scholarly journals Study of Anaemia in Children with Severe Acute Malnutrition

2018 ◽  
Vol 37 (3) ◽  
pp. 250-253 ◽  
Author(s):  
Deepak Dwivedi ◽  
Veerendra Singh ◽  
Jyoti Singh ◽  
Sangita Sharma
Keyword(s):  
Severe Acute Malnutrition ◽  
Tertiary Care ◽  
Severe Anaemia ◽  
Acute Malnutrition ◽  
Folic Acid Deficiency ◽  
Care Hospital ◽  
Macrocytic Anaemia ◽  
Normal Children ◽  
Co Morbidity ◽  
Morphologic Type

Introduction: Severe anaemia is a leading cause of paediatric morbidity, hospitalization, and mortality and it is very important co morbidity in children with severe acute malnutrition. Severe Acute Malnutrition (SAM) with anaemia has been shown to have 2.62 times higher mortality as compared to SAM with no anaemia. So this study was done to evaluate this co-morbidity further. The aim of present study was to determine the prevalence and type of anaemia and to evaluate the possible aetiologies of anaemia in severe acute malnourished (SAM) children.Material and Methods: In tertiary care hospital a cross sectional study was conducted over a period of 8 month with 100 cases of SAM children and 101 cases of normal children. In both cases disorders of primary haematological problem were excluded. Auto analysers were used to measure blood counts. Blood smear was analysed by pathology consultant of institute and recorded for all patients with anaemia. Grade of anaemia and morphologic type of anaemia was analysed. Data were entered in Excel spreadsheets and analysed using SPSS 20.0.Results: Patient with SAM 42% had moderate anaemia and 19% had severe anaemia in contrast 41.6% and 16.8% in NON SAM child respectively. Predominant morphologic type in SAM patient was macrocytic anaemia (33%), while in controls microcytic anaemia (40.6%) was more prevalent.Conclusion: There was a high prevalence of anaemia in SAM children. Major morphologic type in SAM children was macrocytic anaemia which may indirectly show vitamin B12 or folic acid deficiency in these children.  

Ultrasonographic prevalence and proposed morphologic classification of bilobed gallbladder in cats

2021 ◽  
pp. 1098612X2110556
Author(s):  
Heather N Spain ◽  
Dominique G Penninck ◽  
Michael Thelen
Keyword(s):  
Classification Scheme ◽  
Ultrasound Examination ◽  
Abdominal Ultrasound ◽  
Complete Evaluation ◽  
Ultrasound Evaluation ◽  
Plane Image ◽  
Morphologic Type ◽  
The Relationship ◽  
Abdominal Ultrasound Examination

Objectives Morphologic anomalies of the feline gallbladder (GB) have been previously reported in the literature. These morphologic variants are frequently encountered on routine abdominal ultrasound examination. The aim of this study was to provide an ultrasonographic classification system of these variants and document the overall incidence in the feline population. Methods A prospective, descriptive study was undertaken; cats that had an abdominal ultrasound examination that included at least one sagittal and transverse plane image of the GB were included. GB shape was evaluated and categorized based on a classification scheme of morphologic variants modified from the human literature. Septated (S), bilobed (B1, B2, B3), duplex (D) and complex (C) categories were described. Results Of 516 cats included in the study, 389 had normal GB morphology, while 127 had anomalous GB morphology. The overall incidence rate of anomalous GB morphology was 24.61%. When examined by morphologic type, the septated (S) morphology had an incidence of 9.69%. A bilobed (B) morphology was the most commonly observed classification; incidence was 14.35% within our population; incidence of B1, B2 and B3 subtypes were 2.91%, 6.98% and 4.46%, respectively. Duplex GBs only made up 0.39% of the total population. The incidence of complex (C) morphologies was 0.19%. Conclusions and relevance The incidence of GB morphologic anomalies was higher in our population than previously reported. Identification of these anomalies on routine ultrasound evaluation is common; numerous different morphologies can be identified and a standardized classification scheme is proposed. Complete evaluation of morphology can be challenging, particularly with regard to cystic duct anatomy. Clinical significance is uncertain and future studies are warranted to determine the relationship between morphologic variants and hepatobiliary disease.

scholarly journals Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis

2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
Nilüfer Onak Kandemir ◽  
Figen Barut ◽  
Banu Doğan Gün ◽  
Nilgün Solak Tekin ◽  
Sevinç Hallaç Keser ◽  
...  
Keyword(s):  
Cavernous Hemangioma ◽  
Histopathological Examination ◽  
Early Stage ◽  
Kaposi Sarcoma ◽  
Classical Type ◽  
Cutaneous Lesions ◽  
Vascular Structures ◽  
Superficial Dermis ◽  
Morphologic Type ◽  
Hiv 1

Aim. Cavernous hemangioma-like Kaposi sarcoma is a rare morphologic type of Kaposi sarcoma. So far there are no cases in the literature defining the histological features of this morphologic spectrum in detail. In this study we presented two classical-type cutaneous Kaposi sarcoma cases with histologic findings resembling cavernous hemangioma in company with clinical and histopathological data.Cases. One hundred and eighty-five classical-type cutaneous Kaposi sarcoma lesions in 79 patients were assessed retrospectively in terms of histopathological features. Findings of two cases showing features of cavernous hemangioma-like Kaposi sarcoma whose clinical data could be accessed were presented in accompany with the literature data. Both cases were detected to have bluish-purple, protruded, irregularly bordered cutaneous lesions. Histopathological examination revealed a lesion formed by cavernous hemangioma-like vascular structures organized in a lobular pattern that became dilated and filled with blood. Typical histological findings of early-stage KS, consisting of mononuclear inflammation, extravasated erythrocytes, and a few immature vascular structures in superficial dermis, were observed. All cases were serologically HIV-1 negative. A positive reaction with HHV-8, CD31, CD34, and D2-40 monoclonal antibodies was identified at both cavernous hemangioma-like areas and in immature vascular structures.Results. Cavernous hemangioma-like Kaposi sarcoma is a rare Kaposi sarcoma variant presenting with diagnostic challenges, that may be confused with hemangioma. As characteristic morphological features may not be observed in every case, it is important for diagnostic purposes to show immunohistochemical HHV-8 positivity in this variant.

scholarly journals Functional changes in human leukemic cell line HL-60. A model for myeloid differentiation

1979 ◽  
Vol 82 (2) ◽  
pp. 315-322 ◽  
Author(s):  
PE Newburger ◽  
ME Chovaniec ◽  
JS Greenberger ◽  
HJ Cohen
Keyword(s):  
Cell Line ◽  
Leukemia Cell ◽  
Leukemic Cell ◽  
Leukemia Cell Line ◽  
Bacterial Killing ◽  
Functional Changes ◽  
Myeloid Development ◽  
Human Leukemic Cell Line ◽  
Time Required ◽  
Morphologic Type

Polar solvents induce terminal differentiation in the human promyelocytic leukemia cell line HL-60. The present studies describe the functional changes that accompany the morphologic progression from promyelocytes to bands and poly-morphonuclear leukocytes (PMN) over 9 d of culture in 1.3 percent dimethylsulfoxide (DMSO). As the HL-60 cells mature, the rate of O(2-) production increase 18-fold, with a progressive shortening of the lag time required for activation. Hexosemonophosphate shunt activity rises concomitantly. Ingestin of paraffin oil droplets opsonized with complement or Ig increases 10-fold over 9 d in DMSO. Latex ingestion per cell by each morphologic type does not change significantly, but total latex ingestion by groups of cells increases with the rise in the proportion of mature cells with greater ingestion capacities. Degranulation, as measured by release of β-glucuronidase, lysozyme, and peroxidase, reaches maximum after 3-6 d in DMSO, then declines. HL-60 cells contain no detectable lactoferrin, suggesting that their secondary granules are absent or defective. However, they kill staphylococci by day 6 in DMSO. Morphologically immature cells (days 1-3 in DMSO) are capable of O(2-) generation, hexosemonophosphate shunt activity, ingestion, degranulation, and bacterial killing. Maximal performance of each function by cells incubated in DMSO for longer periods of time is 50-100 percent that of normal PMN. DMSO- induced differentiation of HL-60 cells is a promising model for myeloid development.

scholarly journals A New Approach - Use of effectiveness and efficiency concepts in the identification of activities related to occupational safety management on motorways

2018 ◽  
Vol 2 (2) ◽  
pp. 12-20
Author(s):  
José Eduardo Silva ◽  
Carlos Rodrigues
Keyword(s):  
Occupational Safety ◽  
Safety Management ◽  
Weather Conditions ◽  
Delphi Panel ◽  
Expansion Joints ◽  
Traffic Characteristics ◽  
Use Of Resources ◽  
Efficiency And Effectiveness ◽  
Operational Activities ◽  
Morphologic Type

The need to improve the safety management in the maintenance and operational works on a motorway is a request that all the organizations demand to achieve better goals on safety and in the use of resources. The use of instruments linked to efficiency and effectiveness is one possible solution to this problem. The objective of the present investigation is to prove that it is possible to identify the main activities contained in the A area of an ABC curve and linked to the Pareto´s concepts, defining this way the 20% most dangerous maintenance and operational activities on motorway works. The methodology used was a DELPHI panel formed by experts from different areas linked to safety at work on motorways. The statistic treatment was made through the informatic program IBM SPSS Statistics 24. The results show that it is possible to identify 36 main activities in maintenance and operational works, being relevant the activities related to emergency response, safety guards, expansion joints, provisional signaling and the access to working stations in toll areas. The conclusions of the study reveal that these 36 activities represent the 20% most dangerous activities in maintenance and operational works on a motorway, and show that besides the risks of the work itself, there are four crucial traffic factors to develop a correct risk analysis: weather conditions, traffic characteristics, pavement characteristics and motorway morphologic type.

scholarly journals How to Classify Pituitary Neuroendocrine Tumors (PitNET)s in 2020

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 514 ◽  
Author(s):  
Jacqueline Trouillas ◽  
Marie-Lise Jaffrain-Rea ◽  
Alexandre Vasiljevic ◽  
Gérald Raverot ◽  
Federico Roncaroli ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Early Recognition ◽  
Pituitary Tumors ◽  
Operative Management ◽  
Prognostic Impact ◽  
Null Cell ◽  
Ki 67 ◽  
Standardized Report ◽  
Proliferative Markers ◽  
Morphologic Type

Adenohypophyseal tumors, which were recently renamed pituitary neuroendocrine tumors (PitNET), are mostly benign, but may present various behaviors: invasive, “aggressive” and malignant with metastases. They are classified into seven morphofunctional types and three lineages: lactotroph, somatotroph and thyrotroph (PIT1 lineage), corticotroph (TPIT lineage) or gonadotroph (SF1 lineage), null cell or immunonegative tumor and plurihormonal tumors. The WHO 2017 classification suggested that subtypes, such as male lactotroph, silent corticotroph and Crooke cell, sparsely granulated somatotroph, and silent plurihormonal PIT1 positive tumors, should be considered as “high risk” tumors. However, the prognostic impact of these subtypes and of each morphologic type remains controversial. In contrast, the French five-tiered classification, taking into account the invasion, the immuno-histochemical (IHC) type, and the proliferative markers (Ki-67 index, mitotic count, p53 positivity), has a prognostic value validated by statistical analysis in 4 independent cohorts. A standardized report for the diagnosis of pituitary tumors, integrating all these parameters, has been proposed by the European Pituitary Pathology Group (EPPG). In 2020, the pituitary pathologist must be considered as a member of the multidisciplinary pituitary team. The pathological diagnosis may help the clinician to adapt the post-operative management, including appropriate follow-up and early recognition and treatment of potentially aggressive forms.

scholarly journals Peliosis Hepatis—The Chameleon: An Unusual Presentation Mimicking Liver Abscess

2019 ◽  
Vol 02 (02) ◽  
pp. 126-129
Author(s):  
Ruchi Rastogi ◽  
Parveen Batra ◽  
Subhash Gupta ◽  
Anjali K. Gupta ◽  
Bharat Aggarwal ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Liver Abscess ◽  
Liver Parenchyma ◽  
Unusual Presentation ◽  
Peliosis Hepatis ◽  
Morphologic Type

AbstractPeliosis hepatis is a rare vascular condition characterized by multiple randomly distributed blood-filled cavities throughout the liver, ranging in size from a few millimeters to several centimeters in diameter. The appearance of peliotic lesion on imaging varies depending on morphologic type, concomitant hemorrhagic component, and presence or absence of background hepatic steatosis. Here, we report an unusual presentation of peliosis hepatis as an exophytic mass arising in liver parenchyma, mimicking a liver abscess.

scholarly journals A case series of aggressive angiomyxoma: Using morphologic type and hormonal modification to tailor treatment

2021 ◽  
Vol 36 ◽  
pp. 100765
Author(s):  
Joni Kooy ◽  
Vanessa Carlson ◽  
Lana Šačiragić ◽  
Summit Sawhney ◽  
Gregg Nelson
Keyword(s):  
Case Series ◽  
Aggressive Angiomyxoma ◽  
Morphologic Type

scholarly journals Nonrandom involvement of the 12p12 breakpoint in chromosome abnormalities of childhood acute lymphoblastic leukemia

Blood ◽  
1986 ◽  
Vol 68 (1) ◽  
pp. 69-75 ◽  
Author(s):  
SC Raimondi ◽  
DL Williams ◽  
T Callihan ◽  
S Peiper ◽  
GK Rivera ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Clinical Manifestations ◽  
Chromosome 12 ◽  
Cell Phenotype ◽  
Reciprocal Translocations ◽  
Hla Dr ◽  
Modal Chromosome Number ◽  
Failed Induction ◽  
Morphologic Type

We studied the presenting clinical and biologic features of 23 children with acute lymphoblastic leukemia (ALL) whose leukemic marrow karyotypes contained abnormalities involving the short arm of chromosome 12. Nineteen of the abnormalities were assigned to the 12p12 breakpoint. The median age of the children was 5 years (range 2 to 13 years) and their initial leukocyte counts ranged from 1,800 to 424,000/microL (median 30,000/microL). Twenty-one patients (91%) had common phenotype ALL (CALLA+, HLA-DR+), including three cases with a pre-B cell phenotype (CIg+). The remaining two cases were T cell in origin. The French-American-British (FAB) morphologic type of lymphoblastic leukemia was L1 in all cases but one. With a median follow-up of 11 months, four patients have relapsed and another failed induction therapy. The modal chromosome number in all cases was less than 50. Three distinct cytogenetic patterns, with apparently similar clinical manifestations, were noted: terminal deletions of chromosome 12 in 10 cases, apparently balanced reciprocal translocations in 6, and unbalanced translocations in 7. All translocations were between the 12p arm and different donor chromosomes except for chromosomes 7, 9, and 17, which participated twice. Only two patients had identical translocations: t(7;12)(q11;p12). This unusual variation in donor chromosomes and breakpoints suggests that translocations involving the 12p are specific with respect to only one member of the translocation pair, namely chromosome 12. The relatively high frequency of the 12p abnormalities in this study (10% of all completely banded cases seen over a 35-month period) warrants further investigation.

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