Cerebellar liponeurocytoma: a rare intracranial tumor with possible familial predisposition. Case report

The biological origin of cerebellar liponeurocytomas is unknown, and hereditary forms of this disease have not been described. Here, the authors present clinical and histopathological findings of a young patient with a cerebellar liponeurocytoma who had multiple immediate family members who harbored similar intracranial tumors. A 37-year-old otherwise healthy woman presented with a history of progressive headaches. Lipomatous medulloblastoma had been diagnosed previously in her mother and maternal grandfather, and her maternal uncle had a supratentorial liponeurocytoma. MRI revealed a large, poorly enhancing, lipomatous mass emanating from the superior vermis that produced marked compression of posterior fossa structures. An uncomplicated supracerebellar infratentorial approach was used to resect the lesion. Genetic and histopathological analyses of the lesion revealed neuronal, glial, and lipomatous differentiation and confirmed the diagnosis of cerebellar liponeurocytoma. A comparison of the tumors resected from the patient and, 22 years previously, her mother revealed similar features. Cerebellar liponeurocytoma is a poorly understood entity. This report provides novel evidence of an inheritable predisposition for tumor development. Accurate diagnosis and reporting of clinical outcomes and associated genetic and histopathological changes are necessary for guiding prognosis and developing recommendations for patient care.

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EPID-21. THE NATIONAL SPECTRUM OF NEWLY-DIAGNOSED BRAIN TUMORS IN ADULT PATIENTS VARIES SIGNIFICANTLY BY PATIENT DEMOGRAPHICS

Neuro-Oncology ◽

10.1093/neuonc/noz175.321 ◽

2019 ◽

Vol 21 (Supplement_6) ◽

pp. vi79-vi79

Author(s):

Matthew Torre ◽

Mustafa Ascha ◽

Maya Harary ◽

Timothy Smith ◽

Ayal Aizer ◽

...

Keyword(s):

Brain Tumors ◽

Patient Characteristics ◽

Intracranial Tumor ◽

Adult Patients ◽

Intracranial Tumors ◽

Newly Diagnosed ◽

Patient Demographics ◽

Common Diagnosis ◽

History Of ◽

Tumor Types

Abstract INTRODUCTION Herein we examine the epidemiology and outcomes of the entire spectrum of intracranial tumors in the contemporary era. METHODS Adult patients (≥20yo) presenting between 2010–2015 where the first evidence of cancer involves an intracranial tumor were queried from the National Cancer Database, which comprises >70% of cancers newly-diagnosed in the U.S. Tumor types were classified by WHO2016 ICD-O3, and stratified by patient characteristics. RESULTS 361,841 adults without a history of cancer presented with intracranial tumors between 2010–2015. Across all ages, these were comprised of 1) brain metastases (BMs; 25%: 29% in males vs. 23% in females); 2) meningiomas (25%: 15% in males, but 34% in females) including atypical (n=4,565) and anaplastic (n=833); 3) diffuse infiltrative gliomas (21%: 26% in males vs. 17% in females), mostly GBMs (14%); followed by 4) sellar (14%), 5) cranial nerve (6%), and PCNSL (3%) tumors. The remaining types each comprised ≤2 % of brain tumors, including mesenchymal non-meningothelial tumors (2%), intracranial ependymal (0.8%), mixed neuronal-glial (0.7%), circumscribed “other astrocytomas” (0.6%, mostly pilocytic astrocytomas n=1,307 and PXAs n=272), CNS embryonal (0.3%), pineal (0.2%), GCTs (0.1%), and choroid plexus (0.1%) tumors. In the 91,686 patients presenting with a BM, the most common primaries were lung adenocarcinoma (39%), lung SmallCC (14%), lung SqCC (8%), breast (8% of females), melanoma (3%), kidney (3%), colorectal (2%), and esophageal (1%). The distributions of brain tumor types differed significantly by age, sex, race/ethnicity, and insurance status. CONCLUSIONS In adult patients where the first manifestation of cancer includes an intracranial tumor, the most common diagnosis is either metastatic disease (predominantly from NSCLC) in males or benign meningiomas in females; but varies substantially by age group. Notably, our results adjust the traditional teaching that half of all new brain masses are BMs, which in fact represent only ~25% of new intracranial masses.

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Association of family risk and lifestyle/comorbidities in ovarian cancer patients

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.61.03.234 ◽

2015 ◽

Vol 61 (3) ◽

pp. 234-239 ◽

Cited By ~ 3

Author(s):

Natália Teixeira ◽

Maria Aparecida Azevedo Koike Folgueira ◽

Simone Maistro ◽

Giselly Encinas ◽

Geertruida Hendrika de Bock ◽

...

Keyword(s):

Ovarian Cancer ◽

Mutation Detection ◽

Regression Analyses ◽

Family Risk ◽

Familial Predisposition ◽

Factors Associated ◽

System A ◽

History Of ◽

Psychiatric Conditions ◽

The Impact

Summary Objectives: to analyze factors that might indicate familial predisposition for ovarian cancer in patients diagnosed with this disease. Methods: in a prospective single center cohort study at the Institute of Cancer of the State of São Paulo (ICESP), 51 women diagnosed with ovarian cancer were included. Familial predisposition for ovarian cancer was defined as having a higher than 10% chance of having a BRCA1/2 mutation according to the Manchester scoring system, a validated method to assess the likelihood of mutation detection. Each patient was interviewed with a standardized questionnaire on established risk factors for ovarian cancer and other factors that might influence the risk to develop ovarian cancer. Logistic regression analyses were performed to estimate the impact of the evaluated factors on the likelihood of mutation detection, by calculating odds ratios and 95% confidence intervals. Results: seventeen out of 51 patients had a family history of breast and/or ovarian cancer, four patients had a history of breast or endometrial cancer, 11 were diagnosed before the age of 50, and 12 presented a risk of familial predisposition to ovarian cancer higher than 10%. Patients with comorbidities, such as hypertension, diabetes, hormonal disorders, dyslipidemia and psychiatric conditions, presented a lower chance of having a familial predisposition for ovarian cancer (OR: 0.22; 95% CI: 0.06-0.88; p=0.03). Conclusion: in this study, having comorbidities was associated with a lower risk of having a familial predisposition for ovarian cancer. Other factors associated with the risk of ovarian cancer did not have an impact on this predisposition.

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Extreme Lateral Supracerebellar Infratentorial Approach to the Lateral Midbrain

Journal of Neurological Surgery Part B Skull Base ◽

10.1055/s-0038-1669981 ◽

2018 ◽

Vol 79 (S 05) ◽

pp. S415-S417

Author(s):

M. Kalani ◽

William Couldwell

Keyword(s):

Cranial Nerves ◽

Sudden Onset ◽

Superior Cerebellar Artery ◽

Entry Zone ◽

Cerebellar Artery ◽

Sensory Disturbances ◽

History Of ◽

Supracerebellar Infratentorial Approach ◽

The Right ◽

Piecemeal Resection

This video illustrates the case of a 52-year-old man with a history of multiple bleeds from a lateral midbrain cerebral cavernous malformation, who presented with sudden-onset headache, gait instability, and left-sided motor and sensory disturbances. This lesion was eccentric to the right side and was located in the dorsolateral brainstem. Therefore, the lesion was approached via a right-sided extreme lateral supracerebellar infratentorial (exSCIT) craniotomy with monitoring of the cranial nerves. This video demonstrates the utility of the exSCIT for resection of dorsolateral brainstem lesions and how this approach gives the surgeon ready access to the supracerebellar space, and cerebellopontine angle cistern. The lateral mesencephalic safe entry zone can be accessed from this approach; it is identified by the intersection of branches of the superior cerebellar artery and the fourth cranial nerve with the vein of the lateral mesencephalic sulcus. The technique of piecemeal resection of the lesion from the brainstem is presented. Careful patient selection and respect for normal anatomy are of paramount importance in obtaining excellent outcomes in operations within or adjacent to the brainstem.The link to the video can be found at: https://youtu.be/aIw-O2Ryleg.

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Medulloblastoma Presenting as Severe Headache during Pregnancy: A Case Report and Review of the Literature

Medicina ◽

10.3390/medicina58010127 ◽

2022 ◽

Vol 58 (1) ◽

pp. 127

Author(s):

Francesca Gabriela Paslaru ◽

Anca Maria Panaitescu ◽

Elena Nestian ◽

George Iancu ◽

Alina Veduta ◽

...

Keyword(s):

Clinical Symptoms ◽

Imaging Techniques ◽

Diagnostic Procedures ◽

Intracranial Tumor ◽

Neurological Deficits ◽

Physiological Changes ◽

Intracranial Tumors ◽

Review Of The Literature ◽

Common Complaint ◽

Persistent Headache

Headache is a common complaint during pregnancy and the puerperium. The differentiation between a benign headache and a headache that has an underlying more endangering cause, such as an intracranial tumor, can be difficult and often requires diagnostic procedures and brain imaging techniques. We report the case of an 18-year-old female patient who developed clinical symptoms—persistent headache followed by neurological deficit—in the last part of her pregnancy. A medulloblastoma (MB) was diagnosed and treated after delivery. We review 11 other cases of MB in pregnancy reported in the literature. The most common clinical manifestation at diagnosis was headache followed by neurological deficits. We discuss the association of brain tumor growth with physiological changes during pregnancy. We conclude that clinical features of intracranial tumors can be misinterpreted as pregnancy-related symptoms and should not be dismissed.

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A Frontal Lobe Meningioma in a Child Leading to Visual Loss

Case Reports in Ophthalmological Medicine ◽

10.1155/2015/420964 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Nedime Sahinoglu-Keşkek ◽

Gokhan Soker ◽

Şakir Özgür Keşkek ◽

Sehire Sahinoglu ◽

Figen Unal ◽

...

Keyword(s):

Visual Loss ◽

Clinical Presentation ◽

Low Vision ◽

Optic Chiasm ◽

Intracranial Tumor ◽

Intracranial Meningioma ◽

Resonance Imaging ◽

Blurred Vision ◽

History Of ◽

Meningeal Tumors

Objective. Meningiomas are benign primary meningeal tumors and are seen rare in children and adolescents.Clinical Presentation and Intervention. A 15-year-old Turkish boy reported a 1-month history of headache and blurred vision in both eyes. His visual acuity was 0.3 in both eyes with papilledema. Magnetic resonance imaging showed a77×97×77 mm intracranial-extra-axial frontal lesion which compresses the chiasm. He was diagnosed with intracranial meningioma and referred to neurosurgery clinic.Conclusion. Ophthalmologists should be aware of the fact that papilledema and low vision can be caused by an intracranial tumor which compresses optic chiasm.

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Is the Recurrence of Fibroma of the Tendon Sheath Underestimated? An Instructive Case Report and a Review of the Literature

Case Reports in Orthopedics ◽

10.1155/2020/5357329 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

E. Lüdke ◽

G. Kohut ◽

H. C. Bäcker ◽

M. Maniglio

Keyword(s):

Scientific Literature ◽

Healthy Woman ◽

Tendon Sheath ◽

Gadolinium Enhancement ◽

Complete Excision ◽

History Of ◽

Initial Outcome ◽

The Right ◽

Instructive Case

We report a case of a 21-year-old healthy woman with a history of a painful growing mass in the palm of the right hand, with a trigger finger phenomenon. The mass was surgically entirely excised, and the histological findings of the tumor were those of a fibroma of the tendon sheath (FTS) starting from the flexor tendons. Although the initial outcome was good, the patient experienced the same symptoms at the same location 4.5 years later. The MRI demonstrated a 50×10×5 mm mass of low intensity on T1-weighted images and high intensity on T2-weighted images and gadolinium enhancement. A second complete excision of the tumor was performed by the same senior surgeon, and the histology confirmed the recurrence of the FTS. We also reviewed the scientific literature about FTS in the hand. Most recent studies show a low rate or no recurrence at all. We hypothesize that a lot of recurrences are missed because of a short follow-up and that the recurrence rate may be higher than thought.

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COVID-19-associated brief psychotic disorder

BMJ Case Reports ◽

10.1136/bcr-2020-236940 ◽

2020 ◽

Vol 13 (8) ◽

pp. e236940 ◽

Cited By ~ 7

Author(s):

Colin M Smith ◽

Jonathan R Komisar ◽

Ahmad Mourad ◽

Brian R Kincaid

Keyword(s):

Mental Illness ◽

Family History ◽

Psychotic Disorder ◽

Neuropsychiatric Symptoms ◽

Healthy Woman ◽

Psychotic Symptoms ◽

First Case ◽

Brief Psychotic Disorder ◽

History Of ◽

New Onset

A 36-year-old previously healthy woman with no personal or family history of mental illness presented with new-onset psychosis after a diagnosis of symptomatic COVID-19. Her psychotic symptoms initially improved with antipsychotics and benzodiazepines and further improved with resolution of COVID-19 symptoms. This is the first case of COVID-19-associated psychosis in a patient with no personal or family history of a severe mood or psychotic disorder presenting with symptomatic COVID-19, highlighting the need for vigilant monitoring of neuropsychiatric symptoms in these individuals.

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Cesarean Section in a Pregnant Woman with COVID-19: First Case in Portugal

Acta Médica Portuguesa ◽

10.20344/amp.13883 ◽

2020 ◽

Vol 33 (6) ◽

pp. 429 ◽

Cited By ~ 17

Author(s):

Joana Lyra ◽

Rita Valente ◽

Marta Rosário ◽

Mariana Guimarães

Keyword(s):

Cesarean Section ◽

Healthy Woman ◽

Maternity Hospital ◽

Prior History ◽

Protective Equipment ◽

Bishop Score ◽

Term Pregnancy ◽

First Case ◽

History Of ◽

Maternal And Neonatal Outcomes

We report the first cesarean delivery in a woman with COVID-19 in a level III hospital in Portugal. It refers to a healthy woman with a term pregnancy that tested positive for COVID-19 on the day of labor induction. Given a Bishop score < 4 and the prior history of a cesarean section, the team decided to perform a surgical delivery. Appropriate personal protective equipment and safety circuits were employed, as described in more detail in the case report. Both the mother and the newborn are well. With this report we aimed to share our concerns, clinical management, maternal and neonatal outcomes, and to present our current circuits and adjustments regarding the COVID-19 pandemic in our maternity hospital.

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Seek and Hide: Public Health Departments and Persons with Tuberculosis, 1890–1940

The Journal of Law Medicine & Ethics ◽

10.1111/j.1748-720x.1993.tb01253.x ◽

1993 ◽

Vol 21 (3-4) ◽

pp. 289-295 ◽

Cited By ~ 4

Author(s):

Sheila M. Rothman

Keyword(s):

Social History ◽

Urban Areas ◽

Health Departments ◽

Familial Predisposition ◽

Public Health Departments ◽

The Poor ◽

The Social ◽

History Of ◽

First Time ◽

Old Females

In 1882 Koch discovered the tubercle bacillus and transformed both the medical and the social history of tuberculosis and the experiences of those who contracted it. For the first time, the absence or presence of the bacillus made it possible to define, in Koch’s terms, “the boundaries of the diseases to be understood as tuberculosis.” And for the first time the sick became subject to oversight and discrimination.Prior to Koch’s discovery, tuberculosis, or as it was then called, consumption, was considered a hereditary and non-contagious disease, albeit a very deadly and persistent one. Over the first half of the nineteenth century, it was responsible for one out of every five deaths. It crossed all boundaries of geography, social class, age, and sex affecting residents in rural as well as urban areas, the prosperous as well as the poor, the young even more notably than the old, females more often than males. Physicians assumed a familial predisposition existed (as in the case of insanity); following the precepts of humoral medicine, they postulated that the disease originated in “irritations” whose sources were to be found in the interaction of an inherited constitution with a particular lifestyle and environment.

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