scholarly journals POTENTIAL OF JAMBLANG (Syzygium cumini L.) LEAF EXTRACT ON BODY WEIGHT OF WISTAR RATS METABOLIC SYNDROME MODEL

2021 ◽  
Vol 10 (2) ◽  
pp. 139-147
Author(s):  
Ida Nurwati ◽  
Risya Cilmiaty AR ◽  
Danus Hermawan ◽  
Betty Saptiwi ◽  
Dyah Ratna Budiani ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Ethanolic Extract ◽  
Syzygium Cumini ◽  
Anova Test ◽  
Antioxidant Agents ◽  
Reduce Weight Loss ◽  
Metabolic Syndrome Model

Jamblang (Syzygium cumini L.) leaves contain several phytochemical compounds. These phytochemicals are thought to have roles as antihyperglycemic, antihyperlipidemic, and antioxidant agents. This study aims to prove that there is an effect of giving ethanolic extract of jamblang leaves on body weight (BW) of metabolic syndrome (MS) Wistar rats induced by high-fat high-fructrose diet (HFFD) and injection of Streptozotocin (STZ)-Nicotinamide (Na), to determine different doses effect on the weight of Wistar rats. Laboratory experimental research with pre-post test control group. Samples were 8 weeks male Wistar (Rattus noverigicus) weighing 150-200 grams chosen by purposive random sampling method. Thirty rats were divided into 5 groups, each consisting of 6 rats. Normal group, metabolic syndrome group, 3 treatment groups MS were given jamblang leaf extract 100 mg/KgBW, 150mg/KgBW, 200mg/KgBW for 28 days. Data were analyzed by one way ANOVA test and repeated ANOVA test. The study showed an ethanolic extract of Jamblang leaves can reduce weight loss in Wistar rats with a metabolic syndrome model, and that the best dose used in this experiment is 150 mg/kgBW per day in Wistar rats with a metabolic syndrome model.

scholarly journals THE ROLE OF ETHANOLIC EXTRACT OF SYZYGIUM CUMINI STEM BARK ON FEMALE REPRODUCTIVE SYSTEM IN WISTAR RATS

2020 ◽  
Vol 8 (4.2) ◽  
pp. 7835-7840
Author(s):  
Mergu Prasad ◽  
◽  
Satya Prasad Venugopal ◽  
Keyword(s):  
Body Weight ◽  
Reproductive System ◽  
Wistar Rats ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Treated Group ◽  
The Body ◽  
Syzygium Cumini ◽  
Female Reproductive System ◽  
Traditional Practitioners

Background: The medicinal plant's role is well established in folklore medicine in India. Among numerous health complications, infertility is a crucial condition that bothers modern society. The traditional practitioners are using various parts of plants to overcome infertility in women. One such plant is Syzygium cumini (stem bark), used by traditional practitioners for pro-fertility in females without the scientific literature endorsing the fact. Material and Methods: Wistar rats approximately six months age and weighing 190-210 g were used for the experimental study. The rats were treated with 500 mg/kg body weight of Syzygium cumini stem bark ethanol extract with a vehicle through oral administration. The ether anaesthesia was given on the day of sacrifice and noted the body weight. The ovaries were carefully dissected, cleaned, weighed and processed for histological studies. Results: The body and ovarian weights were slightly increased in the treated group but not statistically significant. The microscopic structure of the ovary showed a normal histo-architecture. The ovarian corpora lutea number increased and was statistically significant in the treated group when compared to control. Conclusions: So, from the present study, it can be concluded that the ethanolic extract of stem bark of Syzygium cumini brings about the pro-fertility effect on the female reproductive system in Wistar rats. KEY WORDS: Estrous cycle, Hormones, Reproductive system, Syzygium cumini.

scholarly journals Haematopoietic Potential of Ethanolic Leaf Extract of Talinum triangulare in Wistar Rats

2019 ◽  
pp. 1-7
Author(s):  
A. I. Airaodion ◽  
E. O. Ogbuagu ◽  
J. A. Ekenjoku ◽  
U. Ogbuagu ◽  
E. O. Airaodion
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Ethanolic Extract ◽  
The Body ◽  
Local Market ◽  
Cell Parameters ◽  
Soxhlet Apparatus ◽  
Significant Difference ◽  
Talinum Triangulare

Aim: This study focuses on assessing the haematopoietic potential of ethanolic extract of Talinum triangulare leaves in Wistar rats. Methods: Fresh plants of T. triangulare were purchased from a local market in Orita-Challenge area of Ibadan, Nigeria. They were air dried at room temperature in an open laboratory space for 21 days and milled into powder. The extraction was done using soxhlet apparatus and ethanol as the solvent. The ethanol was evaporated in a rotary evaporator at 35°C with a yield of 2.76 g which represents a percentage yield of 11.04%. Ten adult male Wistar rats with body weight between 150 and 170 g were used for this study. They were randomly divided into two groups of five rats each. Animals in group A were administered saline solution while those in group B were administered T. triangulare leaf extract. The administration was done 12 hourly for twenty-eight days at 100 mg/kg body weight via oral route since the plant is consumed orally. At the end of the treatment, animals were fasted overnight and anaesthetized using diethyl ether. Blood samples were collected by cardiac puncture into heparinized bottles. Haematological parameters were determined using standard methods. Results: A  significant increase was observed in the PCV, Hb, RBC, MCV, WBC, lymphocyte and platelet counts of control animals when compared with those treated with leaf extract of T. triangulare at p<0.05. However, treatment had no significant difference on the neutrophil of animals. Conclusion: The significant increase observed in the erythrocyte parameters of animals used in this study indicates that T. triangulare leaves have haematopoietic properties and can be used to boost blood level especially in menstruating and pregnant women as well as anaemia patients. Its ability to significantly increase white blood cell parameters is an indication that T. triangulare leaves can boost the immune system and thus defend the body against xenobiotics.

scholarly journals Assessment of anti-diabetic activity of alcoholic and hydro-alcoholic extract of Terminalia arjuna & Syzygium cumini in streptozotocin-induced diabetes in Wistar rats

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1870-1882
Author(s):  
Takru Harshit ◽  
Dixit Praveen K ◽  
Kumar Kapil ◽  
Nagarajan K
Keyword(s):  
Body Weight ◽  
Glucose Level ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Diabetic Rats ◽  
Terminalia Arjuna ◽  
Alcoholic Extract ◽  
Syzygium Cumini ◽  
Liver And Pancreas ◽  
Streptozotocin Induced Diabetes

We aimed to evaluate the effect of anti-diabetic activity of Terminalia arjuna, and Syzygium cumini extracts in Streptozotocin (STZ) induced diabetes in Wistar rats. STZ (55mg/kg) followed by nicotinamide (100mg/kg) was given to rats by intraperitoneal route to induce diabetes. Oral administration of alcoholic and hydro-alcoholic extracts of T. arjuna (TAAE) (250mg/kg and 500mg/kg), S. cumini (SCAE) (200mg/kg and 400mg/kg) and their composite extract were given to rats along with standard anti-diabetic drug Glibenclamide (5mg/kg). We evaluated body weight, glucose level, lipid profile and biochemical parameters in STZ induced diabetic rats. Also, histopathological studied were done in liver, kidney and pancreatic tissues of rats. Our finding revealed that TAAE and TAHE at 250mg/kg b.w. and 500mg/kg b.w., SCAE and SCHE at 400mg/kg b.w. and combination of TAAE (250mg/kg b.w.)+SCAE (400mg/kg b.w.) had a positive effect in lowering the blood glucose level and body weight on 28th day as compared to the initial observation on 0th day and also restored all the biochemical parameters such as LDL, VLDL, triglycerides and total Cholesterol and HDL towards the normal levels as well as histopathological improvement in Kidney, Liver and Pancreas. Data analysis showed that composite extract of TAAE (250mg/kg) and SCAE (400mg/kg ) improved diabetic consequences more effectively than composite extract of TAHE (500mg/kg) and SCHE (400mg/kg). TAAE and SCHE, in combination, demonstrate as a potential therapeutic agent against diabetes.

scholarly journals Lead-Induced Toxicity in Wistar Rats: Amelioration by Palm Wine

2020 ◽  
pp. 1-9
Author(s):  
Femi A. Egbeleke ◽  
Kehinde O. Shittu ◽  
Ayobola A. Iyanda
Keyword(s):  
Body Weight ◽  
Total Protein ◽  
Wistar Rats ◽  
Histological Study ◽  
Lead Nitrate ◽  
Lead Toxicity ◽  
Study Groups ◽  
High Dose ◽  
Palm Wine ◽  
Antioxidant Agents

Lead a free-radical generating agent is a multi-systemic toxicant which affects major body systems especially the hepatic axis. Several natural products rich in antioxidant agents have been used to ameliorate lead toxicity. Vitamin C present abundantly in palm wine has been noted for its ability to modulate oxidative stress. This study investigated the ameliorative effects of palm wine in lead-induced hepatotoxicity in Wistar rats. Adults Wistar rats randomly divided into Groups A-H, consisting of 7 rats per group were used for the study. Groups A and B were administered with distilled water and palm wine respectively. Groups C, E, and G were dosed daily with lead nitrate at dosage levels of 50 (low dose), 150 (intermediate dose) and 600 (high dose) mg/kg body weight (BW). On the other hand, Groups D, F, and H were administered daily with lead nitrate at dosage levels of 50, 150 and 600 mg/kg body weight (BW) as well as palm wine (10 mL/kg BW). All experimental animals were allowed access to standard feed and water without any form of restriction. Estimation of biochemical parameters i.e. total protein, albumin, alkaline phosphatase and aminotransferases (ALT; AST) took place using standard biochemical methods. The liver was harvested and processed for histological study using haematoxylin and eosin staining techniques. Statistical analysis was done using one-way analysis of variance (ANOVA) and Student’s t-test. P< 0.05 was considered significant. While albumin concentrations were not significantly different, both total protein and globulin concentrations in lead administered rats were significantly reduced compared with control. Periportal and interstitial hepatitis and necrosis occurred from lead exposure at different levels suggesting hepatotoxicity. Meanwhile, lead and palm wine-administered rats featured similar histologic results. In conclusion, the results of the study, therefore, indicate that palm wine does not possess an ameliorative effect on lead-induced hepatotoxicity.

scholarly journals Cardioprotective Activities of Ethanolic Extract Root of Ageratum conyzoides on Alloxan-Induced Cardiotoxicity in Diabetic Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Abdulfatai Ojewale ◽  
Sanusi Mada ◽  
Samson Oyebadejo ◽  
Adam Afodun ◽  
Okikioluwa Aladeyelu ◽  
...  
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
The Body ◽  
Blood Collection ◽  
Ageratum Conyzoides ◽  
Cardiac Tissues

Diabetes mellitus has developed into one of the debilitating diseases disturbing the health of many people living with cardiovascular diseases in modern times. The root of Ageratum conyzoides was investigated for its effects on alloxan-induced diabetic Wistar rats’ cardiac tissues. Thirty-two (32) Wistar rats weighing between 180 and 190 g were randomly divided into four groups. The animals in groups B-D were induced with a single dose of 150 mg/kg body weight of alloxan (ALX) intraperitoneally. They were confirmed hyperglycemic after 72 hours of induction and then sustained in hyperglycemic condition for 2 weeks. Animals in groups C and D received AC intervention, as stated above, for four weeks. The body weight of the experimental animals and blood collection for glucose estimation were taken weekly for six weeks using appropriate instruments. Biochemical assays for lipid profile, antioxidant enzymatic, and nonenzymatic markers were carried out. Histopathological changes in the cardiac tissues were also studied. Administration of 150 mg/kg of ALX to experimental rats induced diabetes and significantly reduced the body weights, significantly ( p < 0.05 ) increased the glucose level, triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) levels, and decreased the levels of high-density lipoprotein (HDL) and antioxidant enzymatic markers such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) while the antioxidant nonenzymatic marker such as malondialdehyde (MDA) level was significantly increased. By contrast, rats given the ethanolic extract root of A. conyzoides had significantly ( p < 0.05 ) increased the body weight gain, whereas the glucose levels significantly ( p < 0.05 ) improved in treated diabetic rats. This extract also improved the cardiovascular system of the diabetic rats by significantly decreasing TG and LDL levels, significantly ( p < 0.05 ) increasing the HDL level, significantly reducing the cardiac contents of CAT, SOD, and GPx, and significantly ( p < 0.05 ) decreasing MDA. Ethanolic extract root of A. conyzoides exhibited antihyperglycemic and antihyperlipidemic activities and mitigates damage to the heart from the ALX-induced myocardial toxicity associated with type-1 diabetes.

scholarly journals Oral Acute & Sub-Chronic Toxicity Assessment of Ethanol Leaf Extract of Simarouba glauca

2020 ◽  
pp. 81-100
Author(s):  
Sammydavies E. Osagie-Eweka ◽  
Noghayin E. J. Orhue ◽  
Eric K. I. Omogbai ◽  
Fabian O. Amaechina
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Chronic Toxicity ◽  
Plasma Creatinine ◽  
Plasma Sodium ◽  
Plasma Urea ◽  
Hepatocellular Damage ◽  
Simarouba Glauca ◽  
Control Plasma

Traditional herbal medicine and their preparations have been widely used for thousands of years and are still in use in developing and developed countries owing to their medicinal values and their presumed relative safety. This belief that medicinal plants are not toxic or are with less side effect due to their natural origin is debatable; hence this study was conducted to evaluate the safety and (or) toxicity of Ethanol leaf extract of Simarouba glauca (EESG) on liver, kidney and heart functions of Wistar rats. The oral acute toxicity of EESG was evaluated in line with Lorke’s method. The sub-chronic toxicity of EESG was carried out according to the OECD guidelines with modification and using a total of twenty-four (24) male Wistar rats; divided into four groups of six rats each, following a two-week acclimatization. Test rats were orally administered EESG at doses of 500, 1000 and 2000 mg/kg body weight respectively daily for thirty (30) days, while the control was given only feed and water ad libitum. At the end of the experiment, the rats were fasted overnight and sacrificed under chloroform anesthesia; relevant biochemical and histopathology analyses were carried out. The data obtained from the oral acute test indicate that the LD50 was above 5000 mg/kg and there was no death recorded. There were significant increases (P ˂ 0.05) in percentage (%) body weight of rats administered respective doses of EESG. There were significant reductions (P˂0.05) in mean liver: body weight ratio of rats administered EESG 500 and 2000 mg/kg respectively, significant reductions (P˂0.05) in mean kidney: body weight ratios of rats given EESG 1000 and 2000 mg/kg respectively; significant reductions (P˂0.05) in mean heart: body weight ratios of test rats administered EESG 2000 mg/kg; whereas others were not significantly different (P˃0.05) relative to their respective control. Plasma ALT and GGT activities of rats administered respective dose of EESG were significantly reduced (P˂0.05); plasma ALP activities were significantly elevated (P˂0.05) relative to the control after 30 days. There were no significant differences (P˃0.05) in plasma total proteins and albumin levels. Plasma total and unconjugated bilirubin of rats administered respective dose of EESG were not significantly different (P˃0.05); whereas, rats given EESG recorded significant reduction in plasma conjugated bilirubin. Plasma urea was significantly elevated (P˂0.05) in rats administered EESG 1000 and 2000 mg/kg respectively. Test rats given EESG 500 and 1000 mg/kg respectively recorded significant elevations in plasma creatinine and rats given EESG 2000 mg/kg recorded significant decrease in plasma creatinine levels; others were not significantly different relative to the control. Plasma chloride and potassium ion levels of rats administered respective doses of EESG were not significantly different (P˃0.05); significant reduction (P˂0.05) in plasma sodium ions concentration in all group compared to the control. Plasma calcium ion levels in all group were not significantly different (P˃0.05); whereas there were significant reductions (P˂0.05) in plasma bicarbonate ion levels relative to their respective controls. Although plasma ALP activity were significantly elevated, there were no elevations in specific liver function enzymes and no visible hepatocellular damage. Furthermore, the conspicuous elevations observed in plasma urea and creatinine levels do not exclusively indicate EESG-induced organ injury. Therefore, it is suggestive that EESG was not significantly toxic to the to the liver, kidney and heart respectively and may be administered at lower doses in further studies.

scholarly journals Hepatotoxic and Nephrotoxic Effect of Ethanol Leaf Extract of Scoparia Dulcis (Linn) in Wistar Rats

2021 ◽  
Vol 2 (4) ◽  
pp. 20-27
Author(s):  
Olubodun A. Adebiyi ◽  
Danladi A. Ameh ◽  
Elewechi Onyike ◽  
Dorcas B. James
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Hematological Parameters ◽  
Relative Weight ◽  
Animal Group ◽  
Scoparia Dulcis ◽  
Significant Difference ◽  
Liver And Kidney ◽  
G Ratio

Scoparia dulcis (Linn) is a widespread herbal medicine; it bears an enormous number of pharmacological activities. The present study was undertaken to find out the chronic toxicity profile of oral administration of Scoparia dulcis ethanol leaf extract (SDELE) on the liver and the kidney of wistar rats. The animals were grouped into four and administered varying doses of SDELE (100 mg/kg, 200 mg/kg, 400 mg/kg body weight and 0.2 ml distilled water respectively) for a period of fourteen weeks (100 days). The acute toxicity, body weight, relative organ weight, hematological parameters, biochemical markers for liver and kidney damage were monitored and histopathology of the liver and kidney of the rat were carried out. The LD50 of SDELE was found to be 1131 mg/kg body weight. There was a significant (p<0.05) reduction in weight of the rat administered 400 mg/kg and 200 mg/kg when compared with the control though there was no significant difference (p>0.05) in the relative weight of the organs. There was also a significant increase (p<0.05) in the lymphocytes, serum level of aspartate amino transferase (ASP), alanine amino transferase (ALT), alkali phosphatase (ALP), total protein, A/G ratio, creatinine, urea, uric acid, total cholesterol, triacylglycerol, low density lipoprotein cholesterol and potassium ions while there was a significant decrease in HDL-cholesterol and sodium ions in the animal group administered 400 mg/kg body weight of the extract. Histopathology of the liver and kidney revealed haemorrhage and vascular congestion at 200 mg/kg doses and renal damage at 400 mg/kg body weight doses respectively. However, there was no significant difference (p>0.05) in any of the parameters studied in the group administered 100 mg/kg body weight dose when compared with the controlled group. Ethanol leaf extracts of Scoparia dulcis showed hepatotoxic and nephrotoxic tendencies and should be used with caution especially when employed in the treatment of chronic diseases

scholarly journals Biosupplementation of Ethanolic Extract of Cashew Leaf (Anacardium occidentale L.) to Improve Weight Gain and Immunity of Jawa Super Chicken

2019 ◽  
Vol 7 (2) ◽  
pp. 57-65
Author(s):  
Manesta Edelweis Jingga ◽  
Haris Setiawan ◽  
Ardaning Nuriliani ◽  
Hendry Trisakti Saragih
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Growth And Development ◽  
Leaf Extract ◽  
Histological Analysis ◽  
Ethanolic Extract ◽  
Anacardium Occidentale ◽  
Bursa Of Fabricius ◽  
White Pulp ◽  
One Way Anova

Effect of ethanolic extract of cashew leaf (Anacardium occidentale L.) in the feed on the weight gain and immunity were investigated on Jawa Super Chicken. Ninety chicken were divided into 6 groups those were basal feed group and 5 different concentration of chasew leaf extract groups. Experiment was conducted for 16 days started by 2 days acclimatization after hatching. Body weight was measured every 3 days starting from 0th day. On 16th day, the chicken were sacrificed, spleen and bursa of Fabricius were collected to quantify some histological parameters such as white pulp and follicle area as well as follicle thickness of those organs. The data were analyzed by regression and one way ANOVA followed by Tuckey test. Histological analysis was performed using optilab and Image Raster software. The results showed that growth and development of immune system of chicken increased significantly as could be seen in body weight, organs weight and index, as well as histological parameters. The regression results showed that spleen and bursa of Fabricius weight influenced increasing of body weight by 64.2% and 38.4% respectively. It could be concluded that biosupplementation of cashew leaf extract in basal feed could increase growth and immunity of Jawa Super Chicken.

scholarly journals Evaluation of potentials of aqueous ethanolic extract of Psidium guajava on reproductive functions of male Albino rats

2021 ◽  
Vol 19 (3) ◽  
pp. 174-181
Author(s):  
S.A. Abwage ◽  
S.T. Agu ◽  
S.A. Saganuwan ◽  
A.H. Abu
Keyword(s):  
Body Weight ◽  
Leaf Extract ◽  
Ethanolic Extract ◽  
Psidium Guajava ◽  
Reproductive Organs ◽  
Sperm Parameters ◽  
Albino Rats ◽  
Reproductive Parameters ◽  
Aqueous Ethanolic Extract ◽  
Ethanolic Leaf Extract

The therapeutic utilization of plants for managing several diseases by people of all continents, especially Africa, is as old as tradition. The objective of this study was to evaluate the potentials of aqueous ethanolic leaf extract of Psidium guajava on male reproductive parameters. Twenty-four male Albino rats were randomly assigned into four groups of six rats per group. Rats in the control group were administered Tween 20®. Rats in groups 2, 3, and 4 were administered Psidium guajava aqueous ethanolic leaf extract orally at the doses of 100, 200, and 400 mg/kg body weight, respectively, once daily for 60 days. The body weights of the rats were determined at the beginning and end of the experiment. Sperm parameters and some reproductive organs weight of each rat was also determined, some organs were collected for histopathology. Assay for follicle-stimulating hormone, luteinizing hormone, and testosterone was done using Enzyme-Linked Immunosorbent methods. Some reproductive organs were collected for histopathological analyses. The results showed a dose-dependent increase (p<0.05) in the weight of male reproductive organs, sperm parameters, and hormones. The extract significantly increased (P < 0.05) serum testosterone in the group treated 400 mg/kg body weight when treated groups were compared with control. Furthermore, the results of FSH and LH revealed a significant (p < 0.05) increase when the treated groups were compared with the control. The histopathological analysis did not reveal any form of damage to the architectural integrity of the testis. However, there was degenerating germinal epithelium in the group administered 400 mg/kg of the aqueous ethanolic leaf extract of P. guajava. Conclusion: aqueous ethanolic extract of P. guajava has positive effects on male reproductive parameters.

scholarly journals The Role of Serum Alpha-Amylase and Glycogen Synthase in the Anti-Diabetic Potential of Terminalia catappa Aqueous Leaf Extract in Diabetic Wistar Rats

2019 ◽  
pp. 1-11
Author(s):  
Ezekiel E. Ben ◽  
Asuquo E. Asuquo ◽  
D. U. Owu
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Glycogen Synthase ◽  
Alpha Amylase ◽  
Distilled Water ◽  
Terminalia Catappa ◽  
Aqueous Leaf Extract

Background: The endocrinal abnormalities in diabetes mellitus as one of the numerous metabolic disorders is associated with derangement in exocrine functions of the pancreas and ultimately influences blood glucose regulation. Aim: The study was aimed at assessing the role of alpha-amylase and glycogen synthase in anti-diabetic potential of Terminalia catappa in diabetic rats.  Materials and Methods: Thirty five (35) Wistar rats were assigned to 5 groups of 7 animals each. Group 1 served as the control administered distilled water at 5ml/kg bodyweight and group 2 was a non diabetic group given orally, 130/kg body weight of aqueous leaf extract of Terminalia catappa.  Groups 3, 4 and 5 received a single dose of 150mg/kg body weight of alloxan solution intraperitoneally to induce diabetes and rats with blood glucose levels ≥200mg/dl after 72 hours were considered diabetic. This was followed by oral administration of 5ml/kg bodyweight of distilled water, 130mg/kg body weight of Terminalia catappa leaf extract orally and subcutaneous administration of insulin, 0.75U/kg body weight to groups 3 (diabetic), 4(diabetic + extract) and 5 (diabetic + insulin) respectively. Results: The results showed significant (P<.05) increase in serum level of alpha-amylase and glycogen synthase in both non-diabetic extract treated and diabetic groups when compared to control. But these enzymes significantly (P<.05) reduced in diabetic extract and insulin treated groups when compared to the diabetic group.  Conclusion: Therefore the hypoglycaemic potential of Terminalia catappa leaf extract could be attributed to its ability to reduce alpha-amylase level while lowered glycogen synthase might be secondary to reduction in blood glucose.

Sign in / Sign up

Export Citation Format

Share Document