scholarly journals A PROPOLIS AS A HEALING AGENT FOR PULP INJURIES

2021 ◽  
Vol 1 (2) ◽  
pp. 68-76
Author(s):  
Mirza Aryanto ◽  
Siti Nur Khairunnisa Alala
Keyword(s):  
Traditional Medicine ◽  
Biological Functions ◽  
Active Components ◽  
Pharmacological Activities ◽  
Natural Resin ◽  
Healing Agent ◽  
Anti Inflammatory ◽  
Online Library ◽  
Biological And Pharmacological Activities

As one of the natural resin materials produced by bees, propolis has been used as a traditional medicine for various diseases because of its biological and pharmacological activities. The purpose of this study was to analyze the potential of propolis as a healing agent for pulp injuries. A total of 35 journals from PubMed, Ebsco, ResearchGate, Wiley Online Library, and other international journal databases were analyzed. Propolis is very rich in active components such as flavonoids that have biological functions such as anti-inflammatory, antibacterial, antifungal and antioxidant which can act as a potential healing agent

scholarly journals Oleanane- and ursane- type triterpenoids from Eugenia grandis

2019 ◽  
Vol 18 (1) ◽  
pp. 50-57
Author(s):  
Manoharan Karuppiah Pillai ◽  
David James Young
Keyword(s):  
Spectral Data ◽  
Stem Bark ◽  
Chloroform Extract ◽  
Ayurvedic Medicine ◽  
Asiatic Acid ◽  
Pharmacological Activities ◽  
Arjunolic Acid ◽  
Anti Inflammatory ◽  
Biological And Pharmacological Activities

Arjunolic acid (an oleanane-type triterpenoid) and asiatic acid (an ursane-type triterpenoid) were obtained as an inseparable mixture from a chloroform extract of stem-bark of Eugenia grandis (Myrtaceae). They were characterised mainly by analysis of their spectral data. Arjunolic acid and asiatic acid are reported to have a variety of biological and pharmacological activities, which include antibacterial, anti-inflammatory, antioxidant, antidiabetic, antihyperlipidemic, cardiacprotective, antitumor, anticancer and hepatoprotective activities. Arjunolic acid has been used as a cardio-protective phytotonic in traditional Ayurvedic medicine for centuries.

scholarly journals Overview of Phytochemical Compounds and Pharmacological Activities of Ananas Comosus L. Merr

2020 ◽  
Vol 11 (3) ◽  
pp. 4760-4766
Author(s):  
Hartati R ◽  
Suarantika F ◽  
Fidrianny I
Keyword(s):  
Traditional Medicine ◽  
Biological Activities ◽  
Scientific Work ◽  
Ananas Comosus ◽  
Pharmacological Activities ◽  
Phytochemical Compounds ◽  
Anti Inflammatory ◽  
Vitro Analysis

Ananas comosus L. Merr, known as pineapple, belongs to the Bromeliaceae family. This plant has been used as traditional medicine and continues until now in conventional herbal medicine. The pineapple was distributed in some countries such as China, India, Indonesia, Malaysia, Thailand and originated from South America. This article delved the scientific work about Ananas comosus focussing their usage as traditional medicine, chemical compounds and biological activities. All of the pieces of information were obtained from the scientific literature such as Science Direct, Google Scholar, Scopus and PubMed. Based on the literature survey,different parts of pineapple (Ananas comosus) are used in traditional medicine, used asan anti-inflammatory agent,anti-oedema, digestive disorder, antimicrobial, vermicide, and purgative. Phytochemical compounds from A. comosus have been provided, including ascorbic acid, quercetin, flavones-3-ol, flavones, and ferulic acid. The crude extracts of A. comosus have many pharmacological activities such as anti-fungal, anti-inflammatory, antioxidant, antibacterial. This discovery becomes possible due to scientific isolation and in vivo or in vitro analysis of A.comosus.

Anti-inflammatory Agents Produced from Plant Latex

2020 ◽  
Vol 10 ◽  
Author(s):  
Bruna da Silva Souza ◽  
Mayck Silva Barbosa ◽  
Ana Clara Silva Sales ◽  
Lucas Arruda Moita ◽  
Naylla Veras de Moraes Oliveira ◽  
...  
Keyword(s):  
Traditional Medicine ◽  
Therapeutic Potential ◽  
Inflammatory Diseases ◽  
Pharmacological Activities ◽  
In Vivo Assays ◽  
Medicinal Use ◽  
Anti Inflammatory ◽  
Pharmacological Potential ◽  
Plant Latex

: Plants have been the main source of molecules for treatment of diseases through the years. They have been used in traditional medicine based on experience and practice. Many molecules from plant latex have been isolated, identified and tested for pharmacological activities, including reduction of inflammation. This review provides an overview about the latexes released from different plant species and their anti-inflammatory properties. Different in vivo and in vivo assays have been performed trying to confirm this pharmacological potential. Many studies suggest that latexes from plants have therapeutic potential to treat inflammatory diseases and support their traditional medicinal use.

Tenuigenin exhibits anti-inflammatory activity via inhibiting MAPK and NF-κB and inducing Nrf2/HO-1 signaling in macrophages

2016 ◽  
Vol 7 (1) ◽  
pp. 355-363 ◽  
Author(s):  
Hongming Lv ◽  
Wenzhi Ren ◽  
Yuwei Zheng ◽  
Lidong Wang ◽  
Gejin Lu ◽  
...  
Keyword(s):  
Chinese Herb ◽  
Inflammatory Activity ◽  
Pharmacological Activities ◽  
Polygala Tenuifolia ◽  
Anti Inflammatory ◽  
Anti Inflammation ◽  
Biological And Pharmacological Activities

Tenuigenin (TNG), isolated from the root of the Chinese herb Polygala tenuifolia, possesses various biological and pharmacological activities, including anti-oxidation and anti-inflammation activities.

scholarly journals Phytochemical characterization of essential oils from shoots, mature leaves and branchlets of Litsea elliptica (Lauraceae) collected in Brunei Darussalam

2019 ◽  
Vol 17 (2) ◽  
Author(s):  
Manoharan Karuppiah Pillai ◽  
Farazimah binti Hj Yakop ◽  
Nurzaidah binti Metussin ◽  
Malai Haniti binti Sheikh Abd Hamid ◽  
Hartini binti Hj Mohd Yasin ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Traditional Medicine ◽  
Geranyl Acetate ◽  
Pharmacological Activities ◽  
Therapeutic Applications ◽  
Mature Leaves ◽  
Brunei Darussalam ◽  
Biological And Pharmacological Activities

Essential oils from shoots, mature leaves and branchlets of Litsea elliptica were analyzed for their phytochemical compositions by GC-MS. A total of 12 compounds were identified from all three essential oils of L. elliptica.7-Decen-2-one (44.60%), 9-decen-2-ol (23.65%) and 2,7-octadienyl acetate (13.80%) were the major constituents of the essential oil from the shoots. p-Menthan-8-ol, (18.57%), 7-decen-2-one (10.62%), 9-decen-2-ol (25.09%) and α-terpineol (34.54%) were the major constituents of the essential oil from the mature leaves. Geranyl acetate (58.51%) and α-terpineol (20.95%) were the major constituents of the essential oil from the branchlets. L. elliptica has therapeutic applications in traditional medicine. Essential oils and/or extracts from various parts of this plant are reported to have promising biological and pharmacological activities.

scholarly journals Bioactive Compounds from Zingiber montanum and Their Pharmacological Activities with Focus on Zerumbone

2021 ◽  
Vol 11 (21) ◽  
pp. 10205
Author(s):  
Hari Prasad Devkota ◽  
Keshav Raj Paudel ◽  
Md. Mahadi Hassan ◽  
Amina Ibrahim Dirar ◽  
Niranjan Das ◽  
...  
Keyword(s):  
Essential Oils ◽  
Bioactive Compounds ◽  
Antioxidant Activities ◽  
Scientific Information ◽  
Pharmaceutical Products ◽  
Active Components ◽  
Pharmacological Activities ◽  
Traditional Medicines ◽  
Anti Inflammatory ◽  
Promising Source

The genus Zingiber consists of about 85 species and many of these species are used as food, spices, and medicines. One of the species, Zingiber montanum (J. Koenig) Link ex A. Dietr. is native to Southeast Asia and has been extensively used as traditional medicines and food. The aim of this review was to collect and critically analyze the scientific information about the bioactive compounds and pharmacological activities of Z. montanum with focus on one of the main components, zerumbone (ZER). Various studies have reported the analysis of volatile constituents of the essential oils from Z. montanum. Similarly, many phenylbutanoids, flavonoids and terpenes were also isolated from rhizomes. These essential oils, extracts and compounds showed potent antimicrobial, anti-inflammatory and antioxidant activities among others. Zerumbone has been studied widely for its anticancer, anti-inflammatory, and other pharmacological activities. Future studies should focus on the exploration of various pharmacological activities of other compounds including phenylbutanoids and flavonoids. Bioassay guided isolation may result in the separation of other active components from the extracts. Z. montanum could be a promising source for the development of pharmaceutical products and functional foods.

scholarly journals Screening Anti-Inflammatory Effects of Flavanones Solutions

2021 ◽  
Vol 22 (16) ◽  
pp. 8878
Author(s):  
Paola Bustos-Salgado ◽  
Berenice Andrade-Carrera ◽  
Valeri Domínguez-Villegas ◽  
Natalia Díaz-Garrido ◽  
María J. Rodríguez-Lagunas ◽  
...  
Keyword(s):  
Traditional Medicine ◽  
Computational Study ◽  
Kidney Diseases ◽  
Experimental Models ◽  
Biologically Active ◽  
Active Components ◽  
Ear Edema ◽  
Tetradecanoylphorbol Acetate ◽  
Anti Inflammatory

There are a large number of remedies in traditional medicine focused on relieving pain and inflammation. Flavanones have been a potential source in the search for leading compounds and biologically active components, and they have been the focus of much research and development in recent years. Eysenhardtia platycarpa is used in traditional medicine for the treatment of kidney diseases, bladder infections, and diabetes mellitus. Many compounds have been isolated from this plant, such as flavones, flavanones, phenolic compounds, triterpenoid acids, chalcones, sugars, and fatty acids, among others. In this paper, natural flavanone 1 (extracted from Eysenhardtia platycarpa) as lead compound and flavanones 1a–1d as its structural analogues were screened for anti-inflammatory activity using Molinspiration® and PASS Online in a computational study. The hydro alcoholic solutions (FS) of flavanones 1, 1a–1d (FS1, FS1a–FS1d) were also assayed to investigate their in vivo anti-inflammatory cutaneous effect using two experimental models, a rat ear edema induced by arachidonic acid (AA) and a mouse ear edema induced by 12-O-tetradecanoylphorbol acetate (TPA). Histological studies and analysis of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 were also assessed in AA-inflamed rat ear tissue. The results showed that the flavanone hydro alcoholic solutions (FS) caused edema inhibition in both evaluated models. This study suggests that the evaluated flavanones will be effective when used in the future in skin pathologies with inflammation, with the results showing 1b and 1d to be the best.

scholarly journals Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update

2021 ◽  
Vol 12 ◽  
Author(s):  
Yiping Lin ◽  
Yuke Li ◽  
Yuanlian Zeng ◽  
Bin Tian ◽  
Xiaolan Qu ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Antitumor Activity ◽  
Molecular Mechanisms ◽  
Antibacterial Activities ◽  
Active Components ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Japanese Herbal Medicine ◽  
Pharmacological Data ◽  
Anti Inflammatory

Magnolol (MG) is one of the primary active components of Magnoliae officinalis cortex, which has been widely used in traditional Chinese and Japanese herbal medicine and possesses a wide range of pharmacological activities. In recent years, attention has been drawn to this component due to its potential as an anti-inflammatory and antitumor drug. To summarize the new biological and pharmacological data on MG, we screened the literature from January 2011 to October 2020. In this review, we provide an actualization of already known anti-inflammatory, cardiovascular protection, antiangiogenesis, antidiabetes, hypoglycemic, antioxidation, neuroprotection, gastrointestinal protection, and antibacterial activities of MG. Besides, results from studies on antitumor activity are presented. We also summarized the molecular mechanisms, toxicity, bioavailability, and formulations of MG. Therefore, we provide a valid cognition of MG.

Contemporary Progress in the Synthetic Strategies of Imidazole and its Biological Activities

2020 ◽  
Vol 16 (8) ◽  
pp. 1078-1104 ◽  
Author(s):  
Jay Soni ◽  
Ayushi Sethiya ◽  
Nusrat Sahiba ◽  
Dinesh K. Agarwal ◽  
Shikha Agarwal
Keyword(s):  
Aromatic Compound ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Environmentally Friendly ◽  
Biological Profile ◽  
Pharmacological Activities ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Biological And Pharmacological Activities

: Heterocyclic compounds are pervasive in many areas of life and one of the heterocycles, imidazole is a unique heterocyclic five-membered aromatic compound having two sp2 hybridized nitrogen atoms. Its integral name is 1, 3 diazole and previously, it was known as glyoxalin. This moiety has achieved a considerable place among scientists in recent years by reason of its divergent synthetic strategies and uncommon biological and pharmacological activities, for example, anti-convulsant, anti-microbial, anti-cancer, anti-inflammatory, anti-tumor, anti-viral, anti-ulcer, analgesic, etc. Due to distinct therapeutic actions, it is still an engrossed area of research. Researchers currently are inventing new greener methods to synthesize its derivatives and to improve its pharmacological activities. The purpose of this review is to study the literature that can help researchers to explore this area, its prevailing program for synthesis in environmentally friendly conditions and biological profile throughout past decades.

scholarly journals A novel fermented Yi traditional medicine efficiently suppresses the replication of SARS-CoV-2 in vitro

2020 ◽  
Author(s):  
Shisong Fang ◽  
Benhong Xu ◽  
Xiangrong Song ◽  
Wukun Liu ◽  
Yongmei Xie ◽  
...  
Keyword(s):  
Traditional Medicine ◽  
Global Economy ◽  
Antioxidant Activities ◽  
Fermentation Broth ◽  
Selection Index ◽  
Active Components ◽  
Anti Inflammatory ◽  
Crude Polysaccharide ◽  
Fermentation Technology

AbstractCurrently, the coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a worldwide epidemic, causing more than 80 million infections and more than 1.7 million deaths. The pandemic has led to the closure of enterprises and schools in many countries, resulting in serious disruption of the global economy and social activities. Remdesivir is currently approved by the FDA for the treatment of COVID-19, but the WHO declared that Remdesivir is almost ineffective against COVID-19. The research and development of vaccines has made great progress, but it will take at least several months for safe and effective vaccines to be widely used clinically. Clinical studies revealed that some Traditional Chinese Medicines, such as Lianhua Qingwen Capsule and Huoxiang Zhengqi Water, exhibited excellent therapeutic effect on COVID-19. However, until now, there is still no cure for COVID-19. Therefore, there is an urgent need to find medicines that can effectively fight against the SARS-CoV-2. In this study, JIE BEN No. 10 (JB10), a fermentation broth produced by Yi traditional medicine fermentation technology, was explored for its anti-coronavirus activity. The in vitro data showed that JB10 could significantly suppresses the replication of the SARS-CoV-2 with an EC50 of 769.1 times dilution and a selection index of 42.68. Further studies indicated that JB10 had significant anti-inflammatory and antioxidant activities. The analysis of active components suggested that JB10 contained a large amount of superoxide dismutase (SOD), flavones, polyphenols, crude polysaccharide, etc. which may explain the anti-coronavirus activity, anti-inflammatory and antioxidant effects. Our study provides a new potentially therapeutic strategy for COVID-19.

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