An evaluation of serum Otolin-1 & Vitamin-D in benign paroxysmal positional vertigo

2021 ◽  
pp. 1-8
Author(s):  
Harsha Yadav ◽  
DVK Irugu ◽  
Lakshmy Ramakrishanan ◽  
Archana Singh ◽  
Ransi Abraham ◽  
...  
Keyword(s):  
Vitamin D ◽  
Inner Ear ◽  
Test Group ◽  
Control Group ◽  
Vitamin D Levels ◽  
Head Roll ◽  
And Control ◽  
The Relationship ◽  
Paroxysmal Positional Vertigo

BACKGROUND: Serum otolin-1 is an inner ear protein exclusively expressed in otoconia and cells of vestibule and cochlea. Serum otolin-1 is found to be quantifiable in patients with BPPV. Low Vitamin-D is associated with pathogenesis of BPPV. Since otoconia degeneration contributes to BPPV, lack of Vitamin-D may impact otoconia structure and integrity. OBJECTIVE: We aimed at studying the s.otolin-1 as biomarker and significance of vit-D in BPPV. MATERIAL AND METHOD: 23 patients in test and control groups respectively were chosen within the age of 20 to 65 years. All the patients were diagnosed using Dix Hallpike menouver and head roll test, patients were treated with appropriate Canal Reposition Menouver (CRM). RESULTS: Serum Otolin-1 levels among the test ranged from 366 to 882 pg/mL with mean of 585.17 pg/mL whereas in control group ranged from 223 to 462 pg/mL with mean of 335.26 pg/mL. Mean Vitamin-D levels among the test group was 22.67 ng/mL (Range = 6.3–68.4) and that of control 15.43 pg/mL (Range = 5.4–27.7) respectively. The relationship between the serum Otolin-1 and Vitamin-D was not statistically significant. CONCLUSION: Otolin-1 levels is increased in BPPV patients and is sensitive in BPPV, specificity needs to be validated. Role of vitamin-D with respect to inner ear proteins needs further investigation.

scholarly journals Role of Vitamin D in Near Sightedness

2020 ◽  
Vol 36 (2) ◽  
Author(s):  
Yasir Iqbal Malik ◽  
Aqsa Malik ◽  
Rabbia Shabbir ◽  
Atteaya Zaman ◽  
Sohail Zia ◽  
...  
Keyword(s):  
Vitamin D ◽  
Sampling Technique ◽  
Control Group ◽  
Mean Values ◽  
Group I ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Azad Kashmir ◽  
And Control

Purpose: To determine the levels of Vitamin D in children with myopia and to compare them with age matched controls. Study Design:  Case control study. Place and Duration of Study:  The study was conducted in Naseer Memorial Hospital, Dadhyal Azad Kashmir from March 2016 to March 2017. Material and Methods:  Two hundred patients were selected using convenient sampling technique and were divided two groups (group I Myopic and group II control). Myopia was labeled if after subjective refraction a Spherical Equivalent (SE) of −0.50 diopters (D) or more was found. Vitamin D levels were measured by radioimmunoassay technique with Diasorin SR® kit following the user’s manual. Vitamin D levels less than 20 ng/ml were considered Vitamin D deficient following the standards of American academy of pediatrics. The collected data was entered in the statistical package for social sciences (SPSS) version 21 for analysis. Independent t–test was used to determine the significant difference of means between controls and patients. P-values less than 0.05 were considered significant. Results:  Mean age of controls and myopes were 10.65 ± 3.9 and 10.20 ± 2.5 years respectively. Vitamin D levels in myopic children were found to be 14.95 ± 3.75 ng/ml and there was no significant difference in mean values of Vitamin D levels in myopic and control group. Conclusion:  We found no difference in Vitamin D levels of myopic and non myopic children and concluded that Vitamin D has no role in development or progression of myopia.

scholarly journals THE EFFECT OF VITAMIN D LEVELS ON INFLAMMATION IN PATIENTS WITH CHRONIC RENAL FAILURE

2020 ◽  
Vol 15 (4) ◽  
pp. 166-178
Author(s):  
Nilüfer Bulut ◽  
Mehmet Çağatay Taşkapan ◽  
Hülya Taşkapan
Keyword(s):  
Vitamin D ◽  
Renal Failure ◽  
High Sensitivity ◽  
Control Group ◽  
Reactive Protein ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Hs Crp ◽  
And Control ◽  
The Relationship

It is suggested that a number of environmental and genetic factors trigger the formation of progressive kidney damage and complications. One of these factors is inflammation, it occurs as a result of a series of mechanisms included within a number of cytokines. Vitamin-D, IL-6, PCT and hs-CRP are also valuable biomarkers in terms of mortality in dialysis patients in this sense. Vitamin D deficiency is common in patients with chronic kidney disease (CKD) and is associated with inflammation. In recent years, some randomized controlled trials have revealed the effect of Vitamin D on inflammation in CKD patients, but the results are conflicting. The aim of this study is to investigate the relationship between Vitamin D, high-sensitivity C Reactive Protein (hs-CRP), procalcitonin and IL-6, and to evaluate the relation of Vitamin D levels with inflammation in PD patients, HD patients and controls. This study was carried on with 40 patients receiving on hemodialysis treatment, 40 patients receiving peritoneal treatment with renal failure disease and with a control group consisting of 40 healthy individuals. Vitamin D levels were measured by HPLC, PCT and IL-6 levels were measured by chemiluminescent method, hs-CRP is measured by nephelometric method. For Vitamin D, there was no differences between the groups. For PCT, there was a significant difference between all groups. For IL-6, while there was no difference between peritoneal and hemodialysis groups, a significant difference was determined between the peritoneal dialysis and control groups. For hs-CRP, there was a significant difference among all groups. While correlation was found between serum PCT levels with IL-6 and hs-CRP, no correlations were found between serum PCT with Vitamin D levels. Although a correlation was found between serum IL-6 levels and hs-CRP, no correlation was detected between serum IL-6 and Vitamin D levels. No correlations were detected between Vitamin D andPCT, IL-6 and hs-CRP.

scholarly journals Study The Overprescription Of Proton Pump Inhibitors And Their Relation With Recurrent Community Aquired Infections In Outpatient Refilled Prescriptions Of Chronic Diseases Patients

2016 ◽  
Vol 12 (6) ◽  
pp. 116
Author(s):  
Aysha Abedalhameed Alkhalaylah ◽  
Maisan Mahmoud Hayajneh ◽  
Shireen Imad Hijazeen ◽  
Tahanie Ali Alqhewii ◽  
Eva Raji Haddad ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Neutrophil Count ◽  
Inflammatory Biomarkers ◽  
Control Group ◽  
Study Group ◽  
Study Participants ◽  
And Control ◽  
The Relationship

Background: proton pump inhibitors are widely used worldwide and studies have demonstrated that the use of PPIs to be associated with various diseases such as several types of infection. Study objectives: to explore the effect of using PPIs on patients through studying some inflammatory biomarkers including WBC, neutrophil count, ESR, CRP, and IL-6. Methods and subjects: a retrospective study design was followed to collect data from study participants. The study included 62 patients receiving PPIs and 60 persons without being prescribed for PPIs. A working sheet was created for each patient and included the following information: age, WBC, neutrophil count, ESR, CRP, and IL-6. Data analysis was carried out using SPSS version 20. The relationship between variables was tested using independent T test. Significance was considered at alpha level < 0.05. Study findings: age was not varied significantly between study group and control group. All inflammatory biomarkers under study were significantly elevated in study group compared with control group. Conclusions: the findings of the present study showed that the use of PPIs was associated significantly with increased inflammatory biomarkers. We think that health settings should pay much attention to the role of pharmacists and pharmacy doctors to increase the awareness about the use of PPIs.

scholarly journals Association of gestational diabetes mellitus with changes in gut microbiota composition at the species level

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fang Chen ◽  
Yu Gan ◽  
Yingtao Li ◽  
Wenzhi He ◽  
Weizhen Wu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gut Microbiota ◽  
Gestational Diabetes Mellitus ◽  
Fasting Glucose ◽  
Species Level ◽  
Control Group ◽  
And Control ◽  
The Relationship

Abstract Background Gestational diabetes mellitus (GDM), a common endocrine disorder with rising prevalence in pregnancy, has been reported to be associated with alteration of gut microbiota in recent years. However, the role of gut microbiome in GDM physiopathology remains unclear. This pilot study aims to characterize the alteration of gut microbiota in GDM on species-level resolution and evaluate the relationship with occurrence of GDM. Methods An analysis based on 16S rRNA microarray was performed on fecal samples obtained from 30 women with GDM and 28 healthy pregnant women. Results We found 54 and 141 differentially abundant taxa between GDM and control group at the genus and the species level respectively. Among GDM patients, Peptostreptococcus anaerobius was inversely correlated with fasting glucose while certain species (e.g., Aureimonas altamirensis, Kosakonia cowanii) were positively correlated with fasting glucose. Conclusions This study suggests that there are large amounts of differentially abundant taxa between GDM and control group at the genus and the species level. Some of these taxa were correlated with blood glucose level and might be used as biomarkers for diagnoses and therapeutic targets for probiotics or synbiotics.

scholarly journals Reinforcing Risk Perception to Induce Exercise Intention: Role of Systematic Interaction from Social Marketing Perspectives

2019 ◽  
Vol IV (II) ◽  
pp. 24-38
Author(s):  
Farooq Ahmad ◽  
Muhammad Nawaz Qaisar ◽  
Syed Ali Raza Hamid
Keyword(s):  
Risk Perception ◽  
Fear Appeals ◽  
Control Group ◽  
Fear Appeal ◽  
Treatment Conditions ◽  
And Control ◽  
Exercise Intention ◽  
The Impact ◽  
The Relationship

The study examined the relationship between systematic interaction, fear appeals, and exercise intention using group-centered and participatory approaches. The longitudinal experimental design was used to understand the phenomenon of fear appeals (risk perception) for adopting sustained physical activities. The sample comprised two treatment conditions i.e. experimental group and control group to measure the impact of interventions for verification of the proposed conceptual model. The findings indicate that risk perception mediated the relationship between systematic interaction and exercise intention. Moreover, systematic interaction has a positive effect on risk perception and exercise intention. The findings conceptually advance the fear appeal theory with a new lens using a participatory paradigm to augment sustained behavior change. We advocate that use of systematic interaction adds value in expanding the scope of a theoretical base for marketing.

scholarly journals Role Of Vitamin D And Adipose Tissue Hormones In Women With Reproductive Disorders

Folia Medica ◽  
2015 ◽  
Vol 57 (1) ◽  
pp. 5-10
Author(s):  
Presiyana V. Nyagolova ◽  
Mitko D. Mitkov ◽  
Maria M. Orbetsova
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Polycystic Ovary ◽  
Serum Vitamin ◽  
Reproductive Function ◽  
Reproductive Disorders ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Relationship

Abstract The role of vitamin D beyond that it plays in bone metabolism and calcium homeostasis has been lately quite emphasized. In this respect, vitamin D deficiency has been associated with higher risk of cardiovascular disease, metabolic syndrome, and reproductive disorders. Growing evidence has suggested that vitamin D deficiency is implicated in the pathogenesis of insulin resistance and the development of metabolic disorders in the polycystic ovary syndrome. The goal of the review is to present contemporary concepts of the relationship between hormones affecting the metabolic body status, serum vitamin D levels and the reproductive function.

The Effects of Injected Vitamin D on Prognosis of Patients with Urosepsis

2018 ◽  
Vol 50 (05) ◽  
pp. 383-388
Author(s):  
Abolfazl Jokar ◽  
Koorosh Ahmadi ◽  
Ali Taherinia ◽  
Farshideh Didgar ◽  
Fatemeh Kazemi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Uric Acid ◽  
Standard Treatment ◽  
Vital Signs ◽  
Control Group ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Calcium Phosphorus ◽  
The Difference ◽  
And Control

AbstractThe aim of this study was to evaluate the effect of prescribing vitamin D on improving the symptoms of patients diagnosed with urosepsis. The participants were randomly divided into two equal groups (each consisting of 50 patients). The patients in the first group received standard treatment with 300 000 units of injected vitamin with a volume of 1 cc. As for the patients in the second group, they received standard treatment along with 1 cc normal saline injected to them as placebo. Vital signs of the patients were checked every 6 h, while their CBC, EXR, CRP, creatinine, urea, and uric acid were checked 0, 24, 48, and 72 h following the interventions. Calcium, phosphorus, and vitamin D levels were measured 72 h following injection of the medicine. A significant difference was observed between the two groups in terms of the number of WBC’s in 24th, 48th, and 72nd hours. A similarly significant difference was reported between the case and control group in terms of the average BUN within 24th, 48th, and 72nd hours. The difference observed between the two groups in terms of average Cr within the 0th, 24th, 48th, and 72nd hours and in terms of days of hospitalization was also significant. Considering these results and keeping in mind the fact that no particular side effects were reported as a result of utilizing muscular injections of vitamin D and the easy and cheap use of this medicine, it can be used in auxiliary treatment of patients with urosepsis.

scholarly journals Adamalysines as Biomarkers and a Potential Target of Therapy in Colorectal Cancer Patients: Preliminary Results

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Katarzyna Walkiewicz ◽  
Joanna Strzelczyk ◽  
Dariusz Waniczek ◽  
Krzysztof Biernacki ◽  
Małgorzata Muc-Wierzgoń ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Distant Metastases ◽  
Serum Levels ◽  
Control Group ◽  
Colorectal Cancer Patients ◽  
And Control ◽  
The Relationship ◽  
Increased Activity

Colorectal cancer is one of the most common cancers in the world. Due to its still undetermined pathogenesis, we are searching for signaling pathways that are important in the development of colorectal cancer. In this article, we present results of study on the role of ADAM proteins in colorectal cancer. The study included 85 adult colorectal cancer patients (48 men, 37 women) and 25 patients in the control group (after diagnostic colonoscopy—without cancer). During hospitalization, a serum sample (3 cm3) was collected from the study and control group, anthropometric measurements were conducted and others clinical data were analyzed. In the serum ADAM10, 12, 17, and 28, protein concentrations were determined and, in the next step, examined the relationship between ADAMs concentrations and selected clinical parameters in both groups. The analysis showed that serum levels of ADAM10 and ADAM28 are significantly higher in patients with colorectal cancer and correlate with histopathological grading and with presence of distant metastases. Moreover, noticed the trend to correlate concentrations of adamalysines with higher BMI score. One of the functions of adamalysines is the activation of growth factors involved in cancer, including IGF and TNFα. The increased activity of adamalysines in patients may play a role in the pathogenesis of colorectal cancer. Our study highlights the prevalence of metabolic disorders in the group of patients with diagnosed CRC, and this cancer seems to be a further complication of obesity.

scholarly journals The Association Between Serum Vitamin D Levels and Benign Paroxysmal Positional Vertigo

2021 ◽  
pp. 014556132110085
Author(s):  
Kanokporn Sarsitthithum ◽  
Tosapohn Wisupagan ◽  
Sivaporn Kiatthanabumrung ◽  
Chanchai Jariengprasert
Keyword(s):  
Vitamin D ◽  
Benign Paroxysmal Positional Vertigo ◽  
Serum Vitamin ◽  
Control Group ◽  
P Value ◽  
Serum Vitamin D ◽  
Positional Vertigo ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Paroxysmal Positional Vertigo

Objective: This study aimed to evaluate the association between serum vitamin D levels and benign paroxysmal positional vertigo (BPPV). Participants and Methods: This prospective study consisted of 137 participants. There were 69 participants in the BPPV group compared with 68 healthy participants. Blood samples from both groups were collected from all participants to assess serum vitamin D levels. Results: No significant difference in demographic data between BPPV and control groups. The results showed that the mean serum vitamin D levels in the BPPV group was lower than that of the control group ( P value = .001). Among BPPV participants, there was no statistically significant difference between mean serum vitamin D levels of participants with recurrent BPPV, and that of newly diagnosed BPPV participants ( P value = .313). Conclusion: A statistically significant association between lower mean serum vitamin D levels in the BPPV group compared with that of the control group. Therefore, low serum vitamin D levels may be one of the risk factors for BPPV.

scholarly journals The Impact of Vitamin D Supplementation as an Adjuvant Therapy on the Abundance of Treg Cells in Patients with Atopic Dermatitis

2021 ◽  
Author(s):  
Payam Payandeh ◽  
Maryam Rastin ◽  
Farzaneh Iravani ◽  
Maryam Khoshkhui ◽  
pouran Layegh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Immune System ◽  
Treg Cells ◽  
Control Group ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
And Control ◽  
The Impact ◽  
Experimental Group

Abstract BackgroundAtopic dermatitis (AD) is a chronic, inflammatory, and severely Pruritus cutaneous disease that has an immunologic base. The most common treatments are topical steroids, which bring many adverse side effects. Vitamin D can adjust the immune system; therefore, in this study, we investigated the effect of vitamin D on the abundance of Treg cells in AD patients. MethodsIn this interventional study, 40 subjects who completed the intervention were enrolled, including 20 AD patients (as the experimental group) and 20 healthy subjects (as the control group). Accordingly, the subjects whose vitamin D levels was less than 30 ng/ml were assigned to receive vitamin D (1000 IU) daily for a 2-month duration. The severity of AD was evaluated based on SCORAD (Scoring Atopic Dermatitis) and the amount of CD4+CD25+Foxp3+Treg cells was also assessed using Flow cytometry. ResultsAverage serum level of vitamin D before performing the treatment in the experimental (14/90±4/5) and control groups (15/95±5/0) was lower than that of after the treatment (experimental group 24/60±5/2 and control group 23/60±7/3) (P<0.001). As well, there was a significant difference between the average scores of SCORAD after the vitamin D intervention (P<0.001). The amount of Treg cells significantly increased in the experimental group (P=0.002, Diff=0.35) after performing the intervention.Conclusionit was found that besides conventional medicines, Vitamin D can be adjusted as an effective complementary therapy by modulating the immune system.Trial registration: IRCT20150716023235N13, Registered 11 Feb 2018, https://www.irct.ir

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