scholarly journals Optimalisasi Informasi Citra T1 W1 Post-Contrast Dengan Fat Saturation dan Pengaturan Time Repetition: Studi pada Pemeriksaan Magnetic Resonance Imaging Brain dengan Kasus Tumor

2015 ◽  
Vol 1 (1) ◽  
pp. 36-43
Author(s):  
Akhmad Haris Sulistiyadi ◽  
Ari Suwondo ◽  
Sugiyanto Sugiyanto
Keyword(s):  
Brain Tumor ◽  
White Matter ◽  
Gray Matter ◽  
Surrounding Tissue ◽  
Resonance Imaging ◽  
Post Contrast ◽  
Image Information ◽  
Fat Saturation ◽  
Contrast Image ◽  
Selection Of

Background: Fat saturation is an alternative technique to improve image information in T1 WI post contrast MRI of brain tumor. It can increase lesion conspituity by suppressing normal tissue’s signal. To optimize image information by using fat saturation, selection of Fat Saturation type and Time Repetition (TR) value are important.Objectives: to analyze the differences in T1 WI post-contrast image information in MRI of brain tumor in various type of Fat Saturation and TR value.Methods: Experimental study with factorial design conducted in  Telogorejo Hospital-Semarang. Nine combinations (9 groups) of three Fat Saturation types (none, weak, and strong) by three TR values (700 ms, 750 ms, and 800 ms) were given to 12 patients of MRI brain tumor. Image informations were assessed by measuring  SNR (white matter, gray matter, lesions, surrounding tissue), CNR (white matter- gray matter, white matter-CSF, gray matter-CSF, lesion- surrounding tissue), lesion conspituity, artifacts, and contrast image in general.Results: The results showed that there were significant differences in SNR of white matter, gray matter, and in surrounding tissue (p 0.05); CNR of white matter-CSF, gray matter-CSF, lesion-tissue surrounding tissue (p 0.05); and lesion conspituity (p 0.05) between groups with no sat fat, weak fat sat, and strong fat sat. There were significant differences in SNR of white matter, gray matter, and surrounding tissue (p 0.05); and CNR of white matter-CSF, gray matter-CSF, and lesion- surrounding tissue (p 0.05) between group TR 700 ms, TR 750 ms, and TR 800 ms.Conclusion: Combination of strong fat saturation and TR 700 ms can produce the most optimal image information.

scholarly journals Multimodal Magnetic Resonance Imaging reveals alterations of sensorimotor circuits in restless legs syndrome

SLEEP ◽  
2019 ◽  
Vol 42 (12) ◽  
Author(s):  
Ambra Stefani ◽  
Thomas Mitterling ◽  
Anna Heidbreder ◽  
Ruth Steiger ◽  
Christian Kremser ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Gray Matter ◽  
Disease Duration ◽  
Gray Matter Volume ◽  
Resonance Imaging ◽  
Iron Storage ◽  
Matter Volume ◽  
The Right

Abstract Study Objectives Integrated information on brain microstructural integrity and iron storage and its impact on the morphometric profile is not available in restless legs syndrome (RLS). We applied multimodal magnetic resonance imaging (MRI) including diffusion tensor imaging, the transverse relaxation rate (R2*), a marker for iron storage, as well as gray and white matter volume measures to characterize RLS-related MRI signal distribution patterns and to analyze their associations with clinical parameters. Methods Eighty-seven patients with RLS (mean age 51, range 20–72 years; disease duration, mean 13 years, range 1–46 years, of those untreated n = 30) and 87 healthy control subjects, individually matched for age and gender, were investigated with multimodal 3T MRI. Results Volume of the white matter compartment adjacent to the post- and precentral cortex and fractional anisotropy (FA) of the frontopontine tract were both significantly reduced in RLS compared to healthy controls, and these alterations were associated with disease duration (r = 0.25, p = 0.025 and r = 0.23, p = 0.037, respectively). Corresponding gray matter volume increases of the right primary motor cortex in RLS (p < 0.001) were negatively correlated with the right FA signal of the frontopontine tract (r = −0.22; p < 0.05). Iron content evaluated with R2* was reduced in the putamen as well as in temporal and occipital compartments of the RLS cohort compared to the control group (p < 0.01). Conclusions Multimodal MRI identified progressing white matter decline of key somatosensory circuits that may underlie the perception of sensory leg discomfort. Increases of gray matter volume of the premotor cortex are likely to be a consequence of functional neuronal reorganization.

Quantitative contrast-enhanced magnetic resonance imaging to evaluate blood-brain barrier integrity in multiple sclerosis: a preliminary study

2001 ◽  
Vol 7 (2) ◽  
pp. 75-82 ◽  
Author(s):  
N C Silver ◽  
P S Tofts ◽  
M R Symms ◽  
G J Barker ◽  
A J Thompson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
White Matter ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Resonance Imaging ◽  
Post Contrast ◽  
Time Points ◽  
Normal Appearing White Matter ◽  
Blood Brain

Gadolinium enhanced magnetic resonance imaging detects focal blood-brain barrier breakdown in new inflammatory multiple sclerosis lesions, but such lesions do not correlate with disease progression. To explore whether the latter might relate to subtle but widespread blood-brain barrier (BBB) breakdown with low grade inflammation mediating tissue damage, quantitative techniques were used to detect subtle gadolinium enhancement within otherwise normal-appearing white matter and within lesions not showing visible enhancement. T1-weighted imaging was performed prior to and at 5, 20 and 40 min following injection of 0.3 mmol/kg gadopentate dimeglumine in 33 patients with multiple sclerosis and five healthy control subjects. In healthy controls, a significant increase in white matter signal 5 min following contrast injection was observed (1.8%, P < 0.0005); the signal returned to baseline values by 20 min. In multiple sclerosis patients, a non-significant trend was noted for signal to remain elevated in normal-appearing white matter at the 20 and 40 min post-contrast time points; this was most apparent in primary progressive multiple sclerosis. Significant increases in signal intensity were noted at all time points post contrast in apparent non-enhancing lesions. The transient post contrast signal increase in controls is likely due to intravascular gadopentate dimeglumine. The persistent increases in signal intensity in non-enhancing lesions suggest more widespread abnormalities in BBB than is visually apparent, but substantiation of BBB leakage in normal appearing white matter will require further study using more sensitive methods.

Measurement of Glioma Viscoelasticity Using a Handheld Palpation Imitation Device

2017 ◽  
Author(s):  
Shigeto Hayashi ◽  
Atsushi Sakuma ◽  
Takashi Sasayama ◽  
Eiji Kohmura
Keyword(s):  
Computed Tomography ◽  
Brain Tumor ◽  
Elastic Modulus ◽  
White Matter ◽  
Gray Matter ◽  
Tumor Tissue ◽  
Viscoelastic Behavior ◽  
En Bloc ◽  
Tomography Image ◽  
Computed Tomography Image

We examined glioma tissues immediately after en-bloc removal during surgery and measured elastic modulus, viscosity, and viscoelasticity of the gray and white matter to confirm the feasibility of measurement using an indentation device. Measurements were obtained from excised parenchymal brain tumor tissue of four adult patients. The white matter exhibited higher elastic modulus than the gray matter in all patients. Viscoelasticity analysis was performed in two patients, with viscoelastic behavior observed in the white but not in the gray matter in both patients. The loss of viscoelasticity in the white matter observed in one patient may be related to the calcification visible in the preoperative computed tomography image.

Elevated Aortic Pulse Wave Velocity Relates to Longitudinal Gray and White Matter Changes

2021 ◽  
Author(s):  
Corey W. Bown ◽  
Omair A. Khan ◽  
Elizabeth E. Moore ◽  
Dandan Liu ◽  
Kimberly R. Pechman ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Brain Magnetic Resonance Imaging ◽  
Aortic Pulse Wave Velocity ◽  
Resonance Imaging ◽  
Gray Matter Volumes ◽  
Over Time

Objective: To determine whether baseline aortic stiffness, measured by aortic pulse wave velocity (PWV), relates to longitudinal cerebral gray or white matter changes among older adults. Baseline cardiac magnetic resonance imaging will be used to assess aortic PWV while brain magnetic resonance imaging will be used to assess gray matter and white matter hyperintensity (WMH) volumes at baseline, 18 months, 3 years, 5 years, and 7 years. Approach and Results: Aortic PWV (m/s) was quantified from cardiac magnetic resonance. Multimodal 3T brain magnetic resonance imaging included T 1 -weighted imaging for quantifying gray matter volumes and T 2 -weighted fluid-attenuated inversion recovery imaging for quantifying WMHs. Mixed-effects regression models related baseline aortic PWV to longitudinal gray matter volumes (total, frontal, parietal, temporal, occipital, hippocampal, and inferior lateral ventricle) and WMH volumes (total, frontal, parietal, temporal, and occipital) adjusting for age, sex, race/ethnicity, education, cognitive diagnosis, Framingham stroke risk profile, APOE (apolipoprotein E)-ε4 carrier status, and intracranial volume. Two hundred seventy-eight participants (73±7 years, 58% male, 87% self-identified as non-Hispanic White, 159 with normal cognition, and 119 with mild cognitive impairment) from the Vanderbilt Memory & Aging Project (n=335) were followed on average for 4.9±1.6 years with PWV measurements occurring from September 2012 to November 2014 and longitudinal brain magnetic resonance imaging measurements occurring from September 2012 to June 2021. Higher baseline aortic PWV was related to greater decrease in hippocampal (β=−3.6 [mm 3 /y]/[m/s]; [95% CI, −7.2 to −0.02] P =0.049) and occipital lobe (β=−34.2 [mm 3 /y]/[m/s]; [95% CI, −67.8 to −0.55] P =0.046) gray matter volume over time. Higher baseline aortic PWV was related to greater increase in WMH volume over time in the temporal lobe (β=17.0 [mm 3 /y]/[m/s]; [95% CI, 7.2–26.9] P <0.001). All associations may be driven by outliers. Conclusions: In older adults, higher baseline aortic PWV related to greater decrease in gray matter volume and greater increase in WMHs over time. Because of unmet cerebral metabolic demands and microvascular remodeling, arterial stiffening may preferentially affect certain highly active brain regions like the temporal lobes. These same regions are affected early in the course of Alzheimer disease.

Multiple Sclerosis: White Matter versus Gray Matter Involvement (The Cause of Disability in MS)

2017 ◽  
Author(s):  
Massimo Filippi ◽  
Maria A. Rocca
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
White Matter ◽  
Gray Matter ◽  
Resonance Imaging ◽  
Factors Associated ◽  
The Central Nervous System ◽  
Magnetic Resonance Imaging Mri

The classic view of multiple sclerosis (MS) as a chronic, inflammatory-demyelinating condition affecting solely the white matter (WM) of the central nervous system (CNS) has been challenged by the demonstration, from pathologic and magnetic resonance imaging (MRI) studies, of an extensive and diffuse involvement of the gray matter (GM). This observation has driven the application of modern MR technology and methods of analysis to quantify the extent and distribution of damage to the different compartments of the CNS, with the ultimate goal of improving our understanding of the factors associated with the accumulation of clinical disability and cognitive impairment in these patients.

Precentral and cerebellar atrophic changes in moyamoya disease using 7-T magnetic resonance imaging

2019 ◽  
Vol 61 (4) ◽  
pp. 487-495
Author(s):  
Hyeong Cheol Moon ◽  
Byeong Ho Oh ◽  
Chaejoon Cheong ◽  
Won Seop Kim ◽  
Kyung Soo Min ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Moyamoya Disease ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Healthy Controls ◽  
Resonance Imaging ◽  
Matter Volume ◽  
Age Range

Background Chronic repeated transient ischemic changes are one of the common symptoms of moyamoya disease that could affect cortical and subcortical atrophy. Purpose We aimed to assess the cortical gray matter volume and thickness, white matter subcortical volume, and clinical characteristics using 7-T magnetic resonance imaging (MRI) and MR angiography (MRA). Material and Methods In this case-control study, whole-brain parcellation of gray matter and subcortical volumes were manually assessed in nine patients with moyamoya disease (18 hemispheres; median age = 34 years; age range = 10–60 years) and nine healthy controls (18 hemispheres; median age = 29 years; age range = 20–62 years) matched for age and sex, who underwent both 7-T MRI and MRA. The volumes were measured using high-resolution image (<1 mm) processing based on the Desikan-Killiany-Tourville (DKT) atlas, via an automated segmentation method (FreeSurfer version 6.0). Results The gray matter volume of the left precentral cortex and the white matter volume of the subcortical cerebellum were lower in both hemispheres in the patients with moyamoya disease compared to the healthy controls. Conclusion Gray matter atrophy in the precentral cortex and cerebellar white matter were detected in this 7-T MRI volumetric analysis study of patients with moyamoya disease who experienced repeated transient ischemic changes. Cortical atrophy in precentral cortex and cerebellum could explain the transient motor weakness in patients with moyamoya disease, as one of the early findings was that patients with moyamoya disease do not have detectable infarction changes on conventional MRI images.

Association Study Between White Matter Microstructure and Intelligence Decline in Schizophrenia

2021 ◽  
pp. 155005942110633
Author(s):  
Junya Matsumoto ◽  
Kenichiro Miura ◽  
Masaki Fukunaga ◽  
Kiyotaka Nemoto ◽  
Daisuke Koshiyama ◽  
...  
Keyword(s):  
White Matter ◽  
Functional Connectivity ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Region Of Interest ◽  
Healthy Controls ◽  
Resonance Imaging ◽  
White Matter Microstructure ◽  
Magnetic Resonance Imaging Mri ◽  
Diffusion Tensor Imaging Dti

Patients with schizophrenia can exhibit intelligence decline, which is an important element of cognitive impairment. Previous magnetic resonance imaging (MRI) studies have demonstrated that patients with schizophrenia have altered gray matter structures and functional connectivity associated with intelligence decline defined by a difference between premorbid and current intelligence quotients (IQs). However, it has remained unclear whether white matter microstructures are related to intelligence decline. In the present study, the indices of diffusion tensor imaging (DTI) obtained from 138 patients with schizophrenia and 554 healthy controls were analyzed. The patients were classified into three subgroups based on intelligence decline: deteriorated (94 patients), preserved (42 patients), and compromised IQ (2 patients) groups. Given that the DTI of each subject was acquired using either one of two different MRI scanners, we analyzed DTI indices separately for each scanner group. In the comparison between the deteriorated IQ group and the healthy controls, differences in some DTI indices were noted in three regions of interest irrespective of the MRI scanners, whereas differences in only one region of interest were noted between the preserved IQ group and the healthy controls. However, the comparisons between the deteriorated and preserved IQ groups did not show any reproducible differences. Together with the previous findings, it is thought that gray matter structures and functional connectivity are more promising as markers of intelligence decline in schizophrenia than white matter microstructures.

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