scholarly journals Metabolic Syndrome—Role of Dietary Fat Type and Quantity

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1438 ◽  
Author(s):  
Peter Clifton
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Dietary Fat ◽  
Saturated Fat ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Fasting Insulin ◽  
Polyunsaturated Fat ◽  
Monounsaturated Fat ◽  
The Impact

Background: Metabolic syndrome increases the risk of cardiovascular disease (CVD) over and above that related to type 2 diabetes. The optimal diet for the treatment of metabolic syndrome is not clear. Materials and Methods: A review of dietary interventions in volunteers with metabolic syndrome as well as studies examining the impact of dietary fat on the separate components of metabolic syndrome was undertaken using only recent meta-analyses, if available. Results: Most of the data suggest that replacing carbohydrates with any fat, but particularly polyunsaturated fat, will lower triglyceride(TG), increase high density lipoprotein (HDL) cholesterol, and lower blood pressure, but have no effects on fasting glucose in normal volunteers or insulin sensitivity, as assessed by euglycemic hyperinsulinemic clamps. Fasting insulin may be lowered by fat. Monounsaturated fat (MUFA) is preferable to polyunsaturated fat (PUFA) for fasting insulin and glucose lowering. The addition of 3–4 g of N3 fats will lower TG and blood pressure (BP) and reduce the proportion of subjects with metabolic syndrome. Dairy fat (50% saturated fat) is also related to a lower incidence of metabolic syndrome in cohort studies.

Dietary fat intake, body composition and blood lipids of university men and women

2012 ◽  
Vol 21 (3) ◽  
pp. 173-185 ◽  
Author(s):  
Marita M Neville ◽  
J Geppert ◽  
Y Min ◽  
G Grimble ◽  
Michael A Crawford ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Composition ◽  
Dietary Fat ◽  
Saturated Fat ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Men And Women

Background: Cardiovascular disease rates are high in the UK, particular in men, and are related to dietary fat intake. We conducted a pilot study to investigate relationships between saturated and unsaturated dietary fat intakes, body composition and blood lipid parameters in Caucasian men and women at university. Methods: Volunteers (52 men and 52 women; age range 20–50 years) were recruited from staff and students of London Metropolitan University. Dietary intake, body composition, blood pressure and fasting blood glucose and lipids were assessed. Gender differences between the measured variables and their relationships were assessed by Mann–Whitney U-test, and by multi-linear (stepwise) regression, respectively. Results: Men consumed more saturated fat (29.5 vs 20.5 g/day, p < 0.001), and had elevated levels of glucose (5.34 + 0.74 vs 4.85 + 0.49 mmol/l, p < 0.001), low-density lipoprotein (LDL) cholesterol (2.99 + 1.5 vs 2.62+ 0.74 mmol/l, p < 0.05), systolic blood pressure (126.4 + 11.0 vs 112.6 + 17.2 mm/Hg, p < 0.001), and lower high-density lipoprotein (HDL) cholesterol (1.41 ± 0.34 vs 1.83 ± 0.43, p < 0.001). Saturated fat was positively associated with total body fat (  p < 0.05), trunk fat (  p < 0.001), HDL cholesterol (  p < 0.05) and systolic blood pressure (  p < 0.001) in women, while in men docosahexaenoic acid and total cholesterol (  p < 0.05), total omega-3 fatty acids and LDL cholesterol (  p < 0.001), total omega-3 fatty acids and triglycerides (  p < 0.01) were positively related. Similar n-3 fatty acid intakes were reported in nutritionally aware students and other university subjects. Conclusions: The data of this study indicate gender-related differences in response to dietary fat, and widespread low compliance with n-3 fatty acid recommendations. Although the men are highly health conscious and physically active, their blood lipid levels are indicative of a risk of cardiovascular disease. In addition to enhanced nutritional education to increase seafood intakes in this age group of men and women, customised dietary and lifestyle advice may be required in the men.

scholarly journals Dietary fat modifications and blood pressure in subjects with the metabolic syndrome in the LIPGENE dietary intervention study

2010 ◽  
Vol 104 (2) ◽  
pp. 160-163 ◽  
Author(s):  
Hanne L. Gulseth ◽  
Ingrid M. F. Gjelstad ◽  
Audrey C. Tierney ◽  
Danielle I. Shaw ◽  
Olfa Helal ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Dietary Fat ◽  
Dietary Intervention ◽  
Saturated Fat ◽  
Monounsaturated Fat ◽  
High Fat ◽  
Pufa Supplementation ◽  
The Metabolic Syndrome ◽  
Dietary Intervention Trial

Hypertension is a key feature of the metabolic syndrome. Lifestyle and dietary changes may affect blood pressure (BP), but the knowledge of the effects of dietary fat modification in subjects with the metabolic syndrome is limited. The objective of the present study was to investigate the effect of an isoenergetic change in the quantity and quality of dietary fat on BP in subjects with the metabolic syndrome. In a 12-week European multi-centre, parallel, randomised controlled dietary intervention trial (LIPGENE), 486 subjects were assigned to one of the four diets distinct in fat quantity and quality: two high-fat diets rich in saturated fat or monounsaturated fat and two low-fat, high-complex carbohydrate diets with or without 1·2 g/d of very long-chain n-3 PUFA supplementation. There were no overall differences in systolic BP (SBP), diastolic BP or pulse pressure (PP) between the dietary groups after the intervention. The high-fat diet rich in saturated fat had minor unfavourable effects on SBP and PP in males.

scholarly journals Impact of the Level of Adherence to Mediterranean Diet on the Parameters of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Observational Studies

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1514
Author(s):  
Dimitra Rafailia Bakaloudi ◽  
Lydia Chrysoula ◽  
Evangelia Kotzakioulafi ◽  
Xenophon Theodoridis ◽  
Michail Chourdakis
Keyword(s):  
Metabolic Syndrome ◽  
Mediterranean Diet ◽  
Observational Studies ◽  
Positive Impact ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Central Registry ◽  
High Adherence ◽  
The Impact

High adherence to the Mediterranean diet (MD) has been associated with a lower prevalence of Metabolic Syndrome (MetS). The present study aimed to investigate the impact of MD adherence on parameters of MetS. A systematic literature search was performed in PubMed, Cochrane Central Registry of Clinical Trials (CENTRAL), Scopus, EMBASE, Web of Science and Google Scholar databases. Observational studies that recorded adherence to MD and components/measures of the MetS, such as waist circumference (WC), blood pressure (BP), fasting blood glucose (FBG), high-density lipoprotein (HDL) cholesterol and triglycerides (TG), were included in this study. A total of 58 studies were included in our study. WC and TG were significantly lower in the high adherence MD group (SMD: −0.20, (95%CI: −0.40, −0.01), SMD: −0.27 (95%CI: −0.27, −0.11), respectively), while HDL cholesterol was significantly higher in the same group (SMD: −0.28 (95%CI: 0.07, 0.50). There was no difference in FBG and SBP among the two groups (SMD: −0.21 (95%CI: −0.54, 0.12) & SMD: −0.15 (95%CI: −0.38, 0.07), respectively). MD may have a positive impact on all parameters of MetS. However, further research is needed in this field.

scholarly journals Dietary Fat and Protein Intakes in Relation to Plasma Sphingolipids As Determined by a Large-Scale Lipidomic Analysis

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 861-861
Author(s):  
Jowy Seah Yi Hoong ◽  
Wee Siong Chew ◽  
Federico Torta ◽  
Chin Meng Khoo ◽  
Markus R Wenk ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Dietary Fat ◽  
Large Scale ◽  
Saturated Fat ◽  
Dietary Fatty Acids ◽  
Fat Intake ◽  
Polyunsaturated Fat ◽  
Nutrient Intakes ◽  
The Impact ◽  
Long Chain

Abstract Objectives Sphingolipid concentrations have been associated with risk of type 2 diabetes and cardiovascular diseases. Because sphingolipids can be synthesized de novo from saturated fatty acids (SFA), dietary fatty acids may affect plasma sphingolipid concentrations. We aimed to evaluate dietary fat and protein intakes in relation to circulating sphingolipid levels. Methods We used cross-sectional data from 2860 ethnic Chinese Singaporeans collected from 2004–2007. Nutrient intakes were estimated on the basis of a validated 159-item food frequency questionnaire. We quantified 79 molecularly distinct sphingolipids in a large-scale lipidomic evaluation from plasma samples. Results Higher saturated fat intake was associated with higher concentrations of 16:1; O2 sphingolipids including ceramides, monohexosylcermides, dihexosylceramides, sphingomyelins, and sphingosine 1-phosphates. Higher polyunsaturated fat intake was associated with lower plasma long-chain ceramides and long-chain monohexosylcermide concentrations. Protein intake was inversely associated with concentrations of most subclasses of sphingolipids, with the exception of sphingolipids containing a 16:1; O2 sphingoid base. Lower intake of saturated fat and higher intake of polyunsaturated fat and protein may decrease plasma concentrations of several sphingolipid classes. Conclusions These findings may represent a novel biological mechanism for the impact of nutrient intakes on cardio-metabolic health. Funding Sources This work was supported by the National Research Foundation Investigatorship grant (NRF-NRFI2015–05, to MRW), A*STAR (I1901E0040), and the National University Health System (NUHSRO/2014/085/AF-Partner/01, DRH). FT was supported by the NRF and A*STAR IAF-ICP I1901E0040.

Dietary Approaches to Stop Hypertension (DASH): potential mechanisms of action against risk factors of the metabolic syndrome

2019 ◽  
Vol 33 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Masoumeh Akhlaghi
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Saturated Fat ◽  
Hdl Cholesterol ◽  
Reduce Blood Pressure ◽  
Overweight And Obesity ◽  
Cross Sectional ◽  
Dash Diet ◽  
The Metabolic Syndrome

AbstractThe metabolic syndrome is a cluster of disorders dominated by abdominal obesity, hypertriacylglycerolaemia, low HDL-cholesterol, high blood pressure and high fasting glucose. Diet modification is a safe and effective way to treat the metabolic syndrome. Dietary Approaches to Stop Hypertension (DASH) is a dietary pattern rich in fruits, vegetables and low-fat dairy products, and low in meats and sweets. DASH provides good amounts of fibre, K, Ca and Mg, and limited quantities of total fat, saturated fat, cholesterol and Na. Although DASH was initially designed for the prevention or control of hypertension, using a DASH diet has other metabolic benefits. In the present review, the effect of each dietary component of DASH on the risk factors of the metabolic syndrome is discussed. Due to limited fat and high fibre and Ca content, individuals on the DASH diet are less prone to overweight and obesity and possess lower concentrations of total and LDL-cholesterol although changes in TAG and HDL-cholesterol have been less significant and available evidence in this regard is still inconclusive. Moreover, high amounts of fruit and vegetables in DASH provide great quantities of K, Mg and fibre, all of which have been shown to reduce blood pressure. K, Mg, fibre and antioxidants have also been effective in correcting glucose and insulin abnormalities. Evidence is provided from cross-sectional investigations, cohort studies and randomised controlled trials, and, where available, from published meta-analyses. Mechanisms are described according to human studies and, in the case of a lack of evidence, from animal and cell culture investigations.

scholarly journals Comparison of the Effects of Brazil Nut Oil and Soybean Oil on the Cardiometabolic Parameters of Patients with Metabolic Syndrome: A Randomized Trial

Nutrients ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 46 ◽  
Author(s):  
Lívia Martins Costa e Silva ◽  
Maria Luisa Pereira de Melo ◽  
Fernando Vinicius Faro Reis ◽  
Marta Chagas Monteiro ◽  
Savio Monteiro dos Santos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Soybean Oil ◽  
Stress Reduction ◽  
Cardiovascular Health ◽  
Low Density Lipoprotein ◽  
Saturated Fat ◽  
Density Lipoprotein ◽  
Brazil Nut ◽  
Unsaturated Fat

Recent evidence suggests that replacing saturated fat with unsaturated fat is beneficial for cardiovascular health. This study compared the effects of Brazil nut oil (BNO) and soybean oil (SO) supplementation for 30 days on anthropometric, blood pressure, biochemical, and oxidative parameters in patients with metabolic syndrome (MS). Thirty-one patients with MS were randomly allocated to receive 30 sachets with 10 mL each of either BNO (n = 15) or SO (n = 16) for daily supplementation. Variables were measured at the beginning of the study and after 30 days of intervention. No change in anthropometric and blood pressure variables were observed (p > 0.05). Total (p = 0.0253) and low-density lipoprotein (p = 0.0437) cholesterol increased in the SO group. High-density lipoprotein cholesterol decreased (p = 0.0087) and triglycerides increased (p = 0.0045) in the BNO group. Malondialdehyde levels decreased in the BNO group (p = 0.0296) and total antioxidant capacity improved in the SO group (p = 0.0110). Although the addition of oils without lifestyle interventions did not affect anthropometric findings or blood pressure and promoted undesirable results in the lipid profile in both groups, daily supplementation of BNO for 30 days decreased lipid peroxidation, contributing to oxidative stress reduction.

scholarly journals Prevalence of metabolic syndrome and the association with sociodemographic characteristics in adult population of Banja Luka

2018 ◽  
Vol 75 (5) ◽  
pp. 447-452
Author(s):  
Verica Petrovic ◽  
Gordana Tesanovic ◽  
Ljiljana Stanivuk
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Adult Population ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Sociodemographic Characteristics ◽  
Level Of Education ◽  
Significant Difference ◽  
Banja Luka

Background/Aim. Metabolic syndrome (MS) is a cluster of metabolic and hemodynamic disorders that increase the risk of developing atherosclerotic cardiovascular diseases and type 2 diabetes mellitus. The aim of this study was to determine the prevalence of MS and its components in adult population of Banja Luka and association with sociodemographic characteristics. Methods. A total of 685 participants (348 men and 337 women), aged 18 years and over, were analyzed. The diagnosis of the MS was based on definition set by the International Diabetes Federation (IDF). Results. The prevalence of the MS was high (37.5%), slightly higher in women (38.3%) than in men (36.8%), but without statistically significant difference (p = 0.686). Prevalence of each individual component of the MS in the study group was over 30% (systolic blood pressure ? 130 mmHg ? 42.0%; diastolic blood pressure ? 85 mmHg ? 31.0%; triglycerides ? 1.7 mmol/L ? 36.1%; high density lipoprotein (HDL) cholesterol ? 1.03 for men and ? 1.29 for women ? 31.2%; glucose ? 5.6 mmol/L ? 32.8%; central obesity ? 94 cm male and ? 80 cm female ? 62.6%). The prevalence of the MS was not associated with gender, but with age. A number of participants increased with incresed age in the group with the MS with statistically significant difference compared to the group without the MS. The study showed an association between level of education and the MS. Low level of education was associated with the appearance of the MS with statistically significant differences (df = 3; p = 0.013). Association between level of education and the MS was shown in women (df = 3; p = 0.000), but not in men (df = 3; p = 0.883). Retirees and housewives were significantly present in the group with the MS, students and unemployed in the group without the MS, while employed participants showed no statistically significant difference. Conclusion: The MS was diagnosed in over one-third of adults in Banja Luka. Prevalence of MS was not associated with gender, but it was associated with age, level of education as well as with some categories of employment.

scholarly journals Assessment of Biological Parameters that (Influence) Affect the Quality of Life in a Group of Patients with Metabolic Syndrome

2021 ◽  
Vol 26 (3) ◽  
pp. 18-23
Author(s):  
Ovidiu Boitor ◽  
Laura Ștef ◽  
Gabriela Boţa ◽  
Romeo Mihăilă
Keyword(s):  
Quality Of Life ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Age Groups ◽  
Hdl Cholesterol ◽  
Biological Data ◽  
Age Group ◽  
Low Hdl ◽  
The Impact

Abstract The study included a group of 42 patients with metabolic syndrome and 32 patients without metabolic syndrome. The following biological data: BMI, blood pressure, type 2 diabetes, low HDL cholesterol levels were statistically compared using the ANOVA test. To assess the impact on quality of life, patients in both groups completed the EQ-5D-3L questionnaire. To verify the statistical confirmation of the results we used the Chi 2 test. In order to correlate the results with the gender and age of the patients, we formed the following age groups 45-54 years, 55-64 years, 65-74 years and over 75 years. We found that the dimensions that affect the quality of life differ depending on the age group as follows: in the 55-64 age group pain / discomfort predominates p = 0.009 and in the 65-74 age group the mobility and self-care dimensions p = 0.043 predominate. We did not obtain statistical confirmation by the Chi 2 test in patients with metabolic syndrome and the variable blood pressure Chi 2 = 5.27 and p = 0.072

scholarly journals Relation between circulating oxidized-LDL and metabolic syndrome in children with obesity: the role of hypertriglyceridemic waist phenotype

2017 ◽  
Vol 30 (12) ◽  
Author(s):  
Valeria Calcaterra ◽  
Rachele De Giuseppe ◽  
Ginevra Biino ◽  
Melissa Mantelli ◽  
Sonia Marchini ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Oxidative Damage ◽  
Oxidized Ldl ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Normal Weight ◽  
Obese Children ◽  
Hypertriglyceridemic Waist ◽  
Hypertriglyceridemic Waist Phenotype

AbstractBackground:The association between oxidative stress (OS) and metabolic syndrome (MetS) has been reported in adults. We analyzed the relation between circulating oxidized low-density lipoproteins (Ox-LDL) and MetS in pediatric ages in order to define whether plasma Ox-LDL levels are correlated to obesity and whether oxidative damage, using serum Ox-LDL levels as a proxy, are associated with MetS.Methods:We enrolled 178 children (11.8±2.6 years). On the basis of a body mass index (BMI) threshold, the subjects were classified as: normal weight BMI <75th percentile; overweight BMI 75–97th percentile; obese BMI >97th percentile. Patients were classified as having MetS if they met three or more of the following criteria for age and sex: BMI >97th percentile, triglyceride levels >95th percentile, high-density lipoprotein (HDL) cholesterol level <5th percentile, systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) >95th percentile and impaired glucose tolerance.Results:Obese children showed increased MetS prevalence (p=0.001) and higher Ox-LDL levels compared to normal- and overweight subjects (p<0.05), with a limited relation between Ox-LDL and MetS (p=0.06). Waist-to-height ratio (W/HtR) (p=0.02), triglycerides (TG) (p=0.001) and LDL-cholesterol (p<0.001) resulted independent predictors of increased plasma Ox-LDL levels.Conclusions:Oxidative damage was correlated with a hypertriglyceridemic waist phenotype and can be a precocious marker of MetS and cardiometabolic risk in obese children.

scholarly journals A case-control study to find out the prevalence of metabolic syndrome in patients with psoriasis as compared to age and sex matched controls

2021 ◽  
Author(s):  
Shilpa Patwekar ◽  
Nitin Chaudhari ◽  
Chandrakant B. Poulkar ◽  
Swapna S. Khatu ◽  
Abhishek S. Patokar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Sugar ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Severity Index ◽  
Case Control ◽  
Fasting Blood Sugar ◽  
Control Study

<p><strong>Background: </strong>Psoriasis is an immune mediated chronic inflammatory dermatosis and it is associated with high risk of cardiovascular events. Aim of the study was to estimate the prevalence of metabolic syndrome and its association with disease severity in patients with psoriasis.</p><p><strong>Methods:</strong> This was a case control study which included 150 cases of chronic plaque psoriasis and 150 healthy controls. All subjects underwent detailed history and clinical examination including measurement of blood pressure and waist circumference and psoriasis area and severity index (PASI) score. Fasting blood sugar, triglyceride, cholesterol, and high-density lipoprotein cholesterol levels were tested following overnight fasting. Various parameters of metabolic syndrome were compared in two groups using chi square test and fisher’s exact test. Statistical analysis of the data was done using epi-info <sup>TM</sup> software.</p><p><strong>Results:</strong> Prevalence of metabolic syndrome was more common in patients of psoriasis than in control (56.67% vs. 17.33%; p&lt;0.0001). Psoriatic patients had higher prevalence of abdominal obesity (57.33% vs. 27.33%; p=0.0037), elevated blood pressure (32% vs. 12%; p=0.0001), elevated fasting blood sugar level (62% vs. 22%; p&lt;0.0001), hypertriglyceridemia (44.66% vs. 32%; p=0.0326), low level of HDL cholesterol (64% vs. 21.33%; p&lt;0.0001 and alcohol abuse (22.22% vs. 14.66%; p=0.0154).</p><p><strong>Conclusions:</strong> The findings in our study demonstrated a robust association between psoriasis and metabolic syndrome and its components, irrespective of psoriasis severity.</p>

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