scholarly journals Epidemiological Analysis of the Incidence of Hemorrhagic Fever with Renal Syndrome in the Jewish Autonomous Region in 2003 - 2016

2017 ◽  
Vol 16 (3) ◽  
pp. 90-95
Author(s):  
E. I. Andaev ◽  
A. V. Sevostianova ◽  
N. V. Breneva ◽  
A. K. Noskov ◽  
P. V. Kopylov ◽  
...  
Keyword(s):  
Large Scale ◽  
Hemorrhagic Fever ◽  
Gene Fragment ◽  
Rt Pcr ◽  
High Increase ◽  
Epidemiological Analysis ◽  
Autonomous Region ◽  
Natural Foci ◽  
Taxonomic Affiliation ◽  
Operational Data

Retrospective epidemiological analysis of hemorrhagic fever with renal syndrome (HFRS) was performed in the Jewish Autonomous Region based on archival, statistical and operational data of 133 HFRS cases. Total 63 mammal samples were examined by ELISA and RT-PCR. Large-scale flooding in 2013 sharpened the epizootological condition and created the preconditions for epidemiological complications. The high increase in HFRS incidence in 2014 was characterized by the epidemiological process intensity displacement from the southern areas to least affected by flooding northern parts of the region and alteration of the seasonality corresponding to the maximum number of carriers in natural foci. Since 2015 a decrease of morbidity is observing. RNA and antigen of Hantaviruses were found in Apodemus agrarius and Microtus maximowiczii. Sequencing of L-gene fragment (334 bp) of RNA-containing samples showed their taxonomic affiliation to the three Hantaviruses: Khabarovsk, Hantaan and Puumala.

scholarly journals Results of epizootic monitoring of natural foci of particularly dangerous infections common to humans and animals in Rostov Oblast

2021 ◽  
Vol 12 (4) ◽  
pp. 83-90
Author(s):  
E. Y. Lukshina ◽  
V. V. Batashev ◽  
E. V. Kovalev ◽  
G. V. Karpushchenko ◽  
V. V. Balakhnova ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Q Fever ◽  
Hemorrhagic Fever ◽  
Rostov Oblast ◽  
Laboratory Research ◽  
West Nile Fever ◽  
Natural Focus ◽  
Epidemiological Analysis ◽  
Blood Sucking ◽  
Natural Foci

Objective: To analyze the results of epizootic monitoring of natural foci of particularly dangerous infections common to humans and animals in Rostov Oblast to establish their activity.Materials and Methods: The data of epizootic monitoring conducted by zoologists; the results of laboratory research of field material obtained in natural foci of infectious diseases. Descriptive, zoological, genetic, serological methods, and retrospective epidemiological analysis were used.Results: The results of the conducted epizootic monitoring showed the presence in Rostov Oblast of natural foci of particularly dangerous infectious diseases common to humans and animals. While the natural focus of the plague is in a depressed state and does not show activity, in the foci of tularemia, West Nile fever (WNF), Crimean hemorrhagic fever (CHF), ixodic tick-borne borreliosis (ITB), hemorrhagic fever with renal syndrome (HFRS), Q fever, Batai fever, California serogroups, Syndbis revealed the antigens of these pathogens in biological material obtained from small mammals and blood-sucking insects, which indicates the epizootic activity of these foci. In the natural foci of WNF, CHF, ITB, HFRS, cases of these disease among the population were recorded, which confirms the epidemic activity of these foci.Conclusion: The obtained results of epizootic monitoring over the period from 2008 to 2020 emphasize the relevance and necessity of continuing these studies in natural foci in Rostov Oblast.

scholarly journals Salmonella in Captive Reptiles and Their Environment—Can We Tame the Dragon?

2021 ◽  
Vol 9 (5) ◽  
pp. 1012
Author(s):  
Magdalena Zając ◽  
Magdalena Skarżyńska ◽  
Anna Lalak ◽  
Renata Kwit ◽  
Aleksandra Śmiałowska-Węglińska ◽  
...  
Keyword(s):  
Public Health ◽  
Antimicrobial Resistance ◽  
Detection Rate ◽  
Large Scale ◽  
Isolation And Identification ◽  
Epidemiological Analysis ◽  
High Occurrence ◽  
Salmonella Serovars ◽  
Floor Surfaces

Reptiles are considered a reservoir of a variety of Salmonella (S.) serovars. Nevertheless, due to a lack of large-scale research, the importance of Reptilia as a Salmonella vector still remains not completely recognized. A total of 731 samples collected from reptiles and their environment were tested. The aim of the study was to assess the prevalence of Salmonella in exotic reptiles kept in Poland and to confirm Salmonella contamination of the environment after reptile exhibitions. The study included Salmonella isolation and identification, followed by epidemiological analysis of the antimicrobial resistance of the isolates. Implementation of a pathway additional to the standard Salmonella isolation protocol led to a 21% increase in the Salmonella serovars detection rate. The study showed a high occurrence of Salmonella, being the highest at 92.2% in snakes, followed by lizards (83.7%) and turtles (60.0%). The pathogen was also found in 81.2% of swabs taken from table and floor surfaces after reptile exhibitions and in two out of three egg samples. A total of 918 Salmonella strains belonging to 207 serovars and serological variants were obtained. We have noted the serovars considered important with respect to public health, i.e., S. Enteritidis, S. Typhimurium, and S. Kentucky. The study proves that exotic reptiles in Poland are a relevant reservoir of Salmonella.

scholarly journals Detection of multiple enteric virus strains within a foodborne outbreak of gastroenteritis: an indication of the source of contamination

2004 ◽  
Vol 133 (1) ◽  
pp. 41-47 ◽  
Author(s):  
C. I. GALLIMORE ◽  
C. PIPKIN ◽  
H. SHRIMPTON ◽  
A. D. GREEN ◽  
Y. PICKFORD ◽  
...  
Keyword(s):  
Arabian Gulf ◽  
Enteric Virus ◽  
Multiple Infections ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Epidemiological Analysis ◽  
Viral Aetiology ◽  
Polymerase Chain ◽  
Most Probable Explanation ◽  
Virus Strains

An outbreak of acute gastroenteritis of suspected viral aetiology occurred in April 2003 in the British Royal Fleet Auxillary ship (RFA) Argus deployed in the Northern Arabian Gulf. There were 37 cases amongst a crew of 400 personnel. Of 13 samples examined from cases amongst the crew, six enteric viruses were detected by reverse transcriptase polymerase chain reaction (RT–PCR). Five different viruses were identified including, three norovirus genotypes, a sapovirus and a rotavirus. No multiple infections were detected. A common food source was implicated in the outbreak and epidemiological analysis showed a statistically significant association with salad as the source of the outbreak, with a relative risk of 3·41 (95% confidence interval of 1·7–6·81) of eating salad on a particular date prior to the onset of symptoms. Faecal contamination of the salad at source was the most probable explanation for the diversity of viruses detected and characterized.

Cross-contamination in molecular laboratories: A challenge to COVID-19 testing in Bangladesh

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Mohammad Jahidur Rahman Khan ◽  
◽  
Selim Reza ◽  
Farzana Mim ◽  
Md Abdullah Rumman ◽  
...  
Keyword(s):  
Public Health ◽  
Large Scale ◽  
Diagnostic Testing ◽  
Diagnostic Errors ◽  
Laboratory Diagnosis ◽  
Cross Contamination ◽  
Rt Pcr ◽  
Public Health Response ◽  
Surveillance Programs ◽  
The Government

Rapid and accurate laboratory diagnosis of SARS-CoV-2 infection is crucial for the management of COVID-19 patients and control of the spread of the virus. At the start of the COVID-19 pandemic, Bangladesh had only one government molecular laboratory where real-time RT-PCR will be performed to diagnose SARS-CoV-2 infection. With the increasing number of suspected cases requiring confirmation diagnostic testing, there was a requirement to quickly expand capacity for large-scale testing. The government of Bangladesh established over 100 molecular laboratories within one year to test COVID-19. To fulfil the requirement for expanded testing, the government was compelled to recruit laboratory employees with inadequate experience, technical knowledge, and skills in molecular assays, particularly in processing specimens, interpreting results, recognizing errors, and troubleshooting. As a result, the risk of diagnostic errors, such as cross-contamination, is increased, as is that the risk of false-positive results, which might risk the patient’s health and undermine the efficacy of public health policies, public health response, surveillance programs, and restrictive measures aimed toward containing the outbreak. This review article aims to explain different sources of crosscontamination in the COVID-19 RT-PCR laboratories and the way to forestall them in efficient and practical ways.

On complex treatment and ways of preventing deaths in hemorrhagic fever with renal syndrome

1985 ◽  
Vol 66 (3) ◽  
pp. 186-188
Author(s):  
T. A. Bashkirev
Keyword(s):  
Hemorrhagic Fever ◽  
Complex Treatment ◽  
Natural Foci ◽  
Middle Volga ◽  
Active Natural

In recent years, the most active natural foci of hemorrhagic fever with renal syndrome (HFRS) have been identified in the regions of the Middle Volga and Ural regions, where more than 70% of registered diseases occur in the RSFSR and a tendency to further growth is observed.

scholarly journals Equine-Origin Immunoglobulin Fragments Protect Nonhuman Primates from Ebola Virus Disease

2018 ◽  
Vol 93 (5) ◽  
Author(s):  
Hualei Wang ◽  
Gary Wong ◽  
Wenjun Zhu ◽  
Shihua He ◽  
Yongkun Zhao ◽  
...  
Keyword(s):  
Large Scale ◽  
Nonhuman Primates ◽  
Ebola Virus ◽  
Virus Disease ◽  
Hemorrhagic Fever ◽  
West African ◽  
Clinical Testing ◽  
The Past ◽  
Over 40 Years

ABSTRACT Ebola virus (EBOV) infections result in aggressive hemorrhagic fever in humans, with fatality rates reaching 90% and with no licensed specific therapeutics to treat ill patients. Advances over the past 5 years have firmly established monoclonal antibody (MAb)-based products as the most promising therapeutics for treating EBOV infections, but production is costly and quantities are limited; therefore, MAbs are not the best candidates for mass use in the case of an epidemic. To address this need, we generated EBOV-specific polyclonal F(ab′)2 fragments from horses hyperimmunized with an EBOV vaccine. The F(ab′)2 was found to potently neutralize West African and Central African EBOV in vitro. Treatment of nonhuman primates (NHPs) with seven doses of 100 mg/kg F(ab′)2 beginning 3 or 5 days postinfection (dpi) resulted in a 100% survival rate. Notably, NHPs for which treatment was initiated at 5 dpi were already highly viremic, with observable signs of EBOV disease, which demonstrated that F(ab′)2 was still effective as a therapeutic agent even in symptomatic subjects. These results show that F(ab′)2 should be advanced for clinical testing in preparation for future EBOV outbreaks and epidemics. IMPORTANCE EBOV is one of the deadliest viruses to humans. It has been over 40 years since EBOV was first reported, but no cure is available. Research breakthroughs over the past 5 years have shown that MAbs constitute an effective therapy for EBOV infections. However, MAbs are expensive and difficult to produce in large amounts and therefore may only play a limited role during an epidemic. A cheaper alternative is required, especially since EBOV is endemic in several third world countries with limited medical resources. Here, we used a standard protocol to produce large amounts of antiserum F(ab′)2 fragments from horses vaccinated with an EBOV vaccine, and we tested the protectiveness in monkeys. We showed that F(ab′)2 was effective in 100% of monkeys even after the animals were visibly ill with EBOV disease. Thus, F(ab′)2 could be a very good option for large-scale treatments of patients and should be advanced to clinical testing.

scholarly journals Analisis Perkembangan Kasus COVID-19 Berkaitan dengan Kebijakan Pemerintah di Pulau Jawa

2021 ◽  
Vol 9 (1) ◽  
pp. 01-12
Author(s):  
Charvia Ismi Zahrani ◽  
Setia Pramana
Keyword(s):  
Local Government ◽  
Large Scale ◽  
Government Policies ◽  
High Increase ◽  
Public Places ◽  
The Public ◽  
Social Restriction ◽  
Almost All ◽  
Death Cases ◽  
Very High

AbstractCOVID-19 is a serious problem that faced by almost all countries in the world. Since announced as a pandemic by WHO on March, the number of positive COVID-19 cases in Indonesia has reached 287,008 patients until the end of September 2020. COVID-19 cases dispersion depends on the local government policies and the awareness of the public to obey. About 60 percent of positive cases and 65 percent of death cases were in Java. Therefore, the aim of this study is to analyze the growth of the COVID-19 case in Java from March to September 2020 in relation to the local government policies. The results showed that six provinces in Java had the same pattern. The large-scale social restriction (PSBB), which was implemented since April 10 2020, seen to be able to contain the dispersion of cases because from April to June the positive cases did not increase significantly. A very high increase occurred in August and September, this was probably due to the easing of the PSBB become new-normal where various public places and facilities have been reopened. Meanwhile, death cases, the number is very high in mid-April and June and late July to September 2020. For cured cases, there was a significant increase in late August to September 2020. The importance of information about the growth of the COVID-19 cases can help government to formulate strategies and policies to prevent the dispersion of COVID-19.Keyword: COVID-19, Pandemic, Java, cases growth AbstrakCOVID-19 merupakan suatu masalah serius yang sedang dihadapi oleh hampir seluruh negara. Sejak diumumkan sebagai pandemi oleh WHO pada Maret lalu, jumlah kasus positif COVID-19 di Indonesia mencapai 287.008 pasien hingga akhir September. Penyebaran kasus COVID-19 sangat bergantung pada kebijakan yang ditetapkan oleh pemerintah serta kesadaran masyarakat untuk mematuhinya. Sebesar 60 persen kasus positif dan 65 persen kasus meninggal berada di Pulau Jawa. Oleh karena itu, tujuan penelitian ini adalah menganalisis perkembangan kasus COVID-19 di Pulau Jawa sejak Bulan Maret-September 2020 dikaitkan dengan kebijakan pemerintah setempat. Hasil penelitian menunjukkan bahwa keenam provinsi memiliki pola yang sama. Pembatasan Sosial Berskala Besar (PSBB) yang dilakukan sejak 10 April 2020 terlihat dapat menahan penyebaran kasus karena pada bulan April-Juni 2020 kasus positif tidak mengalami kenaikan yang signifikan. Kenaikan yang sangat tinggi terjadi pada bulan Agustus dan September 2020, hal ini mungkin disebabkan oleh dilonggarkannya kebijakan PSBB menjadi PSBB Transisi dimana berbagai tempat dan fasilitas umum telah dibuka kembali. Sementara untuk kasus meninggal, angka tertinggi terjadi pada pertengahan April dan Juni serta akhir Juli hingga September 2020. Untuk kasus sembuh, terjadi peningkatan yang signifikan pada akhir Agustus hingga September 2020. Pentingnya informasi tentang perkembangan kasus COVID-19 ini dapat membantu pemerintah daerah untuk membuat strategi dan kebijakan untuk mencegah penyebaran rantai virus COVID-19.Kata Kunci: COVID-19, Pandemi, Jawa, perkembangan kasus 

scholarly journals MAIN TRENDS OF MONITORING OF VIRAL HEMORRHAGIC FEVERS ACTIVITY IN THE NATURAL FOCI

2018 ◽  
pp. 68-78
Author(s):  
Галина Компанец ◽  
Galina Kompanets
Keyword(s):  
Russian Federation ◽  
Viral Infections ◽  
Hemorrhagic Fever ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fevers ◽  
Innovative Methods ◽  
Viral Hemorrhagic Fevers ◽  
Natural Foci ◽  
Severe Fever

This paper includes review of innovative methods of monitoring of activity of natural foci of epidemically important for Russian Federation such viral infections as hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF), and the analysis of probability to control such «exotic» infections, as Denge fever and severe fever with thrombocytopenia syndrome (SFTS).

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