for Children with Infectious-Inflammatory Diseases of the Urinary System

2021 ◽  
Vol 6 (5) ◽  
pp. 270-275
Author(s):  
V. V. Bezruk ◽  
◽  
M. I. Velia ◽  
O. V. Makarova ◽  
O. Y. Yurkiv ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Medical Care ◽  
Inflammatory Diseases ◽  
Regional Level ◽  
Rational Approach ◽  
Urinary System ◽  
Medical Aid ◽  
Improved Model

The purpose of the study was to substantiate and develop the improved model of the specialized nephrology care for the children with infectious inflammatory diseases of the urinary system at the regional level. Materials and methods. The official statistical data have been studied (reports on the state of medical care for children in the Chernivtsi region and data from the Center of medical statistics of the Ministry of Healthcare from 2006 to 2017), information-analytical and statistical methods have been used. The modern etiological structure of uropathogens – urinary tract infection pathogens among the children of the Chernivtsi region (2009-2016) was studied. Clinical and laboratory examination of 3,089 children (0-17 years old) was conducted in the region; the regional spectrum of sensitivity to antibacterial drugs was determined among the main groups of urinary tract infection pathogens; their age, gender and administrative-territorial differences among the children's population of the region are analyzed. Results and discussion. During 2012-2017 there was a significant increase (by 23.0%) in the incidence of infectious and inflammatory groups of the urinary system diseases among children of 0-14 years old, while among adolescents there was simultaneously an intensive decrease in indicators (by 40.0%) compared to 8.7% in 2006-2011. The ratio of indicators and their dynamics suggests that the growth of sick adolescents is largely due to the insufficient effectiveness of medical care, while children of 0-14 years old is due to their low and insufficient prevention. The data formed the foundation for substantiation and development of an improved functional-organizational model of the system. In addition to the existing and functionally changed elements the model contains new elements: regional/inter-regional center of specialized medical aid for children with infectious-inflammatory diseases of the urinary system. Conclusion. Implementation of the elements of the suggested improved model in a part of a rational approach in distribution of functions concerning medical observation of patients at the stages of providing medical aid enabled to make the period of hospitalization of nephrological patients by 11.40% shorter and an average period of treatment of patients with infectious-inflammatory diseases of the urinary system by 2.93% shorter. Efficiency of implementation of certain elements of the suggested model with its positive evaluation by independent experts and its compliance with the strategy of branch reforms enables to recommend the improved functional-organization model of providing medical aid for children with infectious-inflammatory diseases of the urinary system at the regional level to be introduced into the health care system of Ukraine

NATRIURETIC PEPTIDES LEVEL AND THE STATUS OF THE RENIN – ANGIOTENSIN-ALDOSTERONE SYSTEM IN CHRONIC KIDNEY DISEASE IN PATIENTS WITH CONGENITAL MALFORMATIONS OF THE URINARY SYSTEM

2018 ◽  
Vol 22 (5) ◽  
pp. 45-50
Author(s):  
A. M. Mambetova ◽  
A. M. Inarokova ◽  
N. N. Shabalova ◽  
D. V. Bizheva ◽  
A. T. Mahiyeva
Keyword(s):  
Congenital Malformations ◽  
Control Group ◽  
Healthy Children ◽  
Urinary System ◽  
Renin Angiotensin Aldosterone System ◽  
Natriuretic Hormone ◽  
Renin Angiotensin ◽  
Group I ◽  
The Status ◽  
Sick Children

THE AIM. To determine the concentration of natriuretic peptide in the blood serum in children with congenital malformations of the urinary system (CM US) and to compare with the activity of renin-angiotensin-aldosterone system (RAAS).MATERIALS AND METHODS.119 patients with CM US aged 3 to 18 years were examined. A control group of 10 clinically healthy children. 3 groups were assigned: group I – 55 children with  congenital vesicoureteral reflux, and group II – 34 children with  congenital hydronephrosis and ureterohydronephrosis, III group – 30 children with other forms of dysembryogenesis of the US. Following indicators were identified by ELISA in the blood: renin, aldosterone,  N – terminal propeptide natriuretic hormone (NT-рroВNР). RESULTS.NT-рroВNР, renin and aldosterone hyperproduction were diagnosed in 59,6%, 69,7%, 54.6 % of sick children relatively. Concentrations were higher in all variants of  malformations in comparison with the control group. Significant  differences were revealed in obstructive species, where arterial  hypertension (AH) was diagnosed more often. Patients with AH  recorded significantly higher concentrations of NT-proВNР and renin.CONCLUSION.The key point in pathological processes developmentand progression in the cardiovascular system and kidneys is the  activation of RAAS. The system of natriuretic factors is important in maintaining the compensated state of patients due to the blockade of RAAS.

Antibiotic resistance in urological patients with inflammatory diseases of the upper urinary tract

2019 ◽  
Vol 11 (2) ◽  
pp. 106-110
Author(s):  
A.B. Bochkarev ◽  
◽  
S.V. Kostuykov ◽  
E.I. Shamatrina ◽  
D.S. Merinov ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Urinary Tract ◽  
Inflammatory Diseases ◽  
Upper Urinary Tract

Антимікробна резистентність провідних збудників інфекцій сечових шляхів у Києві (Україна)

2017 ◽  
Vol 1 (2) ◽  
pp. 48-60
Author(s):  
A.G. Salmanov ◽  
A.V. Rudenko
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Klebsiella Pneumoniae ◽  
Staphylococcus Epidermidis ◽  
Klebsiella Oxytoca ◽  
Enterobacter Aerogenes ◽  
Enterobacter Cloacae ◽  
Proteus Vulgaris ◽  
Providencia Rettgeri ◽  
E Coli

Мета роботи — вивчити резистентність до антибіотиків бактеріальних збудників інфекцій сечових шляхів (ІСШ), виділених у пацієнтів урологічного стаціонару в м. Києві. Матеріали і методи. Досліджено 1612 штамів бактерій, виділених із сечі хворих з ІСШ (цистит, уретрит, пієлонефрит), госпіталізованих в урологічне відділення ДУ «Інститут урології НАМН України» у м. Києві протягом 2016 р. Серед пацієнтів переважали жінки — 1201 (74,5 %). Вік хворих становив від 17 до 74 років. Для збору даних використано медичну документацію лікарні. Мікробіологічні дослідження виконано у лабораторії мікробіології ДУ «Інститут урології НАМН України». Аналізували результати культурального дослідження зразків сечі, зібраних за наявності клінічних ознак ІСШ. Дослідження клінічного матеріалу та інтерпретацію отриманих результатів проводили загальноприйнятими методами. Вивчено чутливість уропатогенів до 31 антибіотика дискодифузійним методом відповідно до рекомендацій Інституту клінічних та лабораторних стандартів США (Clinical and Laboratory Standards Institute (CLSI)). Результати та обговорення. Аналіз мікробного спектра сечі виявив домінування серед уропатогенів штамів Escherichia coli (32,0 %), Enterococcus faecalis (19,5 %), Klebsiella pneumoniae (10,9 %), Staphylococcus epidermidis (8,9 %), S. haemolyticus (6,5 %) та Pseudomonas aeruginosa (6,4 %). Частка Enterococcus faecium, Enterobacter aerogenes і Streptococcus viridans становила відповідно 2,5, 2,2 і 1,6 %, Enterobacter cloacae, Klebsiella oxytoca, Acinetobacter baumannii, Proteus vulgaris та Providencia rettgeri — менше 1,0 %. У більшості випадків (69,7 %) мікроорганізми виділено у монокультурі, у решті випадків — у мікробних асоціа- ціях. Високу резистентність до тестованих антибіотиків виявили штами E. aerogenes (45,1 %), E. cloacae (45,7 %), E. faecium (40,9 %), E. faecalis (40,7 %), E. coli (39,9 %), P. aeruginosa (34,0 %), K. pneumoniae (28,6 %). Найбільш активними до уропатогенів були іміпенем (E. coli — 87,6 %, P. aeruginosa — 75,7 %, E. cloacae — 67,3 %, E. aerogenes — 72,6 %, K. pneumoniae — 93,2 %), меропенем (E. coli — 89,1 %, P. aeruginosa — 76,7 %, K. pneumoniae — 82,6 %), лефлоцин (E. coli — 74,5 %, ентерококи — 78,7 %, P. aeruginosa — 76,7 %, E. cloacae — 73,9 %, E. aerogenes — 80,4 %, K. pneumoniae — 83,5 %), амоксицилін/клавуланат (ентерококи — 84,6 %), фурагін (ентерококи — 82,6 %), цефоперазон (K. pneumoniae — 89,2 %, P. aeruginosa — 73,8 %), цефтріаксон (K. pneumoniae — 80,1 %). Висновки. Антибіотикорезистентність збудників ІСШ — важлива терапевтична проблема. Найбільшою активністю до уропатогенів характеризуються іміпенем, меропенем, лефлоцин, амоксицилін/ клавуланат, фурагін, цефоперазон, цефтріаксон, які можна розглядати як препарат вибору для призначення стартової терапії ІСШ. Необхідно здійснювати постійний моніторинг за резистентністю до дії антибіотиків. Політику використання антибіотиків у кожному стаціонарі слід визначати залежно від локальних даних щодо резистентності до протимікробних препаратів.

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