scholarly journals Clinical translation of nanomaterials for early detection of genetic abnormalities in fetus and retinopathy in neonates and adults

2017 ◽  
Author(s):  
◽  
Shreya Ghoshdastidar
Keyword(s):  
Nuclear Medicine ◽  
Early Detection ◽  
Comparative Studies ◽  
Target Therapy ◽  
Future Research ◽  
Biological Applications ◽  
Amide Ligands ◽  
Biodistribution Studies ◽  
Genetic Abnormalities ◽  
Grp Receptors

Nuclear medicine covers a wide variety of radionuclides to meet demands of disease. In the current study, first we have looked at the application of mono-amine mono-amide ligands for Re(V), 99mTc(V), and 186Re(V) with respect to bombesin for receptor targeting in the pancreas. While procedures for synthesizing 99mTc complexes is similar to other reported procedures, rhenium complexes were synthesized using [ReO(citrate)2] - as the starting material, simplifying purification and isolation. Further studies for the 222-MAMA-BBN complex set included biodistribution studies, which determined that the 99mTc-BBN complex binds to GRP receptors in the pancreas, [about]3% ID/g. The 323-MAMA complex and derivatives were investigated to determine if the 222- or the 323-MAMA backbone provide: an easier preparation, a better framework for chelating given metals, and better transport as a targeting receptor. It is found that, in comparative studies, the 222-MAMA derivates are more preferred in chelation. However, in either case, once the metal is chelated, there is no conversion of products upon the addition of a more preferred ligand system. Another avenue of target therapy being pursued is the study of 105Rh. We are specifically looking at the study of chelation with tetrathioether complexes, to rhodium(III) to translate to the radiotracer scale. Three product isomers are formed in the reaction of rhodium, using SnCl2, with 222-S4-diAcOH. The carboxylate arm can either be free dangling, one bound to the metal, or both (removing bound chlorides respectively); all of these isomers can be easily separated using HPLC. These three species will be avoided when translated to the ligand bombesin analog. Future research in this area will be done with the 105Rh radiotracer for biological applications.

scholarly journals Synthesis design and nuclear medicine applications for radiometal, beta and gamma emission, chelated complexes

2017 ◽  
Author(s):  
◽  
Ashley N. Dame
Keyword(s):  
Nuclear Medicine ◽  
Comparative Studies ◽  
Target Therapy ◽  
Future Research ◽  
Biological Applications ◽  
Gamma Emission ◽  
Amide Ligands ◽  
Synthesis Design ◽  
Biodistribution Studies ◽  
Grp Receptors

Nuclear medicine covers a wide variety of radionuclides to meet demands of disease. In the current study, first we have looked at the application of mono-amine mono-amide ligands for Re(V), 99mTc(V), and 186Re(V) with respect to bombesin for receptor targeting in the pancreas. While procedures for synthesizing 99mTc complexes is similar to other reported procedures, rhenium complexes were synthesized using [ReO(citrate)2] as the starting material, simplifying purification and isolation. Further studies for the 222-MAMA-BBN complex set included biodistribution studies, which determined that the 99mTc-BBN complex binds to GRP receptors in the pancreas, [about]3 percent ID/g. The 323-MAMA complex and derivatives were investigated to determine if the 222- or the 323-MAMA backbone provide: an easier preparation, a better framework for chelating given metals, and better transport as a targeting receptor. It is found that, in comparative studies, the 222-MAMA derivates are more preferred in chelation. However, in either case, once the metal is chelated, there is no conversion of products upon the addition of a more preferred ligand system. Another avenue of target therapy being pursued is the study of 105Rh. We are specifically looking at the study of chelation with tetrathioether complexes, to rhodium(III) to translate to the radiotracer scale. Three product isomers are formed in the reaction of rhodium, using SnCl2, with 222-S4-diAcOH. The carboxylate arm can either be free dangling, one bound to the metal, or both (removing bound chlorides respectively); all of these isomers can be easily separated using HPLC. These three species will be avoided when translated to the ligand bombesin analog. Future research in this area will be done with the 105Rh radiotracer for biological applications.

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis

2011 ◽  
Vol 11 (1) ◽  
pp. 130-133
Author(s):  
Astra Zviedre ◽  
Arnis Engelis ◽  
Mohit Kakar ◽  
Aigars Pētersons
Keyword(s):  
Early Detection ◽  
Acute Appendicitis ◽  
Inflammatory Mediators ◽  
Potential Role ◽  
Clinical Symptoms ◽  
Future Research ◽  
Mesenteric Lymphadenitis ◽  
Proper Diagnosis ◽  
Near Future

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis Although, AAP and AML have different etiological factors, clinical symptoms are very much similar but treatment tactics in both the disease differ a lot. In case of AML, treatment is more conservative and does not require hospitalization while in case of AAP immediate hospitalization and maybe further surgery can be mandatory. With the identification of group of cytokines serum inflammatory mediators IL-8, IL-10, IL-12[p70], IL-17, TNF-a and MCP-1, it is believed early and proper diagnosis of AAP in the near future. Research of cytokines-serum inflammatory mediators has opened new opportunities for an early detection and differentiation of these two diseases in children.

Applying personalized medicine to adult severe asthma

2021 ◽  
Vol 42 (1) ◽  
pp. e8-e16 ◽  
Author(s):  
Angelica Tiotiu
Keyword(s):  
Personalized Medicine ◽  
Severe Asthma ◽  
Negative Impact ◽  
Target Therapy ◽  
Asthma Management ◽  
Future Research ◽  
Biologic Therapies ◽  
Eosinophilic Asthma ◽  
Definition Of ◽  
Structured Approach

Background: Severe asthma is a heterogeneous disease that consists of various phenotypes driven by different pathways. Associated with significant morbidity, an important negative impact on the quality of life of patients, and increased health care costs, severe asthma represents a challenge for the clinician. With the introduction of various antibodies that target type 2 inflammation (T2) pathways, severe asthma therapy is gradually moving to a personalized medicine approach. Objective: The purpose of this review was to emphasize the important role of personalized medicine in adult severe asthma management. Methods: An extensive research was conducted in medical literature data bases by applying terms such as “severe asthma” associated with “structured approach,” “comorbidities,” “biomarkers,” “phenotypes/endotypes,” and “biologic therapies.” Results: The management of severe asthma starts with a structured approach to confirm the diagnosis, assess the adherence to medications and identify confounding factors and comorbidities. The definition of phenotypes or endotypes (phenotypes defined by mechanisms and identified through biomarkers) is an important step toward the use of personalized medicine in asthma. Severe allergic and nonallergic eosinophilic asthma are two defined T2 phenotypes for which there are efficacious targeted biologic therapies currently available. Non-T2 phenotype remains to be characterized, and less efficient target therapy exists. Conclusion: Despite important progress in applying personalized medicine to severe asthma, especially in T2 inflammatory phenotypes, future research is needed to find valid biomarkers predictive for the response to available biologic therapies to develop more effective therapies in non-T2 phenotype.

scholarly journals Terrorism, Trust and Tourism

2017 ◽  
Vol 5 (2) ◽  
pp. 25
Author(s):  
Susanne Jensen ◽  
Gert Tinggaard Svendsen
Keyword(s):  
Competitive Advantage ◽  
Comparative Studies ◽  
Western Europe ◽  
Social Trust ◽  
Interesting Case ◽  
Terrorist Attacks ◽  
Future Research ◽  
The World ◽  
Quantitative And Qualitative Methods ◽  
Country People

How does terrorism affect social trust and tourism? The rising number of terrorist attacks in Western Europe has caused safety problems not only for local citizens but also for tourists. In fact, terrorists challenge the formal violence monopoly of the state thus creating a sense of anarchy and distrust. Social trust is about trusting strangers, so when less predictable behaviour occurs in, a given country, people become more careful as they tend to trust most other people less. An interesting case for future research is Scandinavia as the level of terrorism is still low and, at the same time, Scandinavia can record most social trust in the world meaning a competitive advantage when attracting tourists. Arguably, a double dividend is created from fighting terrorism, namely more social trust accumulated and more tourists attracted. Future research should therefore try to further test our model by both quantitative and qualitative methods, for example by undertaking extensive comparative studies between Scandinavia and other countries with more terrorism and less trust.

scholarly journals Victims and Perpetrators of Child Sexual Abuse: Abusive Contact and Penetration Experiences

2021 ◽  
Vol 18 (18) ◽  
pp. 9593
Author(s):  
Marta Ferragut ◽  
Margarita Ortiz-Tallo ◽  
Maria J. Blanca
Keyword(s):  
Gender Differences ◽  
Sexual Abuse ◽  
Child Sexual Abuse ◽  
Early Detection ◽  
Physical Contact ◽  
First Episode ◽  
Future Research ◽  
Male Victims ◽  
Research And Practice ◽  
Female Perpetrator

Child sexual abuse (CSA) includes abusive contact experiences, which habitually impact the victim’s whole life. This study aims to analyze the characteristics of six CSA experiences with physical contact, including penetration, in a representative sample of the Spanish population. Participants were 1071 Spanish adults (53% males; Mage: 45.37) who completed the Child Sexual Abuse Experiences Questionnaire. The victim’s age at the first episode, the perpetrator’s characteristics, and the number of times that each experience occurred were analyzed, taking into account gender differences. Results were reported for every experience independently. The most prevalent age at the first experience was from 6 years old onwards, but with differences in some experiences. The abuses usually happened more than once, committed by the same person. The most prevalent perpetrator is a male, although a female perpetrator is more prevalent in male victims. Most of the abuses were committed by an adult acquaintance, a strange adult, and other minors, with some gender differences. The implications of the results concerning every CSA experience are discussed, highlighting their value for future research and practice, the design of preventive programs, and early detection of CSA.

scholarly journals Analytical Review of Major Nocturnal Pests’ Detection Technique using Computer Vision

2018 ◽  
Vol 11 (3) ◽  
pp. 179-182
Author(s):  
Deven J. Patel ◽  
Nirav Bhatt
Keyword(s):  
Computer Vision ◽  
Early Detection ◽  
Review Article ◽  
Pink Bollworm ◽  
Detection Technique ◽  
Future Research ◽  
White Grub ◽  
Analytical Review ◽  
Pest Detection ◽  
The Right

Research in agriculture is increasing quality and quantity, but pest reduces it. To prevent the effect of these pests, insecticides are used. But excessive use of pesticides is very harmful to production and environment. So initially pest detection is necessary. We work on nocturnal pests because that can be easily attracting using night trapping tools. The purpose of this review article is to analyse the popular techniques and find the right technique for the initial diagnosis and early detection of major nocturnal flying pests like Pink Bollworm, White Grub, Helicoverpa and Spodoptera. The importance of early detection can be in identifying and classifying the pests in a digital view. We have concluded our results with the various methods and the prospects of future research.

Conclusion

2020 ◽  
pp. 251-260
Author(s):  
Frank Towers
Keyword(s):  
Nineteenth Century ◽  
North American ◽  
American History ◽  
Comparative Studies ◽  
Future Research ◽  
Nation State ◽  
Research Questions ◽  
National Framework

Whereas the introduction to this volume focused on the question of sovereignty and the nation-state, our conclusion takes stock of another important theme of this volume, writing North American history outside of a national framework. Riding the crest of a wave of studies on transnational and global comparative studies of the nineteenth century, historians working in this field would do well to pause briefly to take stock of its achievements, limitations, and future research questions....

Recent advances in supramolecular block copolymers for biomedical applications

2020 ◽  
Vol 8 (36) ◽  
pp. 8219-8231
Author(s):  
Wumaier Yasen ◽  
Ruijiao Dong ◽  
Aliya Aini ◽  
Xinyuan Zhu
Keyword(s):  
Block Copolymers ◽  
Biomedical Applications ◽  
Future Research ◽  
Biological Applications ◽  
Research Directions ◽  
Recent Advances ◽  
Future Research Directions ◽  
Reversible Nature

Supramolecular block copolymers with a dynamically reversible nature and hierarchical microphase-separated structures can greatly enrich the library of pharmaceutical carriers and outline future research directions for biological applications.

Journal of entrepreneurship in emerging economies (JEEE): reflecting on the past five years while thinking about the future

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Wen Li Chan ◽  
Michael James Mustafa
Keyword(s):  
Content Analysis ◽  
Emerging Economies ◽  
Comparative Studies ◽  
Design Methodology ◽  
Emerging Economy ◽  
Detailed Account ◽  
Future Research ◽  
Content Type ◽  
The Past ◽  
Practical Implications

Purpose The purpose of this paper is to provide an overview of studies published in the Journal of Entrepreneurship in Emerging Economies (JEEE) between 2014 and 2019. The review also provides suggestions for future research in JEEE. Design/methodology/approach Integrative literature of 90 empirical and conceptual articles published in JEEE between 2014 and 2019. The selected articles were analyzed using content analysis. Findings Analysis of the 90 published articles shows that JEEE has covered a number of relevant topics related to entrepreneurship and innovation in emerging economies. In particular, scholars have adopted a variety of methods to describe such activities in emerging economies. The review also highlights the lack of comparative studies in JEEE and studies, which significantly take into account or focus on the emerging economy context. Practical implications The findings suggest that future scholars wishing to submit to JEEE should consider taking a more detailed account of the emerging context. Originality/value Since its first publication in 2014, this study represents the first review of articles found in JEEE. Specifically, the study provides a platform for future scholars wishing to submit to JEEE to take stock of the studies in the journal, thus giving them a better understanding of the field. The study also provides directions regarding areas of possible future research, which might be of interest to scholars wishing to submit to JEEE.

scholarly journals Metabolomics Biomarkers for Detection of Colorectal Neoplasms: A Systematic Review

Cancers ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 246 ◽  
Author(s):  
Vanessa Erben ◽  
Megha Bhardwaj ◽  
Petra Schrotz-King ◽  
Hermann Brenner
Keyword(s):  
Early Detection ◽  
Colorectal Neoplasms ◽  
Literature Search ◽  
Web Of Science ◽  
Current Knowledge ◽  
External Validation ◽  
Performance Characteristics ◽  
Future Research ◽  
Non Invasive ◽  
And Performance

Background: Several approaches have been suggested to be useful in the early detection of colorectal neoplasms. Since metabolites are closely related to the phenotype and are available from different human bio-fluids, metabolomics are candidates for non-invasive early detection of colorectal neoplasms. Objectives: We aimed to summarize current knowledge on performance characteristics of metabolomics biomarkers that are potentially applicable in a screening setting for the early detection of colorectal neoplasms. Design: We conducted a systematic literature search in PubMed and Web of Science and searched for biomarkers for the early detection of colorectal neoplasms in easy-to-collect human bio-fluids. Information on study design and performance characteristics for diagnostic accuracy was extracted. Results: Finally, we included 41 studies in our analysis investigating biomarkers in different bio-fluids (blood, urine, and feces). Although single metabolites mostly had limited ability to distinguish people with and without colorectal neoplasms, promising results were reported for metabolite panels, especially amino acid panels in blood samples, as well as nucleosides in urine samples in several studies. However, validation of the results is limited. Conclusions: Panels of metabolites consisting of amino acids in blood and nucleosides in urinary samples might be useful biomarkers for early detection of advanced colorectal neoplasms. However, to make metabolomic biomarkers clinically applicable, future research in larger studies and external validation of the results is required.

Sign in / Sign up

Export Citation Format

Share Document