β-Endorphin-like immunoreactivity increases in human lumbar cerebrospinal fluid following routine metrizamide myelography

1984 ◽  
Vol 60 (4) ◽  
pp. 800-802 ◽  
Author(s):  
Jacob R. Rachlin ◽  
Richard G. Fessler ◽  
Eugene E. Duda ◽  
Frederick D. Brown ◽  
Victor Fang ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Contrast Material ◽  
Endogenous Opiates ◽  
Content Type ◽  
Before And After ◽  
Lumbar Cerebrospinal Fluid ◽  
The Brain ◽  
Lumbar Subarachnoid Space ◽  
Stimulation Of

✓ Much interest has recently been focused on the possible role of the endogenous opiates in the perception of pain in humans. Several investigators have examined the levels of these substances in human cerebrospinal fluid (CSF) in attempts to identify the mechanisms by which electrical stimulation of the brain might induce analgesia. Most of these CSF samples were collected at the time of ventriculography or myelography. In the present study, the levels of β-endorphin in the CSF of 22 patients undergoing myelography were examined before and after the injection of a contrast agent. β-Endorphin increased an average of 356% (p < 0.0005) 15 to 20 minutes following the injection of contrast material into the lumbar subarachnoid space. Thus, routine myelography may have a profound effect on the levels of β-endorphin measured by radioimmunoassay in human CSF, and great care must be taken in interpreting the significance of changes seen in β-endorphin levels in CSF collected from patients at the time of myelography or ventriculography. The effect of the injection of contrast material on β-endorphin immunoreactivity must be distinguished from the postulated effects of any analgesia-inducing therapy.

Polyol content of cerebrospinal fluid in brain-tumor patients

1989 ◽  
Vol 70 (2) ◽  
pp. 183-189 ◽  
Author(s):  
Satoru Watanabe ◽  
Junko Kamiyama ◽  
Hiroo Chigasaki ◽  
Shigetake Yoshioka
Keyword(s):  
Cerebrospinal Fluid ◽  
Brain Tissue ◽  
Malignant Tumors ◽  
Glioblastoma Cells ◽  
Tumor Patients ◽  
Glucose Content ◽  
Content Type ◽  
Before And After ◽  
The Mean ◽  
The Brain

✓ In order to investigate whether cerebrospinal fluid (CSF) polyols are consumed by brain tissue, the concentration of seven polyols in the CSF and the serum of 30 patients with intracranial tumor and 17 control individuals was measured by gas chromatography. The mean polyol content in the control samples showed that the fructose, inositol, and glucitol levels were significantly greater in CSF than in serum. A comparison of the lumbar CSF from control subjects and 11 patients with malignant tumors exposed to the CSF snowed the fructose and inositol levels to be significantly lower (54% and 45%, respectively) and the glucose content to be slightly higher (110%) in the tumor cases. These differences were markedly greater in the ventricular than in the lumbar CSF and greater in patients with tumors exposed to the CSF space than in those with tumors buried in the brain tissue. In ventricular CSF obtained from seven patients with malignant brain tumors before and after radio— and/or chemotherapy, significant increases in fructose (34%) and glucitol (48%) levels were found, but the other polyols did not change significantly. In culture, the human glioblastoma cell growth rate was higher in the medium containing fructose and glucose than in that containing glucose alone. A notable amount of fructose and glucose was consumed by cultured glioblastoma cells. The roles of polyols contained in CSF and the effects of fructose on the growth of cultured glioblastoma cells are discussed in light of these findings and of previous reports.

Norepinephrine in cerebrospinal fluid of patients with cerebral vasospasm

1982 ◽  
Vol 56 (3) ◽  
pp. 344-349 ◽  
Author(s):  
Taku Shigeno
Keyword(s):  
Cerebrospinal Fluid ◽  
Cerebral Arteries ◽  
Cerebral Aneurysms ◽  
Fluorometric Method ◽  
Content Type ◽  
Highly Sensitive ◽  
Secondary Phenomenon ◽  
Lumbar Cerebrospinal Fluid ◽  
The Brain ◽  
Fine Print

✓ The content of norepinephrine (NE) in the ventricular, basal cisternal, and lumbar cerebrospinal fluid (CSF) was determined in 19 patients with ruptured cerebral aneurysms at different intervals according to the presence or absence of vasospasm. Twelve were operated on within 3 days after subarachnoid hemorrhage (SAH), prior to the occurrence of vasospasm. Postoperatively, CSF was continuously drained from a basal cistern or lateral ventricle. Norepinephrine was assayed by the highly sensitive automated fluorometric method. The concentration of NE increased in all sites of CSF sampling along with the appearance of vasospasm. Above all, the cisternal CSF of patients with vasospasm contained significantly higher NE (0.246 ± 0.049 ng/ml, mean ± SEM) compared to those without vasospasm (0.075 ± 0.001 ng/ml) (p < 0.001). However, since this increase cannot be considered to be high enough locally to constrict cerebral arteries, this might be only a secondary phenomenon due to release of NE into CSF from various sources in the brain.

Neurophysiological and neurochemical alterations during electrical stimulation of human caudate nucleus

1977 ◽  
Vol 46 (3) ◽  
pp. 361-368 ◽  
Author(s):  
James H. Wood ◽  
C. Raymond Lake ◽  
Michael G. Ziegler ◽  
John M. Van Buren
Keyword(s):  
Cerebrospinal Fluid ◽  
Electrical Stimulation ◽  
Caudate Nucleus ◽  
Content Type ◽  
Radioenzymatic Assay ◽  
Lumbar Cerebrospinal Fluid ◽  
Fine Print ◽  
Stimulation Of ◽  
Assay Technique

✓ Lumbar cerebrospinal fluid (CSF) norepinephrine (NE) concentrations were preoperatively determined in five patients using a radioenzymatic assay technique. Stereotaxic thalamotomy was performed using depth coagulating electrodes with stimulating points at 5.0-mm intervals along the shaft. No significant alterations in prestimulation lumbar CSF NE levels were noted 12 days after electrode installation. Stimulating points within the caudate nucleus were anatomically localized using ventricular landmarks and stimulation-induced neurophysiological responses were recorded. Twelve hours after intermittent electrical stimulation of the caudate nucleus, lumbar CSF NE concentrations were significantly decreased. Our data suggest the presence of noradrenergic pathways in man that are inhibited by caudate nucleus stimulation.

Fibrinolytic Activity of Cerebro-Spinal Fluid and the Development of Artificial Cerebral Haematomas in Dogs

1969 ◽  
Vol 21 (02) ◽  
pp. 294-303 ◽  
Author(s):  
H Mihara ◽  
T Fujii ◽  
S Okamoto
Keyword(s):  
Cerebrospinal Fluid ◽  
Carboxylic Acid ◽  
Fibrinolytic Activity ◽  
Clinical Implications ◽  
Trans Form ◽  
Plate Method ◽  
Blood Samples ◽  
Fibrin Plate ◽  
The Brain

SummaryBlood was injected into the brains of dogs to produce artificial haematomas, and paraffin injected to produce intracerebral paraffin masses. Cerebrospinal fluid (CSF) and peripheral blood samples were withdrawn at regular intervals and their fibrinolytic activities estimated by the fibrin plate method. Trans-form aminomethylcyclohexane-carboxylic acid (t-AMCHA) was administered to some individuals. Genera] relationships were found between changes in CSF fibrinolytic activity, area of tissue damage and survival time. t-AMCHA was clearly beneficial to those animals given a programme of administration. Tissue activator was extracted from the brain tissue after death or sacrifice for haematoma examination. The possible role of tissue activator in relation to haematoma development, and clinical implications of the results, are discussed.

Long-term management of patients with multiple brain metastases after shaped beam radiosurgery

2004 ◽  
pp. 406-412
Author(s):  
Paul Okunieff ◽  
Michael C. Schell ◽  
Russell Ruo ◽  
E. Ronald Hale ◽  
Walter G. O'Dell ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Tumor Control ◽  
Content Type ◽  
Negative Results ◽  
Multiple Metastases ◽  
Extracranial Disease ◽  
Successful Control ◽  
The Brain

✓ The role of radiosurgery in the treatment of patients with advanced-stage metastatic disease is currently under debate. Previous randomized studies have not consistently supported the use of radiosurgery to treat patients with numbers of brain metastases. In negative-results studies, however, intracranial tumor control was high but extracranial disease progressed; thus, patient survival was not greatly affected, although neurocognitive function was generally maintained until death. Because the future promises improved systemic (extracranial) therapy, the successful control of brain disease is that much more crucial. Thus, for selected patients with multiple metastases to the brain who remain in good neurological condition, aggressive lesion-targeting radiosurgery should be very useful. Although a major limitation to success of this therapy is the lack of control of extracranial disease in most patients, it is clear that well-designed, aggressive treatment substantially decreases the progression of brain metastases and also improves neurocognitive survival. The authors present the management and a methodology for rational treatment of a patient with breast cancer who has harbored 24 brain metastases during a 3-year period.

Evaluation of endorphin content in the CSF of patients with trigeminal neuralgia before and after Gasserian ganglion thermocoagulation

1981 ◽  
Vol 55 (6) ◽  
pp. 935-937 ◽  
Author(s):  
Giuseppe Salar ◽  
Salvatore Mingrino ◽  
Marco Trabucchi ◽  
Angelo Bosio ◽  
Carlo Semenza
Keyword(s):  
Cerebrospinal Fluid ◽  
Trigeminal Neuralgia ◽  
Control Group ◽  
Gasserian Ganglion ◽  
Content Type ◽  
Group Of Seven ◽  
Idiopathic Trigeminal Neuralgia ◽  
Significant Difference ◽  
Before And After ◽  
Fine Print

✓ The β-endorphin content in cerebrospinal fluid (CSF) was evaluated in 10 patients with idiopathic trigeminal neuralgia during medical treatment (with or without carbamazepine) and after selective thermocoagulation of the Gasserian ganglion. These values were compared with those obtained in a control group of seven patients without pain problems. No statistically significant difference was found between patients suffering from trigeminal neuralgia and those without pain. Furthermore, neither pharmacological treatment nor surgery changed CSF endorphin values. It is concluded that there is no pathogenetic relationship between trigeminal neuralgia and endorphins.

Development of two dosimetry systems based on basic violet dye for possible use as radiation dosimeters

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Nehad Magdy ◽  
Sameh Gafar
Keyword(s):  
Gamma Ray ◽  
Raw Materials ◽  
Absorbed Dose ◽  
Chemical Yield ◽  
Radiation Sensitivity ◽  
Vital Role ◽  
Radiation Chemical ◽  
Content Type ◽  
Before And After

Purpose The purpose of this research paper is to study a comparison between two dosimetry systems, both of them based on basic violet dye (BV). Design/methodology/approach The first system depends on (BV) (incorporating polyvinyl alcohol) as a thin-film dosimeter. The second system also relies on (BV) as a solution dosimeter, which is more sensitive to gamma rays. The two prepared film/solutions have a considerable signal that decreases upon irradiation and the strength of the signal decreases with increasing radiation dose. Findings The gamma ray absorbed dose for these dosimeters was found to be up to 35 kGy for films and 1 kGy for the liquid phase. All dosimetric characteristics as radiation chemical yield, additive substance, dose-response function, radiation sensitivity, also before and after-irradiation stability under various conditions were considered. Practical implications It is expected the vital role of gamma radiation on this dye in its two forms or two media. This reveals their wide applications in the field of gamma irradiation processing. Originality/value These two dosimetry systems which depend upon the same dye are safe to handle, inexpensive, available raw materials and can be applied in various dosimetry applications as mentioned above.

Effect of Pantopaque myelography on cerebrospinal fluid fractions

1973 ◽  
Vol 38 (2) ◽  
pp. 167-171 ◽  
Author(s):  
Darwin J. Ferry ◽  
Ronald Gooding ◽  
Jim C. Standefer ◽  
G. Michael Wiese
Keyword(s):  
Cerebrospinal Fluid ◽  
Inflammatory Reaction ◽  
Total Protein ◽  
Colloidal Gold ◽  
Gamma Globulin ◽  
Content Type ◽  
Electrophoretic Patterns ◽  
Before And After ◽  
Chronic Inflammatory Reaction ◽  
Fine Print

✓ Cerebrospinal fluid (CSF) changes induced by Pantopaque myelography were determined by comparing samples of CSF from 47 patients with disc symptoms, obtained before and after myelography. Cell count, total protein, colloidal gold curve, and CSF protein electrophoretic patterns were compared. An immediate and persistent modest lymphocytosis was found. Total protein and CSF gamma globulin were elevated 3 weeks after myelography and throughout the remainder of the 80-day study period. This CSF profile characterizes a chronic inflammatory reaction induced by Pantopaque.

Celebrity transgression and consumers’ forgiveness: does religiosity matter?

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Anwar Sadat Shimul ◽  
Matthew Barber ◽  
Mohammad Ishmam Abedin
Keyword(s):  
Purchase Intention ◽  
Structural Equation ◽  
Online Survey ◽  
Intrinsic Religiosity ◽  
Content Type ◽  
Equation Modelling ◽  
Before And After ◽  
The Relationship ◽  
Practical Implications

Purpose This paper aims to examine the role of religiosity on consumers’ forgiveness when celebrities get involved in transgression. The celebrity’s reaction and its impact on consumers’ forgiveness is tested as well. In addition, consumers’ attitudes towards the brand and celebrity as well as purchase intention for the endorsed brand are examined both before and after the transgression. Design/methodology/approach Data (n = 356) were collected through a self-administered online survey and analysed though structural equation modelling in AMOS 26. Findings The results show that consumers’ attitude towards celebrity, brand and purchase intention gets weaker once the celebrity gets into transgression. Consumers tend to forgive more if the celebrity apologises (vs denies) for the wrongdoing. The hypothesised relationship between attitude towards celebrity and purchase intention did not sustain after the transgression. In addition, consumers’ intrinsic religiosity strengthens the relationship between attitude towards the celebrity and purchase intention. Practical implications The findings of this research present valuable implications for brands practitioners. Brands should formulate actionable contingency plans to mitigate the negative ramifications of celebrity transgressions. Specifically, intrinsic religiosity and celebrity apologies should assist consumers in forgiving the transgression and negate the implications that could have arisen if the celebrity instead denied the transgressions. Originality/value This research extends the previous research by examining religiosity and forgiveness within the context of celebrity transgressions. To the best of the authors’ knowledge, this is one of the first few research studies to consider the role religiosity plays in consumers’ intention to forgive celebrity transgressions.

Sign in / Sign up

Export Citation Format

Share Document