scholarly journals Ontological Modelling and Execution of Phenotypic Queries in the Leipzig Health Atlas

2021 ◽  
Author(s):  
Alexandr Uciteli ◽  
Christoph Beger ◽  
Jonas Wagner ◽  
Alexander Kiel ◽  
Frank A. Meineke ◽  
...  
Keyword(s):  
Query Language ◽  
Medical Data ◽  
Medical Sciences ◽  
Domain Specific ◽  
Management Platform ◽  
Wide Range ◽  
Data Portal ◽  
Interactive Models ◽  
Ontological Framework ◽  
Cdisc Odm

Sharing data is of great importance for research in medical sciences. It is the basis for reproducibility and reuse of already generated outcomes in new projects and in new contexts. FAIR data principles are the basics for sharing data. The Leipzig Health Atlas (LHA) platform follows these principles and provides data, describing metadata, and models that have been implemented in novel software tools and are available as demonstrators. LHA reuses and extends three different major components that have been previously developed by other projects. The SEEK management platform is the foundation providing a repository for archiving, presenting and secure sharing a wide range of publication results, such as published reports, (bio)medical data as well as interactive models and tools. The LHA Data Portal manages study metadata and data allowing to search for data of interest. Finally, PhenoMan is an ontological framework for phenotype modelling. This paper describes the interrelation of these three components. In particular, we use the PhenoMan to, firstly, model and represent phenotypes within the LHA platform. Then, secondly, the ontological phenotype representation can be used to generate search queries that are executed by the LHA Data Portal. The PhenoMan generates the queries in a novel domain specific query language (SDQL), which is specific for data management systems based on CDISC ODM standard, such as the LHA Data Portal. Our approach was successfully applied to represent phenotypes in the Leipzig Health Atlas with the possibility to execute corresponding queries within the LHA Data Portal.

scholarly journals A New Method for Dispersing Pristine Carbon Nanotubes Using Regularly Arranged S-Layer Proteins

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1346
Author(s):  
Andreas Breitwieser ◽  
Uwe B. Sleytr ◽  
Dietmar Pum
Keyword(s):  
Carbon Nanotubes ◽  
Covalent Modification ◽  
Silica Layer ◽  
Medical Sciences ◽  
Lysinibacillus Sphaericus ◽  
Wide Range ◽  
Catalytic Sites ◽  
Multi Walled Carbon Nanotubes ◽  
Pristine Mwnts ◽  
Walled Carbon Nanotubes

Homogeneous and stable dispersions of functionalized carbon nanotubes (CNTs) in aqueous solutions are imperative for a wide range of applications, especially in life and medical sciences. Various covalent and non-covalent approaches were published to separate the bundles into individual tubes. In this context, this work demonstrates the non-covalent modification and dispersion of pristine multi-walled carbon nanotubes (MWNTs) using two S-layer proteins, namely, SbpA from Lysinibacillus sphaericus CCM2177 and SbsB from Geobacillus stearothermophilus PV72/p2. Both the S-layer proteins coated the MWNTs completely. Furthermore, it was shown that SbpA can form caps at the ends of MWNTs. Reassembly experiments involving a mixture of both S-layer proteins in the same solution showed that the MWNTs were primarily coated with SbsB, whereas SbpA formed self-assembled layers. The dispersibility of the pristine nanotubes coated with SbpA was determined by zeta potential measurements (−24.4 +/− 0.6 mV, pH = 7). Finally, the SbpA-coated MWNTs were silicified with tetramethoxysilane (TMOS) using a mild biogenic approach. As expected, the thickness of the silica layer could be controlled by the reaction time and was 6.3 +/− 1.25 nm after 5 min and 25.0 +/− 5.9 nm after 15 min. Since S-layer proteins have already demonstrated their capability to bind (bio)molecules in dense packing or to act as catalytic sites in biomineralization processes, the successful coating of pristine MWNTs has great potential in the development of new materials, such as biosensor architectures.

scholarly journals Design principles of the Metadata Querying Language (MQL) implemented in the ATLAS Metadata Interface (AMI) ecosystem

2020 ◽  
Vol 245 ◽  
pp. 04044
Author(s):  
Jérôme Fulachier ◽  
Jérôme Odier ◽  
Fabian Lambert
Keyword(s):  
Query Language ◽  
Design Principles ◽  
Domain Specific Language ◽  
Specific Language ◽  
Domain Specific ◽  
Complex Queries ◽  
Structured Query Language

This document describes the design principles of the Metadata Querying Language (MQL) implemented in ATLAS Metadata Interface (AMI), a metadata-oriented domain-specific language allowing to query databases without knowing the relation between tables. With this simplified yet generic grammar, MQL permits writing complex queries more simply than with Structured Query Language (SQL).

scholarly journals Building Quranic stories ontology using MappingMaster domain-specific language

2022 ◽  
Vol 12 (1) ◽  
pp. 684
Author(s):  
Rusul Yousif Alsalhee ◽  
Abdulhussein Mohsin Abdullah
Keyword(s):  
Query Language ◽  
Role Modeling ◽  
Domain Specific Language ◽  
Modeling Language ◽  
Specific Language ◽  
Domain Specific ◽  
The People ◽  
Holy Quran ◽  
The Holy Quran ◽  
Object Role Modeling

<p>The Holy Quran, due to it is full of many inspiring stories and multiple lessons that need to understand it requires additional attention when it comes to searching issues and information retrieval. Many works were carried out in the Holy Quran field, but some of these dealt with a part of the Quran or covered it in general, and some of them did not support semantic research techniques and the possibility of understanding the Quranic knowledge by the people and computers. As for others, techniques of data analysis, processing, and ontology were adopted, which led to directed these to linguistic aspects more than semantic. Another weakness in the previous works, they have adopted the method manually entering ontology, which is costly and time-consuming. In this paper, we constructed the ontology of Quranic stories. This ontology depended in its construction on the MappingMaster domain-specific language (MappingMaster DSL)technology, through which concepts and individuals can be created and linked automatically to the ontology from Excel sheets. The conceptual structure was built using the object role modeling (ORM) modeling language. SPARQL query language used to test and evaluate the propsed ontology by asking many competency questions and as a result, the ontology answered all these questions well.</p>

scholarly journals A case of necrotizing fasciitis due to Klebsiella following local application of steroids

2016 ◽  
Vol 7 (6) ◽  
pp. 97-99 ◽  
Author(s):  
Suhaib Rehaman Abdul ◽  
Robin George
Keyword(s):  
Necrotizing Fasciitis ◽  
Local Application ◽  
Causative Organism ◽  
Site Infection ◽  
Human Beings ◽  
Medical Sciences ◽  
Abdominal Infection ◽  
Clinical Syndromes ◽  
Wide Range ◽  
Intravascular Devices

Klebsiella organisms are known to cause a wide range of clinical syndromes in human beings which include pneumonia, urinary tract infection, abdominal infection, surgical site infection, soft tissue infection and infection of intravascular devices. The incidence is higher among immunocompromised individuals and those with chronic debilitating diseases like diabetes, alcoholism etc. This case report is regarding an elderly diabetic male who developed necrotizing fasciitis of leg following local application of steroids. The causative organism was Klebsiella, which is an unusual pathogen.Asian Journal of Medical Sciences Vol.7(5) 2016 97-99

scholarly journals Measuring Models

2009 ◽  
pp. 147-169 ◽  
Author(s):  
Martin Monperrus ◽  
Jean-Marc Jézéquel ◽  
Joël Champeau ◽  
Brigitte Hoeltzener
Keyword(s):  
Quality Assurance ◽  
Software Development ◽  
Point Of View ◽  
Specific Information ◽  
Model Driven Engineering ◽  
Text Documents ◽  
Model Driven ◽  
Domain Specific ◽  
Wide Range

Model-Driven Engineering (MDE) is an approach to software development that uses models as primary artifacts, from which code, documentation and tests are derived. One way of assessing quality assurance in a given domain is to define domain metrics. We show that some of these metrics are supported by models. As text documents, models can be considered from a syntactic point of view i.e., thought of as graphs. We can readily apply graph-based metrics to them, such as the number of nodes, the number of edges or the fan-in/fan-out distributions. However, these metrics cannot leverage the semantic structuring enforced by each specific metamodel to give domain specific information. Contrary to graph-based metrics, more specific metrics do exist for given domains (such as LOC for programs), but they lack genericity. Our contribution is to propose one metric, called s, that is generic over metamodels and allows the easy specification of an open-ended wide range of model metrics.

Advanced Technologies in DNA-based Nanomedicine

2021 ◽  
Vol 15 ◽  
Author(s):  
Ameneh Mohammadi ◽  
Pooria Gill ◽  
Pedram Ebrahimnejad ◽  
Said Abediankenari ◽  
Zahra Kashi
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Dna Nanostructures ◽  
Medical Sciences ◽  
Rational Engineering ◽  
Advanced Technologies ◽  
Wide Range ◽  
Or Gene

: The application of nanotechnology in medicine and pharmaceutical purpose suggested a novel procedure in the nanotechnology terminology as nanomedicine. There is a wide range of applications for nanotechnology in medicine, such as the use of nanocarriers in drug delivery systems. Recently a remarkable attention to DNA has been made through its amazing functionality and its nature as a nanomaterial in biological systems. Since DNA is a biocompatible, the use of DNA as a nanomaterial in medicine has shown a great perspective of rational engineering of DNA nanostructures. According to new approaches in treatment of diseases in gene levels, gene therapy, using DNA as a nanomedicine possesses an important role in the medical sciences as the researchers published enormous papers and patents in the fields, for instance, the applications of DNA and DNA-based nanostructures as drug or gene nanocarriers, DNA-based diagnostics and DNA nanovasccines. Here, some examples of DNA-based nanomedicine in the patent frame were reviewed.

Feature Matching-based Approaches to Improve the Robustness of Android Visual GUI Testing

2022 ◽  
Vol 31 (2) ◽  
pp. 1-32
Author(s):  
Luca Ardito ◽  
Andrea Bottino ◽  
Riccardo Coppola ◽  
Fabrizio Lamberti ◽  
Francesco Manigrasso ◽  
...  
Keyword(s):  
Computer Vision ◽  
Feature Matching ◽  
State Of The Art ◽  
Design Of Algorithms ◽  
Computational Burden ◽  
Domain Specific ◽  
Gui Testing ◽  
Wide Range ◽  
Full Screen ◽  
Feature Based

In automated Visual GUI Testing (VGT) for Android devices, the available tools often suffer from low robustness to mobile fragmentation, leading to incorrect results when running the same tests on different devices. To soften these issues, we evaluate two feature matching-based approaches for widget detection in VGT scripts, which use, respectively, the complete full-screen snapshot of the application ( Fullscreen ) and the cropped images of its widgets ( Cropped ) as visual locators to match on emulated devices. Our analysis includes validating the portability of different feature-based visual locators over various apps and devices and evaluating their robustness in terms of cross-device portability and correctly executed interactions. We assessed our results through a comparison with two state-of-the-art tools, EyeAutomate and Sikuli. Despite a limited increase in the computational burden, our Fullscreen approach outperformed state-of-the-art tools in terms of correctly identified locators across a wide range of devices and led to a 30% increase in passing tests. Our work shows that VGT tools’ dependability can be improved by bridging the testing and computer vision communities. This connection enables the design of algorithms targeted to domain-specific needs and thus inherently more usable and robust.

Bioresorbable Composites and Implant

2019 ◽  
pp. 57-76
Author(s):  
Divya Zindani
Keyword(s):  
Mechanical Properties ◽  
Surface Modification ◽  
Degradation Rate ◽  
Clinical Applications ◽  
The Body ◽  
Metal Alloys ◽  
Medical Sciences ◽  
Intended Function ◽  
Wide Range ◽  
Modification Rate

Different biomaterials in the form of ceramics, metal alloys, composites, glasses, polymers, etc. have gained wide-range acceptance in the realm of medical sciences. Bioimplants from such biomaterials have been constructed and used widely for different clinical applications. With the continual progress, biomaterials that may be resorbed inside the body have been developed. These have done away with the major challenge of removal of an implant after it has served its intended function. Important factors are taken into consideration in design and development of implants from such biomaterials are mechanical properties, degradation rate, surface modification, rate of corrosion, biocompatibility, and non-toxicity. Given the importance of such materials in clinical applications, the chapter presents an overview of the bioresorable composites and their implants. The related properties and the functions served have been outlined briefly. Further, the challenges associated and the remedies to overcome them have also been delineated.

Bioresorbable Composites and Implant

2021 ◽  
pp. 443-456
Author(s):  
Divya Zindani
Keyword(s):  
Mechanical Properties ◽  
Surface Modification ◽  
Degradation Rate ◽  
Clinical Applications ◽  
The Body ◽  
Metal Alloys ◽  
Medical Sciences ◽  
Intended Function ◽  
Wide Range ◽  
Modification Rate

Different biomaterials in the form of ceramics, metal alloys, composites, glasses, polymers, etc. have gained wide-range acceptance in the realm of medical sciences. Bioimplants from such biomaterials have been constructed and used widely for different clinical applications. With the continual progress, biomaterials that may be resorbed inside the body have been developed. These have done away with the major challenge of removal of an implant after it has served its intended function. Important factors are taken into consideration in design and development of implants from such biomaterials are mechanical properties, degradation rate, surface modification, rate of corrosion, biocompatibility, and non-toxicity. Given the importance of such materials in clinical applications, the chapter presents an overview of the bioresorable composites and their implants. The related properties and the functions served have been outlined briefly. Further, the challenges associated and the remedies to overcome them have also been delineated.

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