scholarly journals RISK OF THROMBOSIS IN PATIENTS WITH GYNECOLOGICAL CANCERS OF VARYING EXTENT

2021 ◽  
Vol 21 (2) ◽  
pp. 8-12
Author(s):  
P. Ya. Bodnar
Keyword(s):  
Blood Coagulation ◽  
Anticancer Therapy ◽  
Reproductive Organs ◽  
Blood Parameters ◽  
Coagulation System ◽  
Economic Losses ◽  
Control Group ◽  
Thromboembolic Complications ◽  
Blood Clots ◽  
Female Reproductive Organs

The tumour process in the female reproductive organs is known as a trigger for the development of thromboembolic complications. Tumour growth, surgery, anticancer therapy, venous catheters and physical inactivity contribute to the risk of thrombosis. There are numerous instances when even under adequate thromboembolism prevention patient may develop deep vein thrombosis resulting in further thrombi migration throughout the body. Such migration can lead to lethal outcome and, unfortunately, nullifies all treatment measures carried out as well as results in significant economic losses. Viewing the problem in a whole requires constant monitoring of blood parameters in dynamics with the interpretation and evaluation of the findings obtained. The purpose of this study is to compare blood parameters of gynaecological patients with a tumour process in the reproductive organs, who are undergoing treatment, have already undergone surgery or have sought medical assistance for the first time. The study included 43 women, who were divided into groups: the control group involved 14 patients; 17 women with cervical cancer; 8 women with the uterine body cancer; 4 women with ovarian cancer. In all groups, except for the control group, the investigations were carried out before the beginning of treatment, during and after the treatment. The comparison of the blood indicators in the women during the treatment and in post-operative period following the tumour removal demonstrated insignificant changes in the indices of coagulation system, even when taking into account the measures to prevent thrombogenesis. After the counting, the indices confirmed their statistical significance. All women, except those in the control group, demonstrated an increase in the level of all blood parameters, which are responsible for the formation of blood clots and indicate hypercoagulation. We noticed that the risk of blood clots in the female patients with tumours of the reproductive organs remained high, regardless of the localization of the process and the methods of treatment. It is not known exactly to what extent blood count findings would have changed without prescribing thromboembolism prevention course for gynaecological cancerous patients. This study has shown the risk of thrombus formation in gynaecological oncology always remains high. The activation of the blood coagulation system occurs in all patients with cancerous diseases of the female reproductive organs of different localization. Surgical intervention or the anticancer therapy stimulates the blood coagulation function, and preventive treatment with pharmacological and mechanical methods does not make it possible to control these indicators in the first days after the operation. The patients with tumours of the female reproductive organs should be included in the group of patients with a high risk of thromboembolic complications.

Changes in Ovarian and Uterine Morphology and Estrous Cycle in CD-1 Mice After Vanadium Inhalation

2019 ◽  
Vol 39 (1) ◽  
pp. 20-29
Author(s):  
Nayeli Meléndez-García ◽  
Fátima García-Ibarra ◽  
Patricia Bizarro-Nevares ◽  
Marcela Rojas-Lemus ◽  
Nelly López-Valdez ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Estrogen Receptor Α ◽  
Reproductive Organs ◽  
Control Group ◽  
Serum Concentrations ◽  
Pregnant Females ◽  
Female Sex Hormones ◽  
Preovulatory Follicles ◽  
17Β Estradiol ◽  
Female Reproductive Organs

Vanadium is a metal present in particulate matter and its reprotoxic effects have been demonstrated in males and pregnant females in animal models. However, the effects of this metal on the reproductive organs of nonpregnant females have not been sufficiently studied. In a vanadium inhalation model in nonpregnant female mice, we found anestrous and estrous cycle irregularity, as well as low serum concentrations of 17β-estradiol and progesterone. A decrease in the diameter of secondary and preovulatory follicles, as well as a thickening of the myometrium and endometrial stroma, was observed in the vanadium-treated mice. There was no difference against the control group with respect to the presence of the estrogen receptor α in the uterus of the animals during the estrous stage. Our results indicate that when vanadium is administered by inhalation, effects are observed on the female reproductive organs and the production of female sex hormones.

Comparative analysis of the results of non-activated thromboelastometry and thromboelastography of venous blood in pregnant women in health and disease

2021 ◽  
Author(s):  
Л.А. Пестряева ◽  
С.В. Кинжалова ◽  
Н.В. Путилова ◽  
С.В. Борисова
Keyword(s):  
Comparative Analysis ◽  
Pregnant Women ◽  
Blood Coagulation ◽  
Main Group ◽  
Coagulation System ◽  
Control Group ◽  
Blood Coagulation Disorders ◽  
Fibrinogen Concentration ◽  
Reference Ranges ◽  
Thrombin Time

Цель исследования: сравнительный анализ неактивированной тромбоэластографии (ТЭГ) и тромбоэластометрии (ТЭМ) в диагностике нарушений свертывающей системы крови при беременности. Материалы и методы. Обследованы 2 группы женщин в III триместре беременности: 44 женщины с привычным невынашиванием беременности в анамнезе (основная группа) и 35 условно здоровых беременных (контрольная группа). Пациентки основной группы получали профилактику тромботических осложнений низкомолекулярными гепаринами (НМГ). Выполнено стандартное исследование свертывающей системы крови: подсчет тромбоцитов, определение концентрации фибриногена, протромбинового времени (ПТ) по Квику, активированного частичного тромбопластинового времени (АЧТВ), тромбинового времени (ТВ), неактивированная ТЭГ и ТЭМ. Результаты. Значимых различий в значениях фибриногена, АЧТВ, ПТ между группами выявлено не было. В обеих группах при ТЭГ/ТЭМ исследовании установлено укорочение интервалов времени свертывания и времени образования сгустка, увеличение плотности сгустка, что соответствует протромботическим изменениям системы гемостаза при беременности. Определены значения показателей неактивированной ТЭГ/ТЭМ в III триместре физиологически протекающей беременности. Заключение. Методы неактивированной ТЭГ и ТЭМ имеют высокую информативность в диагностике нарушений системы гемостаза и могут быть использованы для контроля состояния свертывающей системы крови при беременности наряду с активированными стандартизованными тестами. Objectives: to conduct a comparative analysis of non-activated thromboelastography (TEG) and thromboelastometry (TEM) in the diagnosis of blood coagulation disorders during pregnancy. Patients/Methods. We examined 2 groups of women in III trimester of pregnancy: 44 women with a history of habitual miscarriage (the main group) and 35 relatively healthy pregnant women (the control group). Patients of the main group received prophylaxis of thrombotic complications with low molecular weight heparins (LMWH). A standard study of the blood coagulation system with platelet count, determination of fibrinogen concentration, prothrombin time (PT) by Quick, activated partial thromboplastin time (APTT), thrombin time (TT), non-activated thromboelastography (TЕG) and thromboelastometry (TEM) was performed. Results. There were no signifi cant differences in fi brinogen level, APTT, PT between the groups. In both groups, TEG/TEM study found shortening of the clotting time intervals and clot formation time, an increase in clot density, which corresponds to hemostasis prothrombotic changes during pregnancy. Reference ranges of nonactivated TEG/TEM parameters in III trimester of physiological pregnancy were determined. Conclusions. Methods of non-activated TEG/TEM are highly informative in the diagnosis of hemostasis disorders and can be used, together with activated standardized tests, to monitor blood coagulation during pregnancy.

scholarly journals Effect of Leaves Infuse (Foeniculum vulgare Mill.) Intake on Reproductive Organs Morphometry of Female Rats (Rattus Sp.) After Parturition

2017 ◽  
Vol 1 ◽  
pp. 27-30
Author(s):  
Najda Rifqiyati ◽  
Jumailatus Sholihah ◽  
Laelatul Soimah
Keyword(s):  
Reproductive Organs ◽  
Female Rats ◽  
Control Group ◽  
Foeniculum Vulgare ◽  
Treatment Groups ◽  
Randomized Design ◽  
Length Width ◽  
Completely Randomized Design ◽  
Layer Chromatography ◽  
Female Reproductive Organs

Fennel (Foeniculum vulgare Mill.) traditionally used by people as antifertility agent for female. Fennel leaves (Foeniculum vulgare Mill.) contain phytoestrogen that has role as antiestrogen or synthesized become antiestrogen. Coumarin is the kind phytoestrogen that can be antiestrogen to female reproductive organs such as ovary and utery. The aim of this research is to find out the influence of fennel leaves infuse (Foeniculum vulgare Mill.) on morphometric of ovary and utery in female rats (Rattus sp.) administered after parturition, to find out the effective dose  affecting the morphometric of ovary and utery and to find out the total coumarin consisted in fennel leaves (Foeniculum vulgare Mill.). This research was carried out by using CRD (Completely Randomized Design) consisted of 2 groups, those are control group (aquades) and treatment groups (doses of fennel leaves infuse 20 g/300 ml, 40 g/300 ml and 60 g/300 ml). The treatment was administered in the morning and afternoon for 15 days. After 15 days of treatment, the rats were sacrificed and dissected to measure the morphometry of reproductive organs (ovary and utery). The data obtained was analyzed by Analysis of Varian (ANOVA) and continued by LSD (Least Significance Different) test with significance of 5%. The measurement of coumarin level was performed by TLC (Thin Layer Chromatography) densitometry method. The result of this research showed that the administration of infused fennel leaves (Foeniculum vulgare Mill.) at dose of 20 g/300 ml, 40 g/300 ml and 60 g/300 ml significantly decreased ovarian weigh in female rats (Rattus sp.) after parturition (p<0,05), but not decreased the  length, width, thick of ovary, length and diameter of utery (p>0,05). No difference was observed between doses 20 g/300 ml, 40 g/300 ml and 60 g/300 ml, and it showed that the dose 20 g/300 ml of fennel leaves infuse was able to be used to decrease the weigth of ovary. Coumarin level observed in leaves is 0,09%, and it is higher than the coumarin content in fruit/seed.

scholarly journals The influence of hypothermia prevention by application of skin moisture absorbent on the value of body temperature, body weight and blood parameters in piglets

2021 ◽  
Vol 73 (5) ◽  
pp. 1058-1066
Author(s):  
M. Mirkov ◽  
I. Radović ◽  
M. Cincović ◽  
M. P. Horvatović ◽  
S. Dragin
Keyword(s):  
Body Weight ◽  
Body Temperature ◽  
Biochemical Parameters ◽  
Blood Parameters ◽  
Economic Losses ◽  
Control Group ◽  
Pig Production ◽  
Hematological And Biochemical Parameters ◽  
Moisture Absorbent ◽  
Skin Moisture

ABSTRACT Reducing the mortality rate is of a great economic importance for pig farming. Therefore, it is necessary to define the conditions in the farrowing unit based on the performance of the piglets, and specific hematological and biochemical parameters. Therefore, the aim of this paper is to examine the importance of using skin moisture absorbent and its influence in preventing hypothermia, which causes great economic losses in pig production. The experiment was set up on a commercial farm in Serbia and included 92 pigs divided into the experimental and control group. Body temperature values, body weight and blood parameters were monitored. The obtained values indicate that there is a significantly positive correlation of body temperature change and body weight values, and body temperature showed a significantly higher increase in the experimental group compared to the control group. The results obtained from hematological and biochemical parameters provide a clearer picture of the metabolic processes in piglets in the farrowing unit and can be used to further improve pig production and as a complement to genetic enhancement.

scholarly journals USING THE THROMBODYNAMICS TEST IN THE INTEGRATED PERIOPERATIVE MONITORING OF THE BLOOD COAGULATION SYSTEM IN SURGICAL PATIENTS

2018 ◽  
Vol 25 (6) ◽  
pp. 44-49
Author(s):  
I. V. [email protected]; ◽  
G. K. Karipidi ◽  
A. G. Barishev ◽  
U. P. Savchenko ◽  
S. B. Bazlov ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Abdominal Cavity ◽  
Statistical Processing ◽  
Perioperative Period ◽  
Surgical Patients ◽  
Coagulation System ◽  
Thromboembolic Complications ◽  
Integrated Monitoring ◽  
Blood Coagulation System ◽  
Venous Thromboembolic

Aim.The research was conducted to evaluate the possibilities of the "Thrombodynamics" test in the integrated monitoring of the blood coagulation system and the choice of the method of prophylaxis of thromboembolic complications in the postoperative period in surgical patients.Materials and methods. 123 patients were operated for acute surgical pathology of abdominal organs. The "Thrombodynamics" test was used in a complex assessment of the state of the blood coagulation system. After the statistical processing by the methods of variation statistics, the results were used to predict the risk of the occurrence and changes in the volume of therapy for thromboembolic complications, taking into account the current understanding of the thrombodynamic properties of the fibrinous clot. Correction of the hemostasis system was based on "Russian Clinical Recommendations for the Diagnosis, Treatment and Prevention of Venous Thromboembolic Complications" approved by the Expert Meeting on May 20, 2015.Results.It was found that 101 (82.1%) patients had abnormalities in the blood coagulation system after the surgery for acute abdominal cavity diseases complicated by peritonitis. We established the direct dependence of the predicted risk of thromboembolic complications on the degree of severity of secondary peritonitis. 52 (42.3%) patients needed a correction of thromboprophylactic therapy, which made it possible to exclude the occurrence of venous thromboembolic complications.Conclusion. The use of the "Thrombodynamics" test in the complex evaluation of the qualitative characteristics of the blood coagulation system in surgical patients with a complicated course of the disease in the perioperative period makes it possible to objectively assess the risks of the thromboembolic complications and to correct a thromboprophylactic therapy to exclude the thromboembolic complications. 

scholarly journals Effect of Citrullus colocynthis on some physiological aspects of female reproductive system in mice as a model for mammals

2011 ◽  
Vol 5 (2) ◽  
pp. 61-66
Author(s):  
Saad S. Al-Dujaily ◽  
Ali H. Hassan ◽  
Fitua M. Aziz ◽  
Akram F. Mahdi ◽  
Essraa M. A. Al Essawe
Keyword(s):  
Reproductive Organs ◽  
Control Group ◽  
Ovarian Activity ◽  
Alcoholic Extract ◽  
Female Reproductive System ◽  
Citrullus Colocynthis ◽  
Pregnant Females ◽  
And Control ◽  
Albino Strain ◽  
Female Reproductive Organs

The study was design to investigate the effect of oral administration of Citrullus colocynthis (CC) on some physiological and histological characters of female reproductive organs in mature mice of Swiss albino strain as a model for mammals. The animals were divided into three groups each contains 8 animals. Group one was treated with 6 mg/ Kg body weight BW/ day of alcoholic extract of CC, group two was treated with 9.6 mg/ Kg BW/day of alcoholic extract of CC and group three served as control throughout eight weeks period. The results of the study showed no significant (P>0.05) difference in the ovarian and uterine weight among groups. Significant (P<0.05) differences were shown in ovarian activity in control and group one compared to group two. The number of corpura lutea was highly significant (P<0.01) improved in group one than that of control group. The number of pregnant females was 50% in group one and control group. However the females treated with 6 mg/ Kg BW/ day of alcoholic extract of CC were gave a significant (P<0.01) results in the number of litters when compared with control group. It is concluded from the present research that treating with limiting dose of CC may accelerated the action of ovarian activity and resulted in improvement in the number of litters.

scholarly journals Pathological study 0f the toxic effect of paracetamol on reproductive organs in white mice

2010 ◽  
Vol 9 (3) ◽  
pp. 1
Author(s):  
A. G. Rhayf, and S. K. Majeed
Keyword(s):  
Dose Group ◽  
Reproductive Organs ◽  
Control Group ◽  
High Dose ◽  
Pathological Study ◽  
Toxic Dose ◽  
Male And Female ◽  
Fourth Group ◽  
The Third ◽  
Female Reproductive Organs

In present study use 40 mice (20 male and 20 females) divided into 4 groups, each grouphas 10 mice.The first group gave distal water considered as control group. The second (lowdose group) gave 28.5 mg / kg B.W. paracetamol. The third group(intermediate dose group)gave 57 mg / kg B.W. paracetamol and fourth group(high dose group) gave 114 mg / kg B.W.paracetamol daily for 6 month. Also there was another group considerd as peracute dosegroup(supra toxic) contains from 2 males and 2 females gave 342 mg / kg B.W. (for 2weeks).The toxic and supra toxic dose 0f paracetamol caused macroscopic and microscopicchanges in male and female reproductive organs in white mice

Effect of Annona senegalensis leaves on morphometric parameters of reproductive organs in rabbits

2016 ◽  
Vol 5 (3) ◽  
pp. 122-125
Author(s):  
Dougnon Jacques Tossou ◽  
◽  
Ahossi Philippe Kapko ◽  
Soha Sas Arnaud Sèsséya ◽  
Ohouko Okri Fréjus Hans ◽  
...  
Keyword(s):  
Reproductive System ◽  
Live Weight ◽  
Reproductive Organs ◽  
Morphometric Parameters ◽  
The Other ◽  
Control Group ◽  
Other Hand ◽  
Left And Right ◽  
The Right ◽  
Female Reproductive Organs

The present study aimed to evaluate the effect of the leaves of Annona senegalensis on morphometric parameters of the female reproductive organs in rabbits. A total of 120 rabbits were divided into four batches A, B, C and D of 30 animals each. Lots B, C an d D received 10, 20 and 30 g leaves of Annona Senegalensis / kg of feed respectively, while lot A (control group) was fed with the staple feed (without Annona senegalensis leaves). At the end of the experiment, the animals were dissected and morphometric parameters of the different genital organs were measured. The results sho wed that the average live weight, the average lengths of the left oviduct and the average lengths of the vagina did not vary significantly between different experimental groups (p> 0.05). On the other hand, the weight of the right ovary, the left and right uterus, right oviduct, vagina and reproductive system varied significantly between batches (p <0.05). , the right oviduct length of Lot D was the longest (15.52 cm ± 2.83) with a shorter right uterus (5.87 cm ± 1.43) compared to other lots.

scholarly journals od additive on female reproductive organs and hormones fo AzorubineEffects of in Sprague Dawley rat

2019 ◽  
Vol 42 (2) ◽  
pp. 66-71
Author(s):  
Faraidoon Abdul Sattar Muhamad Amin
Keyword(s):  
Blood Cells ◽  
White Blood Cells ◽  
Reproductive Organs ◽  
Reproductive Hormones ◽  
Food Additive ◽  
Control Group ◽  
Female Rat ◽  
Sprague Dawley ◽  
Follicular Stimulation ◽  
Female Reproductive Organs

The objective of the present study was to assess the effects of various doses of Azorubine which is a food additive on the female reproductive organs in Sprague Dawley rats. Twenty four female Sprgue Dawley rats were divided randomly into 4 equal groups. Group 1(control group), group, 2, 3 and 4 were received Azorubine (5, 10 and 20 mg/kg) orally, daily for 30 days respectively. Blood samples were taken for estimation of white blood cells, red blood cells, hemoglobin and platelets, in addition Luteinizing, follicular stimulation, estrogen and progesterone hormones from the sera. The reproductive hormones levels affected drastically under the effects of different doses of treatment like Luteinizing hormone (0.69±0.25, 0.60±0.75 and 0.55±0.63), Follicular Stimulation hormone (0.17±0.11, 0.13±0.33 and 0.3±0.45), Progesterone hormone (0.50±0.77, 0.14±0.56 and 0.10±0.85), and estrogen hormone (0.45+0.43, 0.30±0.29 and 0.14±0.27) hormones were decreased significantly (P˂0.05) in groups of rats treated with each 5, 10 and 20 mg/kg doses of Azorubine respectively. Histopathologically, the ovaries treated with 5 mg/kg doses of Azorubine showing follicles at the beginning stages of growth with no Graffian follicle while the ovaries with 10 mg/kg doses of Azorubine contain fully grown Graffian follicles with no follicles at various stages as well as those with 20 mg/kg doses of treatment displaying no mature Graffian follicle with many atretic and shrunk follicles. The hematological outcomes are significantly affected by this food additive. The results of this work is concluded that Azorubine can be considered as one of the most important causes of infertility, hormonal disturbances and irregular estrus cycle in the female rat.

Ultrastructural aspects of gymnosperms reproductive organs tissues due to their functional condition

1978 ◽  
Vol 36 (2) ◽  
pp. 440-441
Author(s):  
G. M. Kozubov
Keyword(s):  
Metabolic Activity ◽  
Functional Condition ◽  
Reproductive Organs ◽  
Considerable Change ◽  
Complicated Structure ◽  
Tetrad Stage ◽  
Ubisch Bodies ◽  
Similar Organization ◽  
Female Reproductive Organs ◽  
High Metabolic Activity

The ultrastructure of reproductive organs of pine, spruce, larch and ginkgo was investigated. It was found that the male reproductive organs possess similar organization. The most considerable change in the ultrastructure of the microsporocytes occur in meiosis. Sporoderm is being laid at the late tetrad stage. The cells of the male gameto-phyte are distinguished according to the metabolic activity of the or- ganells. They are most weakly developed in the spermiogenic cell. Ta-petum of the gymnosperms is of the periplasmodic - secretorial type. The Ubisch bodies which possess similar structure in the types investigated but are specific in details in different species are produced in tapetum.Parietal and subepidermal layers are distinguished for their high metabolic activity and are capable of the autonomous photosynthesis. Female reproductive organs differ more greatly in their struture and have the most complicated structure in primitive groups. On the first stages of their formation the inner cells of nucellus are transformed into the nucellar tapetum in which the structures similar to the Ubisch bodies taking part in the formation of the sporoderm of female gametophyte have been found.

Sign in / Sign up

Export Citation Format

Share Document