Study The Overprescription Of Proton Pump Inhibitors And Their Relation With Recurrent Community Aquired Infections In Outpatient Refilled Prescriptions Of Chronic Diseases Patients

Background: proton pump inhibitors are widely used worldwide and studies have demonstrated that the use of PPIs to be associated with various diseases such as several types of infection. Study objectives: to explore the effect of using PPIs on patients through studying some inflammatory biomarkers including WBC, neutrophil count, ESR, CRP, and IL-6. Methods and subjects: a retrospective study design was followed to collect data from study participants. The study included 62 patients receiving PPIs and 60 persons without being prescribed for PPIs. A working sheet was created for each patient and included the following information: age, WBC, neutrophil count, ESR, CRP, and IL-6. Data analysis was carried out using SPSS version 20. The relationship between variables was tested using independent T test. Significance was considered at alpha level < 0.05. Study findings: age was not varied significantly between study group and control group. All inflammatory biomarkers under study were significantly elevated in study group compared with control group. Conclusions: the findings of the present study showed that the use of PPIs was associated significantly with increased inflammatory biomarkers. We think that health settings should pay much attention to the role of pharmacists and pharmacy doctors to increase the awareness about the use of PPIs.

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Evaluation of TP-E Interval and TP-E/QT Ratio in Panic Disorder

Medicina ◽

10.3390/medicina56050215 ◽

2020 ◽

Vol 56 (5) ◽

pp. 215 ◽

Cited By ~ 1

Author(s):

Abdulmecit Afsin ◽

Ramazan Asoğlu ◽

Mehmet Hamdi Orum ◽

Elvan Cicekci

Keyword(s):

Panic Disorder ◽

Ventricular Repolarization ◽

Control Group ◽

Study Group ◽

Panic Disorders ◽

Diagnostic And Statistical Manual ◽

Qt Intervals ◽

Qrs Duration ◽

And Control ◽

The Relationship

Background and Objectives: The autonomic nervous system (ANS) is involved in panic disorders. ANS dysfunction has been shown to be associated with ventricular arrhythmia and increased heterogeneity of ventricular repolarization. However, there remains limited evidence of the relationship between panic disorders and ventricular depolarization markers, including the Tp-e interval and Tp-e/QT ratio. This study aimed to evaluate ventricular repolarization parameters in patients with panic disorder. Materials and Methods: In total, 40 patients with panic disorder, diagnosed using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, were included in the study group. The control group comprised of 50 age- and sex-matched healthy individuals. A standard 12 lead electrocardiogram was recorded on all participants, and heart rate, QT interval, QRS duration, Tp-e interval, and Tp-e/QT ratio were measured. Results: QRS durations and QT intervals were similar in the study and control groups. Compared to the control group, QTd, Tp-e, and cTp-e intervals as well as Tp-e/QT and Tp-e/QTc ratios were significantly increased in patients with panic disorder (p < 0.05 for all). In the study group, the Severity Measure for Panic Disorder—Adult score had a significant positive correlation with the Tp-e interval (r = 0.369, p < 0001), cTp-e interval (r = 0.531, p < 0.001), Tp-e/QT ratio (r = 0.358, p = 0.001), and Tp-e/QTc ratio (r = 0.351, p = 0.001). Conclusion: These findings indicate that panic disorders are associated with increased ventricular repolarization heterogeneity, which may be attributed to ANS dysregulation.

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Postthyroidectomy Throat Pain and Swallowing: Do Proton Pump Inhibitors Make a Difference?

ISRN Otolaryngology ◽

10.1155/2013/135978 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Faisal Zawawi ◽

Keith Richardson ◽

Rickul Varshney ◽

Jonathan Young ◽

Alex M. Mlynarek ◽

...

Keyword(s):

Proton Pump Inhibitors ◽

Proton Pump ◽

Thyroid Surgery ◽

Laryngopharyngeal Reflux ◽

Clinic Visit ◽

Control Group ◽

Study Group ◽

Pain Level ◽

Throat Pain ◽

Average Pain

Objectives. Following thyroid surgery patients complain from swallowing disability and throat pain resembling symptoms of laryngopharyngeal reflux (LPR). The purpose of this study is to assess whether proton pump inhibitors (PPIs) given to patients in the first postoperative week relieve the swallowing disability and throat pain complaints. Materials and Methods. A questionnaire was given to 523 patients who had thyroid surgery between October 2010 and August 2011. In the first postoperative clinic visit each patient was approached to fill out a questionnaire. 208 patients met criteria, 100 of which were on PPIs (study group) and 108 were not on PPIs (control group). Results. When comparing the study group to the control group, the average pain level was 2.57 compared to 3.9 during the first postoperative week, and 1.27 compared to 2.41 at day 7 ( value = 0.001). Swallowing disability was also lower in the study group when compared to the control group, 1.87 and 3.12, respectively, during the first postoperative week and 0.87 and 1.76, respectively, at day 7 ( value = 0.007). Conclusion. Patients treated with PPIs had less pain and swallowing disability in the first week following thyroid surgery, when compared to patients not treated with PPIs.

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The Relationship Between Intraabdominal Hypertension and Preeclampsia

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2016.628 ◽

2016 ◽

pp. 5

Author(s):

Mesut A. Ünsal ◽

Ülkü İnce ◽

Sevil Cengiz ◽

S. Caner Karahan ◽

Turhan Aran

Keyword(s):

Statistical Significance ◽

Intraabdominal Pressure ◽

Control Group ◽

Abdominal Pressure ◽

Study Group ◽

Abdominal Hypertension ◽

Intraabdominal Hypertension ◽

The Mean ◽

And Control ◽

The Relationship

OBJECTIVE: We aimed to measure abdominal pressure and placental levels of malondialdehyde in patients with preeclampsia and investigate the relationship between intraabdominal pressure and clinical features of preeclampsia. STUDY DESIGN: Study was conducted at a tertiary referral clinic. Study group consisted of patients with preeclampsia and control group consisted of normotensive pregnant women. Both placental malondialdehyde and intraabdominal pressure levels were studied in all patients. Intraabdominal pressure was assessed indirectly via a Foley bladder catheter both antepartum and postpartum period. Statistical comparisons among groups were made using the Mann-Whitney U test, independent T test and Chi-square test. Statistical significance was set as p<0.05. RESULTS: Study and control group consisted of 35 pregnant patients. The mean patients’ age, gravidity, parity, weight and BMI were not different between study and control groups. In the study group, Caesarean, preterm delivery and abdominal hypertension rate were significantly higher whereas the mean neonatal birth weight was lower. The mean antepartum and postpartum intraabdominal pressure levels were significantly higher in study group. The mean intraabdominal pressure was highest in patients with oliguria (19.8±1.8 cmH2O). Abdominal hypertension was detected in 30 (86%) patients in study group and in 3 (9%) patients in control group. The mean placental malondialdehyde level was significantly higher in patients with intraabdominal hypertension. CONCLUSION: Abdominal hypertension rate is very high in patients with preeclampsia. Abdominal hypertension may have an additional role in preeclampsia.

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Relationship between mandibular deviation and ocular convergence

Journal of Clinical Pediatric Dentistry ◽

10.17796/jcpd.28.2.mj7311l03m257134 ◽

2005 ◽

Vol 28 (2) ◽

pp. 135-138 ◽

Cited By ~ 13

Author(s):

A. Monaco ◽

O. Streni ◽

M. Marci ◽

L. Sabetti ◽

G. Marzo ◽

...

Keyword(s):

Pediatric Dentistry ◽

Interdisciplinary Cooperation ◽

Controlled Study ◽

Control Group ◽

Study Group ◽

Gender And Age ◽

Mandibular Position ◽

The Relationship ◽

Ocular Convergence

Recent studies have confirmed the relationship between head posture, mandibular position and visual focusing. A case-controlled study was conducted to assess the occurrence of ocular convergence defects between subjects with functional mandibular latero-deviation and healthy subjects in pediatric age. Sixty subjects (the study group) presented mandibular latero-deviation classified as functional according to the use of a clinical examination and frontal and basal tele-radiography. Sixty subjects without functional mandibular laterodeviation (control group) were selected randomly from all subjects seeking pediatric dental care and matched by gender and age to study group. All one hundred and twenty subjects were submitted to orthoptic tests performed by the same operator. These results seemed to confirm that in mandibular latero-deviation subjects ocular convergence defects occurred in greater frequency than in controls underlining the importance of role of pediatric dentistry among interdisciplinary cooperation.

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The role of real-time elastosonography in the diagnosis of quadriceps fat pad edema

Acta Radiologica ◽

10.1177/02841851211058279 ◽

2021 ◽

pp. 028418512110582

Author(s):

Emre Nalbant ◽

Hande Nalbant ◽

Nurdan Cay

Keyword(s):

Real Time ◽

Strain Ratio ◽

Control Group ◽

Imaging Method ◽

Study Group ◽

Fat Pad ◽

Mri Findings ◽

Mri Study ◽

And Control

Background Quadriceps fat pad edema (QFPE) is one of the causes of anterior knee pain. Real-time elastosonography (RTE) has been increasingly used in musculoskeletal disorders. Purpose To evaluate the role of RTE in the diagnosis of QFPE. Material and Methods A total of 23 patients with QFPE on magnetic resonance imaging (MRI) (study group) were prospectively compared with 29 patients with normal MRI findings (control group) using RTE. On MRI, the thickness of the quadriceps fat pad (QFP), and on RTE, strain ratio (SR) of QFP were measured and compared between the two groups. Results The study group contained 23 patients (12 men, 11 women; mean age = 41.6 ± 7.0 years) and the control group contained 29 patients (14 men, 15 women; mean age = 42.3 ± 6.1 years). No significant differences were found in terms of mean age and sex between the two groups ( P = 0.70, P = 0.78, respectively). The median thicknesses of the QFPs were 8.10 mm and 6.75 mm in the study and control groups, respectively ( P < 0.001). The median SR values of the study group and control group were found to be 63.20 and 6.24, respectively. The SR values were significantly higher in patients with QFPE ( P < 0.001). Conclusion RTE may be an effective imaging method for evaluating QFPE.

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Association of gestational diabetes mellitus with changes in gut microbiota composition at the species level

BMC Microbiology ◽

10.1186/s12866-021-02207-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Fang Chen ◽

Yu Gan ◽

Yingtao Li ◽

Wenzhi He ◽

Weizhen Wu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gut Microbiota ◽

Gestational Diabetes Mellitus ◽

Fasting Glucose ◽

Species Level ◽

Control Group ◽

And Control ◽

The Relationship

Abstract Background Gestational diabetes mellitus (GDM), a common endocrine disorder with rising prevalence in pregnancy, has been reported to be associated with alteration of gut microbiota in recent years. However, the role of gut microbiome in GDM physiopathology remains unclear. This pilot study aims to characterize the alteration of gut microbiota in GDM on species-level resolution and evaluate the relationship with occurrence of GDM. Methods An analysis based on 16S rRNA microarray was performed on fecal samples obtained from 30 women with GDM and 28 healthy pregnant women. Results We found 54 and 141 differentially abundant taxa between GDM and control group at the genus and the species level respectively. Among GDM patients, Peptostreptococcus anaerobius was inversely correlated with fasting glucose while certain species (e.g., Aureimonas altamirensis, Kosakonia cowanii) were positively correlated with fasting glucose. Conclusions This study suggests that there are large amounts of differentially abundant taxa between GDM and control group at the genus and the species level. Some of these taxa were correlated with blood glucose level and might be used as biomarkers for diagnoses and therapeutic targets for probiotics or synbiotics.

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Reinforcing Risk Perception to Induce Exercise Intention: Role of Systematic Interaction from Social Marketing Perspectives

Global Economics Review ◽

10.31703/ger.2019(iv-ii).03 ◽

2019 ◽

Vol IV (II) ◽

pp. 24-38

Author(s):

Farooq Ahmad ◽

Muhammad Nawaz Qaisar ◽

Syed Ali Raza Hamid

Keyword(s):

Risk Perception ◽

Fear Appeals ◽

Control Group ◽

Fear Appeal ◽

Treatment Conditions ◽

And Control ◽

Exercise Intention ◽

The Impact ◽

The Relationship

The study examined the relationship between systematic interaction, fear appeals, and exercise intention using group-centered and participatory approaches. The longitudinal experimental design was used to understand the phenomenon of fear appeals (risk perception) for adopting sustained physical activities. The sample comprised two treatment conditions i.e. experimental group and control group to measure the impact of interventions for verification of the proposed conceptual model. The findings indicate that risk perception mediated the relationship between systematic interaction and exercise intention. Moreover, systematic interaction has a positive effect on risk perception and exercise intention. The findings conceptually advance the fear appeal theory with a new lens using a participatory paradigm to augment sustained behavior change. We advocate that use of systematic interaction adds value in expanding the scope of a theoretical base for marketing.

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Adamalysines as Biomarkers and a Potential Target of Therapy in Colorectal Cancer Patients: Preliminary Results

Disease Markers ◽

10.1155/2019/5035234 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Katarzyna Walkiewicz ◽

Joanna Strzelczyk ◽

Dariusz Waniczek ◽

Krzysztof Biernacki ◽

Małgorzata Muc-Wierzgoń ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Distant Metastases ◽

Serum Levels ◽

Control Group ◽

Colorectal Cancer Patients ◽

And Control ◽

The Relationship ◽

Increased Activity

Colorectal cancer is one of the most common cancers in the world. Due to its still undetermined pathogenesis, we are searching for signaling pathways that are important in the development of colorectal cancer. In this article, we present results of study on the role of ADAM proteins in colorectal cancer. The study included 85 adult colorectal cancer patients (48 men, 37 women) and 25 patients in the control group (after diagnostic colonoscopy—without cancer). During hospitalization, a serum sample (3 cm3) was collected from the study and control group, anthropometric measurements were conducted and others clinical data were analyzed. In the serum ADAM10, 12, 17, and 28, protein concentrations were determined and, in the next step, examined the relationship between ADAMs concentrations and selected clinical parameters in both groups. The analysis showed that serum levels of ADAM10 and ADAM28 are significantly higher in patients with colorectal cancer and correlate with histopathological grading and with presence of distant metastases. Moreover, noticed the trend to correlate concentrations of adamalysines with higher BMI score. One of the functions of adamalysines is the activation of growth factors involved in cancer, including IGF and TNFα. The increased activity of adamalysines in patients may play a role in the pathogenesis of colorectal cancer. Our study highlights the prevalence of metabolic disorders in the group of patients with diagnosed CRC, and this cancer seems to be a further complication of obesity.

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Analysis of Hematological Parameters of Non-Sickle Men with Priapism in Yola, Nigeria

10.47363/jcbr/2020(2)110 ◽

2020 ◽

pp. 1-3

Author(s):

Emmanuel Asuquo Etim ◽

◽

Adjekuko Ohwonigho Collins ◽

Jacob Nwonoba Nweke ◽

◽

...

Keyword(s):

Neutrophil Count ◽

Clinical Care ◽

Hematological Parameters ◽

Control Group ◽

Total Leucocyte Count ◽

Mean Cell Volume ◽

Red Cell Count ◽

And Control ◽

Apparently Healthy

Background/Objective: Priapism is a penile erectile abnormality characterized by prolonged painful erection, due to disturbances in regulatory mechanism that controls penile engorgement. Despite the role of hematology in diagnosis and management of priapism in Yola, there is dearth of information regarding hematological parameters of men with priapism therefore; this study aims to evaluate some hematological parameters of men with priapism. Material and Method: 43 subjects participated in this study comprising of 23 men of age 30±2.4years presented with priapism and 20 apparently healthy men without priapism used as control group. Men with priapism in this study presented late with very hard penis and average priapism duration of 5days. Hematological parameters of subjects were determined using Sysmex XN 550 hematological analyzer. Result: Mean erythrocyte count of subject was 3.61±0.3 X106/µl while red cell count of control group was 4.31±0.3 X106/µl at P<0.05. Mean Cell Volume (MCV) of men with priapism was 89.2±0.8fl while MCV of the control group was 75.3±1.0fl. Furthermore, Mean Cell Hemoglobin (MCH) of control and subject groups were 25.8±0.5pg and 32.1±0.6pg respectively. Mean total leucocyte count of subjects and control group were 16.8±1.4 X103/µl and 8.9±1.6 X103/µl respectively and absolute neutrophil counts of men with priapism was 9.9±2.7 X103/µl while neutrophil count of control group was 3.5±2.9 X103/µl. Conclusion: Men with Priapism had mild leukocytosis as well as increase neutrophil count, MCV and MCH values when compare with control group. It is believed that information provided in this study will improve the clinical care of men with priapism in this locality

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Does adiponectin play a role in gestational diabetes?

Current Issues in Pharmacy and Medical Sciences ◽

10.12923/j.2084-980x/26.3/a.03 ◽

2013 ◽

Vol 26 (3) ◽

pp. 258-262

Keyword(s):

Birth Weight ◽

Gestational Diabetes ◽

Fasting Glucose ◽

Laboratory Evaluation ◽

Control Group ◽

Study Group ◽

Control Groups ◽

And Control ◽

Lipid Parameters

Current literature provides contradictory information on the role of adiponectin (AdipoQ) in the course of gestational diabetes (GDM). The aim of the study was to measure AdipoQ concentration in blood of women with GDM and to find relationships between this adipokine and clinical and biochemical parameters. The study group included 50 women diagnosed with GDM between 24 and 28 weeks of gestation who underwent routine prenatal tests for GDM in compliance with the guidelines of the Polish Diabetes Association. All patients underwent clinical and laboratory evaluation at GDM diagnosis. Laboratory tests included serum AdipoQ concentration, fasting glucose, fasting insulin, OGTT and lipid parameters in serum. AdipoQ concentrations did not differ significantly between the groups during gestation (p=0.7054). In the subgroup (2h glucose level in the OGTT 200 mg/dl) the concentration of AdipoQ tended to be decreased as compared to the remaining patients from the study and control groups, though the decline was insignificant (p=0.0541). The concentration of AdipoQ in the subgroup was about 20% lower than in the other patients from the study group. No correlations, except with the neonatal weight (r= - 0.29, p<0.05), were found between AdipoQ and the studied parameters. The GDM group showed significantly elevated fasting glucose, insulin, HOMA-IR values, total cholesterol, LDL-cholesterol and triglicerydes, as compared with the control group (p.05). These results lead to the conclusion that women with newly diagnosed and promptly treated GDM have normal adiponectin level. A negative correlation between AdipoQ level and the birth weight may suggest that this adipokine plays a role in the control of the birth weight especially in the incidence of macrosomia.

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