scholarly journals Effects of brown rice, red rice and purple rice on body weight and serum lipid in mice fed a high fat diet

2018 ◽  
Vol 1 (T5) ◽  
pp. 27-34 ◽  
Author(s):  
Van Ngoc Thanh Nguyen ◽  
Thu Le Anh Nguyen ◽  
Hong Ngoc Nguyen
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Brown Rice ◽  
Red Rice ◽  
High Fat ◽  
Lower Weight ◽  
Group 4 ◽  
Group 3 ◽  
Lower Weight Gain ◽  
Group 2

Brown rice, purple rice and red rice are the basic components of macrobiotic diet. The aim of study was to examine the lower weight gain and antihyperlipidemic activities of brown rice, purple rice and red rice on mice fed high fat diet. The mice were divided into 5 groups: group 1 was normal control mice fed with normal pellet diet; group 2- hyperlipidemic control mice was fed with high fat (15 % wt/wt)/cholesterol (0.5 % wt/wt) supplemented with either corn starch (50 % wt/wt) or cooked brown rice - group 3 or cooked red rice –group 4 or cooked purple rice–group 5 (50 % wt/wt) as the main carbohydrate source for 6 weeks. The results showed that group 2 exhibited significantly increased on weight body and total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL-c) and decreased in HDL-cholesterol (HDL-c) as compared to control group 1. Group 3, 4, 5 exhibited reduction on body weight and significantly decreased in the elevated TC, LDL-c and TG as compared to group 2. Among them, the reduction in body weight and TC and TG of group 4 was lower than other groups; the increase of HDL-c of group 5 was higher than group 3 and group 4. This is the first report identifying lower weight gain and anti-hyperlipidemic activities of cooked brown rice, cooked purple rice and cooked red rice on mice fed high fat diet. The results obtained in the present study indicate that brown rice, red rice and purple rice are health food for lower weight gain, anti-hyperlipidemic agent and prevention of heart diseases.

scholarly journals Effect of a High-Fat Diet and Metformin on Placental mTOR Signaling in Mice

2019 ◽  
Vol 09 (02) ◽  
pp. e138-e143
Author(s):  
Matthew Grace ◽  
Sarah Dotters-Katz ◽  
Chunxiao Zhou ◽  
Tracy Manuck ◽  
Kim Boggess ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Control Diet ◽  
Mtor Signaling ◽  
Control Treatment ◽  
High Fat ◽  
Group 4 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Exposures During Pregnancy

Objective This study was aimed to measure the effects of a high-fat diet and metformin on placental mechanistic target of rapamycin (mTOR) signaling in mice. Study Design Pregnant friend virus B (FVB)-strain mice were allocated on embryonic day (e) 0.5 to one of four groups; group 1: control diet (CD, 10% fat) + control treatment (CT), group 2: CD + metformin treatment (MT), group 3: high-fat diet (HFD, 60% fat) + CT, and group 4: HFD + MT. Metformin (2.5 mg/mL) was provided in water; CT mice received water. Fetuses and placentas were collected. Western blot measured placental p-Akt and p-S6 expression. Results 20 dams (five/group) and 192 fetuses were studied. Compared with CD-fed, HFD-fed dams had higher placental p-Akt protein expression (p < 0.0001). Among HFD-dams, placental p-Akt was higher in metformin-treated compared with control-treated (p < 0.001). Among CD-fed dams, there was no significant difference in placental p-S6 expression in MT versus CT groups. Among HFD-fed dams placental p-S6 expression was lower in those exposed to metformin-treated versus controls (p = 0.001). Conclusion Increased placental mTOR signaling and metformin inhibition of placental mTOR signaling only occurred in the presence of an HFD exposure. These findings suggest that metformin may modulate placental mTOR signaling in the presence of metabolic exposures during pregnancy.

Defensive activity of Hesperidin against Ciprofloxacin induced hepatic injury in rabbits.

2019 ◽  
Vol 10 (03) ◽  
Author(s):  
Hawraa M. Murad ◽  
Tamadhur Hani Hussein ◽  
Audai Sulaiman Khudhair ◽  
Manal Muhi Murad ◽  
Jawad Kadhim Faris
Keyword(s):  
Body Weight ◽  
Bacterial Infections ◽  
Hepatoprotective Activity ◽  
The Body ◽  
Local Breed ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Defensive Activity ◽  
Antioxidant Effects

This study was conducted to find out hepatoprotective activity of hesperidin (HES) 100mg/kg body weight (b.w.) against ciprofloxacin (CPX) 100 mg/kg induced hepatotoxicity in local breed rabbits .CPX is a broad spectrum antibiotic used for treatment of many bacterial infections. Twenty four male rabbits were divided into four groups ,group1: control, (1 ml/kg Saline orally) group 2: CPX (100 mg/kg orally) for (14) consecutive days , group 3: HES (100 mg//kg) orally for (14) consecutive days group 4: CPX (100 mg/kg orally) plus HES (100 mg//kg orally ) for (14) consecutive days. All the rabbits were killed on the (15) day of the experiment, and then the blood, and livers samples were taken. CPX induced hepatotoxicity was proved by a significant (p less than 0.01) reduction in the body weight ,and a significant (p less than 0.01) increased serum aspartate transaminase (AST), alanine transaminase (ALT) , Malonaldehyde enzyme (MAD) and histopathological changes. Protective hepatic toxicity effect and oxidative damage caused by CPX significantly (p less than 0.01) increasing in body weight and significantly (p less than 0.01) decreasing AST , ALT, MAD and improving tissue morphology in HES (100 mg//kg) . These results assure that HES (100 mg//kg) antioxidant effects can protect CPX-induced hepatotoxicity in rabbits.

scholarly journals Anti-hypercholesterolemic effect of Zingiber montanum extract

F1000Research ◽  
2019 ◽  
Vol 7 ◽  
pp. 1798
Author(s):  
Swandari Paramita ◽  
Meiliati Aminyoto ◽  
Sjarif Ismail ◽  
Enos Tangke Arung
Keyword(s):  
Total Cholesterol ◽  
Plant Extracts ◽  
High Fat Diet ◽  
High Cholesterol ◽  
High Fat ◽  
Group 4 ◽  
Cholesterol Levels ◽  
Group 6 ◽  
Diet Control ◽  
Group 2

Background: High cholesterol levels (hypercholesterolemia) has been recognized to cause various disease, most notably the cardiovascular disease. Unfortunately, most anti-hypercholesterolemic drugs deliver several side effects for patients, by which medicinal plants have begun to attract attention for treating hypercholesterolemia. Among others, Zingiber montanum (J.König) Link ex A.Dietr. has traditionally been taken for treating health problems caused by high cholesterol levels. Hence, this work aimed at investigating anti-hypercholesterolemic effects offered by the plant. Methods: This study was conducted on 30 male Wistar rats. During experiments, the subjects were divided into 6 groups (n=5), i.e. no treatment (Group 1, control); high-fat diet (Group 2, control); high-fat diet with simvastatin (Group 3); high-fat diet with plant extracts (Group 4-6 with 100, 200, and 400 mg/kg BW, respectively). After 4 weeks of treatments, blood samples were collected from each group. Then, plasma concentrations of triglycerides, total cholesterol, high density lipoproteins (HDL), and low density lipoproteins (LDL) were measured. Results: There were significant differences in total cholesterol (p=0.000), LDL (p=0.000) and triglycerides (p=0.001) for Groups 4-6 (high-fat diet treated with different plant extract doses) in comparison with Group 2 (high-fat diet, control). Meanwhile, there were no significant differences in HDL levels (p=0.830) between Group 2 (high-fat diet, control) and other groups. The results also showed significant differences in total cholesterol and LDL for subjects treated with plant extracts (Group 4, 100 mg/kg BW, p=0.000;  Group 5, 200 mg/kg BW, p=0.000; Group 6, 400 mg/kg BW, p=0.000) compared to Group 2 (high-fat diet, control). Then, treatments with 400 mg/kg BW (Group 6) discovered significant reductions in total cholesterol, LDL, and triglycerides (p=0.030). Conclusion: Therefore, Z. montanum has been discovered to deliver anti-hypercholesterolemic effects to experimental subjects, making it potential to act as a natural source of anti-hypercholesterolemic agents.

scholarly journals Effects of a probiotic in combination with prebiotics on intestinal lactobacilli and coliforms and activities of bacterial enzymes in 1,2-dimethylhydrazine exposed rats

2011 ◽  
Vol 56 (No. 3) ◽  
pp. 99-106 ◽  
Author(s):  
L. Strojný ◽  
A. Bo ◽  
E. Hijová ◽  
A. Chmelárová ◽  
G. Mojžišová ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Control Group ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Beta Glucosidase ◽  
Alpha Glucosidase ◽  
Beta Galactosidase ◽  
Group 1

Effects of the probiotic (PRO) Lactobacillus plantarum and of the combination of PRO and the prebiotic (PRE) inulin enriched with oligofructose (2%), and PRO with Lini oleum virginale (O) on counts of lactobacilli and coliforms and enzymatic activities in faeces of rats were studied. The rats (n = 60) were divided into 5 groups of 12 subjects. The animals were fed on a high fat diet (10%) for 8 weeks of experiment. Colon cancer was induced by the application of 1,2-dimethylhydrazine (DMH) twice a week in a dose of 20 mg/kg s.c. in groups G2-G5. The rats in group 1 (control 1) received a diet without any supplements. The rats in group 2 (control 2) received 1,2 DMH without any supplements. The rats in group 3 received PRO, group 4 PRO and PRE, and group 5 received PRO and O. A significant decrease (P &lt; 0.05) of coliforms was found out after the application of PRO, PRO-O, and PRO-PRE in comparison with control group G2. Significantly higher (P &lt; 0.05) counts of lactobacilli were determined after the application of PRO-O and PRO-PRE. Significantly lower (P &lt; 0.001) activities of &beta;-galactosidase, &beta;-glucuronidase and &alpha;-glucosidase were observed in PRO, PRO-PRE and PRO-O, while in the case of the enzyme &beta;-glucosidase the activity was lower only after the addition of PRO-O. The protective effect of lactobacilli was observed in the order PRO-O, PRO-PRE, and PRO. It was shown that combinations of PRO-O and PRO-PRE had a synergistic effect which was higher than the effect of administering only PRO.

scholarly journals Evaluation of chemopreventive and chemotherapeutic effect of Artemisia vulgaris extract against diethylnitrosamine induced hepatocellular carcinogenesis in Balb C mice

2020 ◽  
Vol 80 (3) ◽  
pp. 484-496 ◽  
Author(s):  
S. Ali ◽  
M. Ejaz ◽  
K. K. Dar ◽  
S. Nasreen ◽  
N. Ashraf ◽  
...  
Keyword(s):  
Body Weight ◽  
Plant Extract ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Artemisia Vulgaris ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Glutamyl Transferase ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract The main objective of current study was to investigate the chemopreventive and chemotherapeutic activity of Artemisia vulgaris extract on diethylnitrosoamine induced hepatocarcinogenesis in Balb C mice. Diethylnitrosoamine (DEN: 0.9%) was prepared to induce hepatocarcinoma in Balb C mice. The extract Artemisia vulgaris (AV) was prepared by maceration technique. Mice were classified into four groups as follows: Group 1 a control group (N=7) received saline solution (3.5 μl/mg), group 2 (N=14) received diethylnitrosoamine (3.5 μl/mg) intraperitoneally once in a week for eight consecutive weeks, group 3 (N=7) received only plant extract (AV: 150 mg/kg (Body weight) once in a week, while group 4 (N=7) was given in combination of diethylnitrosoamine (3.5 μl/mg) and plant extract (AV: 150 mg/kg (body weight). After eight weeks of DEN administration, mice of group 2 were divided into two subgroups containing seven mice each; subgroup 1 was sacrificed while subgroup 2 was treated with plant extract only (150 mg/kg (body weight)) once in a week for eight consecutive weeks. The DEN injected mice significant decline in levels of albumin with concomitant significant elevations such as aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alpha feto protein, gamma glutamyl transferase, 5 nucleotidase, glucose-6-phosphate dehydrogenase and bilirubin. The administration of A. vulgaris significantly decreased the DEN induced hepatotoxicity. Present study revealed the potential anti-cancerous nature of Artemisia vulgaris, both in case of chemopreventive and post-treatment of A. vulgaris. Further studies are needed to explore the mechanism of prevention and therapy.

scholarly journals Preliminary Study on the Effect of Methanolic Extract of Watermelon (Citrullus lanatus) Rind on Prednisolone Suppressed Immunity in Male Wistar Rats

2021 ◽  
pp. 1-6
Author(s):  
Nyejirime Young Wike ◽  
Mobisson Samuel Kelechi ◽  
Godspower Onyeso ◽  
Okekem Amadi ◽  
Elizabeth Eepho Krukru
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Methanolic Extract ◽  
Citrullus Lanatus ◽  
Control Group ◽  
Group 4 ◽  
Watermelon Rind ◽  
Male Wistar Rats ◽  
Group 3 ◽  
Group 2

Citrullus lanatus thumb (Cucurbitaceae) commonly called watermelon is widely consumed in this part of the world as food and medicine. This study was carried out to examine the effect of methanolic extract of watermelon (Citrullus lanatus) rind on prednisolone suppressed immunity in male wistar rats. A total of 20 male wistar rats weighing 150-294g were used in 4 groups with five rats each. Group 1, the control group was given distilled water and feed, Group 2 was given 200 mg/kg body weight of methanolic extract of watermelon rind, Group 3 rats were given 2.5 mg/kg body weight of prednisolone and Group 4 rats were given 2.5 mg/kg body weight of prednisolone and 200 mg/kg body weight of methanolic extract of watermelon rind. Prednisolone and the methanolic extract of watermelon rind were administered orally for a period of 30 days. Blood samples were collected by cardio puncture from the rats for white blood cell (WBC), lymphocyte, and granulocyte and monocyte counts at the end of the experiment.  The data were statistically analysed using one-way ANOVA (Analysis of variance). Data were considered significant at p<0.05. The results obtained showed that methanolic extract of watermelon rind caused a significant increasen in immune function of rats when compared with the control and immune suppressed rats.

scholarly journals PRODUCTIVE AND BIOLOGICAL TRAITS OF YOUNGS DIFFERENT GENOTYPES OF KAZAKH WHITE-HEADED BREED

2019 ◽  
Vol 4 (2) ◽  
pp. 94-101
Author(s):  
Асемгул Бактыгалиева ◽  
Asemgul Baktygalieva ◽  
Киниспай Джуламанов ◽  
Kinispai Dzhulamanov ◽  
Андрей Ухтверов ◽  
...  
Keyword(s):  
Body Weight ◽  
Positive Impact ◽  
Biological Traits ◽  
Group 4 ◽  
Group 3 ◽  
White Cattle ◽  
Group 5 ◽  
Group 2 ◽  
West Kazakhstan ◽  
Meat Productivity

The research aim is increasing the potential of meat productivity of young Shagatay Zavodska type of livestock based on a heterogeneous selection of Shagatay cows with bulls – Ural type of hereford. The experience carried out on the breeding farm «Sabit» in West Kazakhstan region according to the scheme: group 1 – bull, group 2 – castrated males, group 3 – heifers of Shagatay breed of Kazakh white cattle and hybrids from crossing Shagatay cows with bulls of Ural Hereford, group 4 – bulls, 5 group – castrated males, 6 group – heifers. Groups were formed on the principle of analogues of 12 animals. Bulls by the age of 15 months of the Ural hereford reached the highest body weight and surpassed shagatai peers taking into account this selection feature in regard to sex by 20.4 kg. In castrates at the age of 18 months, this difference was in favor of the youngsters of group 5 and was 23.0 kg. Heter-ogeneous selection had a positive impact on the important productive qualities by heifers. Youngsters of group 6, born due to servicing bulls of the Ural Hereford, dominated in weight in regard to all analyzed periods. The contents of lizo the meyerhold centre in both winter and summer was greater at animal – hybrids of the Ural hereford and Shagatay animals, winter amount was 0,45-0,94 µg/ml in the summer – from 0.06 to 1.97 µg/ml. Significantly lower bactericidal activity of blood serum and slightly increased amount of lysozyme was shown by hybrids from the Ural hereford in the winter. Regardless of gender, the greatest consumption of both protein (8-41 g) and energy (0.48-2.54 MJ) per unit of body weight gained was characterized by descendants from parents of the Shagatai type of Ka-zakh white-headed breed. Hybrids the offspring of the Ural hereford – used crude protein in feeding more often for the synthesis of dietary protein.

scholarly journals Centella Asiatica Extracts Regulates Aluminium Chloride-Induced Neurotoxicity in Rats: Impact on Inflammation, Apoptosis and Biogenic Amine Levels

2018 ◽  
Vol 2 (1) ◽  
pp. 1-8
Author(s):  
Shaik Amjad ◽  
Keyword(s):  
Body Weight ◽  
Therapeutic Potential ◽  
Centella Asiatica ◽  
Aluminium Chloride ◽  
Albino Rats ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Wistar Albino Rats ◽  
Group 1

investigate the therapeutic potential of CA against chronic Aluminium Chloride (AlCl3) exposure induced rats. Wistar albino rats were segregated into four groups: group 1-control rats, group 2-rats received AlCl3 (300 mg/kg body weight, every day orally) for 60 days, rats in group 3-received CA (500 mg/kg body weight, orally) and group 4 rats were initiated with both AlCl3 and CA treatment.

Partial Liquid Ventilation Reduces Fluid Filtration of Isolated Rabbit Lungs with Acute Hydrochloric Acid-induced Edema

2001 ◽  
Vol 94 (6) ◽  
pp. 1045-1049 ◽  
Author(s):  
Stephan A. Loer ◽  
Jörg Tarnow
Keyword(s):  
Body Weight ◽  
Hydrochloric Acid ◽  
Intratracheal Instillation ◽  
Partial Liquid Ventilation ◽  
Liquid Ventilation ◽  
Lung Weight ◽  
Fluid Filtration ◽  
Group 4 ◽  
Group 3 ◽  
Group 2

Background Hydrochloric acid aspiration increases pulmonary microvascular permeability. The authors tested the hypothesis that partial liquid ventilation has a beneficial effect on filtration coefficients in acute acid-induced lung injury. Methods Isolated blood-perfused rabbit lungs were assigned randomly to one of four groups. Group 1 (n = 6) served as a control group without edema. In group 2 (n = 6), group 3 (n = 6), and group 4 (n = 6), pulmonary edema was induced by intratracheal instillation of hydrochloric acid (0.1 N, 2 ml/kg body weight). Filtration coefficients were determined 30 min after this injury (by measuring loss of perfusate after increase of left atrial pressure). Group 2 lungs were gas ventilated, and group 3 lungs received partial liquid ventilation (15 ml perfluorocarbon/kg body weight). In group 4 lungs, the authors studied the immediate effects of bronchial perfluorocarbon instillation on ongoing filtration. Results Intratracheal instillation of hydrochloric acid markedly increased filtration coefficients when compared with non-injured control lungs (2.3 +/- 0.7 vs. 0.31 +/- 0.08 ml.min(-1). mmHg(-1).100 g(-1) wet lung weight, P &lt; 0.01). Partial liquid ventilation reduced filtration coefficients of the injured lungs (to 0.9 +/- 0.3 ml.min(-1).mmHg(-1).100 g(-1) wet lung weight, P = 0.022). Neither pulmonary artery nor capillary pressures (determined by simultaneous occlusion of inflow and outflow of the pulmonary circulation) were changed by hydrochloric acid instillation or by partial liquid ventilation. During ongoing filtration, bronchial perfluorocarbon instillation (5 ml/kg body weight) immediately reduced the amount of filtered fluid by approximately 50% (P = 0.027). Conclusions In the acute phase after acid injury, partial liquid ventilation reduced pathologic fluid filtration. This effect started immediately after bronchial perfluorocarbon instillation and was not associated with changes in mean pulmonary artery, capillary, or airway pressures. The authors suggest that in the early phase of acid injury, reduction of fluid filtration contributes to the beneficial effects of partial liquid ventilation on gas exchange and lung mechanics.

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