Relationship Between Chronic Noise Exposure, Cognitive Impairment, and Degenerative Dementia: Update on the Experimental and Epidemiological Evidence and Prospects for Further Research

2021 ◽  
Vol 79 (4) ◽  
pp. 1409-1427
Author(s):  
Lei Huang ◽  
Yang Zhang ◽  
Yongwei Wang ◽  
Yajia Lan
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Dysfunction ◽  
Noise Exposure ◽  
Treatment Options ◽  
Experimental Studies ◽  
Amyloid Β ◽  
Epidemiological Studies ◽  
Brain Regions ◽  
Future Research ◽  
Degenerative Dementia

Degenerative dementia, of which Alzheimer’s disease is the most common form, is characterized by the gradual deterioration of cognitive function. The events that trigger and promote degenerative dementia are not clear, and treatment options are limited. Experimental and epidemiological studies have revealed chronic noise exposure (CNE) as a potential risk factor for cognitive impairment and degenerative dementia. Experimental studies have indicated that long-term exposure to noise might accelerate cognitive dysfunction, amyloid-β deposition, and tau hyperphosphorylation in different brain regions such as the hippocampus and cortex. Epidemiological studies are increasingly examining the possible association between external noise exposure and dementia. In this review, we sought to construct a comprehensive summary of the relationship between CNE, cognitive dysfunction, and degenerative dementia. We also present the limitations of existing evidence as a guide regarding important prospects for future research.

scholarly journals Anesthesiology and cognitive impairment: a narrative review of current clinical literature

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jillian C. Belrose ◽  
Ruediger R. Noppens
Keyword(s):  
Cognitive Impairment ◽  
General Anesthesia ◽  
Cognitive Dysfunction ◽  
Large Body ◽  
Postoperative Cognitive Dysfunction ◽  
Cognitive Disorders ◽  
Future Research ◽  
Main Body ◽  
Modifiable Factors ◽  
The Impact

Abstract Background The impact of general anesthesia on cognitive impairment is controversial and complex. A large body of evidence supports the association between exposure to surgery under general anesthesia and development of delayed neurocognitive recovery in a subset of patients. Existing literature continues to debate whether these short-term effects on cognition can be attributed to anesthetic agents themselves, or whether other variables are causative of the observed changes in cognition. Furthermore, there is conflicting data on the relationship between anesthesia exposure and the development of long-term neurocognitive disorders, or development of incident dementia in the patient population with normal preoperative cognitive function. Patients with pre-existing cognitive impairment present a unique set of anesthetic considerations, including potential medication interactions, challenges with cooperation during assessment and non-general anesthesia techniques, and the possibility that pre-existing cognitive impairment may impart a susceptibility to further cognitive dysfunction. Main body This review highlights landmark and recent studies in the field, and explores potential mechanisms involved in perioperative cognitive disorders (also known as postoperative cognitive dysfunction, POCD). Specifically, we will review clinical and preclinical evidence which implicates alterations to tau protein, inflammation, calcium dysregulation, and mitochondrial dysfunction. As our population ages and the prevalence of Alzheimer’s disease and other forms of dementia continues to increase, we require a greater understanding of potential modifiable factors that impact perioperative cognitive impairment. Conclusions Future research should aim to further characterize the associated risk factors and determine whether certain anesthetic approaches or other interventions may lower the potential risk which may be conferred by anesthesia and/or surgery in susceptible individuals.

scholarly journals Cognitive impairment as a risk factor for psychosis

2005 ◽  
Vol 7 (1) ◽  
pp. 31-38 ◽  
Keyword(s):  
Risk Factor ◽  
Cognitive Impairment ◽  
Cognitive Functioning ◽  
Brain Function ◽  
Negative Symptoms ◽  
Psychotic Disorders ◽  
Epidemiological Studies ◽  
Psychotic Symptoms ◽  
Future Research ◽  
The Relationship

Since the time of Kraepelin and Bleuler, it has been recognized that schizophrenia is associated with a profound and persistent cognitive impairment. This paper reviews the major clinical and epidemiological studies of cognitive functioning in schizophrenia and other psychotic disorders, and presents several possible models to explain the association between cognitive impairment and psychosis. Cognitive impairment is present in the majority of patients with schizophrenia, and, in some, it is already evident in the premorbid stages of the disorder. This cognitive impairment is not secondary to psychotic symptoms, negative symptoms, or socioeconomic status. Cognitive impairment can also be observed in nonpsychotic family members of psychotic patients. On the basis of this evidence, it has been proposed that abnormal cognitive functioning can be considered as a possible causal risk factor for psychosis. Recent studies assessing the relationship between genetic background, cognition, brain function, and schizophrenia are presented here as an outline for future research.

scholarly journals Detection and Prediction of Mild Cognitive Impairment in Alzheimer’s Disease Mice

2020 ◽  
Vol 77 (3) ◽  
pp. 1209-1221
Author(s):  
Surya Prakash Rai ◽  
Pablo Bascuñana ◽  
Mirjam Brackhan ◽  
Markus Krohn ◽  
Luisa Möhle ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Dysfunction ◽  
Age Of Onset ◽  
Amyloid Β ◽  
Current Approach ◽  
Classification Algorithm ◽  
Wild Type

Background: The recent failure of clinical trials to treat Alzheimer’s disease (AD) indicates that the current approach of modifying disease is either wrong or is too late to be efficient. Mild cognitive impairment (MCI) denotes the phase between the preclinical phase and clinical overt dementia. AD mouse models that overexpress human amyloid-β (Aβ) are used to study disease pathogenesis and to conduct drug development/testing. However, there is no direct correlation between the Aβ deposition, the age of onset, and the severity of cognitive dysfunction. Objective: To detect and predict MCI when Aβ plaques start to appear in the hippocampus of an AD mouse. Methods: We trained wild-type and AD mice in a Morris water maze (WM) task with different inter-trial intervals (ITI) at 3 months of age and assessed their WM performance. Additionally, we used a classification algorithm to predict the genotype (APPtg versus wild-type) of an individual mouse from their respective WM data. Results: MCI can be empirically detected using a short-ITI protocol. We show that the ITI modulates the spatial learning of AD mice without affecting the formation of spatial memory. Finally, a simple classification algorithm such as logistic regression on WM data can give an accurate prediction of the cognitive dysfunction of a specific mouse. Conclusion: MCI can be detected as well as predicted simultaneously with the onset of Aβ deposition in the hippocampus in AD mouse model. The mild cognitive impairment prediction can be used for assessing the efficacy of a treatment.

Insulin and cognitive function in humans: experimental data and therapeutic considerations

2005 ◽  
Vol 33 (5) ◽  
pp. 1037-1040 ◽  
Author(s):  
M.W.J. Strachan
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Memory Function ◽  
Experimental Studies ◽  
Epidemiological Studies ◽  
Therapeutic Benefit ◽  
Systemic Absorption ◽  
Intravenous Insulin ◽  
People With Dementia ◽  
The Impact

Data from experimental studies in animals and from epidemiological studies in humans suggest a link between insulin and cognitive performance. Do these results translate into clinical and therapeutic benefit for people with cognitive impairment? Insulin injected peripherally can readily cross the blood–brain barrier. Intravenous insulin can improve aspects of cognitive function in healthy adults and in individuals with Alzheimer's dementia. Moreover, intravenous insulin increases concentrations of a long form of β-amyloid protein, Aβ42. One potential confounding factor with these data, however, is the need for co-administration of glucose with the insulin to maintain euglycaemia as glucose itself can facilitate memory function. Administration of insulin via the intranasal route is scientifically (and therapeutically) more attractive because the insulin goes directly to the cerebrospinal fluid, with minimal systemic absorption; this obviates the need for a glucose infusion. Intranasal insulin may improve some aspects of memory in healthy individuals, but has yet to be studied in people with cognitive impairment. TZDs (thiazolidinediones) reduce peripheral insulin concentrations by enhancing insulin sensitivity. In adults with Type II (non-insulin-dependent) diabetes, TZD therapy improves memory function, but so does sulphonylurea therapy (which elevates peripheral insulin concentrations). Improved memory is linked to lower blood glucose concentrations, rather than altered insulin levels. However, major trials are currently under way examining the impact of TZDs in people with dementia.

Cognitive functioning and psychiatric symptomatology in patients with chronic hepatitis C

2003 ◽  
Vol 9 (6) ◽  
pp. 847-857 ◽  
Author(s):  
Robin C. Hilsabeck ◽  
Tarek I. Hassanein ◽  
Meghan D. Carlson ◽  
Elizabeth A. Ziegler ◽  
William Perry
Keyword(s):  
Cognitive Impairment ◽  
Hepatitis C ◽  
Cognitive Functioning ◽  
Cognitive Dysfunction ◽  
Hcv Infection ◽  
Public Health Care ◽  
Future Research ◽  
Psychomotor Speed ◽  
Psychiatric Symptomatology ◽  
Chronic Hcv

AbstractHepatitis C virus (HCV) infection is a major public-health-care problem, with over 170 million infected worldwide. Patients with chronic HCV infection often complain of various cognitive problems as well as symptoms of depression, anxiety, and fatigue. Relatively little is known, however, about the specific cognitive deficits that are common among HCV patients, and the influence of psychiatric symptomatology on cognitive functioning. In the current study of 21 chronically infected HCV patients, we assessed subjective cognitive dysfunction, depression, anxiety, and fatigue and compared these symptom areas to cognitive tests assessing visuoconstruction, learning, memory, visual attention, psychomotor speed, and mental flexibility. Results revealed that cognitive impairment ranged from 9% of patients on a visuoconstruction task to 38% of patients on a measure of complex attention, visual scanning and tracking, and psychomotor speed, and greater HCV disease severity as indicated by liver fibrosis was associated with greater cognitive dysfunction. Objective cognitive impairment was not related to subjective cognitive complaints or psychiatric symptomatology. These findings suggest that a significant portion of patients with chronic HCV experience cognitive difficulties that may interfere with activities of daily living and quality of life. Future research using cognitive measures with HCV-infected patients may assist researchers in identifying if there is a direct effect of HCV infection on the brain and which patients may be more likely to progress to cirrhosis and hepatic encephalopathy. (JINS, 2003, 9, 847–854.)

scholarly journals Effects of air pollution exposure on social behavior: a synthesis and call for research

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Chelsea A. Weitekamp ◽  
Hans A. Hofmann
Keyword(s):  
Air Pollution ◽  
Social Behavior ◽  
Animal Studies ◽  
Experimental Studies ◽  
Brain Regions ◽  
Air Pollutant ◽  
Model Systems ◽  
Sufficient Evidence ◽  
Comparative Approach ◽  
Future Research

Abstract Background There is a growing literature from both epidemiologic and experimental animal studies suggesting that exposure to air pollution can lead to neurodevelopmental and neuropsychiatric disorders. Here, we suggest that effects of air pollutant exposure on the brain may be even broader, with the potential to affect social decision-making in general. Methods We discuss how the neurobiological substrates of social behavior are vulnerable to air pollution, then briefly present studies that examine the effects of air pollutant exposure on social behavior-related outcomes. Results Few experimental studies have investigated the effects of air pollution on social behavior and those that have focus on standard laboratory tests in rodent model systems. Nonetheless, there is sufficient evidence to support a critical need for more research. Conclusion For future research, we suggest a comparative approach that utilizes diverse model systems to probe the effects of air pollution on a wider range of social behaviors, brain regions, and neurochemical pathways.

scholarly journals Perineuronal net structure as a non-cellular mechanism of affective state, a scoping review

2021 ◽  
Author(s):  
Jane Morphett ◽  
◽  
Alexandra Whittaker ◽  
Amy Reichelt ◽  
Mark Hutchinson
Keyword(s):  
Scoping Review ◽  
Emotional Processing ◽  
Structural Changes ◽  
Affective State ◽  
Ion Homeostasis ◽  
Experimental Studies ◽  
Brain Regions ◽  
Future Research ◽  
Perineuronal Nets ◽  
Perineuronal Net

Is the perineuronal net structure within emotional processing brain regions associated with changes in affective state? The objective of this scoping review is to bring together the literature on human and animal studies which have measured perineuronal net structure in brain regions associated with emotional processing (such as but not limited to amygdala, hippocampus and prefrontal cortex). Perineuronal nets are a specialised form of condensed extracellular matrix that enwrap and protect neurons (Suttkus et al., 2016), regulate synaptic plasticity (Celio and Blumcke, 1994) and ion homeostasis (Morawski et al., 2015). Perineuronal nets are dynamic structures that are influenced by external and internal environmental shifts – for example, increasing in intensity and number in response to stressors (Blanco and Conant, 2021) and pharmacological agents (Riga et al., 2017). This review’s objective is to generate a compilation of existing knowledge regarding the structural changes of perineuronal nets in experimental studies that manipulate affective state, including those that alter environmental stressors. The outcomes will inform future research directions by elucidating non-cellular central nervous system mechanisms that underpin positive and negative emotional states. These methods may also be targets for manipulation to manage conditions of depression or promote wellbeing. Population: human and animal Condition: affective state as determined through validated behavioural assessment methods or established biomarkers. This includes both positive and negative affective states. Context: PNN structure, measuringPNNs.

scholarly journals Spider Phobia: Neural Networks Informing Diagnosis and (Virtual/Augmented Reality-Based) Cognitive Behavioral Psychotherapy—A Narrative Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Jonas Hinze ◽  
Anne Röder ◽  
Nicole Menzie ◽  
Ulf Müller ◽  
Katharina Domschke ◽  
...  
Keyword(s):  
Augmented Reality ◽  
Behavioral Therapy ◽  
Treatment Options ◽  
Brain Regions ◽  
Current Treatment ◽  
Narrative Review ◽  
Cognitive Behavioral ◽  
Future Research ◽  
Spider Phobia

Recent fMRI studies on specific animal phobias, particularly spider phobia (arachnophobia), have identified a large variety of specific brain regions involved in normal and disturbed fear processing. Both functional and structural brain abnormalities have been identified among phobic patients. Current research suggests that both conscious and subconscious fear processing play a crucial role in phobic disorders. Cognitive behavioral therapy has been identified as an effective treatment for specific phobias and has been associated with neuroplastic effects which can be evaluated using current neuroimaging techniques. Recent research suggests that new approaches using virtual (VR) or augmented reality (AR) tend to be similarly effective as traditional “in vivo” therapy methods and could expand treatment options for different medical or individual scenarios. This narrative review elaborates on neural structures and particularities of arachnophobia. Current treatment options are discussed and future research questions are highlighted.

New Evidence of Impacts of Cell Phone Use on Driving Performance

2013 ◽  
Vol 3 (3) ◽  
pp. 46-61 ◽  
Author(s):  
Quan Chen ◽  
Zheng Yan
Keyword(s):  
Mobile Phone ◽  
Experimental Studies ◽  
Epidemiological Studies ◽  
Future Research ◽  
Mobile Phone Use ◽  
Cell Phone Use ◽  
Car Accidents ◽  
Key Issues ◽  
Future Research Directions ◽  
New Evidence

Mobile phone use when driving is widely considered to be a major cause of car accidents. This paper attempts to review the existing literature by focusing on three key issues: (a) Whether and how seriously does mobile phone use impair driving? (b) How and why does mobile phone use impair driving? (c) What should be done to best prevent from accident? The authors identified a total of 90 epidemiological studies, experimental studies, and observational studies that were published during 2007 to 2012. These most recent studies were systematically reviewed in three major categories, (a) the effect of using a mobile phone when driving on drivers’ performance in terms of information processing and vehicle control, (b) variables related to driving, such as characteristics of drivers and mobile phone types, and (c) context and content of conversation during driving. Both limitations of existing research and future research directions are discussed.

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