Investigation of the fundamental causes of the collapse of the USSR is an urgent task of our science

2021 ◽  
pp. 36
Author(s):  
Alexander Degtyaryov
Keyword(s):  
Fundamental Causes ◽  
Urgent Task

           

C-fos, ERK1/2, MAP2, NOTCH1 Proteins Expression Patterns in Human Cerebral Cortex Neurons after Ischemic Stroke

2020 ◽  
Vol 75 (3) ◽  
pp. 226-233
Author(s):  
Svetlana P. Sergeeva ◽  
Aleksey V. Lyundup ◽  
Valery V. Beregovykh ◽  
Petr F. Litvitskiy ◽  
Aleksey A. Savin ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Ischemic Stroke ◽  
Expression Patterns ◽  
Immunohistochemical Method ◽  
Left Middle Cerebral Artery ◽  
Contralateral Hemisphere ◽  
Human Cerebral Cortex ◽  
Fos Protein ◽  
Urgent Task ◽  
Indirect Immunoperoxidase

Background. The search for protein (these include c-fos, ERK1/2, MAP2, NOTCH1) expression that provide neuroplasticity mechanisms of the cerebral cortex after ischemic stroke (IS) patterns is an urgent task. Aims to reveal c-fos, ERK1/2, MAP2, NOTCH1 proteins expression patterns in human cerebral cortex neurons after IS. Materials and methods. We studied 9 left middle cerebral artery (LMCA) IS patients cerebral cortex samples from 3 zones: 1 the zone adjacent to the necrotic tissue focus; 2 zone remote from the previous one by 47 cm; 3 zone of the contralateral hemisphere, symmetric to the IS focus. Control samples were obtained from 3 accident died people. Identification of targeted proteins NSE, c-fos, ERK1/2, MAP2, NOTCH1 was performed by indirect immunoperoxidase immunohistochemical method. Results. Moving away from the ischemic focus, there is an increase in the density of neurons and a decrease in the damaged neurons proportion, the largest share of c-fos protein positive neurons in zone 2, NOTCH1 positive neurons in zone 1, smaller fractions of ERK1/2 and MAP2 positive neurons compared to the control only in samples of zone 1. Conclusions. With the IS development, the contralateral hemisphere is intact tissue increased activation zone, while the zones 1 and 2 have pathological activation signs. In zone 1 of the range, the adaptive response of the tissue decreases, and in zone 2 it expands. Therefore, a key target for therapeutic intervention is zone 2.

EFFICIENT MANAGEMENT SYSTEM OF TEACHING TECHNICAL MEANS AT CENTRAL KINDERGARTEN PEDAGOGY COLLEGE IN INDUSTRIAL REVOLUTION 4.0

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Vũ Xuân Hùng
Keyword(s):  
Intellectual Development ◽  
Industrial Revolution ◽  
Current Period ◽  
Efficient Management ◽  
Urgent Task ◽  
Creative Learning ◽  
Cognitive Activities ◽  
And Control ◽  
Technical Teaching

In the process of teaching, technical teaching facilities are both a content and a means of conveying information, they help the lecturer organize and control the students' cognitive activities, in addition, they also help students be interested in learning, practice practical skills from which to form active and creative learning methods. Teaching technology is one of the necessary conditions to help teachers carry out their related work of educating, teaching and bringing up, and intellectual development, arouse the inherent intelligence qualities of students. Currently, the management of technical teaching facilities at the Central Kindergartens College has been carried out on a regular basis and achieved certain results, but in fact, there are still many inadequacies. Finding a number of limitations in the management of teaching technical facilities, thereby proposing solutions to overcome those limitations, improve the efficiency of investment, preservation and use of teaching technical facilities in the trend of Industry Revolution 4.0, improving the quality of teaching at Central Kindergarten Pedagogy colleges in the current period is a very important and urgent task.

BUILDING THE MODEL OF INFORMATION, EDUCATION AND COMMUNICATION EFFICIENCY IN CONSERVATION AND PROMOTION OF THE IDENTITY VALUE OF ETHNIC MINORITIES CULTURE IN ETHNIC MINORITY BOARDING GENERAL SCHOOLS, ETHNIC MINORITY SEMI-BOARDING GENERAL SCHOOLS AND LOCAL COMMUNITIES THROUGH LANGUAGE OF ETHNIC MINORITIES

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Ngo Quang Son ◽  
Nguyen Thi Phuong
Keyword(s):  
Ethnic Minority ◽  
Ethnic Minorities ◽  
Traditional Culture ◽  
Cultural Preservation ◽  
Spiritual Values ◽  
Linguistic Identity ◽  
Modern Life ◽  
Urgent Task ◽  
Communication Efficiency ◽  
History Of

Traditional culture of ethnic minorities is the material and spiritual values that are accumulated and preservedin the whole history of ethnic minority development. In thatcommon cultural flow, every ethnic minorities group in ourcountry has its own characteristics in traditional culture.That identity is expressed firstly in language. Language is animportant element of the ethnic minorities character, therefore,the loss of language is the loss of a great asset, thereby leadingto the erasure of art literature, religious beliefs and the custom,customary law.Therefore, in the context of modern life, preserving andpromoting the cultural and linguistic identity of ethnicminorities is an urgent task. In particular, pay specialattention to the method of cultural preservation through thedevelopment of Information, Education and CommunicationModel in ethnic minorities languages in schools and localcommunities.

BUILDING THE PROGRAM OF TRAINING ETHNIC KNOWLEDGE FOR CADRES, CIVIL SERVANTS AND PUBLIC EMPLOYEES UP TO 2030

2019 ◽  
Vol 8 (4) ◽  
Author(s):  
Nguyen Van Dung ◽  
Nguyen Ngoc Minh ◽  
Pham Kim Cuong
Keyword(s):  
Ethnic Minority ◽  
Training Program ◽  
Political System ◽  
Civil Servants ◽  
Public Employees ◽  
Target Groups ◽  
Current Period ◽  
Urgent Task ◽  
Practical Research ◽  
Local Levels

Developing a ethnic knowledge training program for cadres, civil servants and public employees according to 04 target groups (Prime Minister, 2018) in the political system from the central to local levels to meet the requirements of ethnic minority affairs up to 2030 is an urgent task. Because the program is “the core” to create a breakthrough in training ethnic knowledge, improving the capacity of the contingent of cadres, civil servants and public employees in formulating ethnic policies and organizing the implementation of Party and State’s policies in the current period. The article analyzes the results of theoretical and practical research on the development of ethnic knowledge training program and provides the results of developing a program that meets the requirements of Vietnam’s ethnic minority affairs from now to 2030.

The problem of woman’s emansipation in the feuilleton “Amazonia: a very inept story” by Mykola Chirsky

2020 ◽  
pp. 71-76
Author(s):  
Iryna Rusnak
Keyword(s):  
Scientific Understanding ◽  
The Other ◽  
Literary Studies ◽  
Ethical Guidelines ◽  
Compositional Structure ◽  
Urgent Task ◽  
The Subject ◽  
The One ◽  
Artistic Heritage

The author of the article analyses the problem of the female emancipation in the little-known feuilleton “Amazonia: A Very Inept Story” (1924) by Mykola Chirsky. The author determines the genre affiliation of the work and examines its compositional structure. Three parts are distinguished in the architectonics of associative feuilleton: associative conception; deployment of a “small” topic; conclusion. The author of the article clarifies the role of intertextual elements and the method of constantly switching the tone from serious to comic to reveal the thematic direction of the work. Mykola Chirsky’s interest in the problem of female emancipation is corresponded to the general mood of the era. The subject of ridicule in provocative feuilleton is the woman’s radical metamorphoses, since repulsive manifestations of emancipation becomes commonplace. At the same time, the writer shows respect for the woman, appreciates her femininity, internal and external beauty, personality. He associates the positive in women with the functions of a faithful wife, a caring mother, and a skilled housewife. In feuilleton, the writer does not bypass the problem of the modern man role in a family, but analyses the value and moral and ethical guidelines of his character. The husband’s bad habits receive a caricatured interpretation in the strange behaviour of relatives. On the one hand, the writer does not perceive the extremes brought by female emancipation, and on the other, he mercilessly criticises the male “virtues” of contemporaries far from the standard. The artistic heritage of Mykola Chirsky remains little studied. The urgent task of modern literary studies is the introduction of Mykola Chirsky’s unknown works into the scientific circulation and their thorough scientific understanding.

Challenges for income generation methods in monopoly companies

2019 ◽  
Vol 2 (2) ◽  
pp. 54-64
Author(s):  
Ali Zurapov
Keyword(s):  
Market Competition ◽  
Social Needs ◽  
Income Generation ◽  
Working Capital ◽  
Technical Base ◽  
Fundamental Goal ◽  
Urgent Task ◽  
The Social ◽  
The Stability ◽  
Commercial Organization

In conditions of market competition, the fundamental goal of any commercial organization is to obtain the greatest profit, which directly depends on the amount of income received and expenses incurred. Current paper discuses  about main source of development of the material and technical base of the enterprise, replenishment of its own working capital, ensuring the social needs of the companies. Main objectivity is income factor in the stability of the existence and progress of the monopoly companies. In this regard, the management of the income of the organization is currently quite an urgent task for every giant entrepreneur. The article reveals the essence, purpose, objectives and measures in the field of enterprise revenue management. On the example of a particular enterprise, a dynamic and structural analysis of its revenues is carried out.

Microbiological substantiation of application of phytopreparations in treatment of inflammatory periodontal diseases

2019 ◽  
Vol 24 (3) ◽  
pp. 196-202 ◽  
Author(s):  
S. A. Abdurakhmanova ◽  
G. S. Runova ◽  
M. S. Podporin ◽  
E. V. Tsareva ◽  
E. V. Ippolitov ◽  
...  
Keyword(s):  
Tooth Loss ◽  
Periodontal Diseases ◽  
Adult Population ◽  
Experimental Studies ◽  
Herbal Medicines ◽  
Growth Dynamics ◽  
Integrated Approach ◽  
Bacterial Populations ◽  
Streptococcus Constellatus ◽  
Urgent Task

Relevance: Inflammatory-destructive periodontal diseases are the most complicated and became the main cause of tooth loss in adult population. Herbal medicines have a variety of pharmacological properties, so the development and introduction of new forms for the treatment of inflammatory periodontal diseases is an urgent task today.Purpose – experimental evaluation of effectiveness of the use of herbal medicines “Tonzinal” and “CM-1” in relation to the priority periodontal pathogenes.Materials and methods: in experimental studies, the basis for the experiment was the system for the cultivation of microorganisms in real time – the Revers-Spinner RTS-1 bioreactor. With the priority strains of periodontitis pathogens, the study of the growth dynamics of the culture was carried out in several parallels.Results: herbal medicines “CM-1” and “Tonsinal” has a multilateral therapeutic effect, exerting a diverse influence on the key stages of development of such bacterial populations as Aggregatibacter actinomycetemcomitans, Streptococcus constellatus, Candida albicans.Conclusion: tan integrated approach in the treatment of patients with inflammatory periodontal diseases is promising and will contribute to a more prolonged remission and increase the effectiveness of treatment. 

Features of the thyroid status in patients receiving programmed hemodialysis

2020 ◽  
Vol 24 (4) ◽  
pp. 61-66
Author(s):  
V. A. Kovalevskiy ◽  
A. N. Shishkin
Keyword(s):  
Endocrine System ◽  
Hemodialysis Patients ◽  
Thyroid Status ◽  
Average Value ◽  
Urgent Task ◽  
Ckd Stage ◽  
Group 3 ◽  
Group 2 ◽  
And Gender ◽  
People Group

INTRODUCTION. In patients with CKD stage 5 receiving hemodialysis as the main method of renal replacement therapy (RRT), the endocrine system organs, including the thyroid gland, are affected over time. The study of changes in the thyroid status is an urgent task. AIM OF STUDY. Study of functional and gender characteristics of the thyroid status, depending on the duration of patients stay on hemodialysis. PATIENTS AND METHODS. The thyroid status was measured in 108 patients (44 women and 64 men, average age 51.7±15.4 years) undergoing hemodialysis. Patients were divided into quartiles according to the duration of stay on the RRT: group 1 4 – 25 months (28 people), group 2 41 – 59 months (26 people), group 3 68 – 97 months (26 people) and the fourth more than 100 months (28 people). We performed correlation analysis and comparison between groups on the level of free T 4, TSH, the ratio of fT4 to TSH. RESULTS. The average value of fT4 was 11.95±2.07 pmol / ml and TSH 1.5± 0.94 mcME/ml. Significant differences in thyroid status were obtained between the first and second groups in terms of TSH level and ratio fT 4 to TSH (P<0.01) – the level of TSH in the second group is higher (0.74 to 2.1 mсME/ml) and the ratio of fT4 to TSH is lower (13.09 to 4.91). In total, thyroid dysfunction was detected in 20.3% of the examined patients. CONCLUSION. Thus, deviations in the thyroid status occur after 2 years of being on RRT by hemodialysis. In patients who have been on RRT for more than 5 years, the thyroid status stabilizes. The reasons for this phenomenon are completely incomprehensible.

THE LEVEL OF CYTOKINES IN THE SALIVA OF PATIENTS WITH BREAST CANCER

2019 ◽  
Vol 65 (6) ◽  
pp. 825-831
Author(s):  
Lyudmila Belskaya ◽  
Viktor Kosenok
Keyword(s):  
Breast Cancer ◽  
Control Group ◽  
Early Stages ◽  
Promising Tool ◽  
Urgent Task ◽  
Advanced Stages ◽  
New Biomarkers ◽  
Histological Verification ◽  
Control Study ◽  
Biochemical Examination

Currently, the urgent task is to search for new biomarkers as a promising tool for early detection and monitoring of breast cancer. The aim of the study was to study the level of cytokines in the saliva of patients with breast cancer. In the case-control study volunteers participated, which were divided into 3 groups: the main (breast cancer, n = 43), the comparison group (fibroadenoma, n = 32) and the control group (conditionally healthy, n = 39). All participants were questioned; biochemical examination of saliva, histological verification of the diagnosis was carried out. Intergroup differences are estimated by a nonparametric criterion. It is shown that in the context of breast cancer, the level of cytokines (IL-2, IL-4, IL-6, IL-10 and IL-18) is increasing, except for IL-8, the content of which decreases compared to the control group. When the disease progresses by the nature of the dynamics, the parameters are divided into two groups: IL-2, IL-4, IL-18 and IL-6, IL-8, IL-10. For the first group of cytokines, there was a decrease in content during the transition from the early stages to the more common ones. For the second group, when passing from stages T1-2N0M0 to T1-2NjM0, the level of cytokines remains practically constant. In the future, the level of cytokines is observed for stage T3_4N0_2M0, and for IL-2, IL-4 and IL-10, the level of cytokines reaches values corresponding to early stages, whereas for IL-6, IL-8 and IL-18 in the same direction, a significant increase in indicators was noted. Additionally, the IL-6/IL-8 ratio was calculated depending on the tumor size, as well as the presence / absence of metastasis. It is shown that this ratio is statistically significantly increased in the advanced stages of the disease. Particularly interesting is the increase in this ratio in saliva at the initial stages of the disease.

METHODS OF IMPROVING ACCURACY OF MEASURING OUTPUT CHARACTERISTICS OF TENSOMETRIC ELEMENTS AND TESTMODULES

2018 ◽  
pp. 10-19
Author(s):  
S. A. Adarchin ◽  
A. V. Mazin
Keyword(s):  
Pressure Sensors ◽  
Control Object ◽  
Complete Information ◽  
Substrate Material ◽  
Automated Control ◽  
Urgent Task ◽  
Technical Specifications ◽  
Output Characteristics ◽  
Improving Accuracy ◽  
Microprocessor Technology

Over the past few years, thanks to the success of microprocessor technology, there has been a significant leap in the development and application of automated control systems. In such systems, information obtained from a set of sensors installed on the control object and giving complete information about it is used to form the control action. Improving the accuracy of measurement of their characteristics becomes an urgent task. This paper is considered to study of the processes of degradation of microelectromechanical structures of integral measuring tensometric elements, for example, pressure sensors, expressed in the obtaining of the output characteristics of the sensor for the regulations set forth in the technical specifications. The technique allowing to measure the parameters of the output signal of the strain cell with the help of a special installation is developed. The results of the experiments determined that when using material with a small modulus of elasticity can be used for the planting element, any substrate material of test module. The developed technique can be used in the production and design of the strain gauge, and the sensor as a whole.

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