GOUT AND ARTERIAL HYPERTENSION: THERAPY PECULIARITIES

The article highlights the issues on comorbidity between gout and hypertension. Emphasis is placed on the necessity in searching for a well-balanced approach toward the treatment this type of comorbidity. Gout is a major social and economic problem in the modern society that leads to a progressive physical incapability, limitation of professional activity, thus impairing the quality of life. Arterial hypertension occurs in patients with gout in 5 - 50% of cases, and in combination with components of metabolic syndrome its prevalence rises up to 80%. As a result, the development of hypertension in patients with gout leads to a deterioration of the kidney functioning due to the combination of two pathological conditions for which the kidneys are either functioning organs or target organs. Management of arterial hypertension by general practitioner requires the searching for the most optimal approach in using metabolically neutral antihypertensives to avoid provoking medication-induced exacerbation of arthritis. In addition, the treatment of such category of patients should also provide the optimal nephroprotective effect and decrease the uric acid concentration in the serum that will contribute to the additional prevention of gout attacks. The aim of the study is to evaluate the nephroprotective, antihypertensive, hypolipidemic effects of the proposed combined therapy in the patients with comorbidity between gout arthritis and arterial hypertension. The study was conducted at the Regional Medical and Diagnostic Centre of Rheumatological Diseases, M.V. Sklifosovskyi Poltava Regional Clinical Hospital, which is the clinical base of the Department of Family Medicine and Therapy, Ukrainian Medical Stomatological Academy. 60 patients with mean age of 54.2 ± 8.6 years were enrolled to the study. The patients suffering from gout arthritis and comorbid hypertension formed the main group. The control group consisted of 60 patients matched by age, demographic and clinical parameters. Following the 12-month treatment period, we have registered clinical effects of the combination therapy proposed in patients with gout and comorbid hypertension. We observed a decrease in blood lipids values in the study groups: total cholesterol decreased by 16.0% in the main group and by 8.0% in the control group, high-density lipoproteins – by 5.6% in the main group and by 6.4% in the control group, low density lipoproteins – by 3.3% in the main group and by 3.4% in the control group, triglycerides – by 22.2% in the main group and 12.3% in the control group. We observed statistically significant improvement in the glomerular filtration rate in the main group (6.4% of cases vs. 1.3% in the control group). The blood creatinine in the both study groups decreased significantly. The uric acid blood concentration decreased by 32.6% in the main group compared to 24.6% in the control group. During the six month period of the therapy the necessity for non-steroidal anti-inflammatory drugs cut down by 58% in the study group vs. 37% in the control group. Conclusions. After 12 month period of therapy proposed, the patients with gout and comorbid hypertension demonstrated clinically confirmed improvement in both study groups (87.7% of patients in the main group vs. 48.6% in the control group). The efficacy of the proposed treatment was assessed by physicians up to 87%, vs. 88% efficacy assessed by the patients in the main group.

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Effects of Uric Acid Lowering Therapy in Patients With Essential Arterial Hypertension

10.21203/rs.3.rs-140202/v1 ◽

2021 ◽

Author(s):

Krystian Gruszka ◽

Tomasz Drożdż ◽

Wiktoria Wojciechowska ◽

Piotr Jankowski ◽

Michał Terlecki ◽

...

Keyword(s):

Uric Acid ◽

Arterial Hypertension ◽

Elevated Serum ◽

Intima Media Thickness ◽

Volume Index ◽

Control Group ◽

Lowering Therapy ◽

Essential Arterial Hypertension ◽

Hs Crp

Abstract Background Asymptomatic hyperuricemia (AHU) is defined as elevated serum uric acid (UA) concentration without symptoms. This study aimed to determine the effects of AHU treatment with allopurinol on selected hypertension mediated organ damage (HMOD) indices in patients with uncomplicated essential arterial hypertension (AH). MethodsPatients aged 30-70 years with AHU and essential hypertension grade 1-2 with adequate blood pressure (BP) control, without previous urate lowering therapy (ULT) were divided into two groups: a) receiving allopurinol (ULT group) and b) age-and sex matched patients without ULT (control group). Both groups received UA-lowering diet. BP (office, 24 hour and central), echocardiographic parameters, pulse-wave velocity, carotid intima-media thickness (IMT) and lab tests (high-sensitivity C-reactive protein (hs-CRP) were measured at baseline and at 6 months follow-up.ResultsOut of 100 participants 87 completed the study (44 ULT patients and 43 controls). At 6 months follow-up, there was a significantly greater reduction in serum UA concentration in the ULT group than in the control group (464±68.8 µmol/l vs 314±55.6 µmol/l, p<0.0001). Patients receiving allopurinol had significant reductions in office systolic (137±11.8 mmHg vs 134±9.3 mmHg; p=0.025) and diastolic BP (83±9.9 mmHg vs 79±8.7 mmHg, p=0.017), central systolic BP (56±8.9 mmHg vs 51±12.9 mmHg, p=0.046), pulse pressure (43±10.4 mmHg vs 39±11.2 mmHg, p=0.017), IMT (0.773±0.121 mm vs 0.752±0.13 mm, p=0.044), left atrium volume index (40±13.5 ml/m2 vs 38±12.3 ml/m2, p=0.044), and hs-CRP level (3.36±2.73 mg/l vs 2.74±1.91 mg/l, p=0.028) compared to controls. The decrease in UA concentration was significantly related to the reduction in IMT (R=0.37, p<0.001), central SBP (R=0.26, p=0.015) and hs-CRP concentration (R=0.30, p=0.004). Multivariate regression analysis revealed the independent relationship between reduction in IMT and UA lowering (R=0.3234, R2=0.0722, p<0.026).ConclusionsIn patients with AH and asymptomatic hyperuricemia treatment with allopurinol leads to further improvement in BP control and reduction in HMOD intensity, in particular IMT. The decrease in hs-CRP concentration associated with ULT may have a beneficial effect on patient long-term prognosis.

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BIOMARKERS OF OSTEO-DEFFICIENCY IN THE COURSE OF SECONDARY OSTEOPOROSIS IN PATIENTS WITH COMORBID CHRONIC PANCREATITIS AND ARTERIAL HYPERTENSION

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії ◽

10.31718/2077-1096.20.4.16 ◽

2020 ◽

Vol 20 (4) ◽

pp. 16-20

Author(s):

T.I. Viun ◽

L.M. Pasieshvili ◽

S.V. Viun ◽

A.S. Marchenko ◽

O.V. Karaya

Keyword(s):

Chronic Pancreatitis ◽

Acid Phosphatase ◽

Arterial Hypertension ◽

Comparison Group ◽

Practical Importance ◽

Main Group ◽

Secondary Osteoporosis ◽

Control Group ◽

Tartrate Resistant Acid Phosphatase ◽

Detection Of Biomarkers

The prevalence of comorbidities has been growing for the last decades. Therefore, the detection of biomarkers for diagnostic and prognostic purposes is of great practical importance. The aim of this study was to assess the biomarkers of osteo-defficiency in the course of secondary osteoporosis in patients with comorbid chronic pancreatitis and arterial hypertension. We examined 110 patients with chronic pancreatitis: 70 of them had comorbid hypertension, and 40 patients were found as having no comorbidities. The age of patients ranged from 33.2 ± 2.1 (main group) and 32.9 ± 3.1 years (comparison group); women predominated (72.9% and 70%, respectively). The control group includes 78 healthy individuals of the same age and sex. Diagnostic investigation included studying clinical and anamnestic characteristics of patients (duration of the disease, manifestations of the course, frequency of recrudescence, fractures) and biochemical parameters of bone metabolism: osteocalcin, total bone phosphatase and tartrate-resistant acid phosphatase and the establishment of correlations between these parameters and incidence of complications. It was found that in the isolated course of chronic pancreatitis there is a high (R = 0.60) statistically significant (p <0.01) correlation between the levels of osteocalcin and pancreatic elastase-1. A negative statistically significant (p <0.01) mean correlation (R = -0.49) was found between the content of tartrate-resistant acid phosphatase and age of the patients having comorbidity of chronic pancreatitis and hypertension, as well as there is a moderate correlation between the content of tartrate-resistant acid phosphatase and the duration of hypertension, which is statistically significant (R = 0.36, p <0.01). The levels of total bone phosphatase and tartrate-resistant acid phosphatase in the main group exceeded the reference values in 2.5 and 1.9 times respectively (CMU; U = 866.0; p <0.01), while in the comparison group were 2 times (total bone phosphatase) and 1.3 times higher (tartrate-resistant acid phosphatase) times, respectively (CMU; U = 821.0; p <0.01) that enables to diagnose the development of osteopenic conditions. That is, the combined course of chronic pancreatitis and hypertension should be considered as unfavourable tandem in the development of secondary osteoporosis and requires early osteoporotic screening.

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Association of rs556621 Polymorphism with Development of Stroke in Patients with Cardiovascular Pathology

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2019-15-5-634-640 ◽

2019 ◽

Vol 15 (5) ◽

pp. 634-640

Author(s):

S. Yu. Nikulina ◽

V. A. Shulman ◽

A. A. Chernova ◽

S. V. Prokopenko ◽

D. A. Nikulin ◽

...

Keyword(s):

Single Nucleotide Polymorphism ◽

Arterial Hypertension ◽

Main Group ◽

Lipid Lowering ◽

Control Group ◽

Nucleotide Polymorphism ◽

Single Nucleotide ◽

Cardiovascular Pathology ◽

Supraventricular Tachycardias ◽

Brachiocephalic Arteries

Aim. To study the association of single nucleotide polymorphism rs556621 (G> T) with development of stroke in patients of the East Siberian population with cardiovascular pathology and risk factors.Material and methods. The study involved 260 patients (157 men and 103 women) with stroke (mean age 57.0 [51.0-62.0]) and 272 patients (170 men and 102 women) of the control group (mean age 55.0 [51.0-62.0]). The examination of the main group included: collection of complaints, anamnesis, clinical examination, computed tomography of the brain, electrocardiography, echocardioscopy, ultrasound duplex scanning of extracranial brachiocephalic arteries, daily blood pressure and heart rate monitoring, analysis of the blood coagulation system. The patients of the main group have arterial hypertension, paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of the brachiocephalic arteries, disorders of the hemostatic system. The control group was studied in the framework of the HAPIEE international project. Molecular genetic research was performed by real-time polymerase chain reaction.Results. There were no statistically significant differences in the frequencies of genotypes and single nucleotide polymorphism rs556621 alleles (G>T) in the subgroup of patients with stroke and those in the control group. The frequency of the rare TT genotype among patients with stroke was 13.3%±4.16, among healthy individuals – 8.8±3.37% (p=0.1). Gender differences when comparing the frequencies of genotypes and alleles were also not detected (p>0.05). The frequencies of the TT genotype were approximately the same in the subgroup of patients with arterial hypertension (13.1%±4.22) and in the control group (7.4±5.25%; p>0.05). No significant differences were observed in the frequencies of the rare genotype of the studied polymorphism in the subgroup of patients with supraventricular tachycardias (20.0±14.37%), hypercoagulability (15.9±7.64%) and the control group (8.8±3.37%), p>0.05. A statistically significant relationship was found between the rare genotype TT of single nucleotide polymorphism rs556621 (G>T) and the development of stroke in patients with dyslipidemia and atherosclerotic lesions of the coronary arteries (p=0.041; odds ratio 1.86, 95% confidence interval 1.02-3.41).Conclusion. The genotype of TTs of single nucleotide polymorphism rs556621 (G> T) increases the risk of developing stroke in patients with dyslipidemia and atherosclerosis of the brachiocephalic arteries compared with carriers of the GG and GT genotypes. The obtained data are recommended to be considered when prescribing lipid-lowering and antithrombotic therapy.

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Vasculotoxicity of Chemotherapy: Assessment оf Endothelial Dysfunction Biomarkers’ Levels in Gastric Cancer Patients

Kardiologiia ◽

10.18087/cardio.2020.5.n1069 ◽

2020 ◽

Vol 60 (5) ◽

pp. 35-40

Author(s):

Yu. Yu. Kirichenko ◽

Yu. N. Belenkov ◽

E. V. Privalova ◽

Yu. I. Naymann ◽

E. P. Gitel ◽

...

Keyword(s):

Endothelial Dysfunction ◽

Healthy Volunteers ◽

Stomach Cancer ◽

Specific Treatment ◽

Study Groups ◽

Main Group ◽

Control Group ◽

Instrumental Evaluation ◽

Oncological Patients ◽

Before And After

Aim To evaluate dynamics of biomarkers for endothelial dysfunction (ED), including endothelin-1 (ET-1) and von Willebrand factor (VWF) in patients with stomach cancer (adenocarcinoma) before and after polychemotherapy (PCT); to compare these results with respective values in healthy volunteers and patients with cardiovascular diseases (CVD); to study correlations of the ED biomarkers with indexes of instrumental evaluation of endothelial dysfunction.Material and methods The study included 75 participants, including 25 healthy volunteers (control group), 25 patients with documented CVDs (arterial hypertension + ischemic heart disease), and 25 patients of the main group with histologically documented stage II-IV stomach cancer (adenocarcinoma) who received different courses of PCT with platinum-based agents (oxaliplatin, cisplatin) and fluoropyrimidines (5 fluorouracil, capecitabin). Laboratory measurement of ED biomarkers, computerized nailfold video capillaroscopy (CNVC), and finger laser photoplethysmography (PPG) (methods for noninvasive evaluation of vascular wall and ED), electrocardiography, 24-h ECG Holter monitoring, and echocardiography (EchoCG) were performed for all patients of the main group prior to PCT and within one months after the last course completion. This evaluation was performed once for healthy volunteers and patients of the CVD group upon inclusion into the study.Results In the main group, ET-1 levels were non-significantly lower than normal and did not change during the courses of antitumor treatment (0.95 [0.6; 1.4] and 0.94 [0.7; 1.4] pg /ml (р<0.9) before and after PCT, respectively). Statistically significant differences were found between the control group and oncological patients after the treatment (р<0.04). Levels of VWF remained within the normal range in all examined participants and did not significantly differ between study groups, including oncological patients before and after the specific treatment (р>0.05 for all comparisons). The correlation analysis detected significant correlations of ET-1 levels with functional disorders of microcirculation, ET-1 with the occlusion index (rs=0.56; p=0.005), ЕТ-1 with percentage of capillary restoration (PCR, rs= –0.72; p=0.018) and with the incidence rate of supraventricular extrasystole (rs=0.48; p=0.032).Conclusion The dynamics of ED biomarkers was studied for the first time in patients with stomach cancer receiving a specific antitumor therapy. Although no significant changes in ЕТ-1 and VWF were observed during the PCT (probably due to exhaustion of the endothelial system and a small patient sample), these indexes can be considered as early vasculotoxicity markers due to the presence of significant correlations with indexes of impaired endothelial function according to the results of instrumental evaluation.

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Serum uric acid concentration (SUAC): A useful tool to assess extent and severity of chronic plaque psoriasis in Pakistani population.

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.11.692 ◽

2019 ◽

Vol 26 (11) ◽

pp. 1825-1828

Author(s):

Hafiz Bashir Ahmed ◽

Deepa Mohan Lal ◽

Muhammad Suleman Pirzado ◽

Ajmal Rashid ◽

Irfan Anwar ◽

...

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Acid Concentration ◽

Plaque Psoriasis ◽

Critical Role ◽

Elevated Serum ◽

Control Group ◽

Uric Acid Concentration ◽

Chronic Plaque Psoriasis ◽

Serum Uric Acid Concentration

Objectives: Psoriasis is a systemic chronic inflammatory autoimmune disease. Psoriasis can lead to multiple complications and co-morbidities. It has also been observed that raised serum uric acid levels predispose to gouty arthritis and also thought to be a risk factor for cardiovascular mortality and morbidity. The basic aim of this study was to ascertain level of serum uric acid in patients with chronic plaque psoriasis and control cases which might be a useful tool for assessing the extent and severity of chronic plaque psoriasis. Study Design: Case control study. Setting: At Outpatient’s Department (OPD) of Department of Dermatology, PNS Shifa, Karachi. Period: From January 2013 to December 2016. Material & Methods: One hundred and ninety four (194) patients were taken in this study and 97 patients were biopsy proven cases of psoriasis and 97 other participants included as control cases reporting to OPD with other complaint like acne, hair fall and fungal infections. After written and informed consent, 5ml of venous blood was drawn in sterile syringe and using gel sample tube to see the serum uric acid levels. On the basis of laboratory reports the elevated serum uric acid level in psoriatic versus normal controls was recorded on a pre-designed proforma. Results: There were 54.6% (106/194) male and 45.4% (88/194) female. Elevated serum uric level was 4.5 times (Approximate of 4.46) more common in cases than control group (OR: 4.46 95%CI: 1.83 to 10.91). Conclusion: Raised levels of serum Uric acid have been seen frequently in psoriatic patients. Early treatment for higher levels of serum uric acid might play a critical role in the better treatment of psoriatic patients. These results revealed that serum uric acid concentration (SUAC) of psoriasis may play a vital role in assessing the complex multifactorial etiology of the psoriasis, severity and other possible metabolic factors.

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Allantoin as a marker of oxidative stress in human erythrocytes

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2008.244 ◽

2008 ◽

Vol 46 (9) ◽

Cited By ~ 20

Author(s):

Roman Kand'ár ◽

Pavla Žáková

Keyword(s):

Oxidative Stress ◽

Renal Failure ◽

Uric Acid ◽

Chronic Renal Failure ◽

Gradient Elution ◽

Reversed Phase ◽

Control Group ◽

Uric Acid Concentration ◽

Reversed Phase Hplc

Abstract: Uric acid is the final product of purine metabolism in humans. It was determined that this compound has important antioxidative properties and it may be oxidized to allantoin by various reactive oxygen species. Therefore, the measurement of allantoin may be useful for the determination of oxidative stress in humans.: We measured allantoin and uric acid in human plasma and erythrocytes obtained from patients with chronic renal failure before hemodialysis (n=30) and blood donors (n=30). We used a method based on selective isolation of allantoin from deproteinized plasma and erythrocyte lysate samples on AG 1-X8 resin and its derivatization to glyoxylate-2, 4-dinitrophenylhydrazone. Separation of glyoxylate-2, 4-dinitrophenylhydrazone from interfering substances was achieved on reversed phase HPLC with gradient elution and UV/VIS detection at 360 nm. Uric acid was determined by reversed phase HPLC with UV/VIS detection at 292 nm.: We found significant differences in allantoin and uric acid concentration between the patients with chronic renal failure and the control group both in plasma (20.5±6.5 μmol/L and 323.9±62.9 μmol/L vs. 2.1±1.1 μmol/L and 270.1±62.3 μmol/L, p<0.05) and erythrocytes [82.8±39.1 nmol/g hemoglobin (Hb) and 110.7±28.8 nmol/g Hb vs. 20.1±6.1 nmol/g Hb and 82.1±23.7 nmol/g Hb, p<0.05].: Significant higher levels of allantoin in both plasma and erythrocytes of patients with chronic renal failure indicate that allantoin may be used as a good marker of oxidative stress.Clin Chem Lab Med 2008;46:1270–4.

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EFFECT OF SELECTED YOGA TECHNIQUES ALONG WITH ASHWAGANDHA AND VACHA IN DEPRESSION IN THE AGE GROUP 65–75 YEARS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2021.v14i11.42259 ◽

2021 ◽

pp. 65-68

Author(s):

SOUMYA MELEPPURAKKAL ◽

SUNITHA K ◽

JAYAN D

Keyword(s):

Combined Therapy ◽

Holistic Approach ◽

Study Groups ◽

Warm Water ◽

Treatment Modalities ◽

Control Group ◽

Study Group ◽

Age Group ◽

Study Population

Objective: The study was done to compare the effect of selected yoga techniques, drugs, and combined therapy in depression in geriatrics. Methods: 75 patients between 65 and 75 years of age with depression were included in the study which was assessed by HAM D Score. The study population was randomly allocated to one control group and two study groups. The control group was given Aswangandha and Vacha churna with warm water as anupana after food, selected yoga techniques in the first study group, and combined yoga and the drug were given to the second study group. Outcome variables were assessed for the groups after the 30th day and follow-up after 45 days. Results: The results obtained in the study were analyzed using the ANOVA test. Yoga along with drug experienced a comparatively greater reduction in HAM-D score after treatment and follow-up (p<0.05) than other groups. Conclusion: Holistic approach can bring a better and static result than applying the treatment modalities alone.

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Peculiarities of the course of pregnancy in women with common helminth infestations

HEALTH OF WOMAN ◽

10.15574/hw.2020.147.52 ◽

2020 ◽

pp. 52-55

Author(s):

Babashova Fidan Mahmud kizi ◽

Keyword(s):

Pregnant Women ◽

Visual Detection ◽

Study Groups ◽

Main Group ◽

Nausea And Vomiting ◽

Control Group ◽

Rare Form ◽

Helminth Eggs ◽

Acute Yellow Atrophy ◽

Symptom Complex

The objective: peculiarities of pregnancy in women with common worm infestations in Baku. Materials and methods. During the period from 2015 to 2017, 152 women with common worm infestations were examined, in the gestation period from 16 to 40 weeks in the age group from 18 to 38 years. Depending on the nature of the infestation, 2 main groups were formed: the 1st main group included 84 women who had monoinvasia of helminths, and the 2nd main group included 68 women who had mixed helminth infestation. The control group consisted of 42 women who were pregnant without helminthiasis. All women were examined at 16–22, 23–29, 30–36 and 37–40 weeks of pregnancy. Helminthosis diagnostics was performed by detecting helminth eggs in faecal smears, pinworm eggs in scraping from perianal folds, and visual detection of helminth eggs or pinworms in faeces and vomit. Results. Common symptoms of early toxicosis are nausea, hypersalivation, and vomiting. A rare form of morning sickness treat dermatosis pregnant women, pregnant bronchial asthma, tetany, acute yellow atrophy of the liver, osteomalacia. Symptoms of toxicosis were evaluated in 152 pregnant women. The main symptoms of early toxicosis–nausea, hypersalivation and vomiting–were more common in pregnant women with helminthiasis than in women of the control group. In women with helminthiasis, a symptom complex similar to the manifestations of early toxicosis may persist throughout pregnancy, despite ongoing toxicosis therapy. Since persistent nausea and vomiting can be etiologically caused by helminthic-protozoic intoxication, the frequency of nausea and vomiting in different groups in the second and third trimesters was compared. In the second half of pregnancy, women with complaints of nausea and vomiting were present in all study groups, but they were more common in pregnant women with helminthiasis than in women in the control group. Conclusions. The data obtained on the more frequent manifestation of early toxicosis in pregnant women with helminthiasis and its demonstrated resistance throughout pregnancy prove that helminth infestations negatively affect the course of pregnancy. Key words: helminth-protozoal invasion, placental insufficiency, pregnancy.

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Multiple-set resistance exercise in essential arterial hypertension

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2012-6-4-8 ◽

2012 ◽

Vol 11 (6) ◽

pp. 4-8

Author(s):

I. S. Golovunina ◽

F. Yu. Mukharlyamov ◽

M. A. Rassulova ◽

E. S. Ivanova

Keyword(s):

Arterial Hypertension ◽

Resistance Exercise ◽

Lactate Production ◽

Main Group ◽

Weight Lifting ◽

Stage Ii ◽

Exercise Session ◽

Control Group ◽

Hormone Production ◽

Essential Arterial Hypertension

Aim. To assess the effects of the multiple-set resistance exercise on the functional status of patients with Stage II essential arterial hypertension (EAH). Material and methods. In total, 40 patients with Stage II EAH, aged 45-55 years, took part in the physical rehabilitation programme, including exercise training on the resistance exercise machine. In the control group, weight lifting was followed by the complete relaxation of involved muscle groups and, therefore, a fast weight lowering. In the main group, the muscle relaxation after weight lifting was only partial, with a slower weight lowering, which resulted in increased lactate production and muscle ache. Ergospirometry, volumetric compression oscillometry, and resistance tests were used. Results. Blood pressure normalization, myocardial contractility increase, and exercise capacity improvement were more pronounced in the main group (p<0,05), as a greater extent of neuromuscular strain stimulates the hormone production both during and after the exercise session. Conclusion. The complex multiple-set resistance exercise programme demonstrated a marked beneficial effect in patients with Stage II EAH.

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Combined treatment of oligoasthenospermia by postoperative Speroton therapy in patients with varicocele

Andrology and Genital Surgery ◽

10.17650/2070-9781-2020-21-2-64-69 ◽

2020 ◽

Vol 21 (2) ◽

pp. 64-69

Author(s):

E. A. Povelitsa ◽

V. E. Leanovich ◽

N. I. Dosta ◽

O. V. Parhomenko ◽

A. M. Shesternya

Keyword(s):

Spermatic Cord ◽

Varicose Veins ◽

Combined Therapy ◽

Combined Treatment ◽

Sperm Concentration ◽

Study Groups ◽

Reproductive Age ◽

Control Group ◽

Study Objective ◽

Before And After

The study objective is to evaluate the effectiveness of the Speroton complex therapy in combined treatment of oligoasthenospermia in patients with varicocele after microsurgical phlebectomy of varicose veins of the spermatic cord.Materials and methods. Microsurgical phlebectomy of the spermatic cord was performed in 40 men (mean age 33.0 ± 2.3 years) with oligoasthenospermia and varicocele. The patients were divided into 2 groups: the main group included 20 men who were treated with the Speroton complex for 3 months in the postoperative period, and the control group included 20 men who did not take Speroton. The spermogram parameters were evaluated before and after the operation.Results. Three months after the start of treatment, a statistically significant improvement in spermogram indicators was noted in all study groups. It was determined that combined therapy that included the Speroton complex administration for 3 months, statistically significantly led to the more considerable increase in sperm parameters than in control group: the sperm concentration increased to 38.6 and 28.9 mln/ml, respectively, the percentage of progressive motile sperm – to 49.2 and 39.4 %, the percentage of motile forms – to 72.2 and 43.8 %, viable forms – to 67.8 and 58.1 %, and the percentage of sperm with DNA fragmentation decreased to 12.1 and 17.2 %, respectively, in the main and control groups.Conclusion. Combined treatment with postoperative Speroton therapy for men of reproductive age with infertility and varicocele determines the more significant improvement in the parameters of sperm than performing only surgical correction of varicocele.

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